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Taylor Miller Marine Anti-Cancer Compounds

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Page 1: Taylor Miller Marine Anti-Cancer Compounds. What’s the deal?

Taylor MillerMarine Anti-Cancer Compounds

Page 2: Taylor Miller Marine Anti-Cancer Compounds. What’s the deal?

Background

• Cancer still claims the lives of many• 1 out of the 6 cancer treatments

hinders tumor growth

Page 3: Taylor Miller Marine Anti-Cancer Compounds. What’s the deal?

What’s the deal?

• Marine organisms produce anti-cancer compounds

Page 4: Taylor Miller Marine Anti-Cancer Compounds. What’s the deal?

Current status of marine natural products in anticancer preclinical or clinical trials

Compound (figure number)

Source organism Chemical class Molecular target Current status

Ecteinascidin 743 Ecteinascidia turbinate (tunicate; possible bacterial source)

Tetrahydroisoquinolone alkaloid

Tubulin Phase II

Dolastatin 10 Dolabella auricularia/Symploca sp. (mollusc/cyanobacterium)

Linear peptide Tubulin Phase II

Bryostatin 1 Bugula neritina (bryozoan)

Macrocyclic lactone PKC Phase II

Synthadotin Dolabella auricularia/Symploca sp. (synthetic analogue)

Linear peptide Tubulin Phase II

Kahalalide F Elysia rufescens/Bryopsis sp. (mollusc/green alga)

Cyclic depsipeptide Lysosomes/erbB pathway

Phase II

Page 5: Taylor Miller Marine Anti-Cancer Compounds. What’s the deal?

Oceanography

• My future career• Help cure or prevent cancer

Page 6: Taylor Miller Marine Anti-Cancer Compounds. What’s the deal?

Why do you care?

• You may know someone

affected by cancer

Page 7: Taylor Miller Marine Anti-Cancer Compounds. What’s the deal?

What lies ahead?


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