tablet coating lecture
TRANSCRIPT
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Coating of Coating of Pharmaceutical Pharmaceutical
ProductsProducts
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Convertible Coating……………………………………………………….
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Non-Convertible Coating. ………………………………………………………………………………….…..
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Purpose of CoatingPurpose of Coating::1. Protection against light, air and moisture.
2. Protecting API against digestive fluids.
3. Ensure Controlled Release
4. Avoiding Side effects, masking taste.
5. Ensure eligible appearance.
6. Increase drug safety by better identification.4
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Core types
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Core Related Factors affecting Coating process:
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Coating EquipmentCoating Equipment
Coating Liquid
Polymer (Film former). Solvent ( Vehicle ). Plasticizer. Opacifier. Colorant. Flavoring agents and Sweeteners. Wetting agent. Anti-adherent. Others.
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Polymer . Function: film former.A.Immediate Release coating polymers: Readily soluble in aqueous media. a. Cellulose Derivatives: HPMC, HPC,MC. (Have good mechanical properties).
b. Vinyl Derivatives: PVP, PVA.
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B. Modified Release Coating Polymers a. Extended Release Coating polymers: - They are dissolved in organic solvent or dispersed in aqueous medium, such as (EC). b. Enteric Coating polymers - Methacrylic acid and polyacrylate derivatives such as Eudragit. - Phthalate esters like cellulose acetate phthalate (CAP).
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Plasticizers- Increasing elasticity of the coat.
- They have low molecular weight.
- Alter the physical properties of the
polymer.
- Examples:
PEG, Phthalate esters, Castor oil,
monoglycerides and coconut oil. 16
Coating PansCoating Pans
Conventional Coating Pans.
Perforated Coating Pans.
Air suspension Coating systems.
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CoatingCoating ProblemsProblemsLogo Bridging
Twinning
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CoatingCoating ProblemsProblems
Logo Infilling
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Coating problemsCoating problems
Core Erosion
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CoatingCoating ProblemsProblemsPicking and Sticking
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Tablet to tablet color variation
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CoatingCoating problemsproblems
CoatingCoating problemsproblemsOrange peel
roughness
Cracking
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CoatingCoating ProblemsProblems
Peeling
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CoatingCoating ProblemsProblems
Edge Chipping & Erosion
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Thank You for
Your Attention … 47