table of contents

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Volume 20, Number 3, March 2014 THE BOTTOM LINE 291 A ‘‘Window of Opportunity’’ for Patients with Late-Onset Pulmonary Dysfunction after Allogeneic Hematopoietic Cell Transplantation Kenneth R. Cooke 292 Antithymocyte Globulin in Reduced-Intensity Conditioning Allografting: Is the Benefit Simply in the Eyes of the Transplanter? Mehdi Hamadani REVIEW 295 Optimizing Autologous Stem Cell Mobilization Strategies to Improve Patient Outcomes: Consensus Guidelines and Recommendations Sergio Giralt, Luciano Costa, Jeffrey Schriber, John DiPersio, Richard Maziarz, John McCarty, Paul Shaughnessy, Edward Snyder, William Bensinger, Edward Copelan, Chitra Hosing, Robert Negrin, Finn Bo Petersen, Damiano Rondelli, Robert Soiffer, Helen Leather, Amy Pazzalia, Steven Devine BIOLOGY 309 FLT3L and Plerixafor Combination Increases Hematopoietic Stem Cell Mobilization and Leads to Improved Transplantation Outcome Shun He, Jianhong Chu, Sumithira Vasu, Youcai Deng, Shunzong Yuan, Jianying Zhang, Zhijin Fan, Craig C. Hofmeister, Xiaoming He, Henry C. Marsh, Steven M. Devine, Jianhua Yu CLINICAL RESEARCH 314 HLA-Haploidentical Donor Lymphocyte Infusions for Patients with Relapsed Hematologic Malignancies after Related HLA-Haploidentical Bone Marrow Transplantation Amer M. Zeidan, Patrick M. Forde, Heather Symons, Allen Chen, B. Douglas Smith, Keith Pratz, Hetty Carraway, Douglas E. Gladstone, Ephraim J. Fuchs, Leo Luznik, Richard J. Jones, Javier Bola~ nos-Meade 319 Secondary Monoclonal Gammopathy of Undetermined Significance Is Frequently Associated with High Response Rate and Superior Survival in Patients with Plasma Cell Dyscrasias Dehui Zou, Gang An, Guoqing Zhu, Jinhong Wang, Lihui Shi, Hengxing Meng, Yan Xu, Weiwei Sui, Shuhui Deng, Fenghuang Zhan, Lugui Qiu 326 A Novel Reduced-Intensity Conditioning Regimen for Unrelated Umbilical Cord Blood Transplantation in Children with Nonmalignant Diseases Suhag H. Parikh, Adam Mendizabal, Cara L. Benjamin, Krishna V. Komanduri, Jeyaraj Antony, Aleksandra Petrovic, Gregory Hale, Timothy A. Driscoll, Paul L. Martin, Kristin M. Page, Ketti Flickinger, Jerelyn Moffet, Donna Niedzwiecki, Joanne Kurtzberg, Paul Szabolcs Continued

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Page 1: Table of Contents

Volume 20, Number 3, March 2014

THE BOTTOM LINE

291 A ‘‘Window of Opportunity’’ for Patients with Late-Onset Pulmonary

Dysfunction after Allogeneic Hematopoietic Cell TransplantationKenneth R. Cooke

292 Antithymocyte Globulin in Reduced-Intensity Conditioning

Allografting: Is the Benefit Simply in the Eyes of the Transplanter?Mehdi Hamadani

REVIEW

295 Optimizing Autologous Stem Cell Mobilization Strategies to Improve

Patient Outcomes: Consensus Guidelines and RecommendationsSergio Giralt, Luciano Costa, Jeffrey Schriber, John DiPersio, Richard Maziarz,John McCarty, Paul Shaughnessy, Edward Snyder, William Bensinger,Edward Copelan, Chitra Hosing, Robert Negrin, Finn Bo Petersen, Damiano Rondelli,Robert Soiffer, Helen Leather, Amy Pazzalia, Steven Devine

BIOLOGY

309 FLT3L and Plerixafor Combination Increases Hematopoietic Stem

Cell Mobilization and Leads to Improved Transplantation OutcomeShun He, Jianhong Chu, Sumithira Vasu, Youcai Deng, Shunzong Yuan,Jianying Zhang, Zhijin Fan, Craig C. Hofmeister, Xiaoming He, Henry C. Marsh,Steven M. Devine, Jianhua Yu

CLINICAL RESEARCH

314 HLA-Haploidentical Donor Lymphocyte Infusions for Patients

with Relapsed Hematologic Malignancies after RelatedHLA-Haploidentical Bone Marrow TransplantationAmer M. Zeidan, Patrick M. Forde, Heather Symons, Allen Chen, B. Douglas Smith,Keith Pratz, Hetty Carraway, Douglas E. Gladstone, Ephraim J. Fuchs, Leo Luznik,Richard J. Jones, Javier Bola~nos-Meade

319 Secondary Monoclonal Gammopathy of Undetermined Significance Is

Frequently Associated with High Response Rate and SuperiorSurvival in Patients with Plasma Cell DyscrasiasDehui Zou, Gang An, Guoqing Zhu, JinhongWang, Lihui Shi, Hengxing Meng, Yan Xu,Weiwei Sui, Shuhui Deng, Fenghuang Zhan, Lugui Qiu

326 A Novel Reduced-Intensity Conditioning Regimen for Unrelated

Umbilical Cord Blood Transplantation in Children withNonmalignant DiseasesSuhag H. Parikh, Adam Mendizabal, Cara L. Benjamin, Krishna V. Komanduri,Jeyaraj Antony, Aleksandra Petrovic, Gregory Hale, Timothy A. Driscoll, Paul L. Martin,Kristin M. Page, Ketti Flickinger, Jerelyn Moffet, Donna Niedzwiecki,Joanne Kurtzberg, Paul Szabolcs

Continued

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337 Pulmonary Symptoms Measured by the National Institutes of Health

Lung Score Predict Overall Survival, Nonrelapse Mortality, andPatient-Reported Outcomes In Chronic Graft-Versus-Host DiseaseJeanne Palmer, Kirsten Williams, Yoshihiro Inamoto, Xiaoyu Chai, Paul J. Martin,Linus Santo Tomas, Corey Cutler, Daniel Weisdorf, Brenda F. Kurland,Paul A. Carpenter, Joseph Pidala, Steven Z. Pavletic, William Wood, David Jacobsohn,Sally Arai, Mukta Arora, Madan Jagasia, Georgia B. Vogelsang, Stephanie J. Lee

345 Fludarabine and Exposure-Targeted Busulfan Compares Favorably

with Busulfan/Cyclophosphamide-Based Regimens in PediatricHematopoietic Cell Transplantation: Maintaining Efficacy withLess ToxicityI.H. Bartelink, E.M.L. van Reij, C.E. Gerhardt, E.M. van Maarseveen, A. de Wildt,B. Versluys, C.A. Lindemans, M.B. Bierings, Jaap Jan Boelens

354 A Phase II Study of a Nonmyeloablative Allogeneic Stem Cell

Transplant with Peritransplant Rituximab in Patients with B CellLymphoid Malignancies: Favorably Durable Event-Free Survival inChemosensitive PatientsCraig S. Sauter, Juliet N. Barker, Lauren Lechner, Junting Zheng, Sean M. Devlin,Esperanza B. Papadopoulos, Miguel-Angel Perales, Ann A. Jakubowski,Jenna D. Goldberg, Guenther Koehne, Izaskun Ceberio, Sergio Giralt,Andrew D. Zelenetz, Craig H. Moskowitz, Hugo Castro-Malaspina

361 Cytokine and Chemokine Patterns Across 100 Days after

Hematopoietic Stem Cell Transplantation in ChildrenJoseph DiCarlo, Rajni Agarwal-Hashmi, Ami Shah, Paul Kim, Laila Craveiro,Renna Killen, Yael Rosenberg-Hasson, Holden Maecker

370 Antithymocyte Globulin in Reduced-Intensity Conditioning Regimen

Allows a High Disease-Free Survival Exempt of Long-Term ChronicGraft-versus-Host DiseaseRaynier Devillier, Sabine F€urst, Jean El-Cheikh, Luca Castagna, Samia Harbi,Angela Granata, Roberto Crocchiolo, Claire Oudin, Bilal Mohty, Reda Bouabdallah,Christian Chabannon, Anne-Marie Stoppa, Aude Charbonnier,Florence Broussais-Guillaumot, Boris Calmels, Claude Lemarie, J�erome Rey,Norbert Vey, Didier Blaise

375 Treatment of Graft versus Host Disease with Mesenchymal Stromal

Cells: A Phase I Study on 40 Adult and Pediatric PatientsMartino Introna, Giovanna Lucchini, Erica Dander, Stefania Galimberti, Attilio Rovelli,Adriana Balduzzi, Daniela Longoni, Fabio Pavan, Francesca Masciocchi,Alessandra Algarotti, Caterina Mic�o, Anna Grassi, Sara Deola, Irene Cavattoni,Giuseppe Gaipa, Daniela Belotti, Paolo Perseghin, Matteo Parma, Enrico Pogliani,Josee Golay, Olga Pedrini, Chiara Capelli, Sergio Cortelazzo, Giovanna D’Amico,Andrea Biondi, Alessandro Rambaldi, Ettore Biagi

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382 CD341-Selected Stem Cell Boost without Further Conditioning for

Poor Graft Function after Allogeneic Stem Cell Transplantation inPatients with Hematological MalignanciesEvgeny Klyuchnikov, Jean El-Cheikh, Andreas Sputtek, Michael Lioznov,Boris Calmels, Sabine Furst, Christian Chabannon, Roberto Crocchiolo,Claude Lemari�e, Catherine Faucher, Ulrike Bacher, Haefaa Alchalby,Thomas St€ubig, Christine Wolschke, Francis Ayuk, Marie-Luise Reckhaus,Didier Blaise, Nicolaus Kr€oger

387 Symptom Distress Predicts Long-Term Health and Well-Being in

Allogeneic Stem Cell Transplantation SurvivorsMargaret F. Bevans, Sandra A. Mitchell, John A. Barrett, Michael R. Bishop,Richard Childs, Daniel Fowler, Michael Krumlauf, Patricia Prince,Nonniekaye Shelburne, Leslie Wehrlen, Li Yang

396 Single-Unit Cord Blood Transplantation after Granulocyte

Colony-Stimulating Factor–Combined Myeloablative Conditioningfor Myeloid Malignancies Not in RemissionTakaaki Konuma, Seiko Kato, Jun Ooi, Maki Oiwa-Monna, Yasuhiro Ebihara,Shinji Mochizuki, Koichiro Yuji, Nobuhiro Ohno, Toyotaka Kawamata, Norihide Jo,Kazuaki Yokoyama, Kaoru Uchimaru, Shigetaka Asano, Arinobu Tojo,Satoshi Takahashi

402 Hematopoietic Cell Transplant Comorbidity Index Is Predictive of

Survival after Autologous Hematopoietic Cell Transplantation inMultiple MyelomaAyman Saad, Anuj Mahindra, Mei-Jie Zhang, Xiaobo Zhong, Luciano J. Costa,Angela Dispenzieri, William R. Drobyski, Cesar O. Freytes, Robert Peter Gale,Cristina J. Gasparetto, Leona A. Holmberg, Rammurti T. Kamble, Amrita Y. Krishnan,Robert A. Kyle, David Marks, Taiga Nishihori, Marcelo C. Pasquini,Muthalagu Ramanathan, Sagar Lonial, Bipin N. Savani, Wael Saber, Manish Sharma,Mohamed L. Sorror, Baldeep M. Wirk, Parameswaran N. Hari

409 NOD2/CARD15 Single Nucleotide Polymorphism 13 (3020insC) is

Associated with Risk of Sepsis and Single Nucleotide Polymorphism8 (2104C.T) with Herpes Viruses Reactivation in Patients afterAllogeneic Hematopoietic Stem Cell TransplantationEmilia Jaskula, Andrzej Lange, Slawomira Kyrcz-Krzemien, Miroslaw Markiewicz,Monika Dzierzak-Mietla, Wieslaw Wiktor Jedrzejczak, Przemyslaw Czajka,Monika Mordak-Domagala, Janusz Lange, Anna Gronkowska, Jacek Nowak,Krzysztof Warzocha, Andrzej Hellmann, Jerzy Kowalczyk, Katarzyna Drabko,Jolanta Gozdzik, Sylwia Mizia, on behalf of the Polish Donor-RecipientMatching Group

415 Predictors and Impact of Thirty-Day Readmission on Patient

Outcomes and Health Care Costs after Reduced-ToxicityConditioning Allogeneic Hematopoietic Cell TransplantationSherri Rauenzahn, Quoc Truong, Aaron Cumpston, Londia Goff, Sonia Leadmon,Kim Evans, Jianjun Zhang, Sijin Wen, Michael Craig, Mehdi Hamadani,Abraham S. Kanate

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BRIEF ARTICLES

421 Does Total Body Irradiation Conditioning Improve Outcomes of

Myeloablative Human Leukocyte Antigen–Identical SiblingTransplantations for Chronic Lymphocytic Leukemia?Mitchell Sabloff, Ronald M. Sobecks, Kwang Woo Ahn, Xiaochun Zhu,Marcos de Lima, Jennifer R. Brown, Yoshihiro Inamoto, H. Kent Holland,Mahmoud D. Aljurf, Mary J. Laughlin, Rammurti T. Kamble, Jack W. Hsu,Baldeep M. Wirk, Matthew Seftel, Ian D. Lewis, Mukta Arora, Edwin P. Alyea,Matt E. Kalaycio, Jorge Cortes, Richard T. Maziarz, Robert Peter Gale, Wael Saber

425 Hematopoietic Stem Cell Transplantation in Children and Young

Adults with Secondary Myelodysplastic Syndrome and AcuteMyelogenous Leukemia after Aplastic AnemiaAyami Yoshimi, Brigitte Strahm, Irith Baumann, Ingrid Furlan, Stephan Schwarz,Andrea Teigler-Schlegel, Joachim-Ulrich Walther, Brigitte Schlegelberger,Gudrun G€ohring, Peter N€ollke, Monika F€uhrer, Charlotte M. Niemeyer

430 Serial Profile of Vitamins and Trace Elements during the Acute Phase

of Allogeneic Stem Cell TransplantationYasuhito Nannya, Akihito Shinohara, Motoshi Ichikawa, Mineo Kurokawa