TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes

by Roshan L. Shrestha, Naoka Tamura, Anna Fries, Nicolas Levin, Joanna Clark, and Viji M. Draviam

Open BiologyVolume 4(6):130108

June 4, 2014

©2014 by The Royal Society

TAO1-depleted cells display chromosome congression defects.

Roshan L. Shrestha et al. Open Biol. 2014;4:130108

©2014 by The Royal Society

Rescue of TAO1 depletion-induced chromosome congression defects.

Roshan L. Shrestha et al. Open Biol. 2014;4:130108

©2014 by The Royal Society

TAO1 is required to maintain dynamic microtubules during mitosis.

Roshan L. Shrestha et al. Open Biol. 2014;4:130108

©2014 by The Royal Society

TAO1-depleted cells display mis-segregating lagging chromosomes.

Roshan L. Shrestha et al. Open Biol. 2014;4:130108

©2014 by The Royal Society

Taxol or MPS1 inhibitor treatments in TAO1-depleted cells.

Roshan L. Shrestha et al. Open Biol. 2014;4:130108

©2014 by The Royal Society

Correcting erroneous kinetochore–microtubule attachments requires TAO1.

Roshan L. Shrestha et al. Open Biol. 2014;4:130108

©2014 by The Royal Society

Model of TAO1 depletion-induced mis-segregation arising from defective microtubule stability.

Roshan L. Shrestha et al. Open Biol. 2014;4:130108

©2014 by The Royal Society