8/9/2019 Targeting the Wnt Pathway in Cancer Nufv6

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Targeting the Wnt Pathway in Cancer

By Goss, Michael (Editor)

OncoMed Pharmaceuticals Presents Phase 1Data in Solid Tumor ...

of targeting the Wnt pathway in cancer and particularly in cancer stem cells,” noted Paul Hastings, Chief Executive

Officer of OncoMed. “We have made excellent progress with vantictumab and our other clinical

www.oncomed.com/news/pr/press_release_2013_06_03.pdf 

The Cancer Stem Cell-Targeting Wnt Inhibitor VS-507 P6-11-07 ...

The Cancer Stem Cell-Targeting Wnt Inhibitor VS-507 Reduces Breast Cancer Growth and Metastasis Jennifer E.

Ring, Vihren N. Kolev, ... effect of VS-507 on the Wnt/?-catenin signaling pathway to further elucidate its

mechanism of action.

www.verastem.com/attachments/2012_SABCS_Wnt.pdf 

Targeting the Wnt Signaling Pathway with Dishevelled and ...

Targeting the Wnt Signaling Pathway with Dishevelled and Cisplatin Synergistically Suppresses Mesothelioma

Cell Growth ... Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled

overexpression. Oncogene 22: 7218-7221, 2003.

ar.iiarjournals.org/content/27/6B/4239.full.pdf 

Publishes OncoMed Data Demonstrating Potent Anti-Cancer ...

For Immediate Release PNAS Publishes OncoMed Data Demonstrating Potent Anti-Cancer Activity for Novel Wnt

Pathway Antibody OMP-18R5 Targeting Wnt Pathway Inhibits Tumor Growth in Preclinical Models

www.oncomed.com/releases/press_release_2012_07_03.pdf 

Targeting Wnt signaling in Colon Cancer Stem Cells

Targeting Wnt signaling in Colon Cancer Stem Cells Felipe de Sousa E Melo1, Louis Vermeulen1, Dick Richel2

and Jan Paul Medema1,* ... Targeting Wnt pathway components An incredible collection of natural and synthetic

compounds form the basis of intense

clincancerres.aacrjournals.org/content/early/2010/12/18/...

Drug Discovery Approaches to Target Wnt Signaling in Cancer ...

8/9/2019 Targeting the Wnt Pathway in Cancer Nufv6

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will therefore discuss three major areas of targeting the Wnt pathway which have shown promise in recent years:

receptor/ligand interactions, cytosolic signaling ... tArgeting wnt in cAncer And cAncer stem cells As a result of its

role in numerous cancers, the

impactjournals.com/oncotarget/index.php?journal=onco...

Current Cancer Drug Targets, 2004, 653-671 653 Wnt/?-Catenin ...

screening strategy of cancer drugs targeting Wnt/?-catenin signaling pathway. Reporter cell lines that are

responsive to Wnt or ?-catenin activation can be engineered. The reporter ... in targeting the Wnt signaling

pathway, the stage is set for

www.boneandcancer.org/...Targeting%20Wnt%20bCat%20Review...

Inhibition of oncogenic Wnt signaling through direct ...

Wnt pathway perturbants that act upstream of?-catenin can alter levels of the ? ... (2011) Targeting cancer stem

cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol 8(2):97–106. 6. Shan JF, Shi DL,

Wang JM, Zheng J (2005) Identi?cation of a speci?c inhibitor of ...

www.pnas.org/content/109/44/17942.full.pdf 

Dysregulation of the Wnt Pathway in Solid Tumors - Springer

Activation of the WNT signaling pathway has long been implicated in driving cancer pathogenesis from

compelling evidence derived from complementary in vitro and animal studies.

link.springer.com/content/pdf/10.1007/978-1-4419-8023-6...

enhancing cancer Drug Discovery through novel cell signaling ...

to a drug targeting Wnt signaling pathway based on its mechanism of action. Therefore, it is important to have a

whole panel of cell lines for signaling path- ... which reveals cancer pathway deregulation in specific cellular

contexts.

www.la-press.com/redirect_file.php?fileId=5173&filename=...

Wnt pathway inhibition via the targeting of Frizzled ...

Here we demonstrate a therapeutic approach to targeting the Wnt pathway with a monoclonal antibody,

OMP-18R5. ... The role of the Wnt-Fzd pathway in cancer has been the subject of investigation for nearly three

decades following the initial

www.pnas.org/content/early/2012/06/26/1120068109.full.pdf 

8/9/2019 Targeting the Wnt Pathway in Cancer Nufv6

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Targeting the WNT/?-catenin/TCF/LEF1 axis in solid and ...

Among aberrantly regulated signalling pathways in cancer the WNT/b-catenin pathway plays an outstanding role,

since it was shown to be critically involved in a wide range of ... b-catenin signalling activation and examples for

their cancer involvement. 2. Targeting WNT/b-catenin signalling as

old.ecco-org.eu/.../Targeting_the_WNT.pdf 

Chapter 9 Inhibiting the Wnt Signaling Pathway with Small ...

targeting Wnt signaling in cancer. Fig. 9.1 Small-molecule inhibitors that target Wnt signaling at different levels.

(a) ... Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov 5:997–1014 Bartscherer K, Boutros

M (2008) Regulation of Wnt protein secretion and its role in ...

www.researchgate.net/...the_Wnt_Signaling_Pathway_with...

Chapter 1 Targeting the Wnt Signaling Pathway to Treat Colon ...

1 Chapter 1 Targeting the Wnt Signaling Pathway to Treat Colon Cancer Approximately 150,000 people are

diagnosed with colorectal cancer every year in

deepblue.lib.umich.edu/bitstream/handle/2027.42/64688/...

ATRIAL NATRIURETIC PEPTIDE: A MAGIC BULLET FOR CANCER THERAPY ...

cancer cell proliferation, invasion and metastatization and in chemoresistance. ... Wnt pathway have been proposed

as novel targets for cancer therapy. However, the ... of simultaneously targeting two processes crucial for neoplastic

transformation and solid

www.artoi.it/wp-content/uploads/2013/11/Abstract...

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