syrcle_oort mini symposium sr animal studies 30082012
TRANSCRIPT
![Page 1: SYRCLE_Oort mini symposium sr animal studies 30082012](https://reader033.vdocuments.net/reader033/viewer/2022051502/58eec9241a28abe26f8b461d/html5/thumbnails/1.jpg)
Replacement, Reduction and Refinement in
animal experimentation
![Page 2: SYRCLE_Oort mini symposium sr animal studies 30082012](https://reader033.vdocuments.net/reader033/viewer/2022051502/58eec9241a28abe26f8b461d/html5/thumbnails/2.jpg)
More Knowledge with Fewer Animals
2011: Kick-off ZonMw grant program MKMD
Program goals:
• Development of innovative 3R
methods
• Implementation of new and existing 3R methods
![Page 3: SYRCLE_Oort mini symposium sr animal studies 30082012](https://reader033.vdocuments.net/reader033/viewer/2022051502/58eec9241a28abe26f8b461d/html5/thumbnails/3.jpg)
More Knowledge with Fewer Animals
General program conditions:
• Multi-disciplinary research
• Collaboration between relevant stakeholders
• Chain involvement
• Publication of all project results, open access, synthesis of evidence (SR)
• Implementation of results
![Page 4: SYRCLE_Oort mini symposium sr animal studies 30082012](https://reader033.vdocuments.net/reader033/viewer/2022051502/58eec9241a28abe26f8b461d/html5/thumbnails/4.jpg)
More Knowledge with Fewer Animals
Program structure:
• Flexible, set up in modules
• Modules to be commissioned by
different parties
• First three modules have been
commissioned:
Animal-Free Research
Techniques
Amendement 21
New Module: in development
![Page 5: SYRCLE_Oort mini symposium sr animal studies 30082012](https://reader033.vdocuments.net/reader033/viewer/2022051502/58eec9241a28abe26f8b461d/html5/thumbnails/5.jpg)
Module Animal-Free Research Techniques
Focus on Replacement
• Research projects (3.3 M€)
Cancer and other human
diseases
Public-private partnerships
Multi-disciplinary collaborations
• Follow-up ASAT2010 projects
(0.8M€)
• Implementation projects
![Page 6: SYRCLE_Oort mini symposium sr animal studies 30082012](https://reader033.vdocuments.net/reader033/viewer/2022051502/58eec9241a28abe26f8b461d/html5/thumbnails/6.jpg)
Module Amendment 21 (2012-2014)
Focus on 3R knowledge infrastructure
• Publication of negative results
and stimulating the use of the
‘Gold Standard Publication
checklist’ (or ‘ARRIVE
guidelines’)
• Synthesis of Evidence in animal
experimentation (Systematic
Reviews)
![Page 7: SYRCLE_Oort mini symposium sr animal studies 30082012](https://reader033.vdocuments.net/reader033/viewer/2022051502/58eec9241a28abe26f8b461d/html5/thumbnails/7.jpg)
Module Amendment 21
Publication of negative results involving animal studies Target group: ZonMw project leaders
• Additional financial support to publish negative results
• Open access
• ‘Gold Standard Publication Checklist’/ARRIVE
Aim: more awareness of the importance of publishing meaningful negative results (bias in literature, repetition of experiments)
Call open September!
![Page 8: SYRCLE_Oort mini symposium sr animal studies 30082012](https://reader033.vdocuments.net/reader033/viewer/2022051502/58eec9241a28abe26f8b461d/html5/thumbnails/8.jpg)
Module Amendment 21
Synthesis of evidence of animal experimentation (Systematic Reviews)
Target group: researchers considering animal studies (mandatory for MKMD project leaders)
• Synthesis of evidence (SR) workshops (about six)
• Continued support for workshop participants
• Additional training for a few workshop participants
Call open on invitation March 2012
![Page 9: SYRCLE_Oort mini symposium sr animal studies 30082012](https://reader033.vdocuments.net/reader033/viewer/2022051502/58eec9241a28abe26f8b461d/html5/thumbnails/9.jpg)
Systematic Reviews obligatory within ZonMw program: Health Care Efficiency Research (HCER)
![Page 10: SYRCLE_Oort mini symposium sr animal studies 30082012](https://reader033.vdocuments.net/reader033/viewer/2022051502/58eec9241a28abe26f8b461d/html5/thumbnails/10.jpg)
Health Care Efficiency Research (HCER)
Actively promotes research on recognition, assessment
and implementation of cost-effective interventions and
fosters generalisation of knowledge
• Clinical research in patients
• Structural programme (1999)
![Page 11: SYRCLE_Oort mini symposium sr animal studies 30082012](https://reader033.vdocuments.net/reader033/viewer/2022051502/58eec9241a28abe26f8b461d/html5/thumbnails/11.jpg)
Why a systematic review?
To identify knowledge gap / added value of proposed research
Systematic overview: • what’s already known on (cost-)effectiveness of intervention / implementationstrategy under study
• currently ongoing studies on similar subject
Optional: input for powercalculation (effectsize)
![Page 12: SYRCLE_Oort mini symposium sr animal studies 30082012](https://reader033.vdocuments.net/reader033/viewer/2022051502/58eec9241a28abe26f8b461d/html5/thumbnails/12.jpg)
Quality item for reviewers
How do you judge the systematic review?
Consider:
• selection of search terms;
• all relevant databases included;
• selection of papers;
• do you miss any references relevant to this specific
proposal?
• are the conclusions of the systematic review justified?
![Page 13: SYRCLE_Oort mini symposium sr animal studies 30082012](https://reader033.vdocuments.net/reader033/viewer/2022051502/58eec9241a28abe26f8b461d/html5/thumbnails/13.jpg)