The main objectives in TB treatment according to Botswana national tuberculosisprogramme manual to is to: (1) cure the patient of TB by rapidly eliminating most of the bacilli, (2) to prevent death from active TB or its late effects ,(3) prevent relapse of TB by eliminating the dormant bacilli, (4) prevent the development of drug-resistance (by using a combination of drugs) (5) prevent the transmission of TB to others,

The manual presents the first line of drugs that are for treating new and retreatment cases of TB and them are presented in table 1 with their recommended doses. According to the manual These drugs (Anti-TB drugs) possess three main properties which bactericidal action, sterilizing action and the ability to prevent resistance.

Essential drugRecommended daily dose in mg/kg body weight (range)

Isoniazid5 mg (4-6)Maximum 300mg daily

Rifampicin10 mg (8-12)Maximum 600mg daily

Pyrazinamide25 mg (20-30)

EthambutolAdults 15 mg (15-25)Children: 20 mg/kg (range 15-25 mg/kg) daily

Streptomycin15 mg (12-18)Maximum for