tech parks
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Institute of Molecular Biology & BiotechnologyInstitute of Molecular Biology & Biotechnology
TechnologiesTechnologies ModelsModels ServicesServices
…in the postgenomic era
IMBB Investigates... Gene expression under
stress & in differentiation
The nervous system
aging& neurodegeneration
Development & differentiation
Protein trafficking &molecular machines
Mosquitoes andmalaria
IMBB Develops ... Insect control systems
(Minos Biosystems,Bayer)
DNA microchip prognostics ( Breast cancer)
New antibiotics (Pfitzer)
Gene silencing technologies (Crop protection)
Protein products (Enzymes &
Biopharmaceuticals) Acoustic biosensors
Computational Biology& Biomedical Informatics (IMBB-ICS)
Molecular imaging & tomography (IESL-IMBB)
Nano-biotechnology (ΙΜΒΒ-ICE/HT-IESL )
IMBBIMBB Promotes... Interdisciplinary research
IMBB-Industry collaborationsA variety of business models
SecA inhibitors Pfizer
Bayer
SmithKlein Beecham
BOEHRINGER MANNHEIM
BioLabsNEW ENGLAND
Chitin deacetylation
Secretion Biotechnology
Molecular Biology Enzymes
Chitin synthase inhibitorsChitozyme, Marine Biopolymers
The E. coli bacterium – 4.200 genes
“If we understand the biology of E. coli we will know the biology of the elephant”
[J. Monod]
H2Olipid
Bacterial secretion of proteins
H2O
T3SSec
Collaboration principles
Mutual benefit (access to know-how, agility - flexible funding, access to instrumentation)Reasonable charges (100-150% overhead on labor cost)Maintenance and transfer of new IPR (right of first refusal)Research collaboration rather than contractual workFurther development via national (?), European fundingKnowledge discovery and/or cutting edge technologies
Decision Diagramfor the Exploitation of Scientific Discoveries
ScientificDiscovery
ScientificDiscovery
Is itUseful?
Is itUseful? InventionInventionYesYes
No
No
Does it havean economicPotential?
Does it havean economicPotential? Y
esY
es
ScientificPublication
ScientificPublication NoNo
IntellectualProperty
IntellectualProperty
Does it needProtection?
Does it needProtection?YesYes
No
No
PatentApplication
PatentApplication
No No
BusinessSecrete
BusinessSecrete
Does is provideEntrepreneurial
Basis?
Does is provideEntrepreneurial
Basis?
No
No
No
No
YesYes
TechnologyTransfer
TechnologyTransfer
BusinessPlan
BusinessPlan
Drosophila and Genetics – life with 14.000 genes
Identification of insect chitin synthasesBAYER AG
Protection of IPR by patents (EPO, JPO, USPTO)
Chitin exists in the cuticle and the peritrophic membrane of insects
Chitin synthesis is a prime target for of pest control agents
{Epicuticle
(cuticulin layer) Exocuticle
{Endocuticle
{Epidermis
{Procuticle(chitin and proteins)
Synthesis zone
Hemolymph
Drug discovery is a excellent ground for fertile industry – academy research collaborations. Thus academy raises its social and technological awareness while industry overcomes its innovation deficit.Protection of intellectual property rights and technological awareness are vital for the success of innovation and essential for a balanced and a mutual benefit relation.
Understanding live and trying to tame it –basic and applied research – are no separate realms. They are mutually dependent.
Decision Diagramfor the Exploitation of Scientific Discoveries
ScientificDiscovery
ScientificDiscovery
Is itUseful?
Is itUseful? InventionInventionYesYes
No
No
Does it havean economicPotential?
Does it havean economicPotential? Y
esY
es
ScientificPublication
ScientificPublication NoNo
IntellectualProperty
IntellectualProperty
Does it needProtection?
Does it needProtection?YesYes
No
No
PatentApplication
PatentApplication
No No
BusinessSecrete
BusinessSecrete
Does is provideEntrepreneurial
Basis?
Does is provideEntrepreneurial
Basis?
No
No
No
No
YesYes
TechnologyTransfer
TechnologyTransfer
BusinessPlan
BusinessPlan
MINOS trangenesis technologies
Medfly SIT control
Minos + HGHInsect Protein Factories
larvae purification HGH
Mass rearing facility
500 tons / weekyields
HGH
The mouse – 35.000 genesTHE model for human disease
Genetic tranformation of mouse
IMBB-FORTHProducts & Services
MINOTECH BiotechnologyPRODUCTSDNA restriction enzymesDNA modification enzymesCytokines
SERVICESFermentationProtein expressionProtein purification
IMMUNOLOGYPRODUCTSHormonal immunodiagnosticsReproductive management of cowsProcedure employed by DELTA S.A.
MICROCHEMISTRYPRODUCTSCustom DNA oligonucleotides
SERVICESDNA sequencingGMO testing
Science & Technology Parks
and Innovation Policies in GreeceMyths and Reality
“Lefkippos” Technology Park of Attica
Technology & Culture Park - Lavrion
Thessaloniki Technology Park
Science & Technology Park - Epirus
Patras Science Park
Science & Technology Park of Crete
University of Ioannina
University of Patras
Foundation for Research & Technology - Hellas
The Centre for Research & Technology Hellas
NCRS “Demokritos”
National Technical University of Athens
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Crete
Epirus
Lavrio
Lefki
ppos
Patra
s
Thessa
lonik
i
Information Technology-Telecomunications
Construction - Engineering
Commerce
Other
Can low-tech environments favor the Development of Science and Technology
Parks?
Main Objectives of Science and Technology Parks
Technology transfer
Regional or National Development
The Different Groups Interested in Science Parks
Universities-Research Centers
Government-Politicians
Industry
Venture Capital
Objectives of universities and Research Centers
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Technology transfer
Scientific character
Financial aspect
Marketing
Prerequisites (situation in Greece)•Existing methods and centers of technology
transfer
•Number of centers of excellence
•Existing collaboration with the industry
•Funding of research
•Cultural attitude towards commercializing academic results
Objectives of the Government:
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Creation of new jobs
Improve the image of an area
Increase the average income
Development
Prerequisit
esStrategy for regional development
Economic Incentives
Industrial situation
Degree of unemployment in area
Degree of education in area
Image of area
Local politicians
Objectives of the industry
Increase the number of suppliers, or potential clients
Increase the number of inhabitants in the region and their average income
Synergy with new firms
Possibility for the location of subsidiaries of existing companies
Improve image of area
Prerequisites
Type of industry in area (big industry which needs suppliers, or small industries which need more clients)
Size of companies
Degree of R&D in companies
Degree of high-tech of companies
Venture Capital
Spontaneous Development
Silicon ValleyMIT
Univ. of Stanford Route 128
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Association with centers of excellence of different universities and Research Centers
Select locations that have commercial, geographical or financial advantages
Organization and management
Access to International Technology Transfer and Venture Capital