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Sweeteners and Health: The State of the Science
Thursday February 28th 20191:00pm EST
a webinar offering from
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webinar housekeepingYou are muted• Write questions in the chat box
Summary handout and CPE certificate• Must dial-in and join webinar presentation to obtain certificate• Must participate in full webinar to receive certificate• CPE certificate and summary handout will be emailed after the webinar
Continue the conversation• Please use #siggisSessions and follow us on social media @siggisdairy
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webinar speaker
Allison Sylvetsky, PhD
Assistant Professor in the Department of Exercise and Nutrition Sciences and Director of the Bachelor of Science in Nutrition Science undergraduate degree program at The George Washington University
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No conflicts of interest
2
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• Background on Dietary Sugar & Health
• Background on Low-calorie Sweeteners (LCS)
• LCS, Weight & Health: Observational Studies
• LCS, Weight & Health: Proposed Mechanisms
• LCS, Weight & Health: Human Intervention Studies
• LCS, Weight & Health: Future Research Needs
Outline
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Dietary sugars obesity and diabetes
2
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SSB and type 2 diabetes
Not adjusted for adiposity Adjusted for adiposity
Malik 2017, CurrOpin Cardiology
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SSB and type 2 diabetes
Malik 2017, Curr Opin Cardiology
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SSB intake and adverse health outcomes
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• Role of other caloric sweeteners, such as honey and agave are less clear
• Honey contains anti-microbials, flavonoids, polyphenols and has proposed antihyperglycemic effects due to lower glycemic index
• Beneficial effects of honey are likely unrelated to its sugar content but to its numerous additional beneficial constituents
• Important to note that honey, agave, etc. comprise a small proportion (<15%) of US sugar consumption
What about other sweeteners, such as honey?
Arrigoni et al. 2015 Dietary Sugars and Health
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Public health guidance to reduce sugar
World Health Organization recommends a reduced intake of free [added] sugars throughout the life course.
• In both adults and children, WHO recommends reducing intake to less than 10% of total energy intake
• WHO suggests a further reduction of intake to below 5% of total energy intake
What about low-calorie sweeteners (LCS)?
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• Background on Dietary Sugar & Health
• Background on Low-calorie Sweeteners (LCS)
• LCS, Weight & Health: Observational Studies
• LCS, Weight & Health: Proposed Mechanisms
• LCS, Weight & Health: Human Intervention Studies
• LCS, Weight & Health: Future Research Needs
Outline
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Low-calorie sweeteners (LCS)
• Also known as artificial sweeteners, non-nutritive sweeteners, high-potency sweeteners, sugar substitutes
• Potently sweet and contain no or few calories
• Examples: aspartame, sucralose, saccharin, acesulfame-potassium, stevia, monkfruit extract
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OCH3
O
NH
O
NH2OH
O
S
NH
O
O
O
OCl
HO
OH
HO
O
Cl
O
HO
OH
Cl
Saccharin300x
Aspartame160-220x
Sucralose600x
Rebaudioside A300x
Non-nutritive sweetenersCommon LCS
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• Numerous toxicology and clinical studies demonstrate that LCS are generally safe and well-tolerated
• Conducted across species, across FDA-approved sweeteners, at many dosages
• Focus of this presentation is not safety but rather LCS effects on weight and metabolic health
Safety of LCS
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LCS consumption in the United States
0%
5%
10%
15%
20%
25%
30%
35%
40%
45%
All LCS LCS Beverages
Perc
ent C
onsu
mer
s (%
)
Kids 1999-00 Kids 2009-12
Sylvetsky et al. AJCN 2012; Sylvetsky et al. JAND 2017
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LCS consumption in the United States
• Beverages are the most commonly consumed source of LCS
• Prevalence of LCS use increases with age, family income, educational attainment, and body weight and is most common among females and non-Hispanic white individuals
• Significant increases in LCS consumption observed over past two decades across all sociodemographic subgroups
Sylvetsky et al. AJCN 2012; Sylvetsky et al. JAND 2017
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LCS in foods and beverages
Tabletop Packets
Diet Beverages Reduced Sugar/Sugar-Free Foods and
Condiments
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Sylvetsky, & Dietz NEJM 2014; Sylvetsky et al., Int. J Peds, 2014, Sylvetsky et al. AJCN 2017
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American Heart Association 2018
‘There is a scarcity of long-term RCTs to adequately document the efficacy and safety of LCS beverages, particularly relative to SSBs, as a tool to help maintain energy balance, control cardiometabolic risk factors, and reduce risk of cardiovascular events.
This lack of evidence does not mean that LCS beverages are or are not efficacious…Nonetheless, there is a dearth of evidence on the potential adverse effects of LCS beverages relative to potential benefits.
On the basis of the available evidence, the writing group concluded that, at this time, it is prudent to advise against prolonged consumption of LCS beverages by children.’
Johnson et al. 2018 Circulation
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2015 Dietary Guidelines Advisory Committee
“Committee acknowledged that a potential unintended consequence of a recommendation on added sugars might be that consumers and manufacturers replace added sugars with low-calorie sweeteners.”
“Added sugars should be reduced in the diet and not replaced with low-calorie sweeteners, but rather with healthy options, such as water in place of sugar-sweetened beverages.”
DGAC Scientific Report, 2016
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• Background on Dietary Sugar & Health
• Background on Low-calorie Sweeteners (LCS)
• LCS, Weight & Health: Observational Studies
• LCS, Weight & Health: Proposed Mechanisms
• LCS, Weight & Health: Human Intervention Studies
• LCS, Weight & Health: Future Research Needs
Outline
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LCS and metabolic health
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LCS use and weight gain: cohort studies
Weight loss Weight gain
Azad CMAJ 2017
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LCS use is associated with higher BMI
Miller & Perez AJCN, 2013
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LCS and diabetes risk: cohort studies
Azad et al. CMAJ 2017
Lower risk Higher risk
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Stroke, May 2017
Associated with other metabolic outcomes
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• Reverse causation
• Residual confounding by other dietary behaviors or lifestyle factors
• Measurement error in dietary intake assessment
• Rare outcomes require very large sample sizes and long follow-up
Limitations of observational study designs
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Possibility of reverse causality
DIET SODA
Weight Gain
Already overweight, struggling with their
weight, already follow poor diet
DIET SODA
ObesityDiabetesCVD, etc.
Various physiologic
mechanisms
Reverse causality/residual
confounding
Pepino 2015 Phys & Behavior
How to explain epidemiologic findings?
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• Background on Dietary Sugar & Health
• Background on Low-calorie Sweeteners (LCS)
• LCS, Weight & Health: Observational Studies
• LCS, Weight & Health: Proposed Mechanisms
• LCS, Weight & Health: Human Intervention Studies
• LCS, Weight & Health: Future Research Needs
Outline
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Proposed mechanisms explaining the association between NNS and body weight
Weight GainMetabolic Impairments?
Change in taste preferences, appetite, and/or dietary patterns
Impaired predictive relationship between sweet taste and calories
Sweet-taste receptor mediated changes in glucose and insulin
Altered nutrient absorption via changing the gut microbiota
DIET
Pepino, Diabetes Care 2015, Brown & Rother, JCEM 2012
Increased adipogenesis
Proposed mechanisms
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Mesenchymal Stem Cells
Ace-K , Saccharin & Sucralose
3T3-L1 cells: AdipogenesisMature adipocytes: LipolysishMSCs: Lipolysis**
Simon BR, et al. JBC 2013 **Sen (ADA, Endo)
Increased adipogenesis
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Taste receptor cell in mouth Taste receptor cell in gut
Neurotransmitter GLP-1
Taste receptors are not only in the oral cavity!
There are sweet taste receptors in
the pancreas, gut, lungs,
adipose, etc.
Taste receptor signaling
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Rats given unrestricted access to standard
laboratory chow and plain unsweetened
yogurt 3x per week and sweetened yogurt
(glucose or saccharin) 3 times per week for 14
days.
Swithers et al. Behav Brain Res, 2012
Saccharin exposure weight gain in rats
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10 week old mice fed high fat diet supplemented with saccharin for 11 weeks
Suez et al., Nature 2014
LCS and gut microbiome
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36
6 days following transfer of fecal samples from donor mice drinking
saccharin, glucose, water to germ-free mice
Suez et al., Nature 2014
LCS and gut microbiome: glycemic response among transplanted recipients
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Most of these mechanisms have not been studied after
chronic LCS exposure in humans!
??????
11
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• Background on Dietary Sugar & Health
• Background on Low-calorie Sweeteners (LCS)
• LCS, Weight & Health: Observational Studies
• LCS, Weight & Health: Proposed Mechanisms
• LCS, Weight & Health: Human Intervention Studies
• LCS, Weight & Health: Future Research Needs
Outline
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• Meta-analysis of 13 RCTs
• Displacing sugar sweetened beverages (SSBs) or sugar with LCS options may result in modest weight loss
Miller & Perez AJCN 2014
RCTs show benefits or neutral effects on weight
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• Displacing sugar sweetened beverages (SSBs) or sugar with LCS options may result in modest reductions in
• BMI
• Fat mass
• Waist circumference
Miller & Perez AJCN 2014
RCTs show benefits or neutral effects on weight
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Azad et al. CMAJ 2017
RCTs do not support intended benefits of LCS for weight loss
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• Small sample size, short follow-up
• Limited compliance
• Choice of comparison group
• Poorly defined interventions
• Do not reflect “real-world” consumption patterns
• Different types of LCS
• Adults vs. children
• Healthy individuals vs. pre-existing disease
Limitations of RCTs
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De Ruyter et al. NEJM 2012,
Lack of control
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LCS
Water
Peters et al. Obesity 2014
• Had to drink ≥ 3 LCS beverages per week for inclusion
• Comprehensive CB weight loss intervention for 12 weeks
• Monthly behavioral weight loss meetings with diet counseling
Weeks of intervention
% w
eigh
t cha
nge
Habitual consumption
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• Overweight and obese adults (n=318)
• Monthly group counseling
• Weigh-ins, weekly monitoring, feedback on progress
• Greater adherence to intake of diet beverages
• No measure of habitual LCS
Tate et al. AJCN 2012
Intensive behavioral support
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Sylvetsky, & Dietz NEJM 2014; Sylvetsky et al., Int. J Peds, 2014, Sylvetsky et al. AJCN 2017
Unaware of LCS useNo behavioral support/weight loss diet
Low cognitive engagementSubstitution vs. addition?
Real-life
Knowledge of LCS consumptionIntensive behavioral supportHigh cognitive engagement
Calorie restricted diets
RCT
vsDIET
Discrepant results: real-life vs RCT?
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J Nutr 2018;148:1293-1299
What about outcomes other than weight?
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• LCS exert metabolic effects in vitro and in rodent models, yet relevance to humans is unclear
• Some short-term evidence suggests that replacing SSBs with LCS beverages could help in weight management
• Longer-term and higher quality evidence needed on long-term effects of LCS consumption on cardiometabolic disease
• Effects of LCS consumption in children are particularly understudied
48
Summary
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• Improving assessment of LCS intake
• Consideration of contextual factors: life-stage, habitual consumption, motivation for use, etc.
• Consideration of effects by LCS type, food/beverage source, at different intake levels and across different populations
• Particularly limited data on metabolic effects of natural LCS in humans, such stevia and monk fruit extract
• Cardiometabolic implications of inter-generational/early life LCS exposure are largely unknown
Key future research needs