sustainable growth in connected health and the economy
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‘Sustainable Growth in Connected Health and the
Economy’
Wednesday 8th May 2013 at 2pm
‘Sustainable Growth in Connected Health and the Economy Workshop’ Wednesday 8 May 2013 at 2pm (registration and buffet lunch from 1.30 pm),
at the Loughview Suite, Jordanstown Campus (University of Ulster). 1.30pm Registration and Buffet 2pm Professor Jim McLaughlin (Chair) Introduction
2.05 Guest Speaker George MacGinnis – Continua Health Alliance/PA Consulting Group – ‘What role will Connected Health play in driving our economy?’ 2.30 Professor Jim McLaughlin (NIBEC): ‘Connected Health at Ulster and Growth in the NI Economy’ 2.45 Professor Chris Nugent (SERG): ‘Smart Environments and Ambient Assisted Living’ 3.00 Professor Johnny Wallace (Comp & Eng.): ‘Growth in Collaborating with Healthcare Providers’ 3.15 Mr Stephen McComb (CHIC): ‘The Role of Innovation in Growing NI Connected Health’ 3.30 Guest Speaker Professor Brian Caulfield (UCD): ‘A New Connected Health Infrastructure in the Republic of Ireland’ 3.40 Discussion and Wrap-up
4pm -5pm There will also be a tour of the SERG and NIBEC Laboratories
£200 m annual income
£40-60m per annum research income
4 campuses; 3000 staff and 25,000 students
127,000 alumni
Distance learning through Campus One
17 research institutes
6 Faculties: Computing & Engineering; Life and Health Sciences; Arts; Social Sciences; Art, Design and the Built Environment Ulster Business School
The 2008 Research Assessment Exercise confirmed the strength and quality of our research and the advances that we are continually making.
Facts in Figures about Ulster
Ulster is a university with a national and
international reputation for excellence,
innovation and regional engagement.
We make a major contribution to the economic,
social and cultural development of Northern
Ireland and play a key role in attracting inward
investment.
Our core business activities are teaching and
learning, widening access to education, research
and innovation and technology and knowledge
transfer.
Overview of Ulster
Life and Health Sciences in Northern Ireland – Need for Strategy
Randox LaboratoriesHSC Innovations
Almac
lmac Diagnostics
Fusion Antibodies
Gambro
MDS Pharma Services
Norbrook
Perfecseal
Warner Chilcott
BootRooms.com
Intelesens
James Leckey Design
Blue Scope Medical Technologies
Diabetica
Tomcat Systems
Health Tek
Quality Healthcare at Home
Universities
Hospitals
Of over 900 companies in Northern Ireland’s vibrant ICT sector, more than 100
are international investors, including SAP, Fujitsu, Openwave, Microsoft,
Cybersource (VISA) and BTI Systems.
Combined turnover - £500m
5000 jobs
DRIVERS
• Business •Business Models, Economic Assessment
• Nursing •Biomedical Science
•Sports Science
•Personalised Medicine
• Computing Science
• AAL, Big Data, Cloud
• Engineering
• Sensors, Wireless, Integrated Point of Care Systems, Embedded Systems
Engineering Computing
Science
Business Nursing (And Life Sciences)
Professor Jim
McLaughlin: Ulster
Lead
Healthcare Lifestyle
Technology Sweet spot
Connected Health at Ulster (Executive): Will include 3 other representitives
Prof. Chris Nugent: Computing
Science/Intelligent Algorithms and
Connected Health; Large Grant holder
(£5M) and major experience in human
sensor based trials
Prof Jim McLaughlin:
(Physicist) Medical Sensors; Micro
and nanodevices; NIBEC Director
Large Multi-million projects (£23M);
17 patents and founder of ST+D Ltd
Professor Brendan McCormack (Nursing) research work
focuses on gerontological nursing, person-centred nursing
and practice development and he serves on a number of
international editorial boards, policy committees, and
development groups in these areas
Since 2008
Over £15M into
Connected
Health
A
Dr Abbes Amira
B
Mr Mark Beattie
Professor Norman Black
Dr Raymond Bond
Dr Adrian Boyd
Mr William Burns
Dr Tony Byrne
C
Dr Darryl Charles
Dr Liming Chen
Professor Vivien Coates
Dr. Damien Coyle
D
Mr Richard Davies
Dr Dorian Dixon
Dr Mark Donnelly
E
Professor Omar Escalona
F
Dr Dewar Finlay
G
Dr Brendan Galbraith
Dr Leo Galway
H
Dr Leane Hoey
K
Professor George Kernohan
L
Dr Briege M Lagan
M
Prof Paul Maguire
Dr Suzanne Martin
Professor Tanya McCance
Dr. Paul McCullagh
Professor Sally McClean
Professor Brendan McCormack
Professor James McLaughlin
Professor Helene McNulty
Prof Brian Meenan
Dr Vidar Melby
Liz Mitchell
Dr George Moore
Dr Anne Moorehead
N
Dr Peter Nicholl
Professor Chris Nugent
S
Professor Bryan Scotney
Professor Marlene Sinclair
Dr Paul Slater
Dr Eamon Slevin
T
Dr Laurence Taggart
Dr Maria Truesdale-Kennedy
W
Professor Eric Wallace
Professor Jonathan Wallace
Dr Haiying Wang
Dr Mary Ward
Dr Alan Webb
Z
Dr Huiri Zheng
Connected Health at Ulster:
(Main Academic Members - 50):
Education: Postgraduate
Below are a range of our most promising Post Graduate courses and modules which form part of the Connected Health-Ulster’s offering. We also over numerous PhD’s in the Area
Health Informatics (PgCert/PgDip/MSc)
Health and Wellbeing (PgDip/MSc)
Health Promotion and Public Health (PgCert/PgDip/MSc)
Human Nutrition (PgDip/MSc)Non-Medical Prescribing (PgCert)
Psychology (Health)
(PgDip/MSc)Nursing Credit Bearing ModulesRespiratory Health (PG Certificate)
Sport and Exercise Nutrition (Postgraduate Diploma/MSc)
Biomedical Engineering (PgDip/MSc)
Dean of Computing and Engineering
Professor R. Millar
Engineering Research Institute
Director :
Professor Jim McLaughlin
NIBEC
Director Professor Jim McLaughlin
ECRE
Acting Director :
Dr Alistair McIlhagger
AMFo0R
Group Leader Dr Alan Leacock
Computing Science Research Institute
Professor Bryan Scotney
The ERI Faculty Dr Dorian Dixon
Nanocomposites
and Polymer
drug Delivery
Systems
Prof James
Davis: Bio
sensing and
diagnostics
Dr Patrick Dunlop:
Biosensors
Prof. Brian
Meenan:
Biomaterials and
Tissue
Engineering
Prof. Paul Maguire:
Nanofabrication and
Plasma Technology
Prof Jim
McLaughlin:
Nanotechnology
related to carbon
and nano-sensor
fabrication
Prof Pagona
Papankonsta
niou:
Nanotubes
and
Nanodevices
Dr Patrick
Lemoine:
Nano-tribology
and nano-
microscopy
Dr Tony
Byrne:
Photocatalysi
s and Clean
Technology
Dr Adrain Boyd
Nano based-
biomaterials
Alan Brown:
Microfluidics
Dr George
Burke: Cell
Biology
Dr Davide
Mariotti:
Nanoparticle
s and
Plasma
Physics
Dr Abbess Amira
Embedded
Systems in
Connected Health
Dr Alistair
McIlhagger:
Composites /
NIACE
Dr Alan
Leacock:
Metal
Forming /
NIACE
Dr Edward
Archer:
Composites /
NIACE
NA
MR
I
NIBEC
NA
MR
I
ECRE
NA
MR
I
AmFOR
Engineering Research Institute www.eri.ulster.ac.uk
Infrastructure (Nanofab and Characterisation): £17M (since 2001) £7M SRIF/RCIF £8M Government and Industry £3M EU
Major Projects £13M (since 2001) £5 M EU £4M EPSRC £4.8 M Industry/Government
Staff 5 Professors 3 Readers 6 Senior Lecturers 5 Lecturers (ECR’s)
Technology Transfer/Proof of Concept £1.6M (since 2001)
Nanotechnology and Integrated
Bioengineering Centre (NIBEC)
Nanotechnology and Integrated Bioengineering Centre (NIBEC)
Engineering Research Institute
£33million funding since 2001
EPSRC;
INI;
DEL;
Wellcome
Trust;
EU;
NSF (US Irl
Partnership)
BIS;
HEA;
SFI;
MRC;
Leverhulme;
R&D Office;
Industry;
Philanthropic
Multi-disciplinary research centre applying nanotechnology and bioengineering to the following thrusts:
Our CH History: NIBEC founded in 1985 by Professor John Anderson Traced back to Professor Partridges idea of mobile coronary care New building in 1994 and 2004
0.1HR
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1DAY
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THE DISTRIBUTION OF ACUTE CORONARY DEATHSMc NEILLY (BELFAST), 1965-66, 818 DEATHS
THE DISTRIBUTION OF ACUTE CORONARY DEATHSMc NEILLY (BELFAST), 1965-66, 818 DEATHS
00
1010
2020
3030
4040
5050
6060
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9090
100100
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00
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The Acute MIThe Acute MI
Myocardialpreservation %
Myocardialpreservation %
Average patient
response time
Average patient
response time
Hrs. from symptom onsetHrs. from symptom onset
History of Success in CH
• M Health
• Clinical Trials
• Adoption Models
• Economic Assessment
• Spin Outs
• Electrode Fabrication and Characterization
• Carbon Nanotube & Graphene Growth
• Nanoparticles
• Telemetry: Bluetooth, Wi-Fi and Propriety RF
• Electronics
• Embedded Systems
• Pattern Recognition
• PlasmaTechnology
• Microfluidics
• Microfabrication
• Nanofabrication
• Surface Analysis
• Microscopy
• Chemical Analysis
MEMS and Nanodevices
Smart Diagnostic Devices
Smart Systems
Connected Health Solutions
Fully Integrated systems for Chronic Health; Lifestyle and Pharma Monitoring
Nanosensors
ECG, EMG, EEG, Temp, Resp. Rate,
SpO2, PWV, Biosensors, E Nose
The NIBEC Capability
CH Infrastructure
NIBEC: Nanotechnology, Microfluidics; Cell- /Micro- Biology Laboratories; Microfabrication Cleanrooms
SMART WARD
SMART Doctors Surgery
SERG (SSRI): Ambient Assisted Living
Data Analysis/DSP/Labview Project Laboratories
Patient Testing Laboratories
Terrace House and Playing Field Testing
Plans for new Innovation Centre (Manufacturing)…Rapid Proto typing
Connected Health Themes at Ulster
Wireless Vital Signs Monitoring
Point of Care Diagnostics Systems
Sensor Technology
M-Health
Ambient Assisted Living
Clinical Trialing
Economic Assessment and Valuation
Technology Transfer…spin outs and licensing
Personalized Medicine (BSRI)
CTRIC and UUM (ISRC)
Sensor Technology
ECG, EMG, EEG
SpO2 (Reflective)
PWV (piezo)
Accelerometers (MEMS- Motion)
Respiration Rate
GSR
Cardiac Mapping
Biosensors: Glucose and Cardiac Enzymes via IDE’s
Micro- SPR
Micro-Raman
Micro-E-nose (plasma)
Impedance
Micro-E-nose (plasma)
Connected Health Themes at Ulster
All about higher sensitivity &specificity – less false alerts
Key current research topics
AF sensing/pattern recognition
Sleep Apnoea early warning
Smart MEWS based multi-sensing Algorithms
De-hydration Sensing
NIBP systems
Cardiac Mapping
Multiple data analysis – MVA, Big Data analytics
Pulse Wave Velocity
Remote Foetal monitoring
Hypo- detection in Diabetics
Non-Invasive Glucose Monitoring (IR)
Novel Wearable Electrode Systems
Point of Care Diagnostics – Microfluidic Systems
Key Underpinning Materials Areas
Major nanotechnology laboratories
Plasma Technology
Graphene, CNT’s and DLC
Metal Oxides
Nanoceramics and nanoparticles
Si nanoparticles
Microfluidics – Integrated Optics/Impedance
Nanomaterials Characterisation: TEM, SEM. FIB, TOF SIMS, AFM, XPS, Raman, Nanoindentor etc.
Electrical Characterisation of Materials
Electrode and antenna design
The NIBEC POC Cardiac
Enzyme Impedance
Microfluidics – Integrated optical and impedance
platforms; nanoparticle (CNT/Graphene/Si
amplification); and pattern recognition with
wireless communication systems.
CH Enabled AF Treatment for Patients with
a Passive Implantable Atrial Defibrillator
Regional Cloud Hospital
WAN Support
Mainframe Computer
Centre for
Connected
Health
Minimal Critical Care
Setting
AF Patient with an
Implanted PIAD
CH Assisted Cardioversion
with a Passive Implantable
Defibrillator (PIAD) PIAD
Interventional
Cardiology Experts
Public Access Defibrillation Reliability and
Effectiveness Enhancement by Connected Health
Key issues to address:
- AED device automatised regular maintenance/supervision by CH while in the emergency
box; AED could be used only once in 5 years or more.
- AED embedded knowledge based algorithms performance can be enhanced if supported
by a CH centre mainframe computer.
- Soft paramedic assistance from an emergency CH service, while live monitoring patients
vital signs and CPR parameters, would en enhance safety and effectiveness of CPR.
Centre for
Connected
Health
AED with
Embedded Internet Cloud Emergency Services
AED
Maintenance
& Supervision CH Assisted
CPR
CH Assisted PAD for the
AED Knowledge Base and
Live Expert Advice
Mainframe Computer
CH Enabled Cardiac Mapping for Early MI Detection
(within 90 minutes)
Cloud Emergency Services
WAN Support
Mainframe Computer
Centre for
Connected
Health
Patient with Chest Pain at His Home
Current Portable 28-Lead
Cardiac Mapping System
and Disposable Harness
Experts at the
Cardiac Centre
CH Assisted 28-Lead Cardiac Mapping
Smartphone Application for Live MI
Authorised Diagnosis
Clinician Trust/Hospital Hospital/GP/Care Home
Specialising
Dr Ganesh Manoharan / Prof J Adgey
Belfast Health and Social Care Trust
Hospital Cardiology
Dr Hubert Curran
Senior Primary Care Advisor to the Performance
Management and Service Improvement
Directorate of the HSCB
Primary Health Care Primary Health Care
Dr David McEneaney South Eastern Health and Social Care Trust
Hospital Cardiology
Dr Roy Harper South Eastern Health and Social Care Trust
Hospital Diabetics
Sharon Foster (Clinical Nurse)
McElwaine Industry Telehealthcare
Engagements with possible inclusion Dr Paddy Donnelly (Ulster); Dr Maurice O Kane CTRIC; Dr David McCance (RVH)
CLINICAL LINKS
Wireless Vital Signs Platforms
Intelesens has developed its
platform as the basis of OEM
products
Short range or cellular telemetry
Range of vital signs possible
Respiration
Blood oxygen (late 2007)
Temperature
Motion, activity and falls
Cardiac output
ECG
Compact, light, easy to wear
ecg
respiration rate
temperature
SpO2
accelerometer
3. Innovation
Ubiquitous surveillance monitoring system
Full ambulation
Wi-Fi connectivity
Simple, easy, unobtrusive, low-cost
Alert management
Smart: ECG Pattern Recognition
Bradyarrhythmia
Ventricular Tachycardia
Supra Ventricular Tachycardia
Self-terminating Ventricular Fibrillation
Asystole
Atrial Flutter
Atrial Fibrillation
1st Degree Heart Block
2nd Degree Heart Block
3rd Degree Heart Block
Clinical Study complete with Ulster Hospital:
Dr Roy Harper and currently undergoing one at
UI and Dublin
•Congenital heart defects
•Congestive heart failure
•Heart muscle disease
•Heart valve disorders
•Other diseases, such as lung conditions
•External forces such as electric shock or severe
chest injury
Atrial Fibrillation captured with Aingeal device
Example of CSR captured: Cheyne-Stokes respiration
Employing around 60-70 staff directly
Heartsine
Corporate Headquarters: HeartSine Technologies, Inc. 940 Calle Amanecer Suite E San Clemente, CA 92673
United States
Phone: 1.949.218.0092 Fax: 1.949.218.0093 Toll Free: 1.866.HRT.SINE European Office: HeartSine Technologies, Ltd. Canberra House 203 Airport Road West Belfast, BT3 9ED Northern Ireland
Phone: +44 (0)28 9093 9400 Fax: +44 (0)28 9093 9401
http://www.heartsine.com
The 1970’s NIBEC Vision
Recently purchased by Verathron
employed 60 staff directly (at one stage
over 100)
80-Lead Technology Benefits:
Features:
1. J Elect rocard.
Heartscape, the Heartscape symbol, Verathon, and the Verathon Torch symbol are trademarks of Verathon Inc. © 2011, 2012 Verathon Inc.
for a complete view of the heart
Touchscreen color monitor
80-Lead Vest:
58 anterior leads
12 lateral leads
10 posterior leads
A 360º ECG
Non-U.S. Only
Recently acquired by Verathron
The Vision – Self Care Model
Sensor – analysis – diagnostics – feedback – immediate therapy
Vital signs alert and immediate worn therapy
For example – heart attack and possible patch based TPA delivery
Or respiration rate and dosage feedback for therapy
Require POC diagnostics and improved drug delivery techniques
Worn Drug Therapy
Feedback
Cloud Analytics
Worn Vital
Signs Detection
Founder and Managing Director: Dr. Suzanne Roghieh Saffie-Siebert Professor Jim McLaughlin Director and CSO John Hartnett and Tim Brundle (Investors and Directors) Scientists: Drs. Nessim Troabi-Pour; Mukhtar Ahmed; Jeremy Hamill
SiSaf scooped a major prize – for development of an innovative drug-delivery system at the Irish Technology Leadership Group’s
(ITLG) annual awards ceremony in Silicon Valley, California.
The SiSaf Difference
Solubility – Improved up to 40%
Biocompatibility – Organic Solid
Nanoparticles
Active Delivery – Self beneficial
compound
Control Release – Tailor made
release profile
Penetration – Into and through skin
Absorption – Improved through
localization and SR
Localization – High concentrated
molecule
Headed up by Stephen McComb
Connected Health in Northern Ireland Industry led research with global relevance
What is it?
CHIC is an Industry-led group which is
focused on collaborative research to
support the growth of the connected
health market. Funding is largely from
state aid.
Emerging Focus Areas
1.Integrated community care – joining
together existing and new technology
and process.
2.Point of Care Diagnostics – moving
diagnostics closer to the patient.
3.Vital Signs monitors - technology
development to support sign
identification, analysis and
communication.
“Delivering leadership for the development of Connected and Mhealth markets and practice across Europe and beyond”
Joint MOU between DETI and DOH in Northern Ireland (better health and jobs)
Setting up of a NI CH Eco System – Clinicians- Business- Academia Strong links with Boston – Finland – Catalonia – Manchester – NIMAC ECHAlliance Ecosystems – Manchester, Northern Ireland and more to be
announced.
ECH - Alliance and the new Northern Ireland Connected Health Eco System
EU-US eHealth Business
Marketplace – Boston USA 2012
35 patents, 3 companies and many licences
Created over 120 industry jobs across all 3
Connected Health spin-outs; Trained over research
100 staff for CH industries
Saved lives, improved the quality of life and cut
costs - MATCH.
Technologies are used by the Wellcome Trust,
CIMIT and various companies as exemplars of the
future of healthcare.
The concept of Connected Health in Northern
Ireland was derived from much of our early work.
Their more recent work, with over 35 patents, has been commercialised to companies such as Heartsine Inc., Samsung, Intelesens Ltd. Heartscape Inc., Tyco, SHL Telemedicine, Phillips and Air Products. These companies’ products have now been well established and include the world’s best selling disposable ecg electrode, telemedicine based 12 lead electrodes, the most compact AED marketed and a smart wireless chest based ecg, respiration rate, temperature and SpO2 monitor.
Professors McLaughlin, Anderson and McAdams have a 25 year history of developing successful patent exploitation in the area of medical sensors and electro-stimulation devices, following the impact that Pantridge, Adgey and Anderson had on mobile coronary care in Northern Ireland.
Impact of Connected Health @Ulster
This has inspired many initiatives such as the:
BEST Centre, CHIC, ECHCampus (2009-2012) and now the European Connected Health Alliance (2011-); Northern Ireland Connected Health-ECO; culminating with NIMAC which joint agreement between USA, Finland, ROI, Northern Ireland, the Manchester and Catalonia; Northern Ireland DHSSPSNI & DETI signing a strategic and joint Connected Health MOU
The recipe for Connected Health Device Innovation
Good Product design – from concept to scale-up
User needs – cost reduction (evidence) – regulatory
Accurate and flexible business model
A good users based - ECO system (smart market analysis)
Miniaturised and robust technology
Portable – Cloud based solutions – still some security issues
High quality data analytics
Early warning with clear patient & clinical benefits
Smart Back-end systems
And most of all functional & well designed (intuitive) and meets all FDA – CE approvals and easily validated
Conclusion
History of Success
University of Ulster Capability and experience
Strong Clinical Integration
Technology Transfer – spin-outs – CHIC’s future Role
ECHA- The Northern Ireland CH Eco System
Finally - We need a systems and design approach to adopting this new form of delivering Healthcare – with sensors, diagnostics, communications, software, clinical specifications, health economics, regulatory drivers and business models all playing a key role to drive our Healthcare Provision and Economy