summer vacation research scholarship
DESCRIPTION
Summer Vacation Research Scholarship. Lulu Liang. The Prophylactic hypOthermia trial to Lessen trAumatic bRain injury – Randomised Controlled Trial (POLAR-RCT). - PowerPoint PPT PresentationTRANSCRIPT
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Summer Vacation Research Scholarship
Lulu Liang
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ANZIC-RC
Traumatic Brain
Injuries
POLAR
POLAR BEAR
Renal Sub-study
EPO
ARISE Olivier’s Study
Flail Chest Study
Blood Transfusio
n
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The Prophylactic hypOthermia trial to Lessen trAumatic bRain injury –
Randomised Controlled Trial (POLAR-RCT)
To investigate whether prophylactic hypothermia has better neurological outcomes over standard management (normothermia) 6 months post TBI
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BackgroundWhy is this being done?
Affects 1000 Australians every year Health issues:
o Disability and death Economical issues Societal issues Previous studies
o Lab and clinical trials show hypothermia to be neuroprotective
o Previous methodological limitationso First-of-its-kind in Australia
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Method
512 Participan
ts
Normothermia
Hypothermia
Maintained at 37±5°C
Rapidly cooled to
33°C for 72 hours
Gradually rewarmed
End result: Neurological outcome at 6 months follow-up (GOSE)
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Results/DiscussionWhat I observed over a 5 week period: 15 patients were followed Mortality and survival rates at ICU-discharge were
similar Challenges
o Hypothermia: bleeding, infection, logistics with timingo Normothermia: infection
Is hypothermia beneficial in TBI?
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Conclusion
Cannot be drawn as study still in progress. However, the results may potentially change clinical practice on the current management of TBI in an ICU setting.
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Reflections
Video