These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.9.12.19

TECHNICAL DATA SHEET

Amount per serving %DV

20 1000%

50 250%

60 6%

60 15%

250 13%

200 *

200 *

60 5%

150 *

200 *

*

100 *

*

25 *

25,000 *

5 *

*Daily Value not established.

10 500%

100

Vitamin B3 (as Niacinamide)

Vitamin B3 (as Niacin)

Vitamin B6 (as Pyridoxine HCl)

Calcium (as Citrate)

Magnesium (as Citrate)

Manganese (as Citrate)

Copper (as Copper Chelate)

Potassium (as Citrate)

20 100%

40 *

20 *

4 *

White Willow (bark) extract (Salix alba) (25% Salicin)

Bromelain (2400 GDU/gm)

Boswellia serrata (gum resin) extract (70% boswellic acid)

Turmeric (rhizome) (Meriva®)

Valerian (root) extract (Valeriana officinalis) (0.8% valerenic acid)

Devils Claw (root) extract (Harpagophytum procumens) (4:1)

Jamaican Dogwood (bark) (Piscidia piscipula)

Black Cohosh (root) extract (Actaea racemosa) (4:1)

Cordalis yanhusuo (rhizome) extract (Yan Hu Suo) (10:1)

Wild Yam (root) extract (Dioscorea villosa) (10:1)

Feverfew (aerials) extract (T parthenium) (0.8% Parthenolide)

Protease (500,000 HUT/gm)

BioPerine® Black Pepper (Piper nigrum) extract (95% piperine)

Serrapeptase (as Serrazimes 600,000 U/gm)

75 *

INGREDIENTS

Curcumin/Turmeric (Meriva®)Turmeric’s major active constituents are curcuminoids including curcumin diferuloylmethane, a yellow pigment. Its anti-inflammatory activity appears to inhibit cyclooxygenase-2 (COX-2), prostaglandins and leuko-trienes (1). Meriva® uses phytosome technology to combine curcumin with phosphatidylcholine. Pharmacokinetic comparison studies show Meriva® to have up to a 20-fold improvement in bioavailability versus a standardized 95% turmeric extract (2).White Willow Bark White willow bark has been used for centuries for relieving pain and inflammation. Willow bark contains the chemical salicin, which is the precursor to aspirin (acetyl salicylic acid) (3). The active salicin in white willow bark acts as both an analgesic and an antipyretic. The actual mechanism of action of salicin is very similar to that of modern prescription medications in the cyclooxygenase-1 and 2 (COX-1, COX-2) pathways. Salicin is a nonselective COX-1 and COX-2 inhibitor, effectively acting as an anti-inflammatory by blocking prostaglandin release (4). Boswellia (Indian Frankincense)Of the ten leading causes of mortality in the US, chronic, low-level inflammation contributes to the pathogenesis of at least six (5). Boswellia extracts have been used for thousands of years to treat a wide range of conditions caused by inflammation (6).Wild Yam Wild yam is a perennial vine plant with heart-shaped leaves that have hairs on their undersides. Wild yam’s antispasmodic and anti-inflammatory actions make it useful in treating symptoms of rheumatism and arthritis.

50

Serving size: 2 capsules Servings per container: 45

S u p p l e m e n t F a c t s

mg

mg

mgmg

mg

mg

mg

mg

mgmg

mg

mg

mg

mg

mgmg

mg

mgHUT

mg

mg

mcg

New and improved formula!

Immune & Inflammation SupportMUSCULOSKELETAL INJURY™ Musculoskeletal injuries are inevitable. Muscle and body pain, stiffness, soreness, and inflammation are common symptoms of overuse and overexertion. Musculoskeletal Injury™ (MSI) formula is designed to address such injuries with specific nutrients shown to be highly effective in remedying the symptoms of pain and discomfort. We’ve included a comprehensive list of botanicals that have been used for centuries for natural pain relief. Historically, white willow bark was used by both Hippocrates and Galen to ease aches and pains and reduce fevers. Boswellia extract has also been used for thousands of years to treat a wide range of conditions caused by inflammation. Native Americans have effectively used black cohosh as a natural remedy for inflammation and pain. Valerian is often called “nature’s tranquilizer” because it also works as a pain reliever. Devil’s claw relieves joint and muscle aches, and is an effective anti-inflammatory agent. Wild yam contains steroidal saponins to help reduce both pain and inflammation. Meriva® is a patented formulation of curcumin that is readily absorbed and utilized as a potent anti-inflammatory. Our newly improved MSI formula has added Jamaican dogwood, Feverfew and Cordydalis to further reduce pain. In addition to botanicals, we’ve also included B vitamins and specific minerals with therapeutic value in musculoskeletal injuries which further add to the overall efficacy of our formula. Lastly, we added the enzymes bromelain, serrapeptase, and protease, which all work to help address the pain associated with inflammation. MSI formula is truly an exhaustive compilation of the best raw materials nature has to offer to provide natural pain relief.

Other ingredients: vegetarian capsules (hypromellose and purified water)Meriva® is a trademark of Indena S.p.A BioPerine® is a registered trademark of Sabinsa

9953 SW Arctic Dr Beaverton, OR 97005

Valerian RootValerian root has been used as a medicinal herb since at least the time of ancient Greece and Rome. Hippocrates, the “father of medicine” described its therapeutic properties as did Galen, an ancient Greek physician. Valerian extracts are often standardized to contain from 0.25% to 1% valerenic acid which is considered to be the predominate constituent responsible for addressing pain, inflammation and insomnia.

Devil’s Claw The medicinal part of Devil’s claw is the tuber that contains iridoid glycoside constituents including harpagide and procumbide, but primarily harpagoside. Devil’s claw is used for osteoarthritis and other inflammatory conditions because iridoid glycoside constituents seem to have an anti-inflammatory effect (15). Devil’s claw inhibits COX-2 and nitric oxide synthetase, a modulator of inflammation (7). Evidence suggests that the anti-inflammatory effect is due to increased synthesis and release of tumor necrosis factor (TNF)-alpha by compounds other than harpagoside.

Black Cohosh Black cohosh is commonly known as snakeroot, bugbane and rattle weed and has been used by Native Americans for hundreds of years. The triterpene glycosides have been studied and indicate they inhabit cytochrome P450 3A4 (CYP3A4) in vitro up to 44% (8). Black cohosh has anti-rheumatic activity that acts to relieve aches and pain.

Bromelain, Protease and SerrapeptaseThese are all powerful anti-inflammatory agents that benefit the body’s response to painful injuries and swelling. Bromelain exerts an anti-inflammatory effect by altering leukocyte migration and activation. Protease and serrapeptase are both potent enzymes that exhibit strong anti-inflammatory properties. These two proteolytic enzymes reduce inflammation by neutralizing the biochemicals of inflammation (i.e. bradykinins and pro-inflammatory eicosanoids) to levels at which the synthesis, repair and regeneration of injured tissue can take place (9).

Minerals Calcium, magnesium, manganese, copper and potassium are body essentials included in our Musculoskeletal Injury™ formula, and are all in forms that are clinically shown to be the most bioavailable. For example, calcium (citrate-malate) is far better absorbed than calcium carbonate (10). Magnesium is responsible for over 300 enzyme reactions and in the production of cellular energy.

B vitamins (B3 Niacinamide and B6 Pyridoxine) Niacinamide (B3) increases joint mobility, improves muscle strength and decreases fatigue (11). Exercising increases the need of B6, and magnesium increases the amount of B6 that can enter the cell (12).

REFERENCES:10.29.19

Patients: Consult with your healthcare professional for the proper dosage and use of this formula.

For more information about this and other Condition Specific Formulas® please visit our website at:

www.mountainpeaknutritionals.com

Jamaican dogwood (Piscidia piscipula)The root and bark have been used traditionally for pain support. It does contain some isoflavonoid compounds (jamaicine, ichtynone, milletone) that have sedative properties. It has been used to support a healthy inflammatory response, promote comfort for occasional aches and nerve pains, including headaches and cramps, as well as stress and tension. Jamaican dogwood is one of the strongest, non-narcotic herbal analgesics.

Feverfew (Tanacetum parthenium)Feverfew is believed to help migraine sufferers because of the unique plant chemical it contains, parthenolide, which helps relieve smooth muscle spasms and can combat the widening of blood vessels that occurs in migraines. This effect appears to be backed up by research that shows that Feverfew can reduce the frequency of migraines and reduce symptoms such as nausea, vomiting and sensitivity to light (flashing lights). Parthenolide showed significant analgesic and anti-inflammaory properties selectively inhibiting cyclooxygenase-2 (COX-2) (13).

Corydalis yanhusuoCorydalis is one of the most effective analgesics in the Chinese materia medica. It is used to treat pain and acute inflammation. It is effective for treating acute inflammatory or neuropathic pain (14). It can be used orally and topically for pain due to trauma (bruises, sprains, and whiplash), as well as nerve pain (sciatica, trigeminal neuralgia, and migraines). Over 50 million Americans are affected by neuropathic pain and corydalis is the Chinese herb of choice in treating such conditions. In Korea, Corydalis is used to alleviate headaches while in China the plant is used to stimulate blood circulation.

1. Food Chem Toxic 2002;40:1091-972. Chemother Pharacol 2002;60:171-773. University of Maryland Medical Center. Willow bark4. National Standard Willow bark.5. Center for Disease Control gov nchs/fastats/death 9/15/20146. J Pharm Pharmacol 2009Oct;61(10)1281-937. Phytomedicine 2000;6:469-738. J Agric Food Chem 2003;51:5661-709. Miller, Proteolytic enzymes in inflammation 1956 Jan;19:16-2510. J Clin Pharmacol 2000;40:1237-4411. Am Geriatr Soc 1983;31:790-112. J Int Med Res 1990;18:379-8813. Biochem Biophys Res Commmun 1996;226:810-814. Current Biology Volume 24 Issue 2 2014;117-23)15. Phytomedicine 2000;7:177-84

BioPerine® Black PepperBioPerine® is a patented extract obtained from black pepper fruits (Piper nigrum) standardized to a minimum to 95% piperine. BioPerine® has been used to enhance absorption and bioavailability of nutrients by at least 30%.