synapse (3.19.2015)

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SynapseNewspaper The UCSF Student synapse.ucsf.edu | Thursday, March 19, 2015 | Volume 59, Number 11 IN THIS ISSUE Events » PAGE 2 Features » PAGE 3 Columns » PAGE 4 Puzzles » PAGE 5 COLUMNS Let’s Get Physical... Therapy For those wondering what the point is of having such a well- endowed rear... » PAGE 4 FEATURES Knox Medical Diagnostics Bringing once expensive medical diagnostic tools to the personal consumer... » PAGE 3 UCSF Veterans. Student Veterans at UCSF gather at the first UCSF Veteran community reception Courtesy of Sam Lee HOSPITAL » PAGE 6 UCSF Veteran Community Reception a place to mingle and network By Sam Lee Assistant Editor Student Veterans and military service members of UCSF gathered together at the Millberry Union Conference Center on Wednesday, March 11, to meet with fellow students, faculty, and staff to network and share their experiences of student and military life. The reception, hosted by Student Veterans at UCSF, is part of an ongoing effort by Veteran Support Services to reach out to Veterans attending UCSF to help create opportunities for mentorship, educational and financial advice, and camaraderie to help other Veterans transition to academic life. For more information about Veteran Support Services visit veterans.ucsf.edu. Sam Lee is a first-year Family Nurse Practitioner student and MEPN grad Opening of new medical center at Mission Bay By Lauren Shields Staff Writer As advertised on the building during construction, the new Medical Center at Mission Bay achieved a timely opening on February 1, after more than 10 years of planning and construction. Perhaps even more impressive than opening on time, the construction finished under budget. These goals were achieved under the direction of Director of Design and Construction, Stuart Eckblad, who early on integrated contractors and designers to limit risk and save time. “[Achieving our deadlines] was due to the fantastic efforts and talents of the team we were able to pull together,”said the Executive Director of the Mission Bay Hospitals Project, Cindy Lima. The center includes 3 new hospitals— Benioff Children’s Hospital, Bakar Cancer Hospital, and Betty Irene Moore Women’s Hospital – with a total of 289 beds. The center expects to serve 122,000 outpatients and perform around 10,000 surgeries in the first year. But even beyond its medical capabilities, it is state-of-the-art in all aspects—from its eco-friendly design to its fleet of 25 robots that deliver food, linens, medications, and specimens, saving employees a total of 220 deliveries per day. Notably, designers of the hospital gave careful thought to create a medical Postdocs Address Range of Issues By Bryne Ulmschneider Staff Writer Courtesy of Tom Seawell Ostensibly, the ultimate goal of academic training is a tenure track faculty position. Unfortunately, these expectations don’t match reality. Only about 25 percent of UCSF’s postdoc scholars will ultimately make it to a tenure track position. Nationwide, that number is closer to 1 in 10. These stark realities led recently to the creation of P(ostdoc)-Value. The new group hopes to challenge the UCSF community to become leaders in innovating the postdoc as much as UCSF innovates medicine and research. “The root cause of the current problem,” said Saori Haigo, a third-year postdoc and P-Value organizer is how the NIH funding structure incentivized the expansion of postdoctoral positions far past sustainable levels. “Instead of being oriented toward training, because of the NIH funding structure, a lot of POSTDOCS » PAGE 4 LEFT TO RIGHT: Postdoc panelists Lakshmi Subramanian, Saori Haigo, and Stephanie Vlachos prepare to take questions from the audience. Courtesy of Matthew Cook

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Volume 59, Issue 11

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Page 1: Synapse (3.19.2015)

SynapseNewspaperThe UCSF Student

synapse.ucsf.edu | Thursday, March 19, 2015 | Volume 59, Number 11

IN THIS ISSUEEvents » PAGE 2Features » PAGE 3Columns » PAGE 4 Puzzles » PAGE 5

COLUMNSLet’s Get Physical... TherapyFor those wondering what the point is of having such a well-endowed rear... » PAGE 4

FEATURESKnox Medical DiagnosticsBringing once expensive medical diagnostic tools to the personal consumer... » PAGE 3

UCSF Veterans. Student Veterans at UCSF gather at the first UCSF Veteran community reception

Courtesy of Sam Lee

HOSPITAL » PAGE 6

UCSF Veteran Community Reception a place to mingle and networkBy Sam LeeAssistant Editor

Student Veterans and military service members of UCSF gathered together at the Millberry Union Conference Center on Wednesday, March 11, to meet with fellow students, faculty, and staff to network and share their experiences of student and military life. The reception, hosted by Student Veterans at UCSF, is part of an ongoing effort by Veteran Support Services to reach out to Veterans attending UCSF to

help create opportunities for mentorship, educational and financial advice, and camaraderie to help other Veterans transition to academic life.

For more information about Veteran Support Services visit veterans.ucsf.edu.

Sam Lee is a first-year Family Nurse Practitioner student and MEPN grad

Opening of new medical center at Mission BayBy Lauren ShieldsStaff Writer

As advertised on the building during construction, the new Medical Center at Mission Bay achieved a timely opening on February 1, after more than 10 years of planning and construction. Perhaps even more impressive than opening on time, the construction finished under budget.

These goals were achieved under the direction of Director of Design and Construction, Stuart Eckblad, who early on integrated contractors and designers to limit risk and save time. “[Achieving our deadlines] was due to the fantastic efforts and talents of the team we were able to pull together,”said the Executive Director of the Mission Bay Hospitals Project, Cindy Lima.

The center includes 3 new hospitals—Benioff Children’s Hospital, Bakar Cancer Hospital, and Betty Irene Moore Women’s Hospital – with a total of 289 beds. The center expects to serve 122,000 outpatients and perform around 10,000 surgeries in the first year. But even beyond its medical capabilities, it is state-of-the-art in all aspects—from its eco-friendly design to its fleet of 25 robots that deliver food, linens, medications, and specimens, saving employees a total of 220 deliveries per day.

Notably, designers of the hospital gave careful thought to create a medical

Postdocs Address Range of IssuesBy Bryne Ulmschneider Staff Writer

Courtesy of Tom Seawell

Ostensibly, the ultimate goal of academic training is a tenure track faculty position. Unfortunately, these expectations don’t match reality. Only about 25 percent of UCSF’s postdoc scholars will ultimately make it to a tenure track position. Nationwide, that number is closer to 1 in 10.

These stark realities led recently to the creation of P(ostdoc)-Value. The new group hopes to challenge

the UCSF community to become leaders in innovating the postdoc as much as UCSF innovates medicine and research.

“The root cause of the current problem,” said Saori Haigo, a third-year postdoc and P-Value organizer is how the NIH funding structure incentivized the expansion of postdoctoral positions far past sustainable levels. “Instead of being oriented toward training, because of the NIH funding structure, a lot of

POSTDOCS » PAGE 4LEFT TO RIGHT: Postdoc panelists Lakshmi Subramanian, Saori Haigo, and Stephanie Vlachos prepare to take questions from the audience.

Courtesy of Matthew Cook

Page 2: Synapse (3.19.2015)

2 | March 19, 2015 | synapse.ucsf.edu

Events » SACNAS AT UCSF MONTHLY MEETINGThursday, March 19, 5:30-8 p.m., Byers Hall, 215, Mission BayDr. Elizabeth Silva, UCSF MIND program, will talk about her career path through science. Dr. Laurence Clement, UCSF Office of Career and Professional Development (OCPD) will discuss the career resources and opportunities OCPD offers graduate students and postdocs. Food and drinks will be provided!!

CONSULTING CLUB AT UCSF KICK-OFF EVENTThursday, March 19, 6-8 p.m., Rock Hall, 102, Mission BayJoin the Consulting Club at UCSF for their kick-off event. Network with new and current members. Open to all.

MUSLIM FRIDAY PRAYER SERVICES: MISSION BAY Friday, March 20, 1:30-2 p.m., Helen Diller, 160, Mission BayThe Muslim Community at UCSF holds regular Friday prayer services (Jum’a) every week. Come join your fellow brothers and sisters for prayer and socializing. All are welcome!

MUSLIM FRIDAY PRAYER SERVICES: PARNASSUS Friday, March 20, 1-1:30 p.m., Medical Sciences, 157, ParnassusThe Muslim Community at UCSF holds regular Friday prayer services (Jum’a) every week. Come join your fellow brothers and sisters for prayer and socializing. All are welcome!

MISSION BAY RIPSFriday, March 20, 4-5 p.m., Genentech Hall Auditorium, Mission BayRIPS is a seminar series wherein one student and one postdoc present their current research. Talks are 15 minutes in length and are preceded by a 20-minute social. Snacks and beverages are provided.

CAMPUS EVANGELISTIC FELLOWSHIPFriday, March 20, 7-10:30 p.m., Nursing, 517, ParnassusJoin the Campus Evangelistic Fellowship for their weekly meeting with Bible study, hymn singing, and fellowship.

WILS COFFEE TALK: TANJA KORTEMMEMonday, March 23, noon-1 p.m., Genentech Hall, S204, Mission BayLooking for tips and suggestions for grad school? Wondering about the life path for successful women scientists? Join WILS for an informal interview session with Dr. Tanja Kortemme. All students, postdocs, and staff are welcome.

INFORMATION SESSION FOR LEAN LAUNCHPAD FOR LIFE/HEALTHCAREMonday, March 23, 5:30-7:30 p.m., Helen Diller, 160, Mission BayLearn about this leading entrepreneurship course where you can explore your venture idea. At the information session, you will learn about the Lean LaunchPad framework, connect with potential team members or find ideas to work on.h t t p s : / / w w w. e v e n t b r i t e . c o m / e /information-sessionmixer-for-lean-launchpad-for-life-sciencehealthcare-tickets-16028715319?ct=t(Dec

2015-16 GPSA EXECUTIVE COUNCIL: APPLICATIONS DUE MARCH 27Run for the 2015-16 Graduate & Professional Student Association (GPSA) Executive Council and gain valuable interprofessional leadership experience! All students are encouraged to run for one of the six elected positions in the GPSA elections. All candidates for an Executive Council position must submit a candidate application and photo online, including a statement (no more than 500 words) describing your reasons for running, qualifications for office, and goals if elected. Visit the GPSA website for details on how to submit a candidate application. . http://gpsa.ucsf.edu/node/484

Announcements »

CARRY THE ONE RADIO WORKSHOP Tuesday, March 24, 5 -7 p.m., Mission Hall, 1107, Mission BayCarry the One Radio is a UCSF-based science podcast. The show is run completely by a dedicated group of young scientists who want to share their enthusiasm for research with a wider audience. The group meets weekly to workshop various pieces. All are welcome, no radio experience needed.

SYNAPSE MEETINGWednesday, March 25, noon-1 p.m., Millberry Union, 111W, ParnassusSynapse is looking for Mission Bay and Parnassus writers, bloggers, photographers, and designers. Come to the lunch meeting and share your story ideas.

UCSF RUN CLUB Wednesday, March 25, 5:30-6:30 p.m., Millberry Union Central Desk, ParnassusPlease drop by and join UCSF Fit & Rec for a run! Each Wednesday night the Run Club runs various distances (3-6 miles) at a 9-11 minute per mile.

IMN MIDWEEK MEDITATION HOURWednesday, March 25, 5:30-6:30 p.m., Library, CL215, ParnassusThe Integrative Medicine Network invites everyone in the UCSF community to experience a weekly guided meditation. All are welcome, whether you are looking to combat day-to-day stress using meditation or you’d like to uncover subtle layers of your self by diving deep! No experience in meditation is necessary.

ENGLISH CORNERWednesday, March 25, 6-8:30 p.m., Nursing, 527, ParnassusEnglish Corner is an informal Conversational English Class given as a free community service and provided on a voluntary basis by both people born and raised in the United States as well as many people who have, at one time in their lives, experienced life as a new immigrant to the US.

CHANCELLOR’S CONCERT SERIESThursday, March 26, noon-12:45 p.m., Cole Hall, ParnassusLooking for a place to study or relax between classes? CLS Arts & Events has got just what you need. The Chancellor’s Concert Series on Thursdays is a great place to set up your laptop and study or just take a break from classes while listening to classical music. Seating begins at noon. Lunch will be served while supplies last.

TAX WORKSHOP FOR STUDENTS PAID VIA STIPENDThursday, March 26, 3:30-5 p.m., Clinical Sciences, 130, ParnassusJohn Barrett, tax manager for the UC Office of the President, and a member of his staff will lead a discussion designed to help you understand your tax obligations. Barrett will present tax-related information specifically for students who are paid via stipend. Barrett will also discuss general tax obligations as well as IRS and other resources you may turn to for help and information. Sponsors: Graduate Division and Postdoc Office

CELL HACKERS: EMERALD THERAPEUTICSThursday, March 26, 5:30-7 p.m., Rock Hall, Mission Bay

Join Cell Hackers for a discussion about the Emerald Cloud Laboratory, which allows researchers to remotely run life sciences experiments in a central lab over the Internet.

END7 NEGLECTED TROPICAL DISEASESMonday, March 30, noon-1 p.m., Medical Sciences, 157, ParnassusEmily Conron, Sabine Vaccine Institute, will talk about the importance of eradicating seven neglected tropical diseases and the issues that surround this campaign.

ENTREPRENEUR’S CLUB: SEAN DUFFYTuesday, March 31, 5:30-7:30 p.m., Genentech Hall, N114, Mission BayCome hear how Sean Duffy, Co-Founder & CEO of Omada Health, ditched an MD/MBA program at Harvard to embrace the business world and then spin a company out of IDEO. Sean will share his story and the experience of going from an idea to a successful company.h t t p s : / / w w w. e v e n t b r i t e . c o m / e /entrepreneurs-club-with-sean-duffy-omada-health-scratching-the-tech-itch-with-healthcare-tickets-16

STUDENT LOAN MANAGEMENT SEMINARThursday April 2, 3-4 p.m., Nursing, 721, ParnassusWondering how you will manage student loan repayment? The Financial Aid Office of UCSF is offering workshops open to any student interested in learning more about repayment options, forgiveness programs, and strategies to best manage your loan portfolio. Bring a printout of your student loans.

STUDENT LOAN MANAGEMENT SEMINARFriday, April 3, noon-1 p.m., Nursing, 517, ParnassusWondering how you will manage student loan repayment? The Financial Aid Office of UCSF is offering workshops open to any student interested in learning more about repayment options, forgiveness programs, and strategies to best manage your loan portfolio. Bring a printout of your student loans.

GRADUATE & PROFESSIONAL STUDENT ASSOCIATION MONTHLY MEETINGMonday, April 6, 5:30-7:30 p.m., Genentech Hall, N-114, Mission BayMeet your assembly members at the monthly GPSA meeting and be a part of

the discussion on topics relating to student priorities. Dinner provided with RSVP.

GRADUATE DIVISION ALUMNI SEMINAR SERIES: VEENA SINGLA, PHDMonday, April 6, 7-8:30 p.m., Helen Diller, 160, Mission BayJoin the Graduate Division for a new seminar series and learn about the diverse careers of PhD alumni! This month features Veena Singla, Staff Scientist at the National Resources Defense Council, a non-profit environmental advocacy group.http://biophysics.ucsf.edu/seminars-events/ipqb-alumni-speaker-series

STUDENT LOAN MANAGEMENT SEMINARTuesday, April 7, noon-1 p.m., Nursing, 729, ParnassusWondering how you will manage student loan repayment? The Financial Aid Office of UCSF is offering workshops open to any student interested in learning more about repayment options, forgiveness programs, and strategies to best manage your loan portfolio. Bring a printout of your student loans.

8TH ANNUAL CHANCELLOR’S LEADERSHIP FORUM ON DIVERSITY AND INCLUSIONTuesday, April 7, noon -1:30 p.m., Cole Hall, ParnassusHear from senior leadership on diversity initiatives at UCSF. The event will be livestreamed and ASL interpreters will be provided.h t t p : / / l e c t u r e . u c s f . e d u / e t s / P l a y /d356f9622f90447687c7d7aa9d447e411d

CHOOSING A THESIS LABWednesday, April 8, noon-1:30 p.m., Mission Hall, 1401, Mission BayChoosing a thesis lab is an important decision that will affect the direction of your graduate research and your academic success and even your ultimate career choices. A panel of senior students will share their insights and provide advice for selecting a rotation and thesis (dissertation) lab. Learn about factors that are often overlooked. Gain strategies for using your rotation experiences to their fullest. Sponsors: First Generation Support Services, Office of Career and Professional Development, Student Life, Associated Students of the Graduate Division.

Have an event that you would like to submit? Please email to [email protected].

Journal Club

3RD ANNUAL RECYCLED/RECLAIMED ART SHOW: ARTIST WANTEDThursday, May 14, Rutter Community Center, Mission BayThe Visual Arts Club at UCSF, Campus Life Services Arts & Events and Living Green are excited to present The Recycled/Reclaimed Art Show. UCSF, students, staff and facility are invited to join the show. All submittals must be made 99% from recycled, reused or reclaimed material. Applications due April 20.

ARE YOU A FIRST GENERATION TO COLLEGE STUDENT (FG2C)? Register with the First Generation Support Services Office to give you access to all of the First Generation Support Services and helps the office advocate for you!http://bit.ly/firstgenregister

Page 3: Synapse (3.19.2015)

synapse.ucsf.edu | March 19, 2015 | 3

500 Parnassus Avenue, Millberry Union 108W, San Francisco, CA 94143tel: 476-2211 | fax: 502-4537

[email protected] | synapse.ucsf.edu

About Synapse is the UCSF student-run biweekly newspaper which runs on Thursdays during the academic year and publishes online in between print issues. Synapse seeks to serve as a forum for the campus community. Articles and columns represent the views of the authors and not necessarily those of the Board of Publications or the University of California.

Submissions Announcements and letters should be submitted seven days before publication. All submissions must be emailed to [email protected]. All material is subjected to editing.

Advertising Paid advertisements do not necessarily reflect the views of Synapse. Synapse and its editorial board reserve the right to decline advertisements promoting false or misleading claims, known health risks, or content deemed by the editors to be antithetical to the interests of UCSF students or the UCSF community. Synapse does not accept advertisements from tobacco or alcohol manufacturers, or sexually oriented personal ads. Synapse reserves the right to run any ad with a disclaimer.

Visit synapse.ucsf.edu to view the publication schedule and to submit an ad.

StaffJenny Qi | EDITOR-IN-CHIEFTaylor LaFlam | SCIENCE EDITOR Bryne Ulmschneider | CAREER EDITOR Hanna Starobinets | STAFF WRITERAkshay Govind | STAFF WRITERIlka Fensen | STAFF WRITER Yarrow Madrona | STAFF WRITER Yi Lu | STAFF WRITERAnna Nokana | STAFF WRITER Lauren Shields | STAFF WRITER Mayya Shveygert | STAFF WRITERCharllotte Anderson | STAFF WRITERAndrea Villaroman | STAFF WRITER

Synapse The UCSF Student Newspaper

Features »

Synapse Speaks to Startups: KNOX Medical Diagnostics Wants to Let Patients Test Their Lungs at HomeBy Yarrow MadronaStaff Writer

The explosion of smart phones over the last decade has paved the way for an industry of personalized and portable medicine. The combination of smart phone technology and cloud storage is rapidly bringing once expensive medical diagnostic tools to the personal consumer, with everyone from tiny startups to tech behemoths such as Google and Apple getting in on the action, and recent UCSF startups are no exception.

One such UCSF medical diagnostic entrepreneur is former UCSF biomedical imaging master’s student Charvi Shetty. She started KNOX Medical Diagnostics, which is working to develop a home version of the spirometer, a device used to measure air flow. Her team includes software engineer Huyson Lam, hardware engineer Inderjit Jutla, and UCSF pulmonologists Drs. Ngoc Ly and Kensho Uwanga.

A Medical NeedSpirometers are used in the clinic to measure lung capacity and airway tract obstruction, most often in asthmatic children. The current inexpensive, home-based alternative is the peak-flow meter, in which a patient blows into a tube forcing a ball to rise. According to Shetty, these devices are inaccurate. On top of that, Shetty said that children’s desire to please often results in cheating, which leads to false readings.

“Currently people use home peak flow meters that are cheap but inaccurate,” Shetty said. “Spirometers in the clinical setting can cost over $2,000 and that doesn’t include the laptop you have to buy or the lab tech you need to hire.”

Creating a product that can collect clinical grade data at a fraction of the price was the challenge facing KNOX. They have now built a handheld device that interfaces with a mobile app via Bluetooth. The app can not only record data collected using the device but assay the data’s quality. The app also provides initial instructions as well as real-time feedback to the user on ways to improve blowing technique for optimal data collection. Shetty believes the production cost can be reduced to $20 dollars per device and an overall retail price of $200.

Starting the CompanyShetty entered the UCSF Masters of Science of Biomedical Imaging Program in 2012. While working with a team of students, she was introduced to Dr. David Bansickle, an epidemiologist and CEO of Propeller Health, who explained challenges in diagnosing and treating asthma. Shortly thereafter, her team began working with the UCSF Pulmonary Function Testing Lab. Interviews with patients there validated the clinical need for a home spirometer, so they began trying to develop one.

During this time, Shetty also took three popular UCSF entrepreneur courses that she considers key in starting her company: Idea to IPO, Lean Launchpad for Life Science and Healthcare, and Financing New Ventures. In 2013 Shetty was a finalist for the UCSF Early Translational Research Catalyst Award. Soon after, she incorporated KNOX through QB3.

The FutureShetty plans to sell the device as a research tool to hospitals where it can be directly compared to clinical spirometers. To this

end she has begun partnering with the UCSF pulmonologists Ly and Uwanga, who plan to benchmark their device with spirometers in their clinical trials. Fortunately this can all be done without FDA approval. Eventually, after getting FDA approval, she plans to market the device directly to consumers.

Shetty does not plan to stop with home spirometers. “We’re leveraging software and hardware to enable patients to use the device without a lab tech by providing the analysis and troubleshooting through the

KNOX » PAGE 7

Charvi Shetty and her KNOX Medical Diagnostics colleagues may soon partner with Apple and others.

Courtesy of Charvi Shetty

GPSA March Meeting SummaryBy Polina PulyaninaContributing Writer

Casino Night April 16, 2015Join us for the first annual Casino Night at UCSF—an evening filled with games, food, drinks, and a chance to win prizes! Gambling tables include poker, black

jack, craps, and roulette. The Bay Area’s premier band, Ascension, has been invited for your entertainment. Casino Night is happening on Thursday, April 16, 5-8 p.m. at Millberry Union. Please RSVP for the

event at the Events tab of gpsa.ucsf.edu. Space is limited.

Sexual Violence Task ForceThe Sexual Violence Task Force (SVTF) is gaining momentum across the UC campuses. Currently the SVTF is looking for UCSF representatives to attend conferences every 3 to 4 weeks. Students can get involved with planning of events and raising awareness even if they cannot attend all the meetings. Please direct questions to GPSA.

Submit GPSA Position Applications for 2015–2016 by March 27All students are encouraged to run for 1 of 6 positions on the executive board of the Graduate and Professional Student Association. The candidate applications are due Friday, March 27. Being on the board of GPSA will allow you to immerse yourself in exciting and challenging world of student leadership. GPSA students are closely involved with

GPSA » PAGE 6

RUN FOR GPSA OFFICE

Page 4: Synapse (3.19.2015)

4 | March 19, 2015 | synapse.ucsf.edu

Columns »

Let’s Get Physical...Therapy! The Utility of a Well Rounded Gluteus MaximusBy Ilka FelsenStaff Writer

The human gluteus maximus is unique with respect to its substantial size and enlarged cranial portion compared to other primates. Our glute max is much thicker and larger—indeed, it is a whopping 1.6 times greater relative to body mass in humans compared to chimps. For those

wondering what the point is of having such a well-endowed rear, keep reading!

FunctionThe human glute max arises from many sites (the iliac crest, posterior sacrum, fascial aponeurosis of the erector spinae on the sacrum, coccyx, and sacrotuberous

ligament) and converges onto the iliotibial band and femur. It functions primarily to extend the hip backwards, although its anterior fibers can rotate the femur inwards, and posterior fibers can rotate the femurs outwards.

Using EMG recordings of glute max activity, Lierberman et al. have found it particularly active during running, to keep the body upright instead of flopping forward and to keep the front leg from swing uncontrollably forward. Researchers attribute this activity to the reorganization

GET PHYSICAL » PAGE 6

[Exit, Pursued by Science]The Future of Health: Gizmos and Gadgets EditionBy Hanna StarobinetsStaff Writer

Wearable technology, implantable nano-devices, 3D-printed organs and drones are all slowly but surely bringing us to the fabulous science fiction of Star Trek – in which most medical procedures, including brain surgery, could be done via noninvasive external devices. The future is coming, and it’s bringing us some fabulous gizmos and gadgets.

Consumer electronics takes big step toward digital health At its “Spring Forward” event on March 9, Apple Inc. announced the Research Kit: a major new feature of their mobile operating system that will allow iPhone users to participate anonymously in clinical research. “You’re already carrying a powerful medical research tool,” Apple’s website proclaims. Electronics already on board the iPhone such as its microphone, camera, gyroscopes, and accelerometers have the capability to measure and record a person’s voice, heart rate, hand tremors, and walking balance. Variations in these simple tests could help detect and monitor disease from the comfort of one’s home, and be compiled into valuable large data sets for doctors and scientists to analyze.

Research Kit is an open source platform: all the apps in it will be developed by third-party software developers whose health tests can take advantage of built-in as well as plug-in sensors. The first few apps have already been developed by biomedical research institutions including Stanford, Mt. Sinai, Dana-Farber, UPenn, Oxford, and others. They aim to collect data for a variety of diseases, including asthma, Parkinson’s disease, diabetes, breast cancer, and cardiovascular disease.

As Apple enters this new medical arena, it will soon have to face FDA regulation, but so far has avoided direct contact: for example, by not placing specifically health-dedicated biosensors onto the new Apple Watch. However, as wearable technology holds great promise in improving quality of life in both health and disease, Apple is not likely to fall behind on this path toward this inevitable future of digital health.

A big hope for this platform is to collect not only big but also diverse health data

Apple releases Research Kit, an open source platform for participation in clinical trials. The first few are de-signed for diseases including Parkinson’s disease, heart disease, asthma, and breast cancer, and were designed by biomedical research institutions including Stanford, Oxford, Dana-Farber, and others.

Courtesy of Apple Inc. Press Release

EXIT SCIENCE » PAGE 6

UCSF Journal ClubBy Taylor LaFlamScience Editor

CELL BIOLOGY: Early telomerase inactivation accelerates aging independently of telomere length. Xie, Z., et al. (Blackburn, E.H.) Cell. 2015. 160(5):928-939.

Telomeres, repetitive DNA sequences at the end of chromosomes, are essential for DNA protection. Loss of the telomerase enzyme leads to gradual shortening of telomeres—after each cell division—leading, eventually, to a DNA damage response and loss of the ability to keep proliferating.

Previous research has only described the consequences of telomerase inactivity after many cell divisions. This paper from the Blackburn lab, however, presents evidence that deletion of telomerase leads to negative effects long before telomeres substantially shorten.

Working with budding yeast, the authors found an increase in transient DNA damage responses in yeast lacking telomerase and faster aging. This effect was not due to increased reactive oxygen species or deprotected telomeres. It could be rescued by increased dNTP availability.

STEM CELL BIOLOGY: CDK inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.

Huskey, N.E. et al. (Goga, A.). Stem Cell Reports. 2015. Epub ahead of print.

Tumors arising from differentiated tissues, such as breast cancer or lung cancer, often show loss of some of the characteristic features of the starting tissue. In contrast, tumors arising from embryonic stem cells (ESCs), called teratomas, show increased differentiation, at times in a chaotic mix--a tooth-like region here, a gut-like region there.

ESCs also have a slightly different cell cycle progression than differentiated cells, with accelerated expression of certain regulatory proteins, including CDK1. Here, the authors investigated the effect of CDK1 inhibition on ESCs.

They found that this inhibition led to a DNA damage response and activation of certain p53 target genes. Furthermore, they found that CDK1 inhibition could both prevent the onset of ESC-derived tumors and lead to death of already formed tumors.

CELL BIOLOGY: Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion. Osman, C. et al. (Walter, P.). PNAS. 2015. 112(9):E947-56.

JOURNAL CLUB » PAGE 7

This Date in UCSF HistoryBy Taylor LaFlamScience Editor

From 20 Years Ago: Vol. 29, No. 21, March 7, 1985:

From syllabi accessed on tablets to journal articles read on laptops to medication apps viewed on smart phones, today’s medical students have myriad routes to medical resources on the internet.

Two decades ago, the options were more limited but by no means nonexistent, as explored in the article, “Medical Resources on the World Wide Web,” by Robert E. Kuhn. In the opening paragraph, Kuhn declared, “The Internet has transformed education by facilitating access to information. A new subsystem of the net,

the World Wide Web, has expanded the knowledge cornucopia to include pictures, audio, and even video.”

Kuhn provided URLs for a variety of resources, such as anatomy and pathology atlases, radiology teaches slides, practice ER patient case files. He also explained how to explore the web. “Unlike the Internet, the Web is navigated using the mouse. It is as simple as clicking on the appropriate icon.” Elsewhere he noted, “A ‘Home Page’ is just a collection of addresses which point to a myriad of Web sites.”

THIS DATE » PAGE 7

Page 5: Synapse (3.19.2015)

synapse.ucsf.edu | March 19, 2015 | 5

Puzzles »

March 2015 - Issue 2

Edited by Margie E. Burke

HOW TO SOLVE:

(Answer appears elsewhere

in this issue)

Solution to Sudoku

Copyright 2015 by The Puzzle Syndicate

Difficulty : Medium

March 2015 - Issue 2

ACROSS1 Chocolate

alternative6 Swing support,

maybe10 Minor setback14 Set apart15 Telltale sign16 Piercing site17 Kitchen invader18 Emmy-winning

Daly19 Baker's need20 Words of woe22 Get off the

ground?24 Deface25 Type of ceiling27 Follows orders29 Sluggishness34 Washed-out36 Send packing39 Cocoon

contents40 New Year's 67 Informal farewell 8 Water lily painter 35 Mystical glow

word 68 Make eyes at 9 Nominal military 37 Tackle the 41 In the flesh? 69 Crowning point promotion slopes43 Take-charge 70 Dramatic device 10 Narrow opening 38 Needle

type 71 Game animal 11 PBS science 42 Treat a wound44 Swimming hole 72 Part of a letter show 45 Franklin's flier

feeder opener 12 Help in a heist 49 Glitzy trinket46 Truth twister 73 Shade of pink 13 Trait carrier 51 Typeface type47 Storybook villain 21 Silky fabric 53 Equinox month48 Pesky insect 23 Revered one 54 Program 50 Paris river Down 26 Par for the preview52 Shakespeare 1 Pool shot course 56 Sports venue

play, with "The" 2 Kapolei greeting 28 Sprinkle with 57 Green mineral55 Apprehend 3 Caterpillar drops 58 Give a nudge to58 Bargain-hunter's product 30 Noble gas 59 Go ballistic

delight 4 Fairytale starter 31 Ancestor 60 Capri, for one62 "SNL" specialty 5 Parent's demand 32 From the top 61 "Believe" singer64 Allergic reaction 6 Parking place 33 One in a million 63 Edible root65 Pirate's potable 7 Pastoral poem 34 Go to and fro 66 Ring thing

by Margie E. Burke

Copyright 2015 by The Puzzle Syndicate

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The Crossword

SOLUTIONS » PAGE 7

Dear Editor,I was delighted that a medical student who is first-generation college had sent in an important question to Mama M. about navigating medical school [“First-generation medical student struggles in effort to understand program’s hidden curriculum,” March 5]. While I appreciated Mama M.’s support and encouragement to students to trust themselves and value their unique experiences, I felt the issue of the hidden curriculum was misunderstood and, perhaps unintentionally, minimized.

Philip Jackson (1968) is known to have coined the term “hidden curriculum.” He used this term to refer to the implicit values, dispositions and social behaviors that students were expected to learn in the classroom in order to be successful. At the graduate- and professional-school level, the hidden curriculum is often reflective of the unspoken and implicit cultural norms within a profession. Examples include what to wear at clinic, how to respond when you don’t know the answer to your attending’s question or whether to stick around at the end of your shift while on

rotation. Learning about these expectations can make a big difference in one’s academic and professional journey. But access to this kind of information cannot be assumed because it is often passed down informally, and students come from different backgrounds and differential access to a relative, neighbor or community member who talked about such things.

Trusting oneself is important—including one’s sense that one needs more information, resources or help. We don’t do this alone. It takes a village to get a degree for any student. For first-generation college students, populating their village with mentors, trusted professors and supervisors, networks that their peers can introduce them to, fellow travelers with whom to share notes that can be pieced together, etc., can be a helpful way to chip at that barrier of the hidden curriculum while not losing sight of one’s inherent strengths and resources.

Neesha Patel, Ph.D.Director, First Generation Support Services at UCSF

“I see the sunset over the ocean and mountains during late nights in Sim Lab. I walk home from the library at night, close my eyes, and I can smell all of the blossoms that seem to never stop blooming. I walk out of my apartment without a jacket in Janu-ary and catch a glimpse of the Golden Gate Bridge and the bay glimmering in the sunlight before I get to class. I am from the East Coast, and winter in SF is paradise.”

—Patrick WolfgramFirst-year UCSF School of Dentistry Student

Humans of UCSF » Humans of UCSF is a student-run project aimed at putting a name to the faces we see on campus. View the project on our Facebook page (facebook.com/UCSFsynapse) or on our website (synapse.ucsf.edu/humans-of-ucsf).

Photo by Valerie Torricos

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burning to work in academia. “It’s a supply and demand problem,” Haigo said.

“I do think it’s unrealistic that a posdoc will ever go back to being a short one- to two-year position as the standards for publishing are different than they were 20 years ago,” Haigo said.

Even so, Thompson–Peer, Haigo, and others shared in the hope that ultimately postdoc positions will transition back to a position one holds only if they want to actively pursue a research intensive career.

“A postdoc should have to be an active decision that someone makes, not the default,” according to Thompson–Peer.

Another portion of the event focused on actions UCSF could take to support postdocs with families. Child care for an infant takes up 62 percent of a postdoc salary. These financial realities combined with the high cost of living force some postdocs to choose between career and family. One new suggestion from the forum was to designate money paid for child care as pre-tax. Thompson–Peer said it was “a fantastic, practical suggestion that was exactly what we were hoping for.”

Whether or not the administration will act on these suggestions remains to be seen. The postdoc task force formed in 2014 hasn’t finalized its agenda, but postdocs like Thompson–Peer remain hopeful that change is possible.

“Maybe this is naïve, but I do think the University wants to support its people and has resources available to do so. The numbers and facts speak for themselves, and I think the administration will find some of them compelling if we are persuasive,” she said.

Bryne Ulmschneider is a fourth-year Tetrad student.

The complete presentation can be viewed online at http://tiny.ucsf.edu/postdocpanel or by using the QR code

The live-tweeting from the event can be found at https://storify.com/MinorityPostdoc/changethepostdoc.

Articles continued »

experience that is both world class and comfortable for the patient.

Imaging suites were designed in collaboration with GE and Philips to ease patients’ anxieties. In the children’s hospital, they are presented as adventures– from a cable car ride to sailing in the bay – while adult imaging suites come equipped with calming imagery like sunsets and clouds. Rooms are also arranged with the patient in mind. In the children’s hospital, rooms have extendable sofas for overnight stays of family members and a large flat-screen TV, both for entertainment, and to allow patients to join their home classrooms via Skype.

» FROM FRONT PAGE

Hospital Aesthetically, the new medical center features high ceilings, large windows to allow in natural light, and 60,000 square feet of rooftop gardens. Art is also built into the hospitals’ design, accounting for 1 percent of the budget, incorporated as etched leaves and branches in a meditation room in the Women’s Hospital to a 22-foot tall sculpture in the lobby of the Children’s Hospital. In total, the center features 10 major commissioned artworks as well as an array of contributions from patients.

As Lima said, “People say that is the one most fantastic thing we did better than anyone. I see it as we exponentially set a benchmark because all these things came together so well.”

Lauren Shields is a fourth-year BMS student.

universities realized this was a huge source of revenue for obtaining research grants.”

P-Value is seeking “tangible and discrete actions” UCSF could take to address this problem said Katie Thompson–Peer, a second-year postdoc in Yu–dong Jan’s laboratory and P-Value organizer.

In early March, nearly 100 postdocs, graduate students, staff, and faculty attended a P-Value forum in Mission Bay’s Genentech Hall. There, postdocs gave five short presentations covering a range of topics—from creating more autonomous funding for postdocs, to improving mentoring and better tracking postdoc experiences, to improving childcare access for postdocs.

One of the main calls to action from this forum was to institutionalize the postdoc. “People tend to discount the importance the institutional structure can have on how the postdoc experience goes,” said Thompson–Peer. “Often when one is interviewing for a postdoc [position], they only look at the individual lab environment, not the importance of the institution.”

The panel discussed tangible ways in which the postdoc could become more embedded within the structure of the university by providing greater tracking and transparency for postdoc career outcomes and mandatory mentorship training.

Although UCSF has attempted to get partial information on postdoc outcomes through various means, comprehensive data on the 1,057 postdocs currently at UCSF does not exist. One suggestion was to require entrance and exit surveys to start to assess whether the postdocs’ experiences matched their expectations.

Many of the suggestions generated during the panel discussion could immediately improve the day-to-day lives of postdocs, but they are unlikely to stem the never-ending supply of eager young scientists

» FROM FRONT PAGE

Postdocs

of gluteal function following hominids’ switch to bipedalism. Importantly, glute max does not simply function as a postural muscle in upright walking—it’s actually a rather quiet muscle during walking—but rather enables many of the quick activities that occur when upright, particularly climbing and sprinting. Expanding on this work, another study by Bartlett et al. confirmed that glute max activity is much larger in running than walking, and even greater in sprinting than running.

InjuryThe glute max is a key player in running, as well as gluteus medius and gluteus minimus, which are our primary hip abductors. Weak hip abductors have been associated with patellofemoral pain syndrome (PFPS) and iliotibial band syndrome (ITBS), two of the most common running injuries. Fortunately, strengthening these muscles has been found to improve pain in runners with PFPS6 and ITBS. And among novice runners, hip abduction strength greater than normal may reduce the risk of PFPS.

The bottom line: strong hip muscles are a must!

StrengthSo what can you do? Logistically speaking, it’s difficult to manually muscle test your own gluteal strength. However, you can broadly test your strength by seeing how

» FROM PAGE 4

Get Physical long you can hold a bridge position or a side plank. From my personal clinical experience thirty seconds is pretty much the bare minimum. You can also perform a single leg step down from a stair ledge and check your position in the mirror. Level hips, knee tracking directly over the second toe, solid trunk, and no sway are what you are looking for.

To strengthen your gluteals, research on maximum voluntary isometric contraction (MVIC) during common therapeutic exercises has shown two exercises in particular to result in the highest MVIC for glute max and glute med.7 In other words, these two exercises will recruit your gluteals the most:

Glute med: Side lying hip abductionLie on your right side, and check that your shoulders and hips are stacked. Slowly lift your left leg up towards the ceiling and back down. Because endurance of the glute med is crucial, do as many lifts as you can while maintaining perfect form. Then rest for 1 min, and repeat 2 more times. Complete as many lifts as you can for each set, and repeat on the other side.

Glute max: Single leg squatStand on your right leg, and lift your left leg off the floor. Slowly flex your right knee, and slowly straighten back up. Work up to 3 sets of 15 on each leg. Note your form—you should see no aberrant pelvic, trunk or knee motion.

Ilka Felsen is a third-year physical therapy student.

sets. While very large clinical studies can afford to include diverse populations, smaller ones are often skewed toward white populations. The only real bias of the Research Kit is that participants must own an iPhone, which, to be fair, could skew data. But with 191.4 million devices sold in 2014 alone, and taking the lead in the smartphone market share in the fourth quarter, Apple is in a position to collect a vast and unprecedented body of data worldwide. This would certainly improve studies that depend on participants coming into a medical center personally, which limits diversity and scope in far more numerous ways.

Despite the promise of innovation, a partially divided public observes these developments. Some fear losses of privacy, while others worry about dealing with the sheer amount of data this platform would produce. Security has been one of Apple’s strong suits; so far the company has always come up with robust solutions, as in the airtight Apple Pay platform introduced on the iPhone 6. Worries aside, this move is a major step for the future of consumer electronics and digital health. I join those

» FROM PAGE 4

Exit Science who look on with excitement to see where these new technologies will lead. The future is coming.Sources: TechCrunch, Bloomberg, The Wall Street Journal, Wired, Apple.com

Injectable micro-motors for drug deliveryCould you use a tiny robot to deliver drug to an organ or tumor? This was a thought that crossed my mind in a high school biology class. Now, researchers in the UC San Diego Department of Nanoengineering have taken the first step in that direction: they’ve designed tiny gastric acid-powered micro-motors that deliver drug to mouse stomach lining.

Published in ACS Nano in January, these tiny tube-shaped motors were coated in zinc, whose reaction with stomach acids created a stream of bubbles that boosted the motors forward at speeds of 60 micrometers per second. They then attached themselves to the stomach lining, where they could remain attached for 12 hours before dissolving and releasing their cargo – gold nanoparticles – directly into the tissue. Significantly fewer nanoparticles were absorbed when administered orally, and no toxic side effects were observed.Sources: ACS Nano, UCSD, Gizmag

Hanna Starobinets is a fourth-year BMS student.

student organizations, administrative staff and leadership faculty. The current GPSA students will prepare a summary of experiences and recommendations to pass down to the incoming cabinet. To

find out about the available positions and the application process, check out our Elections tab on gpsa.ucsf.edu. Any questions about the process can be directed to the author.

Alcohol Policy Enforced During On-Campus Student EventsUCSF Risk Management is requiring that any student event on campus wishing to

serve alcoholic beverages have a faculty or staff chaperone throughout the duration of the event. The responsibilities of the chaperone include enforcing the legal drinking age of 21 years and monitoring the students for appropriate use of alcohol during the event. Currently, any faculty of staff member above legal drinking age is considered a valid chaperone.

If an event serving alcoholic beverages is being held off-campus, then it may not use any advertisement highlighting affiliation with UCSF. Gatherings held at a facility

with a bartender enforcing the legal age limit do not require a chaperone. Jennifer Rosko of Student Life will meet with any student who wishes to serve alcohol during an event to make sure that both the student’s needs and the campus policy are being met.

GPSA Wants to Hear YOUR Opinion!If you are moved to take action regarding a student issue, or would like to respond to this column, email GPSA at [email protected]. We are listening!

» FROM PAGE 3

GPSA

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Articles continued » Solutions »

March 2015 - Issue 2

Edited by Margie E. Burke

HOW TO SOLVE:

(Answer appears elsewhere

in this issue)

Solution to Sudoku

Copyright 2015 by The Puzzle Syndicate

Difficulty : Medium

March 2015 - Issue 2

Solution to Crossword:

C A R O B L I M B S N A GA L O N E O D O R L O B ER O A C H T Y N E O V E NO H D E A R L E V I T A T EM A R V A U L T E D

O B E Y S T O R P O RP A L E O U S T L A R V AA U L D N A K E D D O E RC R E E K L I A R O G R EE A R W I G S E I N E

T E M P E S T N A BP R I C E W A R S A T I R ER A S H G R O G L A T E RO G L E A C M E I R O N YD E E R W H O M C O R A L

At the time, access to the web was not widely available at UCSF. It was necessary to visit of the library computer rooms.

» FROM PAGE 4

This Date

Since a bacteria became symbiotic with an early eukaryote, giving rise to what we now call the mitochondrion, much of the original bacterial genome has been lost, and most of those that remain have now migrated over to the nuclear genome. A handful, however, remain where they began, as mitochondrial DNA (mtDNA).

mtDNA is present in many copies in each cell and are distributed throughout the cell’s mitochondria. In this paper, Osman and colleagues used a new system for imaging mtDNA dynamics to gain new insights.

The researchers were surprised to find that cells unable to combine and split mitochondria normally nevertheless showed a normal distribution of mtDNA and passed it along successfully during cell division. The mtDNA in these cells was not wholly healthy, however, showing harmful structural changes near the origins of replication.

RESPIRATORY PATHOLOGY: Oxidation increases mucin polymer

» FROM PAGE 4

Journal Club cross-links to stiffen airway mucus gels. Yuan, S. et al. (Fahy, J.V.). Sci Transl Med. 2015. 7(276):276ra27.

Although advances in care over the past generation have substantially increased the life expectancies of people with cystic fibrosis, it remains a dangerous and incurable disease. It is caused by mutations in the CFTR receptor, leading primarily to lung and pancreatic problems.

Previous research has found that the airway mucus in CF patients is more elastic than normal, but how this comes to be was unclear. Here, the researchers provide evidence that this difference can be explained by inflammation-associated oxidation causing increased mucin cross-linking.

The researchers found that high levels of reactive oxygen species in CF correlate with increased disulfide cross-linking, and mucus from healthy individuals exposed to increased oxidizing stimuli showed similar changes. In addition, the authors found that a thiol-carbohydrate was more effective at decreasing mucus elasticity than the thiol-amino drugs such as N-acetylcysteine.

Taylor LaFlam is a fourth-year BMS / sixth-year MSTP student.

app itself. To expand this, we want to take any kind of medical device that currently requires a lab tech and bring it to the home setting where you can collect clinical grade data.”

Partnering with Healthcare, Technology, and Big DataCurrently, Apple is positioning themselves as a health data warehouse through their expanding HealthKit line. Ultimately, Apple and other tech companies want to act as the hub for relaying patient information from patients to physicians through web-based portals.

Shetty explained, “Apple is currently building up its healthcare line. Spirometry is one piece, but they don’t have their own spirometer to collect the measurements. They are partnering with large institutes like the Mayo Clinic. Their physicians are asking for it (spirometers). They approached us and wanted to help with the

user interface and design.”

Shetty said that Bear and Genentech have also expressed interest in using the technology as a remote monitoring tool to drive up their own patient enrollments.

Currently, the data collected is sparse and often incomplete. Patients are treated by relating a few data points to a general model. However, Shetty pointed out that more data points means that patients can be monitored in real time.

Shetty said, “Some people travel up to 3 hours [for a spirometry test]. [Our device] would give the physician the opportunity for real-time patient monitoring rather than the lag time that can stand between office visits. We can see if a medication is working in a couple of days or weeks rather than months or a year.”

Start-up Life Between product development, fundraising, and refining her business plan, Shetty keeps a busy schedule. One recent

day began with a 6 a.m. meeting with an investor on the East Coast and continued with additional meetings, working with her team on product assembly, and a Berkeley Launch Event Accelerator Program in the evening. For Shetty, working from 6 a.m. to midnight is pretty common, and 2 a.m. or even 6 a.m. is not unheard of. Working weekends is a must.

Shetty admitted, “It does consume much of my time and gives me less time with my friends and family. Finding that balance is a challenge.”

Despite her long hours, Shetty remains upbeat and energized. “I don’t even drink coffee. I am just running on the adrenaline and passion I have for this company. The reason I stayed away from the research side is that I want to directly impact lives in a couple of years rather than decades.” Shetty advises that people learn from their mentors. She credits much of her initial success to the UCSF QB3 Lean Launch Pad course she took from Alan May, chairman of the Life Science Angels. She says that

it is important to learn from someone who has done it before and has insight into your

specific field. Shetty was new to the world of business and says that the her master’s program and QB3 family were both very helpful.

Shetty emphasizes, “We (initial team members) were all engineers of some sort and had no idea about starting a company.” For Shetty, those days are rapidly fading into the background as she positions her medical diagnostics business for success.

Yarrow Madrona is a postdoc scholar.

» FROM PAGE 3Knox

The article’s helpful information even included an invitation to get personal assistance: “Good luck, do not be afraid to explore and if you have questions or suggestions E-mail me at [email protected].”

Also from 20 years ago: Alas, the ample medical resources available on the web at the time, as reported above, apparently did not include updates on the first season of the hit show “ER”. Fortunately, Frederick Chen summarized the latest episode of the television program those who missed it.

The episode he described, “Love’s Labor Lost”, featured Dr. Mark Green (Anthony Edwards) struggling to treat a patient with an obstetric emergency. It is a captivating, taut hour of television. No, seriously, I’ve seen that particular episode; it really is one of the show’s best.

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