sweet sensors final presentation
TRANSCRIPT
*GlucoSentient, Inc.
Gluco = GlucoseSentient = Responsive to, perceptive or aware
Direct Read Out of Target
Concentration!
Patient Samples
(Blood/Saliva/ Urine )
Personal Glucose Meter
Drug/Targets
ofinterest
*Diagnostics platform leveraging personal glucose meters:
Therapeutic drug monitoring (TDM)
Clinical trial companion diagnostics
Medical diagnosis of many diseases
Environmental detection of contaminants
~100 GOOTB connections
*I-Corps Video
*Diabetes patients were our initial target market
*Existing glucose meter + need to measure HbA1c
*Key value propositions
*Low cost
*Home testing
*Already have PGM
*Large market
*Patient population is huge
More frequent tests and better diabetes management
Total available market = $1.2
billion
Serviceable Available Market = $600 million
Target market = $120 million
*Initial Hypotheses
Business Model Canvas #1
Diabetics
Sweet SensorsYi Lu, Tian LanNeil KaneChris Sorensen
Clinicians (in rural area)
Triage nurses
Pre-diabetics
Product supports
Patient network/community
Retailers (Walgreen)
Online vendors (Amazon)
Direct sales
Disposable test kit (used repeatedly on a regular basis)
At home
Convenient
Less exposure to infectious diseases in the hospital
Cheaper
More frequent
Better indicator of health (diabetic management)
Conferences
Product R&D
QC
Marketing
IP
Personnel
Glucose monitor manufacturers
Kit manufacturers
Reagent suppliers
Reagents
Manufacture
Licensing
FDA certification?
10-11--2011
*Got out of the building (GOOTB)
The best test is one where the result
affects the behavior. Find a
test where immediate results
have value.
(I) spent a lot of time, money
looking at this (HbA1c) market for
LifeScan – stay away.
*Got out of the building (GOOTB)
“You might even have a flexible Drugs of Abuse
Analyzer “Bank” which is actually a rack which holds a number of small
individual analyzers.”
“The “Holy Grail” now is matching drug dosages to individual patients based on a wide range of factors (age, weight, gender, ethnicity, body chemistry, etc.)So ONE DOSE DOES NOT FIT ALL”
*What we have found….
…….became our value propositions
* Immediacy
* Inexpensive/cost savings
* Multiple tests
* Short and inexpensive development cycles
*We learned that for HbA1c…(is not the right market)
*Home monitoring of HbA1c does not meet immediacy requirement
*Large effort is necessary to promote the usage of home HbA1c test kit in the US
*Competition from product from Bayer
*Large regulatory hurdle
* One market that meets all the value propositions is drug monitoring during clinical trials and after the market
Business Model Canvas #4
Pivoted
to therapeutic
drug
monitorin
g
Diabetics
Sweet SensorsYi Lu, Tian LanNeil KaneChris Sorensen
Clinicians (in rural area)
Pre-diabetics
Product support
Patient network/community
Retailers (Walgreen)
Medical Products Distributors
Disposable test kit (used repeatedly on a regular basis)
Conferences
Product R&D
QC Marketing
IP Personnel
Glucose monitor manufacturers- Abbott?
Kit manufacturers
Reagent suppliers
Reagents
Manufacturing
Licensing
Convenient
Out of clinic
Cheaper
More frequent
FDA approval for in vitro diagnostics
FDA approval for in vitro diagnostics
KOL
Immediacy
Food safety and security related
10-25-2011
Reimbursement strategy
Drug monitoring
Pharmaceutical Cos
Sponsored development or JDALicensing
Pivoted
to therapeutic
drug
monitorin
g
Business Model Canvas #5
Sweet SensorsYi Lu, Tian Lan, Brian WongNeil KaneChris Sorensen
One to one
Conferences
R&D
QC
IP
Personnel
Pharmaceutical companies
R&D
Licensing
Convenient monitoring and safer dosage
Immediacy
11-01-2011
Pharmaceutical companies for Therapeutic Drug Monitoring (TDM)
Pharmaceutical Cos
Sales (to pharmaceutical companies)
Pharmaceutical Cos
Long termGlucometer/strip manufacturer
Exclusive
*We talked to a major pharmaceutical company several times and learned…. (values for pharmas)
*Better drug monitoring reduces the costs of drug development
*“One-drug-for-all” is gone; new drugs are more likely to be effective for certain patients at certain dosage.
*They are willing to provide financial support
*They only want to buy the final products
*Therefore we need to find partners
*Partners
Added value for meter manufacturers
Low cost, fast monitoring improves
clinical trials for pharmaceutical
Meter engineerin
gStrip
designFDA
approval
Provide the targets
Key customersKey market knowledge
GlucoSentient, Inc. Glucose meter companies
Pharmaceutical companies
Business Model Canvas #7
Sweet SensorsYi Lu, Tian Lan, Brian WongNeil KaneChris Sorensen
Direct
Conferences
R&D
IP
Personnel
Pharmaceutical companies
R&D
Licensing
Convenient monitoring and safer dosage
Immediate results
11-15-2011
Pharmaceutical Cos
Product Sales
Long term
Diagnostics companies
Contract research organizations
Pharmaceutical companies for Therapeutic Drug Monitoring (TDM)
Diagnostic companies
Contract research organizationsInvestors
Publicity
Inexpensive
Simple
Insurance Reimbursement
Robust/extensible
Licensing?
Glucometer mfr
Strip mfr
Pharmaceutical Cos
*Competitive Analysis
Time to obtain the test results
Develo
pm
en
t co
sts
Conventional Lab Test
POC tests
Our Technology
Total available market ~$20 billion
Serviceable available Market ~ 2 billion
Target market ~$645 million
Axis Shield (clinic based, fluidics tests for HbA1c, CRP…)acquired Alere for $366 million (10/2011)
Claros (sensitive fluidics device for HIV detection using antibodies) acquired for $46 million by OPKO (11/2011)
*Market size (POC test)
Source: Point of Care Testing, Biophoenix 2010
Source: American Association for Clinical Chemistry
*Next Steps
*Pitch to other pharmaceutical and diagnostic companies
*Develop prototype for the BEST targets in therapeutic drug monitoring to demonstrate our technology
*Apply SBIRs to reduce technical risks
*License the technology from the University of Illinois
*Move into the Research Park at the University of Illinois through the I-Start program
Diabetics
Sweet SensorsYi Lu, Tian LanNeil KaneChris Sorensen
Business Model Canvas #1
Clinicians (in rural area)
Triage nurses
Pre-diabetics
Product supports
Patient network/community
Retailers (Walgreen)
Online vendors (Amazon)
Direct sales
Disposable test kit (used repeatedly on a regular basis)
At home
Convenient
Less exposure to infectious diseases in the hospital
Cheaper
More frequent
Better indicator of health (diabetic management)
IP
Personnel
Reagents
Manufacture
Licensing
FDA certification?
Glucose monitor manufacturers
Kit manufacturers
Reagent suppliers
Conferences
Product R&D
QC
Marketing
* Diabetics
Sweet SensorsYi Lu, Tian LanNeil KaneChris Sorensen
Business Model Canvas #2
Clinicians (in rural area)
Triage nurses
Pre-diabetics
Product supports
Patient network/community
Retailers (Walgreen)
Online vendors (Amazon)
Direct sales
Disposable test kit (used repeatedly on a regular basis)
Better indicator of health (diabetic management)
Glucose monitor manufacturers
Kit manufacturers
Reagent suppliers
Reagents
Manufacture
Licensing
Convenient
At home
Less exposure to infectious diseases in the hospital
Cheaper
More frequent
FDA approval for in vitro diagnostics
Conferences
Product R&D
QC Marketing
FDA approval for in vitro diagnostics
IP Personnel
KOL
* Diabetics
Sweet SensorsYi Lu, Tian LanNeil KaneChris Sorensen
Business Model Canvas #3
Clinicians (in rural area)
Pre-diabetics
Product supports
Patient network/community
Retailers (Walgreen)
Online vendors (Amazon)
Disposable test kit (used repeatedly on a regular basis)
Better indicator of health (diabetic management)
Glucose monitor manufacturers
Kit manufacturers
Reagent suppliers
Reagents
Manufacture
Licensing
Convenient
At home
Less exposure to infectious diseases in the hospital
Cheaper
More frequent
FDA approval for in vitro diagnostics
Immediacy
Food safety and security related
10-18-2011
Conferences
Product R&D
QC Marketing
FDA approval for in vitro diagnostics
IP Personnel
KOL
* Diabetics
Sweet SensorsYi Lu, Tian LanNeil KaneChris Sorensen
Business Model Canvas #4
Clinicians (in rural area)
Pre-diabetics
Product support
Patient network/community
Retailers (Walgreen)
Medical Products Distributors
Disposable test kit (used repeatedly on a regular basis)
Conferences
Product R&D
QC Marketing
IP Personnel
Glucose monitor manufacturers- Abbott?
Kit manufacturers
Reagent suppliers
Convenient
Out of clinic
Cheaper
More frequent
FDA approval for in vitro diagnostics
KOL
Immediacy
Food safety and security related
10-25-2011
Reimbursement strategy
Drug monitoring
Pharmaceutical Cos
Sponsored development or JDALicensing
Reagents
Manufacture
Licensing
FDA approval for in vitro diagnostics
* Diabetics
Sweet SensorsYi Lu, Tian LanNeil KaneChris Sorensen
Business Model Canvas #4
Clinicians (in rural area)
Pre-diabetics
Product support
Patient network/community
Retailers (Walgreen)
Medical Products Distributors
Disposable test kit (used repeatedly on a regular basis)
Conferences
Product R&D
QC Marketing
IP Personnel
Glucose monitor manufacturers- Abbott?
Kit manufacturers
Reagent suppliers
Convenient
Out of clinic
Cheaper
More frequent
FDA approval for in vitro diagnostics
KOL
Immediacy
Food safety and security related
10-25-2011
Reimbursement strategy
Drug monitoring
Pharmaceutical Cos
Sponsored development or JDALicensing
Reagents
Manufacture
Licensing
FDA approval for in vitro diagnostics
Pivoted
to therapeutic
drug
monitorin
g
*
Sweet SensorsYi Lu, Tian Lan, Brian WongNeil KaneChris Sorensen
Business Model Canvas #5b
One to one
Conferences
R&D
QC
IP
Personnel
Pharmaceutical companies
R&D
Licensing
Convenient monitoring and safer dosage
Immediacy
11-01-2011
Pharmaceutical companies for Therapeutic Drug Monitoring (TDM)
Pharmaceutical Cos
Sales (to pharmaceutical companies)
Pharmaceutical Cos
Long termGlucometer/strip manufacturer
Exclusive
*
Sweet SensorsYi Lu, Tian Lan, Brian WongNeil KaneChris Sorensen
Business Model Canvas #6
One to one
Conferences
R&D
QC
IP
Personnel
Pharmaceutical companies
R&D
Licensing
Convenient monitoring and safer dosage
Immediacy
11-01-2011
Pharmaceutical Cos
Sales (to pharmaceutical companies)
Pharmaceutical Cos
Long termGlucometer/strip manufacturer
Exclusive
Contract research organization
Pharmaceutical companies
Glucometer/strip manufacturer
Diagnostic company
Contract research organization
Diagnostics companies
*
Sweet SensorsYi Lu, Tian Lan, Brian WongNeil KaneChris Sorensen
Business Model Canvas # 7 w/changes
Direct
Conferences
R&D
QC
IP
Personnel
Pharmaceutical companies
R&D
Licensing
Convenient monitoring and safer dosage
11-08-2011
Pharmaceutical Cos
Product Sales
Pharmaceutical Cos
Long termGlucometer/strip manufacturer
ExclusiveDiagnostics companies
Contract research organizations
Pharmaceutical companies
Glucometer/strip manufacturer
Diagnostic companies
Contract research organizations
Investors
Publicity
Inexpensive
Simple
Insurance Reimbursement
Robust/extensible
Licensing?
Glucometer mfr
Strip mfr
Immediacy
*
Sweet SensorsYi Lu, Tian Lan, Brian WongNeil KaneChris Sorensen
Business Model Canvas # 8
Direct
Conferences
R&D
Pharmaceutical companies
R&D
Licensing
Convenient monitoring and safer dosage
Immediate results
11-15-2011
Pharmaceutical Cos
Product Sales
Long termDiagnostics companies
Contract research organizations
Pharmaceutical companies
Diagnostic companies
Contract research organizations
Publicity
Inexpensive
Simple
Insurance Reimbursement
Robust/extensible
Licensing?
Glucometer mfr
Strip mfr
IP
Personnel
Pharmaceutical Cos
Investors
*Acknowledgements
* NSF I-Corps program
* The I-Corps teaching team
*UIUC tech transfer terms
*Partners
GlucoSentient
• Added value for meter manufacturers
• Low cost, fast monitoring improves clinical trials
Glucose meter manufacturer• Meter engineering• Strip design• FDA approval
Pharmaceutical / diagnostic companies• Provide the target
of interest• Key customers• Key market
knowledge