taxanes — taxanes are among the most active agents for metastatic breast cancer – docetaxel,...
TRANSCRIPT
Taxanes — Taxanes are among the most active agents for metastatic breast cancer – Docetaxel, Paclitaxel, NabPaclitaxel.
Anthracyclines – Doxorubicin, Epirubicin, Caelyx.
Capecitabine / 5 FU
Eribulin
Vinorelbine
Gemcitabine
Ixabepilone
Etoposide
Cyclophosphamide
Methotrexate
Platinum agents
Combination Chemotherapy
High Dose Chemotherapy and Stem Cell Transplant – no benefit.
Common Adjuvant Regimens
First Generation → Second
Generation → Third Generation
CMF*6 → CAF*6, CEF*6
CMF*6 → FAC*6 → TAC*6
CE(50)F*6 → CE(100)F*6 → FEC*3→D*3
AC*4 →AC*4→Txl*4
q3wk →Dose Dense (CA*4→Txl*4
q2wk)
AC*4 → TC*4
20% 20%
RANDOMIZE
Doxorubicin 60 mg/m2 IV Day 1
Cyclophosphamide 600 mg/m2 IV Day 1
Every 21 days x 4 cycles
Docetaxel 75 mg/m2 IV Day 1
Cyclophosphamide 600 mg/m2 IV Day 1
Every 21 days x 4 cycles
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2nd Generation Adjuvant Chemo Trials
First Generation → Second
Generation → Third Generation
CMF*6 → CAF*6, CEF*6
CMF*6 → FAC*6 → TAC*6
CE(50)F*6 → CE(100)F*6 → FEC*3→D*3
AC*4 →AC*4→Txl*4
q3wk →Dose Dense (CA*4→Txl*4
q2wk)
AC*4 → TC*4
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What’s the Goal?
• Select patients who will require systemic therapy
• Find predictive factors (either before or early in treatment) that allow for accurate tailoring of therapy
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