synthesis of novel l-n-mcd4t as a potent anti-hiv agent

2007 Nucleic acids U 0700 Synthesis of Novel L-N-MCd4T as a Potent anti-HIV Agent. — The title com- pound (I) is synthesized from (R)-epichlorohydrin and found to possess potent anti-HIV-1 activity similar to that of the clinically useful anti-AIDS drug ddI. The bicyclo[3.1.0]hexene key intermediate (II) might be regarded as a new template for the development of anti-HIV agents. — (PARK, A.-Y.; MOON*, H. R.; KIM, K. R.; CHUN, M. W.; JEONG, L. S.; Org. Biomol. Chem. 4 (2006) 22, 4065-4067; Coll. Pharm., Pusan Natl. Univ., Pusan 609-735, S. Korea; Eng.) — Kieslich 12- 213

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Page 1: Synthesis of Novel L-N-MCd4T as a Potent anti-HIV Agent

2007

Nucleic acidsU 0700 Synthesis of Novel L-N-MCd4T as a Potent anti-HIV Agent. — The title com-

pound (I) is synthesized from (R)-epichlorohydrin and found to possess potent anti-HIV-1 activity similar to that of the clinically useful anti-AIDS drug ddI. The bicyclo[3.1.0]hexene key intermediate (II) might be regarded as a new template for the development of anti-HIV agents. — (PARK, A.-Y.; MOON*, H. R.; KIM, K. R.; CHUN, M. W.; JEONG, L. S.; Org. Biomol. Chem. 4 (2006) 22, 4065-4067; Coll. Pharm., Pusan Natl. Univ., Pusan 609-735, S. Korea; Eng.) — Kieslich

12- 213

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