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2006-2007

SYSTEMS PHYSIOLOGY

The MBI receives major funding from the National Science Foundation Division of Mathematical Sciences and is supported by The Ohio State University. The

Mathematical Biosciences Institute adheres to the AA/EOE guidelines.

Director’s Letter The Mathematical Biosciences Institute at the Ohio State University was created in 2002 in order to provide a national forum in research and education for the mathematical biosciences. Funded by the Division of Mathematical Sciences of the National Science Foundation, the Institute’s goals are to catalyze interactions between the mathematical and biological sciences, and to nurture a nationwide community of scholars in this emerging field, through a variety of efforts aimed at the full range from undergraduates to senior researchers. The MBI aims to reinforce and build upon existing research efforts in mathematical biosciences, and quicken intellectual growth in this area.

The MBI runs “Emphasis Year” programs, concentrating on a broad range of topics in one area of bioscience, with six to eight one-week workshops preceded by tutorials. Additional “Current Topics” workshops introduce mathematical scientists to new opportunities for research. In the summer, the MBI runs educational programs based on tutorials and team projects led by MBI postdoctoral fellows. The topics of the first four emphasis years were Mathematical Neurosciences; Mathematical Modeling of Cell Processes; Genomics, Proteomics, and Bioinformatics; and Ecology and Evolution. This year was devoted to Systems Physiology.

The goal of Systems Physiology is to understand how various human organs and tissues are organized and regulated to produce their normal function and pathologies. The year at the MBI examined features of several human organ and tissue systems, including the cardiac system, the respiratory system, the microcirculatory system, the renal system, the visual processing system, the endocrine system, and the auditory system. Although these are at first glance quite different, the underlying theme was how cellular level behavior participates in the function of the whole and how feedback from the function of the whole contributes to the regulation of cellular level behavior. Understanding of these processes may lead to new insights into the causes of diseases and how they can be treated.

The autumn quarter was devoted to the heart and lung. It began with two weeks of workshops which dealt with cardiac electrophysiology and cardiac mechanics, followed by a workshop on the lung and the respiratory system. During winter quarter the MBI hosted a workshop on blood flow in the microcirculation, exploring questions of function, regulation, and adaptation, and another on the kidney, focusing on its cellular, tubular, and vascular physiology. Three spring quarter workshops dealt with the visual system, the auditory system, and insulin secretion and action, including type 2 diabetes. Most of the workshops were preceded by tutorials.

In addition to this rich program, the MBI held three shorter “Current Topic” workshops on Sleep/Wake dynamics (sponsored by the AFOSR); MicroRNA in Development and Cancer; and Chemogenomics. The last two workshops were sponsored by the College of Medicine at OSU.

This year, for the first time, the MBI held a workshop on “Opportunities in Mathematical Biology for Underrepresented Groups” and another one on “Over the fence: Mathematicians and biologists talk about bridging the curricular divide.” Both workshops brought new and very enthusiastic communities into the MBI, and the enthusiastic conclusion was that such activities should continue in the future.

As in previous years, the MBI postdoctoral fellows organized a special workshop for young researchers in mathematical biosciences. Participants included 50 young researchers from all over the country. The workshop included poster presentations by young researchers as well as group discussions. There are currently 15 postdoctoral fellows at the MBI, each having two mentors, one from the mathematical sciences and another from the biosciences. Their research interests include neuroscience, systems biology, cell metabolism, mitochondrial models, immunology, tissue engineering, tumor angiogenesis, multiscale and hybrid modeling in computational biology, bioinformatics, ecology, wound healing, membrane proteins, biochemical networks, tuberculosis modeling, and statistical genetics.

This document provides a summary of events and talks that took place in the fifth year of the MBI. Further details can be found on the MBI website http://mbi.osu.edu.

Avner Friedman Director

Table of Contents

Mission ............................................................................................................................................................ 6 Corporate Members ........................................................................................................................................................6 Industrial Advisory Committee .....................................................................................................................................6 Institute Partners .............................................................................................................................................................6 New location ....................................................................................................................................................................7 Initiate focused math-bio research groups ..................................................................................................................7 Suggest new ideas and programs ..................................................................................................................................7

People .............................................................................................................................................................. 8 Postdoctoral Fellows ......................................................................................................................................10 Committees ....................................................................................................................................................14

Scientific Advisory Committee ...................................................................................................................................14 Financial Advisory Committee ...................................................................................................................................15 External Scientific Advisory Committee ...................................................................................................................15 Local Scientific Advisory Committee ........................................................................................................................15

Visitors ...........................................................................................................................................................16 Long-term visitors .........................................................................................................................................................16 Anticipated visitors .......................................................................................................................................................16 Graduate Students Visitation Program ......................................................................................................................16 Program participation ...................................................................................................................................................17

Workshops .....................................................................................................................................................18 Cardiac Electrophysiology and Arrhythmia ..............................................................................................................18 Cardiac Mechanics and Remodeling ...........................................................................................................................23 Sleep/Wake Dynamics and Cognitive Performance ................................................................................................27 The Lung and the Respiratory (Structure, Oxygen Transport) ..............................................................................28 Blood Flow in the Microcirculation: Function, Regulation, and Adaptation ......................................................33 The Kidney: Cellular, Tubular, and Vascular Physiology ........................................................................................37 Workshop for Young Researchers in Mathematical Biology ..................................................................................43 Opportunities in Mathematical Biology for Under-represented Groups .............................................................47 MicroRNA in Development and Cancer ...................................................................................................................50 Information Processing in the Visual System ...........................................................................................................53 Chemogenomics ............................................................................................................................................................59 Insulin Secretion, Insulin Action, and Type 2 Diabetes ...........................