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#LAMG16 @phylogenomics Arrowhead and Microbial Genomes: Update on the Tree of Life September 18, 2016 Lake Arrowhead Microbial Genomes #LAMG16 Jonathan A. Eisen University of California, Davis @phylogenomics

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#LAMG16 @phylogenomics

Arrowhead and Microbial Genomes: Update on the Tree of Life

September 18, 2016 Lake Arrowhead Microbial Genomes

#LAMG16

Jonathan A. Eisen University of California, Davis

@phylogenomics

TWO KEY THINGS TO REMEMBER

#LAMG16 @phylogenomics

Arrowhead and Microbial Genomes: Update on the Tree of Life

September 18, 2016 Lake Arrowhead Microbial Genomes

#LAMG16

Jonathan A. Eisen University of California, Davis

@phylogenomics

TWO KEY THINGS TO REMEMBER

#LAMG16 @phylogenomics

Arrowhead and Microbial Genomes: Update on the Tree of Life

September 18, 2016 Lake Arrowhead Microbial Genomes

#LAMG16

Jonathan A. Eisen University of California, Davis

@phylogenomics

#LAMG16 @phylogenomics

Arrowhead and Microbial Genomes: Update on the Tree of Life

September 18, 2016 Lake Arrowhead Microbial Genomes

#LAMG16

Jonathan A. Eisen University of California, Davis

@phylogenomics

#LAMG16 @phylogenomics

Arrowhead and Microbial Genomes: Update on the Tree of Life

September 18, 2016 Lake Arrowhead Microbial Genomes

#LAMG16

Jonathan A. Eisen University of California, Davis

@phylogenomics

#LAMG16 @phylogenomics

The Tree of Life

http://phylogenomics.blogspot.com

#LAMG16 @phylogenomics

Arrowhead and Microbial Genomes: Update on the Tree of Life

September 18, 2016 Lake Arrowhead Microbial Genomes

#LAMG16

Jonathan A. Eisen University of California, Davis

@phylogenomics

Arrowhead and Microbial Genomes: Update on the Tree of Life

September 18, 2016 Lake Arrowhead Microbial Genomes

#LAMG16

Jonathan A. Eisen University of California, Davis

@phylogenomics

THREE KEY THINGS TO REMEMBER

#LAMG16 @phylogenomics

Origin of the Meeting

• Who knows how the meeting started?

#LAMG16 @phylogenomics

Origin of the Meeting

• Who knows how the meeting started?

• How could you find out?

#LAMG16 @phylogenomics

Origin of the Meeting

• Who knows how the meeting started?

• How could you find out?

• The Google …

#LAMG16 @phylogenomics

Using the Google

#LAMG16 @phylogenomics

Using the Google

#LAMG16 @phylogenomics

Using the Google

#LAMG16 @phylogenomics

Possible Source of Confusion

#LAMG16 @phylogenomics

Jeffrey van Leeuwenhoek Miller

History of the Meeting

• See http://www.lamg.info/history

#LAMG16 @phylogenomics

Jeffrey van Leeuwenhoek Miller

History of the Meeting

• And see http://microbe.net/lake-arrowhead-microbial-genomes-history/ for 1998-2016 notes

• http://tinyurl.com/LAMG16

#LAMG16 @phylogenomics

Sampling from 1998-2014

#LAMG16 @phylogenomics

Sampling from 1998

#LAMG16 @phylogenomics

Sampling from 1998

#LAMG16 @phylogenomics

Sampling from 1998

#LAMG16 @phylogenomics

The Real Story of 1998?

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

1998 - Doodles Reveal All

#LAMG16 @phylogenomics

Real History of Arrowhead

QUOTES, QUOTES, QUOTES

#LAMG16 @phylogenomics

2014 …

#LAMG16 @phylogenomics

2014 …

• I am spending bioinformatic time up the wazoo

#LAMG16 @phylogenomics

2014 …

• I am spending bioinformatic time up the wazoo

• It may be sh*t to you but it's my bread and butter

#LAMG16 @phylogenomics

2002

#LAMG16 @phylogenomics

2002

• Leave it to Jeff Miller to take a shot at the Gordon Conferences in his intro

#LAMG16 @phylogenomics

2002

• Leave it to Jeff Miller to take a shot at the Gordon Conferences in his intro

• It looks like someone with a bad cold sneezed against the wall

#LAMG16 @phylogenomics

2002

• Leave it to Jeff Miller to take a shot at the Gordon Conferences in his intro

• It looks like someone with a bad cold sneezed against the wall

• Wild mistakes - brilliant guesses

#LAMG16 @phylogenomics

2002

• Leave it to Jeff Miller to take a shot at the Gordon Conferences in his intro

• It looks like someone with a bad cold sneezed against the wall

• Wild mistakes - brilliant guesses• He lied about the size of anthrax

#LAMG16 @phylogenomics

2002

• Leave it to Jeff Miller to take a shot at the Gordon Conferences in his intro

• It looks like someone with a bad cold sneezed against the wall

• Wild mistakes - brilliant guesses• He lied about the size of anthrax• If it grows you win, if it doesn’t you have

to give me your soul for all eternity

#LAMG16 @phylogenomics

2002

• Leave it to Jeff Miller to take a shot at the Gordon Conferences in his intro

• It looks like someone with a bad cold sneezed against the wall

• Wild mistakes - brilliant guesses• He lied about the size of anthrax• If it grows you win, if it doesn’t you have

to give me your soul for all eternity• That’s because she has the arrogance of

the aristocrats#LAMG16 @phylogenomics

2004

#LAMG16 @phylogenomics

2004

• He wanted to keep his finger in the Chlamydia stuff

#LAMG16 @phylogenomics

2004

• He wanted to keep his finger in the Chlamydia stuff

• Engineering other systems that don’t suck

#LAMG16 @phylogenomics

2004

• He wanted to keep his finger in the Chlamydia stuff

• Engineering other systems that don’t suck

• It’s like a tootsie pop

#LAMG16 @phylogenomics

2004

• He wanted to keep his finger in the Chlamydia stuff

• Engineering other systems that don’t suck

• It’s like a tootsie pop• Space time continuum of genes and

genomes

#LAMG16 @phylogenomics

2004

• He wanted to keep his finger in the Chlamydia stuff

• Engineering other systems that don’t suck

• It’s like a tootsie pop• Space time continuum of genes and

genomes• The wormhole that allows us to tunnel

into today’s world

#LAMG16 @phylogenomics

Other years

• Space-time continuum of genes and genomes

#LAMG16 @phylogenomics

Quotes

• Space-time continuum of genes and genomes

• Microbes not only have a lot of sex, they have a lot of weird sex

#LAMG16 @phylogenomics

Quotes

• Space-time continuum of genes and genomes

• Microbes not only have a lot of sex, they have a lot of weird sex

• Gene sequences are the wormhole that allows one to tunnel into the past

#LAMG16 @phylogenomics

Quotes

• Space-time continuum of genes and genomes

• Microbes not only have a lot of sex, they have a lot of weird sex

• Gene sequences are the wormhole that allows one to tunnel into the past

• This is how you do metagenomics on 50 dollars, and that’s Canadian dollars

#LAMG16 @phylogenomics

Quotes

• Space-time continuum of genes and genomes

• Microbes not only have a lot of sex, they have a lot of weird sex

• Gene sequences are the wormhole that allows one to tunnel into the past

• This is how you do metagenomics on 50 dollars, and that’s Canadian dollars

• The human guts are a real milieu of stuff

#LAMG16 @phylogenomics

Quotes

• Space-time continuum of genes and genomes

• Microbes not only have a lot of sex, they have a lot of weird sex

• Gene sequences are the wormhole that allows one to tunnel into the past

• This is how you do metagenomics on 50 dollars, and that’s Canadian dollars

• The human guts are a real milieu of stuff • Antibiotics do not kill things, they corrupt

them #LAMG16 @phylogenomics

Quotes

• There comes a point in life when you have to bring chemists into the picture

#LAMG16 @phylogenomics

Quotes

• There comes a point in life when you have to bring chemists into the picture

• The rectal swabs are here in tan color

#LAMG16 @phylogenomics

Quotes

• There comes a point in life when you have to bring chemists into the picture

• The rectal swabs are here in tan color • If I have time I will tell you about a dream

#LAMG16 @phylogenomics

Quotes

• There comes a point in life when you have to bring chemists into the picture

• The rectal swabs are here in tan color • If I have time I will tell you about a dream • Another thing you need to know" pause

"Actually you don't NEED to know any of this

#LAMG16 @phylogenomics

Quotes

• There comes a point in life when you have to bring chemists into the picture

• The rectal swabs are here in tan color • If I have time I will tell you about a dream • Another thing you need to know" pause

"Actually you don't NEED to know any of this

• I have been influenced by Fisher Price throughout my life

#LAMG16 @phylogenomics

Quotes

• There comes a point in life when you have to bring chemists into the picture

• The rectal swabs are here in tan color • If I have time I will tell you about a dream • Another thing you need to know" pause

"Actually you don't NEED to know any of this

• I have been influenced by Fisher Price throughout my life

• This is going to be ironic coming from someone who studies circumcision#LAMG16 @phylogenomics

Quotes

• And we will bring out the unused cheese from yesterday

#LAMG16 @phylogenomics

Quotes

• And we will bring out the unused cheese from yesterday

• A paper came out next year

#LAMG16 @phylogenomics

Quotes

• And we will bring out the unused cheese from yesterday

• A paper came out next year • It takes 1000 nanobiologists to make one

microbiologist

#LAMG16 @phylogenomics

Quotes

• And we will bring out the unused cheese from yesterday

• A paper came out next year • It takes 1000 nanobiologists to make one

microbiologist • In an engineering sense, the vagina is a

simple plug flow reactor

#LAMG16 @phylogenomics

Quotes

• And we will bring out the unused cheese from yesterday

• A paper came out next year • It takes 1000 nanobiologists to make one

microbiologist • In an engineering sense, the vagina is a

simple plug flow reactor • The human mind can conceive of things

with no basis in physical reality

#LAMG16 @phylogenomics

Quotes

• And we will bring out the unused cheese from yesterday

• A paper came out next year • It takes 1000 nanobiologists to make one

microbiologist • In an engineering sense, the vagina is a

simple plug flow reactor • The human mind can conceive of things

with no basis in physical reality • Thoughts can go faster than the speed of

light #LAMG16 @phylogenomics

Quotes

• We are the environment. We live the phenotype.

#LAMG16 @phylogenomics

Quotes

• We are the environment. We live the phenotype.

• We have been using this word for many years without actually realizing it was correct

#LAMG16 @phylogenomics

Quotes

• We are the environment. We live the phenotype.

• We have been using this word for many years without actually realizing it was correct

• A little bit about time, but I am going to spend a lot less time on time than on space

#LAMG16 @phylogenomics

Quotes

• We are the environment. We live the phenotype.

• We have been using this word for many years without actually realizing it was correct

• A little bit about time, but I am going to spend a lot less time on time than on space

• I am going to wrap up as I hear the crickets chirping

#LAMG16 @phylogenomics

2004

#LAMG16 @phylogenomics

Sampling from 2004

#LAMG16 @phylogenomics

Sampling from 2004

#LAMG16 @phylogenomics

Sampling from 2004

#LAMG16 @phylogenomics

Sampling from 2004

#LAMG16 @phylogenomics

Sampling from 2004

#LAMG16 @phylogenomics

Sampling from 2004

#LAMG16 @phylogenomics

Sampling from 2004

#LAMG16 @phylogenomics

Sampling from 2004

#LAMG16 @phylogenomics

Sampling from 2004

#LAMG16 @phylogenomics

Trends in Topics

#LAMG16 @phylogenomics

Topics Over Time

0

25

50

75

100

1998 2000 2002 2004 2006 2008 2010 2012 2014 2016

Genomes CommunitiesMetagenomes Microbiomes

Topics Over Time

0

25

50

75

100

1998 2000 2002 2004 2006 2008 2010 2012 2014 2016

Genomes CommunitiesMetagenomes Microbiomes

Topics Over Time

0

25

50

75

100

1998 2000 2002 2004 2006 2008 2010 2012 2014 2016

Genomes CommunitiesMetagenomes Microbiomes

Topics Over Time

0

25

50

75

100

1998 2000 2002 2004 2006 2008 2010 2012 2014 2016

Genomes CommunitiesMetagenomes Microbiomes

Topics Over Time

0

25

50

75

100

1998 2000 2002 2004 2006 2008 2010 2012 2014 2016

Genomes CommunitiesMetagenomes Microbiomes

Topics Over Time

0

25

50

75

100

1998 2000 2002 2004 2006 2008 2010 2012 2014 2016

Genomes CommunitiesMetagenomes Microbiomes

Topics Over Time

0

25

50

75

100

1998 2000 2002 2004 2006 2008 2010 2012 2014 2016

Genomes CommunitiesMetagenomes Microbiomes

Topics Over Time

0

25

50

75

100

1998 2000 2002 2004 2006 2008 2010 2012 2014 2016

Genomes CommunitiesMetagenomes Microbiomes

Topics Over Time

0

25

50

75

100

1998 2000 2002 2004 2006 2008 2010 2012 2014 2016

Genomes CommunitiesMetagenomes Microbiomes

Topics Over Time

0

25

50

75

100

1998 2000 2002 2004 2006 2008 2010 2012 2014 2016

Genomes CommunitiesMetagenomes Microbiomes

Possible Talks for 2016?

#LAMG16 @phylogenomics

Possible Talks for 2018?

#LAMG16 @phylogenomics

Microbiome Will GIVE The Talks

#LAMG16 @phylogenomics

#LAMG16 Speakers

#LAMG16 @phylogenomics