supplementary appendix · appendix to disability-adjusted life years (dalys) for 291 diseases and...
TRANSCRIPT
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Supplementary appendixThis appendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors.
Supplement to: Murray CJL, Vos T, Lozano R. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380: 2197–223.
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Appendix to Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
This Appendix provides further supplemental tables on global DALYs in 1990 and 2010.
Table of Contents Web Table 1- Global DALYs (thousands) with 95% UI for 291 causes in both sexes combined, males, and females by age and cause in 2010...................................................................................................................................................................................2
Web Table 2- Global DALYs (thousands) with 95% UI for 291 causes in both sexes combined, males, and females by age and cause in 1990...............................................................................................................................................................................170
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, All Ages
Both Sexes, 0-6 Days
Both Sexes, 7-27 Days
Both Sexes, 28-364 Days
Both Sexes, 1-4 Years
Both Sexes, 5-9 Years
All causes
2,490,384·9 186,364·9 58,452·8 182,671·7 195,846·6 68,664·4 (2,349,249·8–2,637,538·2) (170,397·9–202,129·9) (54,254·8–63,121·0) (168,236·1–203,413·3) (178,574·8–214,426·7) (61,872·4–77,041·2)
Communicable, maternal, neonatal and nutritional disorders
868,024·5 171,632·3 51,113·2 148,616·7 143,406·8 33,748·1 (818,934·4–921,489·5) (155,474·6–187,647·1) (46,883·8–55,920·5) (134,769·9–169,418·6) (126,866·3–161,923·0) (29,488·0–38,785·9)
HIV/AIDS and tuberculosis
130,943·6
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, All Ages
Both Sexes, 0-6 Days
Both Sexes, 7-27 Days
Both Sexes, 28-364 Days
Both Sexes, 1-4 Years
Both Sexes, 5-9 Years
Influenza
19,244·1 1,265·1 1,028·2 4,935·2 3,072·9 501·9 (16,906·2–21,451·5) (930·1–1,726·4) (796·2–1,346·8) (3,958·3–6,130·6) (2,573·2–3,815·6) (416·5–621·9)
Pneumococcal pneumonia
26,906·2 1,541·3 1,247·4 5,954·7 5,623·8 632·3 (23,723·4–29,864·9) (1,127·1–2,035·8) (951·8–1,570·6) (4,809·6–7,312·5) (4,772·2–6,852·6) (527·4–793·1)
H influenza type B pneumonia
21,315·3 1,991·7 1,608·4 7,654·2 4,510·6 549·4 (18,580·7–24,304·9) (1,467·0–2,703·4) (1,251·0–2,052·2) (6,179·8–9,290·1) (3,780·4–5,642·6) (447·4–695·9)
Respiratory syncytial virus pneumonia
20,472·4 3,102·9 2,539·8 11,773·4 2,647·6 26·3 (17,193·2–24,136·0) (2,372·9–4,073·3) (2,039·8–3,153·7) (9,678·8–14,093·7) (2,202·1–3,228·1) (21·9–32·9)
Other lower respiratory infections
27,288·6 1,306·4 1,038·8 4,922·9 5,182·7 1,187·4 (23,756·5–30,810·6) (889·6–1,857·0) (743·3–1,430·9) (3,663·9–6,465·3) (4,245·5–6,577·6) (990·1–1,448·4)
Upper respiratory infections
1,866·3 10·9 10·5 77·2 147·3 215·2 (1,048·8–3,189·2) (8·7–13·7) (8·7–13·0) (57·0–105·2) (83·8–246·1) (109·4–390·0)
Otitis media
4,680·0 4·9 17·1 242·2 527·8 571·2 (2,946·5–7,589·3) (1·1–36·4) (3·2–140·8) (50·0–1,892·0) (323·2–902·0) (369·7–870·1)
Meningitis
29,398·7 1,486·4 2,459·9 7,786·7 5,838·0 1,657·4 (25,583·7–33,327·5) (988·8–2,031·7) (1,882·6–3,180·8) (6,225·4–9,737·0) (4,709·9–7,607·9) (1,325·2–2,068·0)
Pneumococcal meningitis
8,023·8 291·9 483·6 1,484·2 1,624·2 539·6 (6,946·3–9,065·2) (183·0–438·6) (349·0–659·5) (1,136·2–1,941·0) (1,325·3–2,178·3) (424·7–663·0)
H influenza type B meningitis
6,610·6 396·4 664·5 2,073·2 1,922·6 518·4 (5,660·9–7,851·2) (256·3–575·3) (486·5–886·5) (1,631·8–2,642·5) (1,545·1–2,532·5) (397·7–654·0)
Meningococcal infection
5,163·4 206·0 346·3 968·9 1,267·4 351·6 (4,396·7–5,889·9) (114·1–344·7) (232·2–486·8) (698·5–1,320·6) (1,019·2–1,690·5) (285·2–435·8)
Other meningitis
9,563·3 591·9 965·1 3,253·6 1,013·0 242·4 (8,107·8–10,857·7) (392·0–843·5) (726·3–1,240·4) (2,600·2–4,062·3) (827·0–1,308·1) (195·1–297·7)
Encephalitis
7,140·9 290·8 534·5 1,505·0 1,175·3 586·8 (6,148·0–8,273·7) (198·7–448·9) (360·2–789·3) (1,113·3–2,031·4) (843·8–1,653·8) (388·8–861·5)
Diphtheria
235·8 59·3 132·5 25·9 (0·0–2,015·9) – – (0·0–492·1) (0·0–1,151·4) (0·0–223·9)
Whooping cough
7,018·1 5,745·8 1,129·9 60·2 (148·9–33,926·5) – – (116·6–27,584·5) (25·1–5,657·0) (2·0–296·0)
Tetanus
4,663·3 1,638·8 1,845·6 569·0 70·3 68·2 (2,568·5–7,587·5) (748·7–2,986·1) (958·8–3,116·9) (296·2–1,019·3) (0·8–295·1) (0·8–288·5)
Measles
10,419·7 2,762·2 6,224·4 945·6 (3,453·4–24,535·4) – – (938·8–6,474·7) (2,026·2–14,902·8) (317·9–2,161·2)
Varicella
581·1 8·5 15·1 117·8 120·7 35·2 (144·9–2,772·9) (0·0–54·0) (0·0–100·7) (0·2–803·8) (3·0–809·9) (6·7–174·6)
Neglected tropical diseases and malaria
108,738·6 34·3 2,311·9 22,176·8 39,082·2 6,718·0 (87,846·5–137,588·2) (20·8–64·5) (1,334·0–3,789·7) (14,700·5–33,070·3) (27,237·7–55,953·3) (5,297·3–8,447·2)
Malaria
82,685·2
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, All Ages
Both Sexes, 0-6 Days
Both Sexes, 7-27 Days
Both Sexes, 28-364 Days
Both Sexes, 1-4 Years
Both Sexes, 5-9 Years
Leishmaniasis
3,316·9 23·1 349·0 873·2 400·5 (2,179·6–4,890·3) – (12·8–40·5) (197·0–596·6) (514·7–1,413·2) (239·0–635·0)
African trypanosomiasis
560·3 66·5 57·5 (76·3–1,765·9) – – – (8·5–213·7) (8·0–184·9)
Schistosomiasis
3,309·0 104·0 382·4 373·0 (1,705·0–6,259·9) – – (55·8–170·1) (205·9–646·3) (189·9–700·5)
Cysticercosis
503·4
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, All Ages
Both Sexes, 0-6 Days
Both Sexes, 7-27 Days
Both Sexes, 28-364 Days
Both Sexes, 1-4 Years
Both Sexes, 5-9 Years
Obstructed labor
1,792·4 (1,249·3–2,806·2) – – – – –
Abortion
2,137·9 (1,730·8–2,591·5) – – – – –
Other maternal disorders
4,778·2 (3,818·9–5,512·1) – – – – –
Neonatal disorders
201,958·9 151,270·3 29,524·5 11,477·5 1,792·6 1,083·0 (182,137·9–221,900·7) (134,966·2–167,355·4) (25,331·7–34,166·0) (9,315·7–14,074·1) (1,427·0–2,200·3) (814·0–1,380·3)
Preterm birth complications
76,981·7 60,534·8 9,409·8 4,027·9 359·3 303·1 (66,232·6–88,295·4) (50,725·5–70,680·1) (7,580·6–11,582·6) (3,065·2–5,483·5) (281·3–440·9) (224·3–388·4)
Neonatal encephalopathy (birth asphyxia and birth trauma)
50,149·6 37,277·6 4,838·6 1,858·8 930·5 779·9 (40,521·4–59,840·5) (29,016·9–45,826·6) (3,597·1–6,362·0) (1,349·1–2,448·9) (698·2–1,199·7) (566·8–1,020·8)
Sepsis and other infectious disorders of the newborn baby
44,236·5 32,418·9 9,060·4 2,679·1 78·1 (27,348·7–72,418·2) (19,948·7–51,856·3) (5,499·9–14,792·9) (1,412·1–5,007·5) (34·7–158·4) –
Other neonatal disorders
30,591·1 21,039·0 6,215·8 2,911·7 424·6 (25,602·9–37,360·3) (16,733·1–26,903·7) (4,846·2–7,934·8) (2,177·0–3,909·7) (333·4–538·4) –
Nutritional deficiencies
85,340·6
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, All Ages
Both Sexes, 0-6 Days
Both Sexes, 7-27 Days
Both Sexes, 28-364 Days
Both Sexes, 1-4 Years
Both Sexes, 5-9 Years
Hepatitis
13,257·5 0·7 2·0 1,439·8 1,404·7 598·2 (11,363·9–15,855·5) (0·2–1·3) (0·7–4·1) (879·8–2,601·8) (878·8–2,443·1) (386·8–956·5)
Acute hepatitis A
4,350·8 0·4 1·2 954·1 517·8 114·8 (2,411·9–9,025·8) (0·0–0·9) (0·1–2·7) (393·4–2,067·0) (168·8–1,223·0) (56·0–207·5)
Acute hepatitis B
4,674·2 0·3 0·8 475·2 191·9 81·7 (3,188·8–6,051·6) (0·0–0·6) (0·1–1·8) (252·7–864·6) (90·0–318·9) (38·1–141·0)
Acute hepatitis C
518·0 1·3 2·0 5·5 (378·4–712·8) – – (0·2–2·9) (0·4–4·2) (2·1–17·2)
Acute hepatitis E
3,714·5 9·1 693·0 396·2 (1,551·9–7,469·8) – – (3·1–18·9) (217·7–1,789·9) (152·0–904·2)
Leprosy
6·1 0·3 0·5 (2·7–11·3) – – – (0·1–0·7) (0·2–1·2)
Other infectious diseases
17,715·5 1,267·8 1,275·9 3,964·6 3,659·9 1,243·5 (13,382·3–21,538·8) (767·6–1,784·4) (838·1–1,731·1) (2,883·3–5,267·0) (2,877·9–4,613·3) (950·7–1,623·3)
Noncommunicable diseases
1,343,695·6 13,496·3 6,169·8 25,344·6 29,918·6 26,101·6 (1,239,972·6–1,456,773·2) (11,031·2–16,243·6) (5,217·5–7,187·1) (22,032·6–28,131·9) (26,400·2–34,163·2) (22,601·7–30,420·7)
Neoplasms
188,486·8 105·8 82·8 863·3 1,762·8 1,765·2 (174,452·3–199,036·9) (74·0–146·8) (55·8–126·1) (647·3–1,157·6) (1,317·2–2,236·0) (1,419·9–2,039·6)
Oesophagus cancer
8,942·7 (6,697·9–10,821·8) – – – – –
Stomach cancer
16,412·7 (12,290·3–21,536·7) – – – – –
Liver cancer
19,110·8 66·6 (16,655·3–22,910·7) – – – – (44·3–110·3)
Liver cancer secondary to hepatitis B
8,937·9 15·9 (7,728·7–10,877·3) – – – – (10·2–26·0)
Liver cancer secondary to hepatitis C
4,141·1 2·0 (3,541·7–4,858·9) – – – – (1·3–3·2)
Liver cancer secondary to alcohol use
3,781·6 (3,295·1–4,488·2) – – – – –
Other liver cancer
2,250·3 48·7 (1,964·2–2,686·9) – – – – (32·6–79·0)
Larynx cancer
2,366·6 (1,281·0–3,818·1) – – – – –
Trachea, bronchus and lung cancers
32,404·7 (24,400·0–38,333·8) – – – – –
Breast cancer
12,017·9 (11,513·7–12,703·6) – – – – –
Cervical cancer
6,439·6 (4,111·4–8,758·3) – – – – –
Uterine cancer
1,271·9 (629·5–1,825·3) – – – – –
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, All Ages
Both Sexes, 0-6 Days
Both Sexes, 7-27 Days
Both Sexes, 28-364 Days
Both Sexes, 1-4 Years
Both Sexes, 5-9 Years
Prostate cancer
3,786·6 (2,189·0–5,623·3) – – – – –
Colon and rectum cancers
14,422·3 (12,773·8–16,571·3) – – – – –
Mouth cancer
3,227·8 (2,717·9–3,538·4) – – – – –
Nasopharynx cancer
2,007·4 11·5 (1,310·5–2,610·5) – – – – (7·7–17·9)
Cancer of other part of pharynx and oropharynx
2,741·9 (1,577·4–3,412·8) – – – – –
Gallbladder and biliary tract cancer
3,034·5 (1,965·6–4,061·0) – – – – –
Pancreas cancer
6,160·6 (4,644·4–7,693·9) – – – – –
Malignant melanoma of skin
1,169·4 (744·0–1,694·4) – – – – –
Non-melanoma skin cancer
798·4 (557·2–1,068·3) – – – – –
Ovary cancer
4,118·2 (2,929·5–5,115·3) – – – – –
Testis cancer
313·3 (202·1–405·4) – – – – –
Kidney and other urinary organ cancers
3,676·3 35·7 131·2 72·2 (2,856·6–4,922·2) – – (20·9–51·5) (80·8–190·5) (43·7–114·0)
Bladder cancer
3,014·5 (2,335·5–3,562·7) – – – – –
Brain and nervous system cancers
6,059·7 234·9 292·8 (3,668·6–7,455·3) – – – (83·5–516·5) (170·3–381·7)
Thyroid cancer
836·3 (625·3–997·0) – – – – –
Hodgkin's disease
647·0 5·3 2·3 7·0 21·3 29·8 (429·8–920·3) (3·0–8·9) (0·9–5·5) (4·0–11·3) (9·0–41·6) (16·7–45·9)
Non-Hodgkin's lymphoma
5,859·8 47·5 248·1 276·1 (4,609·9–6,450·3) – – (33·0–64·2) (163·9–354·1) (164·4–419·2)
Multiple myeloma
1,474·8 (969·4–2,001·7) – – – – –
Leukemia
9,555·7 299·4 673·6 639·2 (7,661·6–11,231·9) – – (223·5–402·3) (501·9–835·2) (488·8–794·0)
Other neoplasms
16,615·3 100·5 80·5 473·8 453·7 377·0 (11,928·3–19,888·3) (69·5–141·4) (54·0–124·6) (294·2–741·3) (267·0–692·3) (252·5–511·3)
Cardiovascular and circulatory diseases
295,035·8 787·8 543·2 2,896·6 2,836·5 1,429·2 (273,060·9–309,561·8) (626·0–955·1) (430·4–667·3) (2,379·5–3,408·4) (2,364·0–3,439·6) (1,174·8–1,730·8)
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, All Ages
Both Sexes, 0-6 Days
Both Sexes, 7-27 Days
Both Sexes, 28-364 Days
Both Sexes, 1-4 Years
Both Sexes, 5-9 Years
Rheumatic heart disease
10,149·9 211·8 226·7 (9,058·3–11,308·3) – – – (165·3–256·1) (176·4–290·6)
Ischemic heart disease
129,819·9 575·2 518·3 234·3 (119,174·4–138,043·5) – – (325·7–814·3) (330·9–707·7) (151·0–347·5)
Cerebrovascular disease
102,232·3 309·8 210·8 803·5 667·5 293·0 (90,428·1–107,988·6) (212·2–414·1) (139·5–302·0) (470·5–1,183·5) (456·6–917·7) (213·6–386·8)
Ischemic stroke
39,389·4 176·3 156·0 54·1 (36,906·4–45,504·5) – – (107·8–247·9) (104·7–201·5) (42·9–66·3)
Hemorrhagic and other non-ischemic stroke
62,842·9 309·8 210·8 627·1 511·5 238·9 (54,386·1–72,539·7) (224·2–443·2) (146·7–323·0) (368·9–931·6) (302·9–733·8) (166·5–334·9)
Hypertensive heart disease
15,324·2 106·3 117·4 42·9 (12,834·8–18,433·0) – – (72·8–142·8) (82·1–163·4) (32·7–54·2)
Cardiomyopathy and myocarditis
11,150·8 244·3 198·7 595·3 558·1 200·4 (9,759·2–12,881·5) (143·6–379·7) (121·9–323·4) (349·6–884·9) (263·2–944·2) (145·1–276·1)
Atrial fibrillation and flutter
3,598·5 1·3 11·0 (2,756·1–4,578·4) – – – (0·7–2·2) (6·9–16·2)
Aortic aneurysm
3,162·6 (2,280·0–4,235·0) – – – – –
Peripheral vascular disease
994·9
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, All Ages
Both Sexes, 0-6 Days
Both Sexes, 7-27 Days
Both Sexes, 28-364 Days
Both Sexes, 1-4 Years
Both Sexes, 5-9 Years
Cirrhosis of the liver secondary to alcohol use
8,574·9 (6,840·4–10,176·6) – – – – –
Other cirrhosis of the liver
6,010·7
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, All Ages
Both Sexes, 0-6 Days
Both Sexes, 7-27 Days
Both Sexes, 28-364 Days
Both Sexes, 1-4 Years
Both Sexes, 5-9 Years
Mental and behavioral disorders
185,190·1 27·7 30·7 154·9 836·6 5,856·0 (154,646·9–218,496·2) (16·4–49·9) (17·2–53·8) (89·8–291·7) (627·9–1,086·0) (4,545·8–7,421·7)
Schizophrenia
14,999·5 (9,765·8–20,399·2) – – – – –
Alcohol use disorders
17,644·1 0·1 0·2 2·9 11·5 12·3 (12,927·6–23,273·0) (0·0–0·1) (0·1–0·3) (1·7–4·6) (6·7–17·8) (7·3–19·1)
Drug use disorders
19,994·2 27·6 30·3 149·5 207·4 45·3 (15,254·4–25,366·2) (16·2–49·8) (16·8–53·5) (84·9–287·4) (110·1–350·8) (27·0–83·4)
Opioid use disorders
9,151·5 14·1 15·7 76·3 102·3 22·8 (7,066·2–11,443·2) (8·3–24·9) (8·8–27·5) (42·7–145·8) (52·5–172·5) (13·5–42·1)
Cocaine use disorders
1,110·1 0·2* 0·1 0·8* 1·0* 0·3* (644·7–1,727·2) (0·0–0·1) (0·0–0·1) (0·2–0·5) (0·2–0·7) (0·1–0·2)
Amphetamine use disorders
2,616·9 0·2* 0·1 0·8* 1·0* 0·3* (1,469·9–4,108·9) (0·0–0·1) (0·0–0·1) (0·1–0·4) (0·2–0·5) (0·0–0·2)
Cannabis use disorders
2,057·2 (1,348·3–2,928·8) – – – – –
Other drug use disorders
5,058·6 13·3 14·4 71·5 103·2 21·9 (3,555·2–7,041·8) (7·7–24·0) (8·0–24·7) (39·7–130·8) (53·4–175·2) (13·1–39·2)
Unipolar depressive disorders
74,263·7 4·4 2,254·1 (55,670·2–94,239·8) – – – (2·8–6·7) (1,697·4–2,902·1)
Major depressive disorder
63,179·3 4·3 2,086·1 (47,778·6–80,890·9) – – – (2·7–6·5) (1,554·9–2,683·7)
Dysthymia
11,084·4 0·1 168·0 (7,296·6–15,447·4) – – – (0·0–0·4) (109·1–234·1)
Bipolar affective disorder
12,867·1 (8,084·2–18,653·6) – – – – –
Anxiety disorders
26,825·6 0·4 547·1 (18,778·9–36,794·9) – – – (0·1–0·8) (385·7–761·8)
Eating disorders
2,160·6 8·1 (1,519·3–2,948·7) – – – – (5·0–10·9)
Pervasive development disorders
7,665·8 532·7 777·5 (5,354·5–10,564·8) – – – (371·7–731·3) (542·1–1,070·4)
Autism
4,006·7 319·5 407·7 (2,751·6–5,562·6) – – – (218·7–447·6) (278·4–569·8)
Asperger's syndrome
3,659·1 213·2 369·8 (2,463·4–5,149·7) – – – (142·8–306·8) (252·4–526·9)
Childhood behavioral disorders
6,244·8
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, All Ages
Both Sexes, 0-6 Days
Both Sexes, 7-27 Days
Both Sexes, 28-364 Days
Both Sexes, 1-4 Years
Both Sexes, 5-9 Years
Idiopathic intellectual disability
1,042·7 0·1 0·2 2·5 41·1 146·6 (571·7–1,686·8) (0·0–0·1) (0·1–0·4) (0·9–5·6) (19·5–73·6) (80·4–236·8)
Other mental and behavioral disorders
1,482·1 39·1 76·8 (990·2–2,151·8) – – – (23·8–58·3) (47·3–118·0)
Diabetes, urogenital, blood, and endocrine diseases
122,437·2 562·1 468·9 4,275·7 6,766·6 3,591·8 (107,436·7–143,386·8) (388·8–820·7) (318·0–674·7) (3,452·0–5,441·1) (5,157·7–8,939·1) (2,801·5–4,734·2)
Diabetes mellitus
46,823·3 60·6 41·6 352·8 426·5 301·1 (40,085·5–55,214·5) (46·4–79·4) (30·9–55·1) (244·2–504·5) (321·2–559·8) (217·7–413·1)
Acute glomerulonephritis
3,684·2
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, All Ages
Both Sexes, 0-6 Days
Both Sexes, 7-27 Days
Both Sexes, 28-364 Days
Both Sexes, 1-4 Years
Both Sexes, 5-9 Years
Premenstrual syndrome
1,248·6 (62·8–3,336·5) – – – – –
Other gynecological diseases
705·0 (527·0–953·8) – – – – –
Hemoglobinopathies and hemolytic anemias
15,639·8 204·5 142·4 1,300·8 3,319·8 2,002·8 (12,224·8–19,721·7) (122·8–310·9) (87·9–203·9) (984·7–1,695·4) (2,363·3–4,574·1) (1,469·3–2,655·9)
Thalassemias
5,716·7 3·1 6·4 286·9 933·5 772·0 (4,170·0–7,728·2) (2·1–4·4) (4·7–8·9) (208·4–385·5) (668·5–1,273·0) (539·9–1,072·8)
Sickle cell disorders
5,641·0 16·4 36·2 565·4 1,549·8 892·6 (4,243·5–7,245·7) (12·1–22·5) (22·2–53·3) (384·2–765·0) (1,061·4–2,181·5) (608·6–1,298·3)
G6PD deficiency
302·6 0·4 0·8 19·5 62·0 42·0 (244·2–371·9) (0·2–0·6) (0·5–1·3) (13·0–33·4) (43·3–88·4) (29·7–63·0)
Other hemoglobinopathies and hemolytic anemias
3,979·5 184·6 99·0 429·0 774·5 296·2 (2,887·3–5,399·8) (117·6–282·8) (53·6–156·3) (284·0–662·7) (460·4–1,425·2) (201·4–424·9)
Other endocrine, nutritional, blood, and immune disorders
11,357·6 242·7 223·5 1,216·5 1,380·6 627·0 (8,203·6–17,018·7) (124·5–497·3) (109·4–430·8) (772·2–2,232·4) (906·2–2,175·7) (439·4–869·5)
Musculoskeletal disorders
169,624·0 1,607·2 (129,770·6–212,734·3) – – – – (1,116·1–2,164·3)
Rheumatoid arthritis
4,814·8 21·5 (3,705·0–6,056·2) – – – – (14·4–36·8)
Osteoarthritis
17,135·2 (11,883·6–24,255·7) – – – – –
Low back and neck pain
116,703·7 1,542·2 (80,615·1–156,526·8) – – – – (1,049·6–2,096·0)
Low back pain
83,063·5 1,107·1 (56,631·6–111,879·9) – – – – (752·8–1,524·1)
Neck pain
33,640·2 435·1 (23,469·0–46,475·9) – – – – (302·0–605·2)
Gout
114·0 (72·3–166·9) – – – – –
Other musculoskeletal disorders
30,856·3 43·4 (25,815·5–34,582·7) – – – – (28·5–62·4)
Other noncommunicable diseases
127,476·9 11,613·9 4,658·1 12,247·7 7,249·9 5,238·2 (99,171·4–169,615·6) (9,221·6–14,392·6) (3,787·5–5,667·0) (9,644·2–14,446·0) (6,018·0–8,925·6) (3,832·5–7,328·5)
Congenital anomalies
38,887·3 11,609·5 4,108·6 10,151·8 4,640·5 1,429·9 (31,850·5–45,718·6) (9,218·0–14,387·0) (3,366·6–5,137·2) (7,597·6–12,205·8) (3,741·6–5,803·4) (1,188·2–1,758·0)
Neural tube defects
6,372·4 3,103·8 646·3 993·1 496·0 192·1 (3,883·9–9,095·8) (1,703·0–4,966·2) (340·5–1,030·8) (559·3–1,648·3) (268·8–878·5) (114·8–305·0)
Congenital heart anomalies
15,457·2 3,940·4 1,821·2 4,341·9 2,052·6 569·5 (13,675·3–17,753·7) (3,361·6–4,669·3) (1,532·9–2,257·6) (3,408·9–5,547·7) (1,596·3–2,758·5) (460·8–721·5)
Cleft lip and cleft palate
570·5 108·8 57·9 124·5 79·5 43·2 (408·1–746·6) (60·2–173·8) (32·1–94·1) (72·0–197·3) (55·5–110·8) (29·7–59·5)
12
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, All Ages
Both Sexes, 0-6 Days
Both Sexes, 7-27 Days
Both Sexes, 28-364 Days
Both Sexes, 1-4 Years
Both Sexes, 5-9 Years
Down's syndrome
1,775·0 189·1 101·6 320·3 258·0 92·5 (1,226·7–2,462·8) (104·8–334·7) (54·3–176·5) (180·9–535·0) (133·4–435·9) (62·7–132·6)
Other chromosomal abnormalities
1,760·9 562·3 256·3 427·4 125·4 50·8 (1,017·3–2,972·2) (280·7–1,118·0) (130·6–485·3) (209·9–850·1) (62·0–244·6) (32·4–84·9)
Other congenital anomalies
12,951·3 3,705·1 1,225·3 3,944·6 1,629·1 481·7 (8,408·1–17,168·9) (2,219·8–5,335·5) (708·4–1,792·0) (2,250·8–5,860·9) (887·1–2,569·6) (336·5–660·4)
Skin and subcutaneous diseases
36,948·1 4·1 12·1 734·3 2,395·1 2,969·9 (24,800·1–55,671·5) (2·3–7·2) (6·7–21·3) (558·8–956·6) (1,627·9–3,462·0) (1,930·0–4,484·7)
Eczema
8,896·8 951·4 1,176·0 (4,518·4–14,049·2) – – – (474·6–1,513·7) (589·3–1,865·4)
Psoriasis
1,058·7 7·9 21·7 (528·3–1,690·2) – – – (3·7–13·2) (10·8–35·3)
Cellulitis
1,291·5 0·2 0·6 120·3 156·0 58·3 (1,000·1–1,769·5) (0·1–0·5) (0·2–1·4) (88·8–159·5) (98·9–215·9) (37·9–97·1)
Abscess, impetigo, and other bacterial skin diseases
2,869·1 0·8 2·3 468·6 491·0 308·2 (2,099·1–4,174·9) (0·4–1·5) (1·1–4·4) (340·9–612·0) (331·2–719·0) (162·0–555·9)
Scabies
1,579·7 1·9 5·6 87·3 253·8 160·1 (806·9–2,792·0) (0·9–3·6) (2·7–10·5) (43·1–164·1) (128·7–459·3) (81·0–278·4)
Fungal skin diseases
2,302·8 0·2 0·5 7·5 87·3 214·4 (740·4–5,435·3) (0·0–0·4) (0·1–1·2) (2·1–18·9) (27·9–202·4) (67·5–500·7)
Viral skin diseases
2,730·8 146·5 452·1 (1,203·2–4,941·3) – – – (67·4–254·8) (201·1–814·8)
Acne vulgaris
4,001·8 89·5 (1,868·6–7,575·2) – – – – (41·2–169·8)
Alopecia areata
1,352·5 24·5 82·5 (423·8–2,567·0) – – – (7·6–46·4) (25·2–158·3)
Pruritus
2,086·4 0·1 0·3 5·1 25·1 38·2 (1,004·4–3,951·3) (0·1–0·2) (0·1–0·6) (2·4–9·7) (11·7–46·7) (18·2–73·0)
Urticaria
2,599·6 0·8 2·2 34·8 155·2 205·4 (980·1–4,440·5) (0·3–1·4) (0·9–4·1) (13·6–62·9) (59·9–276·0) (77·9–354·0)
Decubitus ulcer
1,205·7 10·4 5·1 (914·3–1,538·9) – – – (6·0–13·3) (3·8–6·3)
Other skin and subcutaneous diseases
4,972·8 0·2 0·6 10·7 86·0 158·3 (2,328·5–9,310·8) (0·1–0·4) (0·3–1·1) (4·7–18·4) (39·8–165·2) (73·3–293·9)
Sense organ diseases
34,733·5 0·2 0·4 5·8 121·3 437·9 (25,167·0–47,662·6) (0·1–0·4) (0·2–0·7) (3·0–10·8) (82·5–183·6) (294·5–661·5)
Glaucoma
943·1 (724·5–1,177·6) – – – – –
Cataracts
4,732·1 (3,646·5–6,010·1) – – – – –
Macular degeneration
1,329·3 (1,025·5–1,667·8) – – – – –
13
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, All Ages
Both Sexes, 0-6 Days
Both Sexes, 7-27 Days
Both Sexes, 28-364 Days
Both Sexes, 1-4 Years
Both Sexes, 5-9 Years
Refraction and accommodation disorders
5,593·0
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, All Ages
Both Sexes, 0-6 Days
Both Sexes, 7-27 Days
Both Sexes, 28-364 Days
Both Sexes, 1-4 Years
Both Sexes, 5-9 Years
Fire, heat and hot substances
19,009·6 62·4 100·1 1,143·3 4,049·8 1,015·5 (13,289·5–24,139·5) (44·0–86·0) (74·7–145·6) (790·2–1,641·9) (2,826·1–5,184·9) (687·1–1,617·7)
Poisonings
8,933·9 49·1 64·1 335·0 969·0 248·8 (6,646·6–11,850·5) (35·1–76·8) (44·1–105·1) (237·5–479·1) (711·0–1,434·2) (181·2–371·3)
Exposure to mechanical forces
11,366·8 32·6 29·5 245·1 1,017·4 484·9 (8,667·7–13,493·2) (23·2–48·7) (20·6–42·6) (150·9–342·3) (706·0–1,569·8) (352·3–750·4)
Mechanical forces (firearm)
4,624·5 19·3 7·5 94·5 347·9 210·5 (3,124·7–6,872·3) (9·8–36·4) (3·3–12·4) (53·8–194·0) (150·9–633·8) (118·5–374·2)
Mechanical forces (other)
7,097·5 13·3 22·0 150·6 672·0 281·9 (4,685·8–8,516·7) (9·1–23·1) (12·8–31·6) (63·9–229·5) (307·4–1,111·2) (164·0–453·5)
Adverse effects of medical treatment
4,081·8 99·3 86·3 411·7 337·8 94·8 (3,333·1–4,729·9) (70·0–140·1) (61·1–119·2) (292·2–549·7) (194·2–495·3) (69·1–125·7)
Animal contact
3,658·7 90·3 74·8 364·5 589·7 343·9 (2,366·3–5,048·5) (38·8–225·1) (37·8–138·1) (159·1–701·3) (291·4–1,001·7) (196·7–575·1)
Animal contact (venomous)
2,729·4 46·3 59·4 264·9 435·9 280·0 (1,544·8–4,805·6) (15·6–127·1) (26·4–112·4) (100·2–542·4) (209·2–924·5) (131·8–568·7)
Animal contact (non-venomous)
929·3 44·0 15·4 99·6 153·8 63·9 (557·9–1,281·2) (17·9–114·7) (5·2–33·4) (39·3–201·5) (62·3–280·6) (35·1–98·5)
Unintentional injuries not classified elsewhere
18,368·6 328·4 375·7 2,866·4 1,517·0 542·1 (16,254·4–20,785·8) (234·5–522·3) (263·8–586·8) (2,204·7–3,780·9) (1,213·2–2,002·4) (420·4–726·0)
Self-harm and interpersonal violence
62,194·8 208·7 72·6 399·8 880·5 395·2 (51,859·0–73,023·3) (141·5–285·4) (42·3–113·1) (279·6–519·6) (621·1–1,163·4) (312·6–487·2)
Self-harm
36,654·3 75·6 (26,890·1–44,649·1) – – – – (52·9–112·5)
Interpersonal violence
25,540·5 208·7 72·6 399·8 880·5 319·5 (20,030·4–32,921·0) (141·5–285·4) (42·3–113·1) (279·6–519·6) (621·1–1,163·4) (244·9–397·4)
Assault by firearm
11,145·5 29·3 24·9 87·7 199·9 99·8 (8,768·6–13,161·1) (16·2–46·6) (5·5–91·1) (49·0–132·1) (98·0–316·1) (66·1–138·8)
Assault by sharp object
7,095·0 22·3 4·5 48·9 119·0 48·5 (4,828·0–10,148·2) (13·2–39·5) (2·6–8·5) (31·4–80·4) (55·5–228·6) (32·1–70·4)
Assault by other means
7,526·4 157·1 43·2 263·2 563·3 174·6 (6,273·9–8,919·6) (107·8–251·7) (23·7–76·7) (199·8–371·1) (323·0–875·4) (137·2–228·4)
Forces of nature, war, and legal intervention
14,346·7 141·7 188·7 608·3 649·1 216·4 (8,968·7–27,860·5) (99·1–202·0) (140·7–254·0) (472·5–810·7) (465·5–901·9) (165·1–292·8)
Exposure to forces of nature
13,386·9 135·9 168·8 537·3 586·4 199·6 (8,177·0–26,226·0) (91·3–193·8) (122·3–233·0) (409·0–734·0) (402·4–839·5) (149·6–274·3)
Collective violence and legal intervention
959·8 5·8 19·9 71·0 62·8 16·7 (708·3–1,479·8) (1·2–12·5) (15·9–28·2) (60·2–87·6) (47·4–84·3) (15·4–18·8)
15
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, 10-14 Years
Both Sexes, 15-19 Years
Both Sexes, 20-24 Years
Both Sexes, 25-29 Years
Both Sexes, 30-34 Years
All causes
69,408·3 98,684·2 123,477·6 128,790·6 124,743·4 (61,446·3–78,993·8) (89,314·9–109,302·1) (114,254·5–133,679·9) (119,138·3–139,656·7) (115,404·0–135,011·6)
Communicable, maternal, neonatal and nutritional disorders
22,251·7 22,543·5 30,576·2 36,416·0 35,910·7 (19,326·4–26,155·4) (20,096·3–25,465·3) (27,920·8–33,162·6) (33,821·6–39,234·0) (33,329·2–38,677·9)
HIV/AIDS and tuberculosis
2,933·2 3,164·0 7,817·7 15,855·8 18,424·1 (2,638·5–3,259·3) (2,793·5–3,560·9) (6,965·7–8,659·1) (14,368·7–17,284·2) (16,913·9–20,015·6)
Tuberculosis
610·5 1,437·3 2,998·8 4,439·3 4,837·2 (477·0–774·5) (1,152·8–1,744·5) (2,340·3–3,683·6) (3,432·4–5,376·3) (3,732·1–5,932·1)
HIV/AIDS
2,322·7 1,726·7 4,818·9 11,416·5 13,586·8 (2,061·5–2,600·5) (1,511·6–1,986·3) (4,210·5–5,393·2) (10,383·4–12,501·1) (12,539·4–14,642·2)
HIV disease resulting in mycobacterial infection
457·8 351·5 911·3 2,112·7 2,465·6 (388·7–529·6) (303·6–408·7) (793·6–1,020·9) (1,910·6–2,329·0) (2,251·3–2,670·8)
HIV disease resulting in other specified or unspecified diseases
1,864·9 1,375·2 3,907·7 9,303·8 11,121·2 (1,612·4–2,132·3) (1,172·1–1,609·2) (3,365·6–4,395·7) (8,394·5–10,223·7) (10,205·0–12,045·6)
Diarrhea, LRI, meningitis, and other common infectious diseases
7,172·3 6,827·5 7,524·5 7,285·4 6,428·4 (5,745·5–8,619·4) (5,454·7–8,143·0) (6,174·6–8,900·6) (6,093·7–8,573·4) (5,400·7–7,466·1)
Diarrheal diseases
1,770·7 1,711·7 2,081·4 2,238·0 1,988·6 (1,389·1–2,299·5) (1,361·7–2,197·6) (1,675·9–2,613·1) (1,826·0–2,815·5) (1,620·1–2,458·2)
Cholera
59·6 59·9 73·1 78·5 68·5 (39·7–90·6) (39·7–87·9) (51·8–105·6) (55·9–112·4) (48·6–95·1)
Other salmonella infections
199·6 185·9 214·4 216·7 178·4 (142·4–277·2) (130·8–264·6) (156·1–294·9) (156·5–304·6) (128·3–241·8)
Shigellosis
245·4 223·7 255·2 257·0 209·8 (175·7–347·3) (160·5–309·3) (187·2–347·8) (186·0–343·5) (158·5–273·8)
Enteropathogenic E coli infection
49·1 41·4 43·4 39·7 28·9 (34·4–69·3) (29·7–58·8) (31·8–58·7) (29·1–54·1) (21·2–39·2)
Enterotoxigenic E coli infection
161·1 166·7 217·8 253·0 245·8 (117·2–224·1) (118·9–232·8) (161·9–288·5) (188·1–334·0) (185·8–321·2)
Campylobacter enteritis
110·6 102·9 120·7 125·6 109·1 (75·6–158·2) (71·9–151·6) (84·0–167·9) (89·0–180·3) (78·1–149·8)
Amoebiasis
51·2 58·1 81·4 100·2 99·1 (35·7–73·4) (40·4–81·3) (58·3–110·8) (71·1–138·9) (71·8–133·9)
Cryptosporidiosis
47·0 44·1 52·0 54·1 46·1 (32·6–67·2) (30·8–62·9) (36·7–71·7) (38·5–75·6) (32·8–61·7)
Rotaviral enteritis
192·2 177·5 206·1 208·6 169·4 (132·5–275·1) (124·6–252·6) (147·3–283·2) (147·9–287·0) (121·2–229·2)
Other diarrheal diseases
654·8 651·6 817·2 904·6 833·4 (449·6–940·3) (451·8–967·3) (573·3–1,160·7) (628·2–1,265·1) (588·8–1,146·2)
Typhoid and paratyphoid fevers
1,337·9 1,325·1 1,170·8 896·0 653·9 (187·4–2,473·9) (178·6–2,476·6) (158·5–2,193·4) (120·9–1,677·8) (90·3–1,213·5)
Lower respiratory infections
1,615·4 1,691·5 2,129·1 2,271·5 2,142·0 (1,330·1–1,998·8) (1,373·8–2,031·3) (1,730·1–2,522·3) (1,779·5–2,718·5) (1,693·5–2,590·1)
16
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, 10-14 Years
Both Sexes, 15-19 Years
Both Sexes, 20-24 Years
Both Sexes, 25-29 Years
Both Sexes, 30-34 Years
Influenza
315·3 345·3 455·9 509·1 501·5 (253·4–401·0) (282·0–414·3) (370·8–542·9) (399·7–609·5) (398·6–606·9)
Pneumococcal pneumonia
287·8 348·5 501·7 588·2 590·7 (234·1–367·5) (280·6–414·5) (407·0–593·6) (462·1–700·3) (463·6–715·4)
H influenza type B pneumonia
287·9 296·6 372·0 389·4 359·8 (226·1–375·1) (242·6–357·5) (304·3–443·9) (305·1–464·9) (284·2–441·5)
Respiratory syncytial virus pneumonia
15·4 16·3 20·8 22·2 20·9 (12·6–19·3) (13·2–19·6) (16·9–24·8) (17·4–26·7) (16·5–25·4)
Other lower respiratory infections
709·0 684·7 778·7 762·6 669·1 (578·3–873·8) (551·5–837·1) (623·4–934·1) (602·0–918·8) (528·0–827·3)
Upper respiratory infections
236·1 167·0 128·6 129·1 125·2 (118·2–426·2) (81·7–298·3) (64·6–228·5) (66·1–227·4) (62·9–221·2)
Otitis media
438·4 335·6 323·1 310·8 283·1 (279·2–666·8) (206·9–520·3) (200·4–509·1) (193·8–490·4) (178·2–442·4)
Meningitis
1,058·3 1,107·8 1,187·5 1,039·5 882·7 (866·5–1,311·1) (935·3–1,289·4) (939·2–1,441·2) (809·4–1,282·2) (691·0–1,104·7)
Pneumococcal meningitis
368·9 405·1 458·2 406·9 341·1 (295·5–468·4) (338·8–483·6) (357·5–564·9) (311·0–510·1) (261·3–427·2)
H influenza type B meningitis
248·4 174·9 111·3 58·8 53·5 (196·1–323·2) (145·1–211·1) (85·3–141·4) (43·6–77·2) (39·6–71·2)
Meningococcal infection
221·7 247·5 266·7 237·4 187·0 (183·3–268·2) (209·4–288·5) (207·3–321·7) (178·5–296·8) (145·8–227·5)
Other meningitis
215·7 278·6 350·2 335·3 300·1 (174·1–269·4) (237·2–331·7) (270·8–429·8) (257·4–413·2) (233·5–374·3)
Encephalitis
371·5 307·5 380·3 310·0 273·3 (242·1–564·2) (223·0–434·6) (242·3–563·6) (204·3–484·0) (180·7–430·9)
Diphtheria
7·3 2·5 1·6 1·3 1·0 (0·0–59·8) (0·0–21·3) (0·0–13·6) (0·0–11·5) (0·0–8·4)
Whooping cough
14·6 10·0 7·8 7·5 6·8 (0·4–71·9) (0·3–49·4) (0·2–38·6) (0·2–37·0) (0·2–33·2)
Tetanus
48·6 36·8 36·3 35·1 36·3 (0·6–199·2) (0·4–154·3) (0·4–150·3) (0·4–148·0) (0·4–158·2)
Measles
250·7 112·0 58·8 27·2 14·3 (83·7–578·5) (37·7–259·0) (19·8–137·6) (9·4–62·2) (5·3–32·0)
Varicella
22·8 19·9 19·3 19·3 21·3 (8·6–80·4) (8·1–65·7) (7·9–64·0) (7·0–70·9) (7·1–83·1)
Neglected tropical diseases and malaria
4,304·8 4,448·6 4,910·3 4,122·6 3,344·6 (3,406·5–5,502·7) (3,566·1–5,665·4) (3,820·5–6,293·4) (3,146·5–5,421·6) (2,506·3–4,528·5)
Malaria
1,919·8 2,508·8 3,013·2 2,444·1 1,865·8 (1,420·0–2,514·6) (1,819·6–3,391·0) (2,111·9–4,255·5) (1,649·0–3,738·8) (1,189·7–2,997·8)
Chagas disease
2·0 4·6 6·1 11·0 18·8 (0·9–4·5) (1·6–12·6) (2·4–15·8) (4·5–28·1) (8·0–45·4)
17
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, 10-14 Years
Both Sexes, 15-19 Years
Both Sexes, 20-24 Years
Both Sexes, 25-29 Years
Both Sexes, 30-34 Years
Leishmaniasis
297·8 253·7 223·9 174·9 140·2 (186·8–451·4) (155·4–392·6) (144·9–325·3) (113·5–259·4) (89·9–212·0)
African trypanosomiasis
59·0 83·4 83·3 65·7 48·8 (7·8–185·6) (11·3–261·8) (11·5–262·5) (9·0–204·1) (6·9–153·7)
Schistosomiasis
322·1 320·6 313·4 263·6 218·2 (153·8–639·4) (147·9–649·5) (146·2–628·9) (125·5–518·4) (106·1–420·2)
Cysticercosis
32·7 57·9 70·1 62·1 52·5 (22·0–46·5) (40·5–77·4) (49·1–94·2) (43·3–85·4) (36·6–72·7)
Echinococcosis
4·9 6·3 8·5 9·6 10·4 (2·1–10·2) (2·7–13·0) (3·9–18·0) (4·3–19·7) (4·7–21·3)
Lymphatic filariasis
108·3 321·5 305·4 280·1 249·8 (69·2–159·6) (202·8–459·5) (198·0–451·3) (177·2–412·4) (161·3–365·4)
Onchocerciasis
37·6 40·7 40·5 39·7 39·0 (25·5–52·8) (27·7–57·0) (27·9–56·0) (27·8–54·1) (28·2–53·0)
Trachoma
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, 10-14 Years
Both Sexes, 15-19 Years
Both Sexes, 20-24 Years
Both Sexes, 25-29 Years
Both Sexes, 30-34 Years
Obstructed labor
76·5 235·6 252·6 246·4 – (53·0–109·8) (179·6–309·8) (187·4–350·0) (171·6–373·8)
Abortion
257·2 559·9 480·6 364·9 – (178·5–354·0) (447·6–715·0) (369·6–606·0) (278·7–477·0)
Other maternal disorders
461·3 1,111·6 1,063·3 858·8 – (338·9–553·7) (873·0–1,314·4) (832·6–1,247·0) (681·3–1,015·0)
Neonatal disorders
994·1 930·1 872·0 755·0 642·0 (736·7–1,262·0) (700·5–1,161·3) (654·1–1,108·1) (570·8–953·5) (478·7–816·8)
Preterm birth complications
289·6 282·5 274·8 246·7 217·4 (215·8–370·7) (209·8–358·6) (207·2–348·5) (184·9–311·7) (162·4–275·3)
Neonatal encephalopathy (birth asphyxia and birth trauma)
704·6 647·6 597·2 508·3 424·6 (503·9–920·8) (469·8–836·7) (435·3–793·2) (366·4–666·9) (304·5–557·4)
Sepsis and other infectious disorders of the newborn baby
– – – – –
Other neonatal disorders
– – – – –
Nutritional deficiencies
5,591·9 4,130·5 4,098·2 3,444·8 2,942·4 (4,041·5–7,610·2) (3,135·1–5,411·5) (3,142·3–5,290·1) (2,640·3–4,412·2) (2,266·9–3,754·7)
Protein-energy malnutrition
490·7 666·9 786·3 680·2 625·2 (351·9–697·6) (455·4–1,012·8) (541·9–1,175·8) (497·2–959·0) (444·2–885·8)
Iodine deficiency
336·1 458·0 523·0 458·0 381·8 (214·6–524·4) (292·8–722·8) (337·5–816·4) (293·8–714·2) (244·8–598·5)
Vitamin A deficiency
187·1 157·5 93·4 73·6 55·5 (138·5–247·1) (117·6–208·2) (69·5–123·0) (54·1–95·0) (40·6–73·5)
Iron-deficiency anemia
4,573·3 2,838·9 2,685·8 2,223·3 1,870·2 (3,020·6–6,589·5) (1,918·6–4,055·1) (1,846·0–3,811·5) (1,545·6–3,137·0) (1,293·6–2,655·2)
Other nutritional deficiencies
4·8 9·1 9·8 9·7 9·7 (3·4–6·2) (6·4–12·7) (7·2–14·1) (7·2–12·9) (7·0–12·6)
Other communicable, maternal, neonatal and nutritional di d
1,255·3 1,309·8 1,651·2 1,531·9 1,398·2 (966·4–1,647·3) (994·8–1,805·7) (1,271·8–2,188·8) (1,219·3–2,027·7) (1,120·7–1,814·0)
Sexually transmitted diseases excluding HIV
48·4 213·0 344·0 296·7 228·0 (30·6–78·7) (122·7–383·9) (190·5–628·1) (175·4–523·7) (137·0–392·2)
Syphilis
7·0 14·6 21·7 25·0 25·5 (4·4–13·9) (9·5–25·4) (12·7–39·6) (14·5–43·2) (13·8–43·4)
Sexually transmitted chlamydial diseases
22·5 120·1 192·8 148·7 97·1 (11·5–39·7) (58·9–221·0) (93·7–355·4) (75·3–268·5) (50·7–171·8)
Gonococcal infection
7·7 33·9 55·0 51·8 45·7 (4·3–12·8) (17·3–58·7) (28·7–96·2) (27·7–90·2) (24·5–79·1)
Trichomoniasis
4·8 27·9 44·9 35·1 23·0 (0·0–14·2) (0·0–82·0) (0·0–132·7) (0·0–104·0) (0·0–67·2)
Other sexually transmitted diseases
6·4 16·5 29·5 36·1 36·7 (4·6–9·3) (11·9–25·0) (21·2–43·6) (24·9–52·7) (25·5–55·4)
19
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, 10-14 Years
Both Sexes, 15-19 Years
Both Sexes, 20-24 Years
Both Sexes, 25-29 Years
Both Sexes, 30-34 Years
Hepatitis
477·6 679·7 839·9 759·1 699·3 (297·3–790·9) (425·0–1,103·7) (569·0–1,325·3) (526·4–1,173·9) (500·3–1,035·1)
Acute hepatitis A
76·3 80·1 117·0 140·4 172·8 (34·4–172·8) (32·0–199·3) (49·7–297·9) (59·9–331·7) (71·6–440·6)
Acute hepatitis B
55·0 75·4 118·1 145·7 184·9 (27·0–93·7) (43·6–118·0) (71·4–181·6) (83·6–250·6) (110·3–297·4)
Acute hepatitis C
6·4 7·4 11·9 19·0 28·2 (3·0–14·0) (4·0–12·5) (6·9–20·7) (11·4–32·9) (16·5–47·5)
Acute hepatitis E
339·9 516·8 592·8 454·0 313·4 (122·2–745·7) (183·1–1,169·6) (250·5–1,171·6) (185·2–984·5) (129·4–632·1)
Leprosy
0·5 0·6 0·6 0·5 0·5 (0·2–1·2) (0·2–1·2) (0·2–1·2) (0·2–1·1) (0·2–1·1)
Other infectious diseases
728·8 416·6 466·8 475·5 470·4 (547·8–978·2) (319·8–562·7) (356·5–614·0) (332·6–615·1) (318·0–608·0)
Noncommunicable diseases
37,487·2 51,395·0 60,261·7 63,837·4 65,583·4 (32,059·2–43,748·3) (44,850·0–59,381·2) (52,977·2–67,903·1) (56,534·3–71,349·2) (58,217·1–73,147·2)
Neoplasms
1,588·4 2,701·9 3,124·1 3,516·1 4,688·7 (1,311·1–1,828·8) (2,239·2–3,086·9) (2,599·8–3,554·2) (3,020·5–3,925·8) (4,156·8–5,105·6)
Oesophagus cancer
10·7 25·5 42·0 72·6 – (6·0–22·0) (17·5–39·8) (28·6–61·7) (48·2–103·4)
Stomach cancer
69·3 138·0 223·1 360·0 – (27·2–129·0) (75·5–211·9) (147·1–299·7) (251·1–476·6)
Liver cancer
68·5 129·4 236·5 365·0 555·4 (44·0–109·8) (90·3–195·2) (163·1–344·1) (267·8–529·4) (411·9–768·9)
Liver cancer secondary to hepatitis B
23·5 53·3 104·9 167·6 259·5 (15·0–38·7) (36·3–82·8) (69·4–155·3) (118·7–247·8) (187·5–366·8)
Liver cancer secondary to hepatitis C
3·0 6·4 11·4 17·6 26·3 (1·9–4·7) (4·5–9·5) (8·1–16·3) (13·0–25·1) (20·0–35·5)
Liver cancer secondary to alcohol use
6·7 33·0 71·0 128·6 – (4·7–10·3) (22·3–48·7) (51·5–106·1) (95·2–182·5)
Other liver cancer
42·0 63·0 87·2 108·9 141·0 (27·1–67·4) (44·5–95·4) (61·5–123·5) (80·7–154·9) (107·3–193·9)
Larynx cancer
5·0 9·2 9·7 21·5 – (2·3–11·1) (4·7–17·8) (4·9–17·7) (10·6–39·9)
Trachea, bronchus and lung cancers
52·4 113·4 174·7 315·6 – (34·4–68·5) (70·9–150·8) (117·3–228·1) (224·1–399·6)
Breast cancer
13·3 47·2 142·2 379·8 – (10·9–16·6) (38·3–58·7) (119·3–168·0) (339·0–428·2)
Cervical cancer
12·0 47·0 127·3 264·1 – (7·6–19·3) (28·8–68·7) (79·6–178·6) (155·3–362·1)
Uterine cancer
5·6 7·6 11·4 18·5 – (2·6–10·1) (3·3–12·2) (5·2–17·4) (7·8–26·6)
20
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, 10-14 Years
Both Sexes, 15-19 Years
Both Sexes, 20-24 Years
Both Sexes, 25-29 Years
Both Sexes, 30-34 Years
Prostate cancer
4·8 6·5 5·3 5·8 – (2·3–8·7) (3·3–12·0) (2·6–8·7) (3·0–10·1)
Colon and rectum cancers
59·5 147·7 229·5 316·3 – (45·9–71·9) (113·5–178·5) (188·6–271·9) (269·2–374·6)
Mouth cancer
24·8 38·2 63·7 97·8 – (15·6–40·7) (24·8–60·5) (40·7–94·9) (65·2–136·2)
Nasopharynx cancer
26·0 44·8 52·4 59·0 76·2 (16·3–41·5) (24·0–78·4) (29·7–91·7) (30·7–111·4) (43·8–132·8)
Cancer of other part of pharynx and oropharynx
21·5 27·2 43·1 70·9 – (11·1–44·6) (13·5–59·5) (20·4–93·9) (32·5–168·1)
Gallbladder and biliary tract cancer
20·2 34·5 43·6 60·4 – (4·0–66·5) (7·6–112·8) (8·8–178·6) (17·4–176·1)
Pancreas cancer
18·4 27·6 38·8 66·7 – (7·5–48·9) (13·3–52·3) (22·5–62·9) (43·5–98·9)
Malignant melanoma of skin
12·1 22·8 33·2 46·3 – (7·2–20·5) (14·7–37·5) (21·2–49·6) (30·7–72·1)
Non-melanoma skin cancer
8·5 12·4 17·3 20·2 – (4·5–12·6) (6·7–17·4) (9·6–24·7) (11·1–29·5)
Ovary cancer
59·7 71·4 78·0 108·6 – (38·0–87·3) (45·5–97·6) (53·1–106·7) (70·0–141·4)
Testis cancer
23·1 48·8 50·2 41·4 – (12·7–33·9) (29·8–69·5) (29·7–69·3) (25·9–57·4)
Kidney and other urinary organ cancers
28·4 31·4 35·8 35·3 43·7 (13·9–57·9) (14·1–90·9) (19·1–70·6) (20·5–60·8) (27·4–70·3)
Bladder cancer
10·8 16·1 19·5 33·0 – (8·0–13·8) (11·7–20·1) (15·3–24·6) (24·8–41·7)
Brain and nervous system cancers
219·4 204·2 212·1 229·6 281·1 (127·6–288·7) (106·5–280·0) (118·0–280·9) (135·0–310·9) (166·3–364·4)
Thyroid cancer
12·6 12·5 16·4 16·2 22·6 (5·8–26·8) (7·5–20·8) (10·6–26·1) (11·2–22·3) (16·2–31·1)
Hodgkin's disease
26·7 38·7 56·1 60·4 53·7 (16·9–39·7) (24·5–56·8) (36·6–81·0) (38·7–87·9) (35·4–79·0)
Non-Hodgkin's lymphoma
216·2 290·1 287·5 241·0 250·8 (140·9–307·8) (203·5–392·5) (208·6–372·5) (183·7–296·8) (188·6–314·0)
Multiple myeloma
18·4 16·4 14·0 15·1 – (7·0–44·1) (6·9–36·0) (6·8–28·8) (8·6–24·4)
Leukemia
616·0 790·5 700·9 548·6 462·4 (479·5–761·1) (601·9–964·0) (516·7–864·7) (413·8–669·1) (351·7–581·0)
Other neoplasms
374·6 710·2 668·8 594·4 628·2 (248·1–515·5) (465·3–958·5) (434·9–899·2) (380·1–808·9) (414·2–851·4)
Cardiovascular and circulatory diseases
1,509·7 2,766·7 4,020·2 4,696·1 5,988·4 (1,285·1–1,775·5) (2,383·9–3,115·1) (3,588·2–4,454·7) (4,191·1–5,186·3) (5,335·8–6,606·7)
21
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, 10-14 Years
Both Sexes, 15-19 Years
Both Sexes, 20-24 Years
Both Sexes, 25-29 Years
Both Sexes, 30-34 Years
Rheumatic heart disease
339·7 477·6 545·5 600·1 612·4 (267·3–430·3) (389·9–585·4) (445·1–661·9) (496·5–741·1) (503·2–744·7)
Ischemic heart disease
268·5 732·1 1,327·8 1,690·7 2,476·9 (191·9–376·5) (574·6–932·5) (1,095·5–1,608·1) (1,437·1–1,985·1) (2,121·9–2,905·1)
Cerebrovascular disease
339·3 629·2 1,004·8 1,148·0 1,476·7 (251·1–432·0) (490·1–756·5) (791·3–1,190·4) (914·0–1,343·3) (1,201·3–1,686·5)
Ischemic stroke
55·3 97·7 152·9 188·5 253·8 (47·2–64·8) (83·6–111·6) (124·9–184·0) (158·3–222·2) (217·2–292·2)
Hemorrhagic and other non-ischemic stroke
284·0 531·5 851·9 959·6 1,222·9 (200·9–396·0) (381·8–680·9) (659·8–1,032·1) (755·6–1,170·0) (992·8–1,461·9)
Hypertensive heart disease
40·4 93·2 150·0 190·3 249·4 (30·8–50·9) (70·9–118·7) (112·5–185·9) (149·5–237·6) (196·1–312·8)
Cardiomyopathy and myocarditis
167·8 283·2 352·5 412·4 447·7 (128·1–221·5) (222·5–361·2) (286·0–437·7) (338·3–500·4) (374·4–543·1)
Atrial fibrillation and flutter
17·6 20·4 22·0 24·4 38·4 (11·2–25·3) (13·2–29·5) (14·6–32·5) (15·9–35·0) (27·4–51·5)
Aortic aneurysm
23·1 31·6 37·7 49·9 – (13·2–36·1) (19·7–52·9) (25·4–56·3) (32·8–80·3)
Peripheral vascular disease
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, 10-14 Years
Both Sexes, 15-19 Years
Both Sexes, 20-24 Years
Both Sexes, 25-29 Years
Both Sexes, 30-34 Years
Cirrhosis of the liver secondary to alcohol use
18·7 102·3 256·5 538·1 – (14·1–26·2) (80·0–141·5) (201·0–331·0) (426·1–705·2)
Other cirrhosis of the liver
147·6 161·9 238·9 322·4 443·1 (101·2–239·3) (127·1–220·1) (193·2–308·0) (262·1–401·8) (366·4–547·6)
Digestive diseases (except cirrhosis)
721·5 1,225·1 1,549·8 1,563·8 1,742·8 (594·3–862·1) (1,018·8–1,473·5) (1,288·9–1,816·5) (1,332·1–1,837·2) (1,462·6–2,043·3)
Peptic ulcer disease
93·2 239·5 339·2 336·4 405·3 (60·6–144·4) (153·0–375·7) (234·5–472·5) (241·7–460·1) (298·0–555·7)
Gastritis and duodenitis
20·9 123·0 104·0 110·5 116·6 (14·7–30·0) (76·4–199·5) (67·4–164·7) (70·7–175·6) (77·4–180·7)
Appendicitis
77·0 83·1 90·1 82·3 75·0 (56·6–110·6) (56·9–119·6) (59·7–127·8) (53·6–119·9) (47·5–108·5)
Paralytic ileus and intestinal obstruction without hernia
78·3 112·2 156·2 149·0 169·9 (52·3–126·6) (80·5–161·1) (106·7–221·4) (100·0–208·0) (118·8–242·6)
Inguinal/femoral hernia
17·6 18·0 22·2 25·1 28·8 (10·1–30·4) (11·1–30·2) (14·0–38·1) (15·5–43·2) (17·9–47·7)
Noninfective inflammatory bowel disease
199·0 214·5 216·4 189·8 176·7 (147·4–267·3) (160·6–287·7) (160·9–283·1) (145·0–243·3) (135·4–227·8)
Vascular disorders of intestine
7·1 9·6 12·7 15·8 17·7 (2·6–15·4) (3·6–19·4) (4·7–25·4) (5·5–39·8) (6·8–41·1)
Gall bladder and bile duct disease
26·5 49·2 75·9 84·5 97·2 (19·1–37·9) (37·2–66·9) (58·8–99·3) (66·7–110·1) (77·2–123·3)
Pancreatitis
16·5 47·2 96·1 149·0 186·2 (11·7–21·8) (32·4–67·4) (69·5–127·7) (104·8–204·1) (136·5–254·1)
Other digestive diseases
185·4 328·7 436·8 421·3 469·4 (137·5–263·3) (241·6–469·8) (329·5–622·6) (320·7–579·8) (355·4–665·8)
Neurological disorders
3,224·0 5,233·5 5,942·9 5,280·3 4,735·0 (2,657·4–3,837·9) (4,223·0–6,314·6) (4,801·7–7,247·6) (4,289·4–6,409·5) (3,812·4–5,728·9)
Alzheimer's disease and other dementias
44·6 39·8 41·1 33·8 37·1 (27·9–69·6) (29·2–54·9) (28·7–61·2) (24·0–47·1) (26·5–51·1)
Parkinson's disease
17·2 15·1 13·1 – – (10·8–25·3) (9·3–21·6) (8·8–17·5)
Epilepsy
1,252·2 1,635·6 1,796·0 1,564·7 1,286·8 (1,021·6–1,473·1) (1,334·8–1,900·4) (1,454·8–2,116·9) (1,291·4–1,847·7) (1,060·5–1,490·9)
Multiple sclerosis
2·4 7·1 30·5 63·1 93·2 (1·1–4·7) (4·0–11·3) (22·6–40·0) (49·4–80·1) (73·8–114·4)
Migraine
1,205·0 2,489·1 2,977·5 2,682·8 2,375·3 (765·8–1,685·2) (1,590·0–3,468·2) (1,915·0–4,127·4) (1,729·3–3,713·0) (1,532·5–3,311·5)
Tension-type headache
61·6 139·9 202·5 207·2 190·1 (36·2–99·1) (82·2–223·7) (119·6–320·9) (122·8–328·8) (112·9–302·0)
Other neurological disorders
658·2 922·0 878·1 713·6 739·5 (397·0–1,057·8) (587·0–1,478·9) (557·7–1,385·7) (447·9–1,157·3) (454·5–1,275·8)
23
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, 10-14 Years
Both Sexes, 15-19 Years
Both Sexes, 20-24 Years
Both Sexes, 25-29 Years
Both Sexes, 30-34 Years
Mental and behavioral disorders
11,350·5 16,886·4 21,068·0 21,655·2 19,559·2 (9,063·3–13,858·6) (13,707·8–20,376·0) (17,267·4–24,821·8) (17,968·2–25,465·2) (16,255·1–22,979·1)
Schizophrenia
30·1 327·6 1,004·1 1,687·8 1,990·7 (16·7–45·8) (203·8–457·9) (634·4–1,385·7) (1,082·0–2,290·8) (1,273·7–2,713·1)
Alcohol use disorders
257·9 1,456·8 1,963·7 1,845·6 1,704·0 (176·8–354·9) (984·7–2,022·0) (1,345·8–2,709·5) (1,300·4–2,496·1) (1,217·9–2,280·7)
Drug use disorders
129·1 1,530·9 4,299·4 4,494·3 3,165·6 (85·5–194·6) (1,118·1–2,017·8) (3,237·7–5,490·5) (3,345·3–5,726·9) (2,358·8–4,073·1)
Opioid use disorders
19·2 297·2 1,821·2 2,226·3 1,567·6 (12·3–34·5) (219·4–383·3) (1,335·7–2,329·0) (1,659·5–2,823·9) (1,181·3–1,978·5)
Cocaine use disorders
0·2 40·1 283·8 326·0 186·3 (0·1–0·2) (23·0–62·4) (166·3–437·1) (192·4–503·2) (108·1–289·6)
Amphetamine use disorders
46·5 354·7 538·7 521·5 407·8 (25·1–72·6) (199·7–552·6) (300·7–846·3) (294·6–806·6) (229·6–642·9)
Cannabis use disorders
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, 10-14 Years
Both Sexes, 15-19 Years
Both Sexes, 20-24 Years
Both Sexes, 25-29 Years
Both Sexes, 30-34 Years
Idiopathic intellectual disability
164·3 156·2 140·5 113·9 88·0 (93·2–261·7) (89·0–252·5) (78·8–225·1) (63·0–184·5) (47·8–144·0)
Other mental and behavioral disorders
107·6 114·0 99·6 86·1 75·6 (65·6–166·9) (71·3–173·6) (63·5–151·8) (55·0–126·9) (49·5–111·8)
Diabetes, urogenital, blood, and endocrine diseases
2,824·9 3,301·4 4,697·9 5,281·9 5,671·2 (2,279·1–3,578·0) (2,774·0–4,067·8) (3,840·2–5,868·7) (4,235·7–6,813·6) (4,617·9–7,202·9)
Diabetes mellitus
368·4 529·9 756·6 1,001·5 1,392·5 (275·1–486·4) (410·3–681·2) (590·0–966·3) (799·1–1,235·0) (1,112·5–1,733·4)
Acute glomerulonephritis
166·8 216·0 201·4 189·8 172·2 (68·3–381·2) (77·8–608·5) (85·6–509·5) (70·2–548·5) (69·6–472·5)
Chronic kidney diseases
302·0 504·4 798·1 776·1 829·8 (227·2–404·2) (413·5–604·2) (661·7–940·3) (669·0–888·9) (709·7–960·8)
Chronic kidney disease due to diabetes mellitus
0·3 1·4 35·9 68·6 104·7 (0·1–0·5) (0·8–2·8) (29·2–43·3) (57·1–80·8) (88·5–123·6)
Chronic kidney disease due to hypertension
45·0 82·0 141·9 149·1 175·3 (33·1–61·7) (67·0–99·0) (116·9–168·7) (126·6–172·6) (151·8–203·4)
Chronic kidney disease unspecified
256·7 421·1 620·3 558·5 549·7 (194·0–342·8) (344·3–504·4) (512·0–733·6) (481·0–643·1) (473·1–644·4)
Urinary diseases and male infertility
74·6 142·8 229·6 306·4 414·4 (57·6–101·2) (107·6–202·3) (178·7–311·8) (238·3–420·6) (318·1–558·4)
Tubulointerstitial nephritis, pyelonephritis, and urinary tract infections
37·8 68·6 92·3 94·9 98·7 (26·0–50·0) (46·8–90·4) (63·2–120·1) (66·5–125·4) (68·7–126·2)
Urolithiasis
10·6 19·9 35·6 50·4 63·7 (6·2–25·6) (12·8–60·9) (23·9–96·5) (33·2–122·0) (43·2–136·7)
Benign prostatic hyperplasia
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, 10-14 Years
Both Sexes, 15-19 Years
Both Sexes, 20-24 Years
Both Sexes, 25-29 Years
Both Sexes, 30-34 Years
Premenstrual syndrome
55·0 343·2 415·6 328·6 – (2·8–146·7) (17·2–916·1) (20·9–1,111·0) (16·5–880·5)
Other gynecological diseases
95·7 104·5 92·6 80·6 – (66·3–134·2) (73·9–146·6) (66·7–127·4) (57·3–111·8)
Hemoglobinopathies and hemolytic anemias
1,458·5 1,030·6 952·2 813·2 665·3 (1,087·6–1,893·4) (813·1–1,291·8) (739·0–1,210·1) (644·9–1,019·3) (517·7–844·4)
Thalassemias
631·8 452·5 395·0 340·3 300·5 (453·9–861·1) (340·0–591·1) (298·8–519·5) (253·4–453·2) (220·1–402·1)
Sickle cell disorders
569·0 355·0 310·4 279·1 226·7 (420·9–743·7) (265·8–459·7) (237·1–399·4) (218·2–353·2) (177·2–287·2)
G6PD deficiency
29·7 20·8 17·7 15·7 13·1 (22·5–39·4) (16·3–26·9) (13·7–23·1) (12·4–20·2) (10·3–17·2)
Other hemoglobinopathies and hemolytic anemias
228·1 202·3 229·1 178·1 125·0 (158·1–333·0) (141·8–288·6) (138·6–335·4) (104·5–268·9) (78·4–182·4)
Other endocrine, nutritional, blood, and immune disorders
454·6 417·1 484·4 484·7 470·3 (330·1–619·4) (267·8–608·0) (312·0–684·1) (315·7–684·0) (312·1–667·0)
Musculoskeletal disorders
5,653·1 8,836·3 10,070·4 11,716·8 12,492·0 (3,938·0–7,595·3) (6,234·7–11,756·4) (7,286·7–13,085·7) (8,839·1–14,806·1) (9,326·7–15,996·7)
Rheumatoid arthritis
46·2 114·4 209·8 265·6 299·4 (33·8–62·0) (84·8–149·3) (155·4–275·5) (192·9–344·7) (221·4–387·3)
Osteoarthritis
46·5 – – – – (31·8–66·8)
Low back and neck pain
5,456·4 7,832·8 8,036·4 8,225·8 9,062·6 (3,754·5–7,392·6) (5,363·7–10,643·8) (5,551·2–10,819·7) (5,705·8–11,081·6) (6,280·7–12,224·8)
Low back pain
3,843·2 5,479·4 5,555·8 5,718·4 6,296·0 (2,601·0–5,325·9) (3,714·3–7,567·8) (3,761·5–7,556·9) (3,900·1–7,688·6) (4,261·9–8,499·7)
Neck pain
1,613·3 2,353·5 2,480·7 2,507·4 2,766·6 (1,117·4–2,242·1) (1,629·9–3,282·7) (1,726·5–3,450·8) (1,740·9–3,473·8) (1,926·7–3,818·7)
Gout
0·1 0·7 1·9 3·5 – (0·0–0·2) (0·4–1·2) (1·1–2·9) (2·1–5·3)
Other musculoskeletal disorders
150·4 888·9 1,823·5 3,223·4 3,080·1 (123·2–179·4) (707·0–1,032·6) (1,419·2–2,129·0) (2,773·4–3,551·1) (2,639·3–3,418·6)
Other noncommunicable diseases
5,988·4 6,220·6 5,189·6 5,012·1 4,919·1 (4,209·4–8,811·7) (4,236·7–9,461·1) (3,588·7–7,697·7) (3,478·9–7,471·0) (3,347·6–7,490·5)
Congenital anomalies
1,018·6 889·6 778·3 672·3 389·5 (819·0–1,281·4) (734·8–1,066·6) (637·8–946·8) (553·8–812·9) (324·8–460·8)
Neural tube defects
167·3 121·4 109·0 104·2 71·3 (99·4–290·2) (78·6–189·3) (72·9–155·9) (66·6–157·2) (44·8–105·6)
Congenital heart anomalies
391·6 410·1 351·3 296·5 140·1 (302·9–543·0) (332·3–514·1) (275·8–458·8) (226·7–400·7) (111·4–174·5)
Cleft lip and cleft palate
34·0 27·2 21·6 15·8 11·7 (23·7–47·0) (18·9–37·6) (15·0–30·4) (10·9–22·4) (8·0–17·3)
26
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, 10-14 Years
Both Sexes, 15-19 Years
Both Sexes, 20-24 Years
Both Sexes, 25-29 Years
Both Sexes, 30-34 Years
Down's syndrome
82·2 77·8 80·4 76·0 57·0 (56·8–115·7) (56·7–104·7) (58·0–110·6) (55·1–101·7) (41·8–75·7)
Other chromosomal abnormalities
43·1 35·1 37·9 33·9 23·5 (27·6–68·2) (25·1–48·9) (25·8–54·7) (23·0–50·1) (16·2–32·0)
Other congenital anomalies
300·5 217·9 178·1 145·9 85·9 (217·7–421·0) (161·3–291·3) (127·5–233·4) (104·0–196·1) (65·7–105·5)
Skin and subcutaneous diseases
3,737·4 4,089·8 2,990·7 2,471·3 2,199·6 (2,407·6–5,809·9) (2,581·2–6,568·1) (1,927·9–4,654·3) (1,625·7–3,717·4) (1,461·6–3,294·4)
Eczema
1,010·1 814·4 726·8 647·6 571·7 (510·6–1,609·7) (413·5–1,292·7) (366·3–1,149·2) (327·8–1,019·4) (290·9–899·4)
Psoriasis
35·3 50·5 67·0 74·4 78·9 (17·2–57·1) (25·2–81·3) (33·6–106·5) (36·5–119·5) (39·3–126·8)
Cellulitis
47·3 56·9 60·3 62·4 64·4 (31·1–79·9) (39·6–88·5) (43·8–87·8) (44·8–90·9) (47·2–93·1)
Abscess, impetigo, and other bacterial skin diseases
185·5 139·8 114·9 109·3 105·9 (100·4–325·1) (86·8–229·7) (78·1–176·3) (74·1–170·0) (73·3–159·0)
Scabies
135·8 122·8 122·4 113·4 102·1 (68·0–240·4) (61·4–218·5) (62·5–217·6) (58·1–202·3) (52·5–179·7)
Fungal skin diseases
267·7 201·3 123·6 132·5 136·5 (84·5–624·8) (64·0–472·6) (39·5–290·7) (42·3–313·5) (43·9–323·2)
Viral skin diseases
628·6 445·2 183·4 155·4 129·7 (270·3–1,166·2) (191·2–848·3) (79·4–338·1) (67·8–284·8) (57·0–235·8)
Acne vulgaris
760·0 1,427·9 805·8 408·8 241·4 (354·0–1,434·9) (667·5–2,697·7) (371·9–1,545·4) (192·7–782·7) (112·6–461·3)
Alopecia areata
118·6 126·0 133·1 128·6 119·0 (36·7–227·4) (39·6–240·0) (41·5–253·4) (39·9–244·8) (37·1–225·4)
Pruritus
55·9 88·4 120·2 143·0 162·4 (26·6–105·4) (41·7–167·7) (56·1–228·0) (66·8–272·0) (77·0–307·2)
Urticaria
215·1 217·1 218·8 205·5 195·5 (81·9–372·4) (81·9–375·5) (81·8–379·2) (77·8–359·0) (73·4–335·1)
Decubitus ulcer
8·0 28·0 36·6 42·7 41·1 (5·9–10·5) (20·3–37·5) (27·7–46·2) (31·1–55·4) (30·9–53·9)
Other skin and subcutaneous diseases
269·5 371·5 277·9 247·7 250·9 (124·3–498·5) (173·0–694·9) (129·5–522·3) (114·9–462·6) (116·5–468·4)
Sense organ diseases
734·7 753·9 840·1 1,101·5 1,348·5 (496·6–1,075·5) (508·5–1,125·6) (564·9–1,245·1) (748·4–1,631·9) (932·7–1,948·9)
Glaucoma
1·9 9·0 18·7 – – (0·9–3·3) (5·9–12·5) (13·6–24·9)
Cataracts
8·6 41·0 100·8 – – (5·5–12·9) (29·5–56·0) (74·9–131·4)
Macular degeneration
– – – – –
27
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, 10-14 Years
Both Sexes, 15-19 Years
Both Sexes, 20-24 Years
Both Sexes, 25-29 Years
Both Sexes, 30-34 Years
Refraction and accommodation disorders
190·5 161·6 106·5 124·1 159·3 (134·0–264·0) (113·8–222·6) (76·1–145·1) (90·4–167·0) (117·7–213·5)
Other hearing loss
389·7 409·2 493·0 636·6 742·1 (215·5–650·0) (230·8–690·4) (279·0–814·3) (368·4–1,063·3) (434·0–1,217·3)
Other vision loss
145·9 175·3 222·9 284·2 321·3 (94·8–227·2) (105·8–286·9) (126·8–376·4) (158·6–485·1) (176·4–554·7)
Other sense organ diseases
8·5 7·6 7·3 6·6 6·3 (2·9–19·6) (2·6–17·7) (2·5–16·2) (2·2–15·1) (2·1–14·5)
Oral disorders
497·7 487·3 580·5 767·0 981·4 (205·6–999·6) (202·4–942·6) (236·8–1,137·9) (329·4–1,478·7) (435·9–1,869·1)
Dental caries
497·7 487·2 559·2 567·3 494·0 (205·6–999·6) (202·3–942·6) (226·1–1,097·5) (231·6–1,104·7) (204·6–947·0)
Periodontal disease
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, 10-14 Years
Both Sexes, 15-19 Years
Both Sexes, 20-24 Years
Both Sexes, 25-29 Years
Both Sexes, 30-34 Years
Fire, heat and hot substances
570·0 1,683·2 1,970·1 1,706·0 1,436·0 (358·1–942·1) (946·9–3,176·9) (1,228·1–3,415·3) (1,009·0–2,716·9) (870·8–2,423·9)
Poisonings
245·1 648·6 986·8 908·1 801·0 (183·5–345·9) (455·7–864·0) (691·0–1,355·3) (627·0–1,282·9) (558·0–1,116·5)
Exposure to mechanical forces
432·9 949·8 1,392·2 1,276·7 1,098·7 (305·4–632·8) (665·3–1,290·5) (952·1–1,828·7) (906·8–1,640·9) (753·3–1,485·2)
Mechanical forces (firearm)
225·0 530·1 721·3 567·1 467·5 (130·4–394·5) (340·7–832·5) (449·0–1,082·9) (361·4–847·2) (307·1–693·4)
Mechanical forces (other)
219·0 439·7 699·7 745·4 667·2 (127·2–366·1) (246·3–690·3) (422·1–983·4) (457·1–1,031·4) (427·1–964·5)
Adverse effects of medical treatment
79·6 157·2 219·7 208·7 189·7 (55·0–112·6) (113·6–209·8) (163·0–295·5) (158·5–277·0) (145·6–243·6)
Animal contact
239·1 243·2 280·1 214·2 180·6 (127·5–416·2) (137·7–418·1) (165·1–467·7) (120·9–374·0) (108·9–299·1)
Animal contact (venomous)
188·3 187·4 216·6 161·4 135·2 (88·7–382·8) (90·9–386·6) (106·5–408·7) (76·5–321·2) (66·4–258·9)
Animal contact (non-venomous)
50·9 55·7 63·4 52·8 45·4 (31·7–81·5) (30·5–88·4) (36·2–98·5) (29·3–81·2) (25·6–71·1)
Unintentional injuries not classified elsewhere
523·2 1,005·1 1,465·9 1,351·8 1,210·8 (403·2–686·8) (803·4–1,260·5) (1,198·3–1,882·2) (1,113·3–1,648·7) (996·0–1,474·0)
Self-harm and interpersonal violence
1,201·0 7,314·3 10,338·2 8,901·9 6,930·6 (880·3–1,651·7) (5,754·6–9,057·7) (8,175·1–12,457·2) (7,188·1–10,692·2) (5,624·6–8,339·9)
Self-harm
743·5 4,373·8 5,500·0 4,484·5 3,615·8 (463·4–1,188·6) (3,034·2–6,086·5) (3,794·8–7,449·3) (3,213·9–5,866·1) (2,636·8–4,762·5)
Interpersonal violence
457·5 2,940·5 4,838·2 4,417·4 3,314·8 (349·2–577·3) (2,237·8–3,567·9) (3,666·5–6,065·3) (3,373·7–5,741·6) (2,489·9–4,381·1)
Assault by firearm
192·3 1,483·5 2,297·7 2,068·3 1,531·0 (132·8–257·7) (1,091·3–1,838·0) (1,823·0–2,750·9) (1,608·8–2,544·1) (1,156·2–1,931·1)
Assault by sharp object
84·5 769·1 1,413·9 1,315·0 1,011·5 (55·8–116·6) (485·1–1,049·9) (889·5–2,031·7) (835·6–1,948·3) (666·9–1,528·2)
Assault by other means
185·3 700·2 1,146·3 1,059·7 801·2 (146·6–232·2) (522·1–897·1) (870·0–1,462·4) (795·0–1,390·1) (598·2–1,056·5)
Forces of nature, war, and legal intervention
1,543·0 1,679·3 1,703·0 1,588·1 1,233·4 (683·9–4,295·6) (805·8–4,155·3) (878·7–3,882·2) (866·5–3,427·0) (714·4–2,480·3)
Exposure to forces of nature
1,476·6 1,593·6 1,607·0 1,502·4 1,155·7 (631·4–4,177·0) (745·7–4,008·0) (810·1–3,697·6) (801·9–3,265·5) (656·6–2,351·8)
Collective violence and legal intervention
66·4 85·7 95·9 85·7 77·7 (44·6–111·0) (57·1–145·9) (63·7–165·5) (57·6–145·1) (52·9–128·3)
29
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, 35-39 Years
Both Sexes, 40-44 Years
Both Sexes, 45-49 Years
Both Sexes, 50-54 Years
Both Sexes, 55-59 Years
All causes
129,297·4 131,203·3 134,557·8 139,205·6 144,814·6 (119,110·7–140,403·1) (120,829·1–142,427·5) (123,961·0–145,791·3) (128,853·9–150,323·6) (135,249·5–155,771·3)
Communicable, maternal, neonatal and nutritional disorders
33,662·8 27,206·2 23,277·4 18,433·8 15,911·9 (30,756·0–36,518·7) (24,816·6–29,933·1) (20,966·0–25,921·2) (16,446·3–20,774·0) (13,984·1–17,941·5)
HIV/AIDS and tuberculosis
17,993·4 13,708·0 10,936·3 7,078·5 5,140·2 (16,295·0–19,743·7) (12,133·3–15,464·1) (9,398·9–12,536·9) (5,811·1–8,419·9) (4,015·0–6,305·0)
Tuberculosis
4,879·1 4,459·0 4,459·1 3,944·4 3,659·9 (3,748·8–6,149·5) (3,486·2–5,540·2) (3,437·6–5,545·9) (2,988·3–4,899·3) (2,844·7–4,560·2)
HIV/AIDS
13,114·4 9,248·9 6,477·2 3,134·1 1,480·2 (11,957·5–14,288·7) (8,188·6–10,373·2) (5,447·8–7,502·9) (2,511·9–4,009·1) (883·6–2,125·0)
HIV disease resulting in mycobacterial infection
2,313·1 1,609·8 1,143·3 567·7 313·4 (2,096·6–2,549·3) (1,409·1–1,826·2) (944·3–1,342·9) (449·4–744·4) (195·4–441·5)
HIV disease resulting in other specified or unspecified diseases
10,801·2 7,639·1 5,333·9 2,566·4 1,166·8 (9,821·2–11,867·2) (6,725·4–8,617·7) (4,471·4–6,217·7) (2,031·2–3,272·3) (685·4–1,697·8)
Diarrhea, LRI, meningitis, and other common infectious diseases
5,907·8 5,232·9 5,287·7 5,318·9 5,394·9 (4,992·5–6,929·7) (4,385·8–6,122·9) (4,490·9–6,173·2) (4,496·5–6,227·8) (4,493·4–6,367·0)
Diarrheal diseases
1,823·5 1,554·9 1,565·5 1,486·6 1,571·4 (1,443·7–2,342·0) (1,234·6–2,031·2) (1,201·7–2,051·6) (1,163·7–1,922·4) (1,170·2–2,178·3)
Cholera
61·6 48·1 42·0 32·8 28·5 (41·5–94·0) (32·3–71·4) (27·6–65·5) (22·1–49·8) (17·8–47·0)
Other salmonella infections
148·8 116·6 109·4 96·4 91·3 (103·3–210·9) (82·7–163·7) (75·7–158·5) (66·6–137·8) (61·9–137·9)
Shigellosis
173·6 139·3 142·3 138·4 149·3 (124·7–241·1) (99·7–195·2) (99·5–204·2) (98·9–191·2) (102·7–220·0)
Enteropathogenic E coli infection
20·2 15·0 17·7 19·5 23·0 (13·5–29·4) (9·5–22·8) (11·7–25·5) (13·4–27·8) (15·5–34·2)
Enterotoxigenic E coli infection
246·5 222·3 216·2 200·1 202·2 (180·0–342·5) (160·0–303·2) (152·0–300·5) (145·4–277·1) (142·6–294·9)
Campylobacter enteritis
98·3 83·2 83·3 78·7 82·5 (67·6–139·5) (57·8–121·1) (56·2–121·7) (53·9–111·8) (54·7–131·7)
Amoebiasis
100·1 91·1 93·3 92·0 99·8 (70·3–142·4) (64·7–128·6) (65·6–133·9) (63·4–131·5) (67·0–159·8)
Cryptosporidiosis
40·2 33·1 32·2 30·1 31·2 (28·1–56·5) (23·1–46·2) (21·8–46·2) (20·8–42·8) (20·9–48·6)
Rotaviral enteritis
140·4 114·7 124·6 128·4 144·9 (97·7–198·3) (81·2–158·4) (86·3–177·9) (87·4–183·4) (97·6–232·4)
Other diarrheal diseases
793·8 691·6 704·4 670·2 718·7 (542·8–1,174·3) (491·5–994·5) (478·6–1,001·0) (466·0–979·4) (467·9–1,079·8)
Typhoid and paratyphoid fevers
486·7 359·3 255·0 176·8 118·2 (66·4–910·6) (49·0–680·2) (34·3–481·4) (24·2–332·0) (17·0–217·0)
Lower respiratory infections
2,121·6 2,023·9 2,282·3 2,487·4 2,704·4 (1,729·0–2,579·1) (1,587·3–2,479·9) (1,840·3–2,767·4) (1,975·2–3,024·8) (2,120·7–3,327·3)
30
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, 35-39 Years
Both Sexes, 40-44 Years
Both Sexes, 45-49 Years
Both Sexes, 50-54 Years
Both Sexes, 55-59 Years
Influenza
519·2 502·8 549·0 579·7 611·2 (424·9–627·6) (394·5–614·9) (442·5–669·3) (460·8–704·9) (480·8–754·0)
Pneumococcal pneumonia
623·6 620·1 701·5 769·6 849·3 (501·8–748·6) (486·7–745·9) (569·0–842·5) (611·4–930·1) (663·2–1,029·5)
H influenza type B pneumonia
352·9 327·2 342·7 345·1 347·2 (286·2–432·4) (258·2–407·3) (277·3–415·3) (273·1–424·8) (270·7–424·5)
Respiratory syncytial virus pneumonia
20·7 19·7 22·2 24·1 26·2 (16·7–25·3) (15·4–24·2) (17·8–27·1) (19·0–29·5) (20·5–32·4)
Other lower respiratory infections
605·3 554·1 666·9 768·8 870·5 (480·0–755·9) (429·7–692·7) (525·6–834·0) (605·0–971·4) (674·4–1,101·1)
Upper respiratory infections
125·3 122·5 106·3 76·9 52·4 (63·1–225·5) (63·7–224·7) (53·6–187·3) (38·5–137·6) (27·9–92·7)
Otitis media
266·3 230·7 197·1 181·1 154·6 (165·4–420·6) (141·4–353·5) (121·0–310·4) (114·0–288·4) (93·4–244·5)
Meningitis
779·7 665·8 622·3 638·7 545·9 (622·4–980·0) (520·5–852·6) (493·9–770·9) (471·5–813·6) (414·2–699·2)
Pneumococcal meningitis
292·6 242·6 220·1 219·6 181·6 (229·6–377·7) (185·3–311·6) (170·1–277·5) (156·6–286·2) (134·6–249·5)
H influenza type B meningitis
49·6 45·1 43·6 46·8 43·0 (37·6–65·3) (33·2–59·9) (32·8–55·4) (33·5–61·4) (31·3–60·4)
Meningococcal infection
159·0 127·5 116·7 115·3 94·1 (125·4–196·3) (99·6–157·6) (91·9–141·4) (86·6–144·1) (71·1–120·9)
Other meningitis
277·5 249·6 241·0 256·2 226·6 (219·3–347·8) (194·3–318·3) (191·6–300·9) (189·2–325·0) (169·8–305·4)
Encephalitis
231·2 206·7 190·1 199·3 164·5 (156·8–365·0) (133·6–327·9) (125·0–290·0) (116·6–316·6) (98·2–268·8)
Diphtheria
0·9 0·8 1·0 1·0 0·8 (0·0–8·4) (0·0–6·5) (0·0–8·4) (0·0–8·3) (0·0–6·8)
Whooping cough
5·7 6·3 6·1 4·4 12·9 (0·2–27·9) (0·2–30·2) (0·3–29·4) (0·2–20·9) (0·8–61·2)
Tetanus
38·1 38·3 40·6 42·9 45·9 (0·5–160·2) (0·4–159·0) (0·5–170·9) (0·5–176·7) (0·5–191·2)
Measles
8·5 6·3 4·1 3·2 2·3 (3·2–19·1) (2·6–13·5) (1·8–8·4) (1·5–6·3) (1·0–4·9)
Varicella
20·0 17·6 17·5 20·6 21·4 (8·2–70·3) (8·0–50·5) (8·6–44·9) (10·3–50·0) (11·6–44·4)
Neglected tropical diseases and malaria
2,889·1 2,649·2 2,419·3 2,218·1 2,003·6 (2,204·0–3,789·4) (1,980·2–3,527·2) (1,853·6–3,157·7) (1,703·8–2,953·7) (1,510·1–2,685·6)
Malaria
1,477·3 1,340·7 1,177·0 1,131·3 1,023·6 (925·6–2,315·7) (855·3–2,035·1) (759·0–1,841·1) (735·9–1,789·1) (636·8–1,651·4)
Chagas disease
26·7 37·1 49·3 59·0 70·5 (12·0–55·8) (16·6–85·5) (21·8–118·8) (27·2–131·9) (32·7–146·0)
31
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, 35-39 Years
Both Sexes, 40-44 Years
Both Sexes, 45-49 Years
Both Sexes, 50-54 Years
Both Sexes, 55-59 Years
Leishmaniasis
125·9 112·5 96·2 77·9 61·1 (80·2–185·6) (72·4–167·1) (62·1–140·4) (51·1–112·5) (40·2–87·6)
African trypanosomiasis
32·7 22·9 17·5 11·9 6·4 (4·6–103·2) (3·1–72·0) (2·3–54·8) (1·7–36·7) (1·0–19·7)
Schistosomiasis
182·5 158·9 141·1 127·6 117·0 (89·3–347·4) (74·4–324·7) (63·3–321·0) (54·8–309·0) (46·8–332·1)
Cysticercosis
45·4 39·3 32·9 27·8 23·6 (31·3–64·0) (26·9–55·4) (23·0–45·4) (18·9–40·2) (15·7–34·5)
Echinococcosis
11·9 12·9 12·9 12·5 12·9 (5·0–25·5) (5·7–26·0) (5·7–26·4) (5·5–25·7) (5·5–27·4)
Lymphatic filariasis
214·6 184·4 238·8 201·6 164·7 (137·7–317·2) (119·5–268·9) (154·6–345·4) (131·4–293·5) (108·1–240·5)
Onchocerciasis
38·3 37·0 35·4 33·6 31·4 (28·1–50·3) (27·2–48·9) (26·5–45·5) (25·2–43·1) (23·5–40·7)
Trachoma
19·1 24·5 29·1 34·7 40·6 (12·7–27·3) (16·8–33·3) (20·2–39·3) (24·4–46·9) (29·0–54·8)
Dengue
36·2 26·5 25·3 18·9 16·4 (13·6–86·6) (10·9–53·8) (10·3–55·8) (7·7–39·1) (7·1–32·4)
Yellow fever
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, 35-39 Years
Both Sexes, 40-44 Years
Both Sexes, 45-49 Years
Both Sexes, 50-54 Years
Both Sexes, 55-59 Years
Obstructed labor
263·2 238·3 215·6 151·2 80·4 (170·9–420·0) (143·0–423·8) (118·9–407·1) (79·6–295·4) (41·4–152·9)
Abortion
281·4 136·6 57·3 (205·7–388·7) (102·6–185·9) (41·3–79·0) – –
Other maternal disorders
667·0 387·7 228·5 (518·0–816·3) (307·8–484·0) (174·3–296·6) – –
Neonatal disorders
583·2 512·4 423·0 343·4 273·9 (436·3–737·1) (384·4–653·5) (316·2–534·5) (257·3–433·0) (208·7–345·4)
Preterm birth complications
205·2 186·8 160·4 135·9 113·4 (153·9–258·6) (139·4–237·7) (119·5–203·0) (101·8–172·8) (84·5–142·3)
Neonatal encephalopathy (birth asphyxia and birth trauma)
378·0 325·6 262·6 207·5 160·5 (270·6–495·6) (234·4–427·7) (187·6–344·2) (146·9–273·5) (115·6–212·8)
Sepsis and other infectious disorders of the newborn baby
– – – – –
Other neonatal disorders
– – – – –
Nutritional deficiencies
2,691·8 2,402·1 2,070·8 1,860·6 1,658·5 (2,072·3–3,479·4) (1,856·0–3,109·1) (1,626·8–2,655·3) (1,443·3–2,392·4) (1,282·2–2,131·4)
Protein-energy malnutrition
621·6 552·5 518·2 487·5 524·1 (428·1–923·0) (372·8–843·6) (364·1–748·8) (335·8–686·8) (356·3–772·3)
Iodine deficiency
328·2 282·3 237·8 197·4 160·3 (209·5–517·7) (179·8–443·5) (150·4–370·3) (125·8–311·1) (101·5–252·6)
Vitamin A deficiency
41·4 32·5 17·0 7·9 4·6 (29·8–54·9) (23·0–43·9) (11·9–23·9) (5·2–11·0) (2·9–6·9)
Iron-deficiency anemia
1,688·5 1,520·4 1,282·8 1,153·4 953·7 (1,162·0–2,420·4) (1,048·6–2,176·4) (883·2–1,828·4) (792·1–1,635·4) (657·3–1,340·3)
Other nutritional deficiencies
12·1 14·4 15·0 14·4 15·9 (8·6–16·2) (10·3–18·9) (10·6–19·1) (10·7–18·0) (12·0–19·9)
Other communicable, maternal, neonatal and nutritional di d
1,374·3 1,416·5 1,395·9 1,463·1 1,360·4 (1,073·5–1,760·6) (1,133·0–1,856·3) (1,062·9–1,936·8) (1,056·5–2,205·9) (1,021·2–1,903·2)
Sexually transmitted diseases excluding HIV
173·3 137·8 65·0 37·6 27·3 (107·3–291·8) (85·8–228·9) (46·5–91·5) (26·6–53·1) (18·2–41·2)
Syphilis
24·5 22·9 20·4 19·4 18·0 (13·0–41·0) (12·3–37·8) (10·9–33·9) (10·3–31·8) (9·5–29·4)
Sexually transmitted chlamydial diseases
60·6 43·3 16·2 4·8 2·0 (31·9–106·0) (22·8–75·5) (9·6–26·6) (3·5–6·9) (1·4–3·2)
Gonococcal infection
39·6 28·8 10·6 3·0 1·5 (21·2–70·2) (15·6–51·0) (6·6–17·1) (2·2–4·4) (1·0–2·4)
Trichomoniasis
14·1 8·8 4·4 1·4 0·8 (0·0–41·3) (0·0–25·5) (0·0–13·1) (0·0–4·1) (0·0–2·5)
Other sexually transmitted diseases
34·6 34·0 13·4 9·1 5·0 (23·2–53·0) (21·0–56·9) (9·7–19·0) (6·7–13·5) (3·6–7·7)
33
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Web Table 1 - Global DALYs (thousands) with 95% UI for 291 causes in both sexes by age and cause, 2010
Cause
Both Sexes, 35-39 Years
Both Sexes, 40-44 Years
Both Sexes, 45-49 Years
Both Sexes, 50-54 Years
Both Sexes, 55-59 Years
Hepatitis
763·5 877·6 926·0 1,011·5 919·3 (531·4–1,140·6) (630·4–1,301·3) (626·8–1,465·0) (653·9–1,750·5) (618·3–1,415·4)
Acute hepatitis A
225·7 291·7 305·1 351·8 321·8 (92·4–602·6) (113·9–750·9) (109·7–784·8) (126·9–987·0) (123·6–809·6)
Acute hepatitis B
275·2 415·6 528·1 569·0 528·0 (171·1–448·7) (260·7–643·0) (295·3–924·9) (338·0–1,058·2) (299·3–898·8)
Acute hepatitis C
44·2 58·4 66·7 71·8 57·4 (26·1–72·7) (34·0–111·3) (42·1–107·1) (42·8–126·8) (36·0–93·0)
Acute hepatitis E
218·4 111·9 26·1 18·8 12·1 (91·0–441·4) (38·8–246·0) (5·8–74·3) (4·8–49·9) (3·3–30·8)
Leprosy
0·5 0·4 0·4 0·3 0·3 (0·2–1·0) (0·2–0·9) (0·2–0·8) (0·1–0·7) (0·1–0·6)
Other infectious diseases
437·0 400·7 404·5 413·6 413·4 (293·0–575·4) (277·5–537·4) (272·5–558·9) (269·8–588·9) (274·5–586·8)
Noncommunicable diseases
74,178·5 84,673·8 94,338·7 105,938·7 116,413·1 (66,487·6–82,319·2) (76,401·1–93,320·7) (85,924·6–103,081·1) (97,605·3–114,892·4) (108,055·4–125,184·1)
Neoplasms
7,381·2 11,444·4 15,902·9 21,023·2 25,551·9 (6,717·2–8,082·8) (10,503·1–12,426·8) (14,736·2–17,081·5) (19,414·7–22,608·1) (23,378·3–27,482·7)
Oesophagus cancer
176·9 425·5 746·7 1,198·5 1,563·2 (123·2–249·9) (292·9–635·2) (517·8–1,014·8) (808·2–1,523·9) (1,042·0–1,984·1)
Stomach cancer
591·7 956·4 1,298·8 1,774·0 2,339·5 (430·8–806·9) (719·6–1,300·7) (968·7–1,730·8) (1,297·4–2,335·2) (1,607·2–3,070·6)
Liver cancer
1,033·3 1,573·1 2,011·9 2,474·5 2,965·0 (758·6–1,452·4) (1,188·8–2,253·5) (1,585·8–2,712·1) (1,977·4–3,096·5) (2,387·0–3,784·6)
Liver cancer secondary to hepatitis B
497·9 770·9 975·6 1,192·3 1,434·7 (355·9–721·6) (558·8–1,129·3) (750·2–1,363·3) (919·1–1,530·5) (1,128·2–1,894·7)
Liver cancer secondary to hepatitis C
66·8 170·0 308·6 484·0 693·4 (50·3–90·3) (130·6–235·2) (250·8–402·6) (387·2–600·3) (572·3–856·1)
Liver cancer secondary to alcohol use
247·5 353·5 428·6 503·7 568·8 (181·0–344·7) (266·0–493·0) (338·1–580·5) (406·9–628·6) (461·7–718·1)
Other liver cancer
221·0 278·7 299·1 294·6 268·1 (163·6–310·5) (212·1–387·8) (241·5–388·7) (236·8–364·8) (218·6–340·1)
Larynx cancer
46·4 128·8 235·9 366·1 399·7 (23·6–79·6) (67·3–216·9) (121·1–410·6) (195�