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“Difficult to combat,But not impossible”

““A REVIEW ON SWINE FLU”A REVIEW ON SWINE FLU”PRESENTED BY,PRESENTED BY,SONALI DIWATE B.SONALI DIWATE B.

M.PHARMM.PHARM(PHARMACOLOGY)(PHARMACOLOGY)

GUIDED BY,GUIDED BY,PROF.CHANSHETTI R.PROF.CHANSHETTI R.

PE Society’sModern college of pharmacy (for ladies),

Moshi, Pune.

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AIMAIMTo review and study the Swine Flu.To review and study the Swine Flu.

OBJECTIVEOBJECTIVE

1.TO COLLECT THE INFORMATION ON SWINE FLU. (LITERATURE SURVEY).1.TO COLLECT THE INFORMATION ON SWINE FLU. (LITERATURE SURVEY).

2. TO SURVEY THE STATUS AND SEVERITY OF DISEASE ALL OVER THE WORLD.2. TO SURVEY THE STATUS AND SEVERITY OF DISEASE ALL OVER THE WORLD.

3. TO DESCRIBE EPIDEMIOLOGY OF DISEASE.3. TO DESCRIBE EPIDEMIOLOGY OF DISEASE.

4. TO STUDY LIFE CYCLE OF VIRUS.4. TO STUDY LIFE CYCLE OF VIRUS.

5. TO EXPLAIN PREVENTION AND TREATMENT OF SWINE FLU.5. TO EXPLAIN PREVENTION AND TREATMENT OF SWINE FLU.

6. TO INVESTIGATE RESEARCH SCOPE IN THIS AREA.6. TO INVESTIGATE RESEARCH SCOPE IN THIS AREA.

7. TO ANALYZE ALL THE PARAMETERS RELATED TO SWINE FLU.7. TO ANALYZE ALL THE PARAMETERS RELATED TO SWINE FLU.

8. TO AWARE PEOPLE ABOUT SWINE FLU. 8. TO AWARE PEOPLE ABOUT SWINE FLU.

9.SUMMERIZATION OF THE INFORMATION AND WRITING OF PROJECT.9.SUMMERIZATION OF THE INFORMATION AND WRITING OF PROJECT. 2

CONTENTSCONTENTS…..…..

1. AIM AND OBJECTIVE1. AIM AND OBJECTIVE2. INTRODUCTION2. INTRODUCTION3. HISTORY OF SWINE FLU3. HISTORY OF SWINE FLU4. STRUCTURE OF VIRUS4. STRUCTURE OF VIRUS5. EPIDEMIOLOGY5. EPIDEMIOLOGY6. SIGN AND SYMPTOMS6. SIGN AND SYMPTOMS7. DIAGNOSTIC TESTS7. DIAGNOSTIC TESTS8. TREATMENT8. TREATMENT9. PREVENTION9. PREVENTION10.CONCLUSION10.CONCLUSION11.BIBLIOGRAPHY11.BIBLIOGRAPHY

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INTRODUCTIONINTRODUCTION[1]

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HISTORY OF VIRUSHISTORY OF VIRUS[2]

Year of Origin Sub-Type

1890 H2N8

1900 H3N8

1918 H1N1 (Spanish Flu)

1957 H2N2 (Asian Flu)

1968 H3N2 (Hong Kong Flu)

1977 HIN1 (Russian Flu)

2009 H1N1 (Swine Flu)

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Death Occurred…1.RIDA SHAIKH (PUNE)

2.MR.FAHMIDA(MUMBAI)

3.MS.P.DIPIKA (PUNE)

Death Occurred…1.RIDA SHAIKH (PUNE)

2.MR.FAHMIDA(MUMBAI)

3.MS.P.DIPIKA (PUNE)

ORIGIN =MEXICO.

ABOUT VIRUSABOUT VIRUS[3]

1] INFUENZA VIRUS A SUB TYPES- H1N11] INFUENZA VIRUS A SUB TYPES- H1N1 H1N2H1N2 H3N1H3N1 H2N3H2N32] SINGLE STRANDED RNA VIRUS .2] SINGLE STRANDED RNA VIRUS .3] FAMILY - ORTHROMYXOVIRIDAE. 3] FAMILY - ORTHROMYXOVIRIDAE. 4] SHAPE - SPHERICAL.4] SHAPE - SPHERICAL.5] DIAMETER - 80-120nm.5] DIAMETER - 80-120nm.

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STRUCTURE OF VIRUSSTRUCTURE OF VIRUS[3]

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FORMATION OF SWINE FLU VIRUS FORMATION OF SWINE FLU VIRUS [4][4]

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EPIDEMIOLOGYEPIDEMIOLOGY[4]

9http://www.youtube.com/watch?v=c-36EiSejFUhttp://www.youtube.com/watch?v=c-36EiSejFU

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NORMAL NORMAL TRACHEAL TRACHEAL MUCOSAMUCOSA

3 DAYS 3 DAYS POST-POST-INFECTIONINFECTION

7 DAYS 7 DAYS POST-POST-INFECTIONINFECTION

SIGN AND SYMPTOMSSIGN AND SYMPTOMS[5]

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RUNNY NOSERUNNY NOSESORE THROATSORE THROAT

COUGHCOUGHFEVERFEVER

BODY ACHEBODY ACHEVOMITING & DIARRHOEAVOMITING & DIARRHOEADIFFICULTY IN BREATHINGDIFFICULTY IN BREATHING

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EMERGENCY WARNING EMERGENCY WARNING SIGNSSIGNS

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BREATHING DIFFICULTYBREATHING DIFFICULTYPAIN IN CHESTPAIN IN CHESTSUDDEN DIZZINESSUDDEN DIZZINESCONFUSIONCONFUSIONSEVERE VOMITINGSEVERE VOMITINGHIGH FEVERHIGH FEVERBLUISH SKIN COLOURBLUISH SKIN COLOUR

• Rapid antigen tests• Immunofluorescent antibody testing• Real-time Reverse Transcriptase-

Polymerase Chain Reaction (RT-PCR)• Collection of nose & throat swab

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DETECTION OF VIRUS DETECTION OF VIRUS [6][6]

TREATMENTTREATMENT[6,7]

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AYURVEDIC

OTHER

HOMEOPATHIC

ALLOPATHIC

ALLOPATHIC TREATMENTALLOPATHIC TREATMENT

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ORALLY ADMINISTERED

DRUGSVACCINES

M2 INHIBITORS NEURAMINIDASE INHIBITORS

NEURAMINIDASE INHIBITORSNEURAMINIDASE INHIBITORS

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ZANAMIVIRZANAMIVIROSELTAMIVIR PO4

M2 INHIBITORSM2 INHIBITORS

AMANTIDINE

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REMANTIDINE

VACCINESVACCINES[8]

1] DEVELOPMENT OF VACCINE STEP 1-IDENTIFICATION OF VIRUS STEP 2-DEVELOPMENT OF PRIMARY SEED STEP 3-TESTING STEP 4-AUTHERIZATION

2]EXAMPLE-AREPANRIX,NASOVAC

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OTHER TREATMENTOTHER TREATMENT

IT INVOLVES,IT INVOLVES,-PLENTY OF REST -PLENTY OF REST -BE PHYSICALLY FIT-BE PHYSICALLY FIT-EAT NUTRITIOUS FOOD-EAT NUTRITIOUS FOOD-MANAGE YOUR STRESS-MANAGE YOUR STRESS -DRINKING OF PLENTY OF WATER-DRINKING OF PLENTY OF WATER

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NEVER GIVE ASPIRIN TO CHILDRENS WHO HAVE NEVER GIVE ASPIRIN TO CHILDRENS WHO HAVE SWINEFLU BECAUSE IT MAY CAUSE REYE’S SYNDROME.SWINEFLU BECAUSE IT MAY CAUSE REYE’S SYNDROME.

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PREVENTIONPREVENTION[8]

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1.AVOID CLOSE CONTACT WITH PEOPLE WHO APPEAR UNWELL AND HAVE FEVER AND COUGH.

2.AVOID TOUCHING EYES, NOSE OR MOUTH WITH UNWASHED HANDS.

3.WASH HANDS FREQUENTLY WITH SOAP AND WATER.

4.AVOID TOUCHING SURFACES THAT MAY BE CONTAMINATED WITH THE FLU VIRUS.

5.REDUCE AS MUCH AS POSSIBLE THE TIME SPENT IN CROWDED SETTINGS.

6.AVOID TRAVELLING N CROWDED AREA

7.USE FACE MASK.

CONCLUSIONCONCLUSION

• The spread of infection has been facilitated by air and land travel and social gatherings. • The better understanding of routes of transmission, clinical features, pathogenesis, and perhaps, response to treatment is required to check the spread of

infection. • Detailed contact and travel histories and knowledge of viral activity in community are essential for prompt case detection by the health personnel. • Real-time RTPCR analysis of throat swabs or lower respiratory samples may offer sensitive means of diagnosis. • Use of oral Oseltamivir may be warranted for the treatment of severe illness. • Above all, there is an urgent need for global coordination in clinical and epidemiologic

research to control this outbreak.

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BIBLIOGRAPHYBIBLIOGRAPHY1. Manish Sinha,; “Review on Swine flu, Journal of Infection and Public Health” Journal of Infection

and Public Health (2009) 2 p.g., 157—166.

2. Paul M.; “Origin of Human Virus Diversity”, Vol 108, feb8,2002, p.g. 305-312. &

Tokiko W.;” Pathogenesis of 1918 pandemic history of influenza virus”, Jan 2011, Vol 7 p.g. 1-5.

3. Rachalle S.; Robert G.; “The Influenza Virus Enginma”, Cell 136, Feb 6,2009. p.g. 402-410

4. www.protienlounge.com & www.direct.gov.uk/swine flu

5. John S., Anice C.; “ Transmission of Influenza virus in a mammalian host is increased by PB2

amino acid 627 and or 627 E/701N Jan 2,2009, Vol-5, p.g. 1-11.

6. http//www.swineflu-india.org.

7. www.homeopathy3fold.com

8. Tokiko W.;” Pathogenesis of 1918 pandemic history of influenza virus”, Jan 2011, Vol 7 p.g. 1-5.

9. Christian R. “The core protein of classical swine fever virus is dispensable for virus propagation In

Vitro”, Mar 2012, Vol 8, Issue 3, p.g. 1-13.

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Thank You…..

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Thank You…..

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