tb kutis print
TRANSCRIPT
![Page 1: Tb Kutis Print](https://reader030.vdocuments.net/reader030/viewer/2022012320/55cf99a6550346d0339e776c/html5/thumbnails/1.jpg)
CUTANEOUS TUBERKULOSIS
![Page 2: Tb Kutis Print](https://reader030.vdocuments.net/reader030/viewer/2022012320/55cf99a6550346d0339e776c/html5/thumbnails/2.jpg)
DEFINITION:
Tuberkulosis is an chronic infectious granulomatous disease. It is caused by
the basil of mycobacterium tuberkulosis.
The transmission of the bacteria are by:
-inhalation
-unpasteurized milk
![Page 3: Tb Kutis Print](https://reader030.vdocuments.net/reader030/viewer/2022012320/55cf99a6550346d0339e776c/html5/thumbnails/3.jpg)
EPIDEMIOLO
GY
•PREDISPOSITION FACTOR : low social status, malnutrition, intravenous drugs, immunodeficiency•skrofuloderma : most common(84%),•tuberkulosis cutis verucosa : (13%), •Lupus vulgaris : rarely found
ETIOLOGY
• *M. tuberculosis (M tb)• *M.bovis• *Vaccine : Bacillus Calmette-
Guerin (BCG)
![Page 4: Tb Kutis Print](https://reader030.vdocuments.net/reader030/viewer/2022012320/55cf99a6550346d0339e776c/html5/thumbnails/4.jpg)
BACTERIOLOGYMycobacterium tuberculosis:
• Aerobic, non–spore-forming, non-motile, facultative.• Curved intracellular rods measuring 0.2-0.5 μm by 2-4 μm. • Their cell walls contain mycolic, acid-rich, long-chain
glycolipids and phospholipoglycans (mycocides) that protect mycobacteria from cell lysosomal attack and also retain red basic fuchsin dye after acid rinsing (acid-fast stain).
BACTERIOLOGIC TEST:
– MICROSCOPIC(Ziehl Neelsen staining)
– CULTURE (Lowenstein Jensen Media)
![Page 5: Tb Kutis Print](https://reader030.vdocuments.net/reader030/viewer/2022012320/55cf99a6550346d0339e776c/html5/thumbnails/5.jpg)
CLASSIFICATION:
1. TRUE CUTANEOUS TB :
-THE BACTERIA CAN BE FOUND ON THE SURFACE OF THE SKIN.
– PRIMARY CUTANEOUS TB:
- Inoculation of primary TB / Tuberculosis chancre
- Miliary Tuberkulosis
– SECONDARY CUTANEOUS TB :
- Scrofuloderma
- Tuberkulosis verucosa cutis
- Tuberkulosis gumosa cutis
- Tuberkulosis cutis orifacialis
- Lupus vulgaris
![Page 6: Tb Kutis Print](https://reader030.vdocuments.net/reader030/viewer/2022012320/55cf99a6550346d0339e776c/html5/thumbnails/6.jpg)
2. Tuberculid• Generalised exanthem in patients with moderate or high
degree of immunity to TB because of previous infection.• Usually in good health with no identifiable focus of active
TB in skin or elsewhere
PAPULE SHAPED:
- Necrotic papule Tuberkulosis
- Liken sklofulosorum
GRANULOMATOUS AND ULSERONODULUS SHAPED:
- Erytema nodosum
- Erythema induratum (bazin disease)
![Page 7: Tb Kutis Print](https://reader030.vdocuments.net/reader030/viewer/2022012320/55cf99a6550346d0339e776c/html5/thumbnails/7.jpg)
TB CHANCRE (primary complex)•Exogen : patient have not been infected before.•*children>>adults•Predilection : face, hand, low extremity
CLINICAL MANIFESTATIONS •innoculation (2-4 weeks) →brownish-red papules, pain (-) → nodule/plaque → ulceration (Tuberculous chancre), 3-8 weeks after being infected→ lyphadenopathy regions(Primary tuberculous complex)
INCUBATION •Incubation period : 2-3 weeks•Can be cured spontaneously in approximately < 1 year, scar (+)
![Page 8: Tb Kutis Print](https://reader030.vdocuments.net/reader030/viewer/2022012320/55cf99a6550346d0339e776c/html5/thumbnails/8.jpg)
MILIARY TUBERCULOSIS CUTIS
•FROM FOCAL POINT TO THE SKIN•ERITHEMA, PAPULE, VESICLE, PUSTULE, SQUAMA,
TRANSMISSION
•NEGATIVETUBERKULIN TEST
•MALAMPROGNOSIS
![Page 9: Tb Kutis Print](https://reader030.vdocuments.net/reader030/viewer/2022012320/55cf99a6550346d0339e776c/html5/thumbnails/9.jpg)
SKOFLURODERMA
•From the organ that had already being infected with TB
TRANSMISSION
•NECK: tonsil, lungs•ARMPIT: apex pleura•LOWER EXTREMITY : lower thighs
LOCATION
•Ununiformed soft mass → (cold abses)→ eruption→ fistule → livid, closed, ununiform seropurulent pus. → cicatrix → skin bridge
![Page 10: Tb Kutis Print](https://reader030.vdocuments.net/reader030/viewer/2022012320/55cf99a6550346d0339e776c/html5/thumbnails/10.jpg)
LUPUS VULGARIS
• Predilection : face, body(lower extremity).
• A group of red nodules that change to yellow in color in time. If pressured is applied they will turn to apple jelly color.
• Confluence: form destructive plaque →ulcus
• Involution: cicatrix (scar)
• Serpiginosa (+)
![Page 11: Tb Kutis Print](https://reader030.vdocuments.net/reader030/viewer/2022012320/55cf99a6550346d0339e776c/html5/thumbnails/11.jpg)
SCLOFULOSORUM LICHEN
FOUND MOSTLY IN CHILDREN.
• Miliar papule, skin like tone, erythema.
• Fairly alligned: sirsinar, fine squama
• Predilection: chest, abdomen, sacral area, buttocks
• Chronic residual
• Heals without cicatrix (scar)
![Page 12: Tb Kutis Print](https://reader030.vdocuments.net/reader030/viewer/2022012320/55cf99a6550346d0339e776c/html5/thumbnails/12.jpg)
ERYTHEMA INDURATUM (BAZIN DISEASE)
• Erythema and indolence nodes
• Predilection: flexor
• Suppurative lession form ulcus
• without suppurative lessions→ regression → hipotrophy
• chronic residual
![Page 13: Tb Kutis Print](https://reader030.vdocuments.net/reader030/viewer/2022012320/55cf99a6550346d0339e776c/html5/thumbnails/13.jpg)
TREATMENT:
Regular medication is crucial in avoiding bacterial resistancy of against antibiotics.
• Combination of drugs, minimum 2 bacterocides are used.
INH + 2 - 3 (bactericidal)
• Treatment plan depends on: economy status of the patient, severity of the disease, contraindication.
![Page 14: Tb Kutis Print](https://reader030.vdocuments.net/reader030/viewer/2022012320/55cf99a6550346d0339e776c/html5/thumbnails/14.jpg)
STANDARD REGIMENT (6MONTHS)1. INITIAL PHASE (3/4 TABS PERDAY FOR 2 MONTHS)
ADULTS CHILDREN
A. isoniazide 300 mg 5-8 mg/w
B. Rifampicin >50kg 600 mg 10-12 mg/w
<50kg 450 mg
C. Pirazinamid >50kg 2g 20-35 mg/W
<50kg 1.5g
Ethambutol >60kg 15 mg/KgBB Not recommended
or <60kg 25 mg/KgBB 15-20 mg/KgBB
Streptomycine 3-4 gr IM
![Page 15: Tb Kutis Print](https://reader030.vdocuments.net/reader030/viewer/2022012320/55cf99a6550346d0339e776c/html5/thumbnails/15.jpg)
2. CONTINUOUS PHASE:
(2 types for 4 months)
Isoniazide + Rifampicin
(dosage is based on the previous table)
![Page 16: Tb Kutis Print](https://reader030.vdocuments.net/reader030/viewer/2022012320/55cf99a6550346d0339e776c/html5/thumbnails/16.jpg)
• Phase 1. Intensive (initial)Kills active bacterias
• Phase 2. (continous)Sterilisation Kills slow growth bacterias.
![Page 17: Tb Kutis Print](https://reader030.vdocuments.net/reader030/viewer/2022012320/55cf99a6550346d0339e776c/html5/thumbnails/17.jpg)
• The combination of HRZ is very potent. Before choosing this type of treatment, check the patients kidney function (SGOT, SGPT, ALK. PHOSPHATASE).
• The level of SGOT, SGPT, ALK. PHOSPHATASE usually rise after 2 weeks of treatment.
• The treatment is still ongoing even after the increment is detected.
• INH (EVERYDAY) + rifampicin (2x/week)