summaries of commercialization stories of russian ips

Overview of High-Technology Projects

Facilitated by the U.S. Industry Coalition

Reflecting a 15 year history of success in guiding industry partners through

technology commercialization projects

United States Industry Coalition, Inc.

Projected/Current Sales:TBD

Commercialization:2003-2004

VECTOR

Koltsovo, Russia

Pacific NorthwestNational Laboratory

Richland, WAAgraQuest, Inc.

Davis, CA

Nematode Biocontrol Agentfor Agriculture

• Soil-borne nematodes (worms)attack agricultural/horticulturalplant roots- Est. 1/4 all plant-grown products in

the world are ruined

• Synthetic chemical controls areextremely toxic to humans,wildlife, and non-targetbeneficial insects

• New fungal biopesticide ispotential alternative treatment- Russians will produce fungal

strains; test against variouseconomically-importantnematodes; collect baselineFDA data

• Goal to have new biocontrolagent on global market within2 years of testing

PNNL

4/2003


Experimental Plant for D&M ofScientific Equipment

Chernogolovka, RussiaPacific Northwest National Laboratory

Richland, WANewark, DE

Computer-aided Discoveryand Development of

Crop Protection Agents

• U.S./Russian Partners aresearching for novel, biologicallyactive chemical compoundseffective as crop protectionagents.

• Areas under study include:- Plant, insect, fungi, biology- Computational chemistry

- Computer-aided molecular analysis

• Goal to improve productionsystems for food, feed, andfiber.

4/2005

Commercialization Started


Institute of ImmunologicalEngineering

Moscow, Russia

Pacific NorthwestNational Laboratory

Richland, WA

New HorizonsDiagnostics Corporation

Columbia, MD

Anti-body Based Therapies forAutoimmune Diseases and Inflammation

• Cytokines are anti-bodies responsible forregulating immune response in humans

• When overproduced, cytokines triggerserious autoimmune diseases

• Cytokines are implicated in theinflammation process in exposure toMustard and other Agents

• Cytokine-blocking therapies have beenshown in trials in the US and Russia to beeffective in treating devastating illnessessuch as:- Rheumatoid and psoriatic arthritis- Multiple sclerosis- Schizophrenia- HIV

• Project goal to develop improved antibodyand address lingering concerns about thecurrent generation of therapies including:- High cost and yield of production- High incidence of adverse reactions in patients

requiring multiple rounds of therapy

3/2006


Advanced Biotherapy, Inc.

Woodland Hills, CA


Lebedev Physical Institute

Moscow, RussiaLawrence Livermore National Laboratory

Livermore, CAValley Forge Composite Technologies

King of Prussia, PA

Advanced Explosive DetectionSystem (EDS)

• Nanotechnology-based EDS detects contraband atmolecular levels- microbursts of gamma rays produce nano-photonuclear

reactions

- illegal substances produce unique signature, allowing system’sdetectors to identify both detailing chemical composition andquantity

• Expandable database allows EDS system to detect &identify explosives; nuclear materials; chemical orbiological agents; illegal drugs; other hazardouscontraband

• Miniature high-energy accelerator penetrates allbarriers- Examines cargo containers, airline passenger baggage, air/land/

sea shipments- Able to penetrate concealment media – water, concrete, steel

• Cost savings realized with automated operation,increased accuracy, lower energy consumption

• System expected to yield unsurpassable detectionrates and faster processing speeds- Triples rate of baggage screening compared to current systems- Eliminates false positives

11/2004


State Rocket Center,Makeyev Design Bureau

Miass, Russia

Lawrence BerkeleyNational Laboratory

Berkeley, CAEmpire Magnetics, Inc.

Rohnert Park, CA

Low-Maintenance WindPower System

• Multi-billion dollar wind powergeneration industry growingin popularity- Need to reduce CO2 emissions- Need to generate electricity cost-

effectively in remote locations forranchers, farmers, villages, deep-wellsurvival

• Small (3-70 kW) wind power systemuses novel Vertical Axis WindTurbine (VAWT) design

• VAWT offers advantages overconventional Horizontal AxisWind Turbine- Lower maintenance costs- Increased durability and reliability- More economically viable in remote

locations

7/2003


Kurchatov Institute of Atomic Energy

Moscow, RussiaBrookhaven National Laboratory

Upton, NYFlowserve Corporation

Los Angeles, CA

Advanced Centrifugal Pumps• Energy, petroleum, chemical, and water

service industries rely on centrifugalpumps

• Current pumps experiencing stress onmechanical system when operating underoff-design conditions

• New advanced centrifugal pumps willincrease equipment reliability by reducinghydraulic forces over a broad flow range- New horizontal multistage pumps with very low

axial thrust variation with flow rate

- New horizontal overhung and between-bearingpumps with excellent shaft and bearing housingvibration signatures

- New higher speed vertical water circulatingpumps

• Advanced centrifugal pumps will operatefor long periods of time underchallenging conditions withoutcorresponding increase in life cycle cost

7/2004


VNIIEF

Sarov, RussiaNNSA Kansas City Plant

Kansas City, MOMillennium Technologies Inc

Kansas City, MO

Deep Sea Probe for Oil Exploration• Petroleum industry needs a rapid, low-cost device

to find offshore oil by analyzing water & coresamples collected from deep ocean floor.

• Accurate analysis will allow industry to tap vastreserves of hydrocarbons, including frozenmethane in seabed sediment.

• Other applications include sea-floor mining,environmental and biodiversity surveys

• Analysis requires a deep sea probe that:- Operates at depths up to 12,000 feet- Easily deployed worldwide- Is wireless and self-contained- Requires less than 4 hours to retrieve sample- Is capable of collecting sealed core and interstitial

water sample- Is resistant to seawater corrosion, extreme environments

• Project goal to design and commercialize a deepsea probe that can retrieve samples at a cost ofless $1,000 per work cycle and that meets theabove requirements.

• Russian personnel will contribute technicalexpertise and knowledge of specialty state-of-the-art materials able to withstand high pressures

5/2006


JSC Biochimmash

Moscow, Russia

Pacific Northwest NationalLaboratory

Richland, WADye Seed Ranch

Pomeroy, WA

Microbes for Oil PollutionDecontamination

• Widespread oil pollution is urgent globalenvironmental concern

• Environment-friendly, economical biologicalapproach relies on microbes able tosurvive, compete and metabolize oil-basedhydrocarbons

• Russian partner has isolated 4microorganisms with high efficiency for bio-remediation of water surfaces and differentsoils

• Field trials indicate microbial persistence insoil with continued hydrocarbondegradation, allowing re-vegetation within ayear in the regions with warm and wetspring/summer seasons and 2-3 years inarid zones

• Conventional clean-up methods sometimesaggravate ecological problems; costs rangefrom $500-$5,000 per acre

• Biological treatment costs expected to beonly $200-$400 per acre

5/2004


Institute of Chemical Meansof Plant Protection

Moscow, Russia

Oak RidgeNational Laboratory

Oak Ridge, TNStable Earth Technology

Louisville, KY

Brown Coal Source of HumicAcid for Soil Remediation at

Contaminated Sites

• Inexpensive brown coalprocessed to derive unique formof humic acid- Similar to humus formed naturally, but

concentrated to produce uniqueproperties

• Application for soil remediation incontaminated areas- Binds heavy metals and radionuclides- Demonstrated effective for PCB

remediation- Improves soil for agriculture- Prevents the uptake of contaminants

into grass or crops

• Commercialized technologyalready in production- Stabilite is trade name in U.S. market- Humosorb is trade name in Russia

5/2004

Electro-Physical &Acoustic Technologies, Ltd.

Moscow, Russia


Y-12

Oak Ridge, TN


Pacific Northwest National Laboratory

Richland, WA

Advanced Pesticides forImproved Crop Production

• Agricultural productivity in both Russiaand U.S. is diminished due to pestsand diseases- Colorado potato beetle- Potato blight- European corn borer- Apple worm and moth- Soil nematodes

• Project will develop new pesticidesand bio-control applications based onSoviet era research in strategic bio-weapons for crop destruction

• Pre-1990 research will form basis ofnew efforts to increase crop qualityand production in both countries

• Improved pest control technologies willalso enable Russia to be more self-sufficient and to expand its agriculturalexport market

4/2006

Western-Ag Resources, Inc.

Kennewick, WA

All Russian Institute of BiologicalPlant Protection (ARRIBPP)

Krasnodar, Russia


Institute of Physics andPower Engineering

Obninsk, Russia

Lawrence BerkeleyNational Laboratory

Berkeley, CAGeneral Atomics

San Diego, CA

Neutronics Computational Toolsfor Medicine and Industry

• Actual WMD technologies adapted to life-savingprocedures- Nuclear particle transport code combined with nuclear &

atomic interaction databases results in 3-dimensionalneutronics algorithm

- New computational tool is accurate, fast, highly-reliable,cost-effective

• Immediate medicalapplication- Enhanced boron neutron

capture therapy computestumor dose more accurately,economically

- Computation engine intabletop computer allowsfaster treatment/therapyplanning for cancer patients

• Potential industrial applications include neutronbeam lines for fission reactors; industrial materialprocessing; anti-terrorist/explosives detection

7/2003


SPEKTR-Conversion

Snezhinsk, RussiaKansas City Plant

Kansas City, MOKirkham Motorsports

Provo, UT

Custom AutomotiveComponent Manufacturing

• Cobra 427 S/C was popular 1960’sroadster

• U.S. firm developed Cobra replica kits

• Russian high-tech weaponsmanufacturer will produce specialtycomponents for S/C kits- titanium and stainless steel mechanical

parts

• Russian expertise will be combinedwith U.S. quality control practices- forging, casting, welding, and metal joining

• Growing U.S. and world marketdemand for customized, collectibleautomobiles- long-term goal to position Russian facility

to attract large automotive after-market

4/2005



TexMet Scientific andManufacturing Company

Dniepropetrovsk, UkraineNNSA, Kansas City Plant

Kansas City, MOPinnacle Technology, Inc.

Lawrence, KS

Advanced Grinding Technologyfor Bio-Source Materials

• Agricultural/forestry waste can beconverted into consumer and industrialproducts- Fillers for plastics; chemicals, fuel; electricity;

animal feed; fertilizer

• Global demand for bio-source productssurging- $23 billion market growing at annual rate of 9%

• Former Soviet space-based weaponsplant has expertise in particulatereduction, analysis and system designtechniques- Technology was adapted and further developed

for grinding bio-source products- Pilot machine designed/built- Full sized machine designed/built- Particle sized reduction tests conducted on

samples of wheat, rice husks and sunflower- Full size machine to be field tested with

agricultural products

• Project goal is to bring unique grindingand separation technology to globalindustrial and agricultural markets

11/2004


High Current Electronics Institute(HCEI)

Tomsk, RussiaLawrence Berkeley National Laboratory

Berkeley, CAArthroCare Corporation

Sunnyvale, CA

Plasma Albation for Soft Tissue &Bone Surgery

• Plasma-based electrosurgery systems haverevolutionized soft tissue surgery in diverseareas: arthroscopy; otolaryngology (ear, nose,throat); spinal, urological and cosmetic surgery

• Existing plasma-based surgical tools for softtissue have been shown to- Increase precision & accuracy- Limit damage to surrounding tissue, reducing pain- Enhance tissue healing- Reduce overall surgical and recovery time

• Bone & other hard tissues require new plasma-based technologies- Faster, less painful surgical devices and procedures

needed to eliminate lengthy, traumatic bone surgeries

• Project goal to develop one multi-purposesurgical system- Replace multiple surgical tools- Reduce procedure cost- Improve patient outcomes

• Project focus on experimental studies of basicplasma processes and computer code tosimulate physics

8/2005


BioPhysical Laboratories (Biofil)

Sarov, RussiaLawrence Livermore National Laboratory

Livermore, CA

Cyclotec Advanced MedicalTechnologies, Inc.

Lauderhill, FL

STIM-2002: Electro-TherapeuticPain Blocking Splints & Bandages

4/2004

• STIM-2002 are revolutionary pain relief devices- Non-invasive; worn or placed directly on body- FDA-approved for treatment of acute/chronic muscle &

joint pain- Safe, effective alternatives to drugs

• Easy-to-use wireless devices deliver low-levelelectrical impulses- CT1 - LCD display with push-button control- CT2 - Remote-control- CT3 - Integration in splints/braces/bandages- CT4 - “Ultra-miniature” Band-Aid™-like units- CT5 - Functional rehabilitation units

• Benefits include pain relief without drugs plus:- NO side effects- NO contraindications- NO addictive potentials- NO limitations on time of use

• Target markets include sportsmedicine / home health care /industrial medicine / rehabilitation /emergency care

R&DAWARD

100

CT4

CT2

CT3

CT1 and CT5



• Needleless (jet) injectors are preferred means formass inoculations in developing countries and inepidemic or military applications in developedcountries

Needleless Injector Manufacturing

CADB/MedEquipment

Voronezh, Russia Kansas City, MOFelton International, Inc.

Lenexa, KS

• Russian institute has 35 years experiencewith injectors

– 18 models designed– 9 models mass-produced

• Novel Russian designs include disposablecap with disease-impermeable membranethat prevents pathogen transfer --concept has been successfullydemonstrated in lab and animal trials

• Needleless injectors eliminate:– Needlestick and subsequent HIV & HepB transfer– Needlephobia– Medical waste problems

• Needleless injectors permit up to 600 injectionsper hour and require lower level of operator skill

• Technology also appropriate for livestock (cattleand hogs) inoculations

4/2004



Biofil

Sarov, RussiaArgonne National Laboratory

Argonne, ILFlint Hills Scientific, LLC

Lawrence, KS

Detection & Control ofNeurological Disorders

• Worldwide, millions ofpeople of all ages suffer fromneurological disordersassociated with abnormalbrain activity

• Closed-loop control of braintemperature for treatment ofneurological disorders

• Breakthrough implantablemedical device can detectand control abnormal activity

4/2004

• Device features 3 components:- Sensors: miniature temperature probe capable of detecting minute

tissue temperature changes associated with abnormal brain activity

- Telemetry: miniature, high-reliability communications signal

- Control device: miniature cooling system capable of predictably,modifying the temperature of localized tissue in the human body

NNSA Kansas City Plant

Kansas City, MO

Pacific NorthwestNational Lab

Richland, WA



Federal State Unitary Enterprise All-RussianResearch Institute of Automatics

Moscow, RussiaBrookhaven National Laboratories

Upton, NYIon Focus Technology, Inc.

Stony Brook, NY

Miniature Neutron Generator forBrachytherapy Tumor Treatment

• Small, portable, low cost,deuterium-tritium (DT) neutrongenerators able to treat cancer byfast-neutron brachytherapy

• Almost all malignancies can becontrolled using fast neutrontreatment, including the mostvirulent diseases whose potentialtumor cell doubling time is a fewdays, e.g. melanoma

• Neutrons are generated at the tip ofa needle and injected directly in oragainst the tumor, avoiding damageto healthy tissue

• Additional advantages of the DTneutron generator:- No need to shield when not in use- Neither patient nor medical personnel

receive unwanted radiation doses

11/2003


Projected/Current Sales:$20 Million in first 3-4 years

Commercialization:2003

SPEKTR

Snezhinsk, RussiaSandia National Laboratories

Albuquerque, NMNumotech, Inc.

Northridge, CA

Generic Total Contact Seat (GTCS)for Treatment & Prevention ofPressure Ulcers

• Wheelchair users/bedridden persons often afflicted bypressure ulcers- Loss of feeling, lack of mobility, poor circulation cause large sores that

can extend to bone; damage leading to sores can occur in 5 minutes- In U.S. alone, > 60K deaths/year attributed to complications; annual

medical care costs now > $8 Billion and growing

• GTCS is FDA-approved Class II medical device- Unique cushion fits in any wheelchair—allows optimal upright position- Biomechanical design systematically compresses tissues, increasing

blood supply, stimulating tissue growth- Promotes wound healing, cuts treatment time by 1/3, reduces

medical costs- Greatly reduces likelihood of developing new sores

• Potential commercial spin-offs include car, truck, plane,train, office, theatre seating

• Russians will optimize GTCS design and manufacture keycomponents- Goal to develop Russian production facility for commercially viable,

inexpensive medical devices for global market

MR Beal & Company

New York, NY

4/2003


Institute of Highly Pure BioPreparations

St. Petersburg, RussiaOak Ridge National Laboratory

Oak Ridge, TNSciClone Pharmaceuticals, Inc.

San Mateo, CA

TB Peptides• Tuberculosis kills 2 million people each year

- Most common infectious disease in world today

• SVC-07 is novel synthetic dipeptidediscovered by Russians- D-glutamyl-L-tryptophan is new class of

immunomodulators

• Promising clinical trial results showstimulation of the immune system,improvement in symptoms (including fever/cough) and significant decrease in patientswith lung damage

• SVC-07 will significantly increase rate atwhich treated tuberculosis patients becomenoncontagious- Helps to contain, prevent spread of disease

• In oral form, SCV-07 may have additionalbenefit for mass immunization

• Russian partner to develop domestic sales;U.S. partner will introduce in global market

4/2005

Y-12

Oak Ridge, TN



Institute for Metal Physics ofNational Academy of Science

Kyiv, UkrainePacific Northwest National Laboratory

Richland, WAADMA Products, Inc.

Hudson, OH

Cost-Effective Production of PowderMetallurgy Titanium Components

• Develop commercial powdermetallurgy-based manufacturingmethods for titanium alloycomponents for high-volumeindustrial applications, such asthe automotive industry

• Cost-effective methodtransforms fine metallic powdersinto parts- Components produced with less

material waste and machining

• Low-cost hydrogenated titanium(patent pending) will be used toproduce 98.5-99.5% densematerial with desiredcomposition, microstructure,chemical homogeneity andminimal impurity content tomeet commercial demands

6/2005

Powder Blending

Powder Blend

Compaction

Part

Ti, Alloying ElementPowders

Densification

Heat Treat


Argonide Corporation

Sanford, FL

Nanosize Ceramic Fibers for Virus/Bacteria Detection and Removal

• Nanoceram™ nano alumina fibershave unique properties- Electrostatic forces attract/retain bacteria,

viruses, other macromolecules betterthan existing microporous membranes

- High surface areas ideal forchemisorbency of dissolved heavy metals

• Product will fill niche in $10+ Billion/year filters industry- Water purification/sterilization- Counter-terrorism (e.g. filtering biological

agents from water)- Concentrator/collector to monitor air/

water for biological agents- Reduce cost of bio separations for

pharmaceutical processing- Artificial bone compositions

• Filters to be manufacturedin Russia

4/2004

VECTOR State Research Center ofVirology and Biotechnology

Novosibirsk, Siberia

National RenewableEnergy Laboratory

Golden, CODesign Technology Center

Tomsk, Siberia

R&DAWARD

100



International Center for Electron Beam Technologies(ICEBT) of E.O. Paton Electric Welding Institute

Kyiv, UkraineGeneral Electric Company

Niskayuna, NY

Next Generation EB-PVD Apparatus

• Electron Beam Physical VaporDeposition (EB-PVD) technologiesprovide wide possibilities for depositionof new materials as well as coatings ofvarious heat resistant and refractorymetal alloys, ceramics and compositeswith unique structures and properties

• EB-PVD is used across manyindustries:- Aeronautical & Industrial gas turbines- Fuel cells- X-ray systems

• Improved apparatus over commercially-available EB-PVD systems will bedeveloped:- Innovative design features- Higher rates of deposition- Reduced time & operating costs

• Enable Ukrainian partner to compete inglobal market

10/2003


Ufa State Aircraft Technical University

Ufa, Russia Los Alamos, NMSanta Fe, NM

Nanostructured Titanium Alloysfor Medical Applications

• Titanium alloys widely used for medical implants and devices

• Nanostructured forms of titanium alloys offer increasedstrength

• Project will develop production process based on EqualChannel Angular Pressing, already demonstrated to beeffective with pure titanium

4/2004

• Nanostructured Ti-6Al-4V applications:- Implants and devices to fix broken bones

- Implants subject to high fatigue load

- Implants for older patients at risk ofosteoporosis

• Nanostructured Ti-6Al-4V applications:- Bone anchors to reattach torn ligaments- Sutures- Microtubing- Dental drills

• Useful to other industries



ULBA Metallurgical Plant

Ust-Kamenogorsk,Kazakhstan

Los Alamos National Laboratory

Los Alamos, NM

Copper Beryllium (CuBe)Production in Kazakhstan

• Project goal to develop world’ssecond largest source of commercialCuBe master alloy at former nuclearweapons plant in Kazakhstan

• U.S. partners will provide:- modernized arc furnace- technical personnel training- ISO-9002 certified quality assurance

procedures

• Kazakhstani partner will operate arcfurnace and provide:- manpower- engineer personnel- feed material

• Growing international demand forCuBe alloy in electronic components:- small appliances- optical media/data storage- automotive electronics- telecommunications- computers

4/2004

Brush Engineered Materials, Inc.

Cleveland, OHRWE Nukem, Inc.

Danbury, CT



Research Institute of Atomic Reactorsand Cyclotron, Ltd.

Dimitrovgrad, RussiaMiami, FL

High Performance Sealed SourcePhantoms for Nuclear Medicine

• Design and production of state-of-the-art devices to calibrateinstruments and check qualityof images produced innuclear medicine.

• Devices will check dailyperformance characteristics ofgamma cameras to providephysicians with reliablemeasurements and accurateimages of patients undergoingradiopharmaceutical testing forcancer and other diseases.

• 3 sealed-sources are beingdesigned and built, using Cobaltand Gadolinium obtained fromRussian nuclear facilities.

• Project will reduce U.S.dependence on foreign sourcesfor these devices.

4/2004

Pacific Northwest National Laboratory

Richland, WA



Kurchatov Institute ofAtomic Energy

Moscow, Russia

Lawrence LivermoreNational Laboratory

Livermore, CASpectra Gases, Inc.

Branchburg, NJ

Medical Isotopes:O-18, C-13, Xe-129

4/2004

• Joint venture to develop low-cost production ofstable isotopes for medical useOxygen-18 (O-18)- Demand for PET procedures, metabolism

studies has led to worldwide shortage- Promising research in treatments for obesity,

diabetes, other diseases

Carbon-13 (C-13)- FDA approval of C-13 breath-tests for ulcers

expected to exhaust world supply- C-13 in MRIs provides unique diagnostic

information on cancer/tumor progression andtreatment response

- Other uses: NMR diagnostics for brain tumors,cerebral blood clots, diabetes, prostatecancer, other conditions

Xenon-129 (Xe-129)- Xe-129 increases MRI sensitivity/suitability for

imaging brain, lungs, whole-body- Enormous potential as diagnostic of many

human ailments

• Goals to establish additional worldproduction capacity in Russia, stimulatemedical research with expanded supply ofkey isotopes

Cryocarbon, Ltd.

Moscow, Russia


United States Industry Coalition, Inc. 1525 Wilson Boulevard, Suite 150 * Arlington, VA 22209

T 703-5269447 F 703-526-0928 www.usic.net

summaries of commercialization stories of russian ips

Technology

new biocontrol agent

eds system

centrifugalpumps current

ca moscow

russia richland

ca miass

ca koltsovo

agents cytokine