The 6th Seminar on Exercise in Medicine

Trondheim 17-18th December 2015

ntnu.edu/cerg @CERG_ntnu cerg_ntnu CERG_NTNU facebook.com/CERG

The 6th

Seminar on Exercise in Medicine, Trondheim, 17-18th

December 2015

Dear Colleagues and Friends:

It is a pleasure to invite you to “The 6th

Seminar on Exercise in Medicine” in Trondheim the 17-18th

of December

2015. The seminar is hosted by the K.G. Jebsen Center of Exercise in Medicine/Cardiac Exercise Research Group

(ntnu.edu/cerg) at the Department of Circulation and Medical Imaging, at Norwegian University of Science and

Technology (NTNU), Trondheim, Norway.

This seminar brings together young and experienced researchers in the field of epidemiology, clinical cardiology,

exercise in medicine and basic mechanism of cardiovascular function. The main purpose is to discuss recent

progress in using exercise as medicine.

In contrast to the large international conferences, an intension by organizing this small seminar is to create an

informal and intimate setting, which we know set the stage for open discussions and brainstorming to create

new ideas for good research.

Thursday will be a very busy day from early morning to late night. The final program closes at 1630. You will have

some time to relax before departure for an outdoor dinner in the forest of Trondheim. Although this seem to be

stressful we promise that we will be taken good care of in a relaxing environment as soon as you have put on

your warmest clothes. We are hoping for nice cold weather with plenty of snow.

Friday we start up with program from the morning of and end the scientific session at 1515. For those of you that

are interested you will be invited to join a seminar called “Man in extreme environment” at 1900 on Friday night,

where you can relax and listen to some of the most experienced “nature explorers” in the world.

As organizers for this seminar we provide “the playing ground”, but it’s the players that make the game fun. We

are therefore deeply grateful if you would like to participate and share your time with us these days. We

welcome you to participate in this multidisciplinary setting.

Pictures from earlier seminars on Exercise in Medicine in Trondheim

Program 17th December 2015 Seminar on Exercise in Medicine, Trondheim

KA 11 – Knowledge Center, St. Olavs University Hospital

0830-0845 WELCOME AND REGISTRATION

Ulrik Wisløff

0845-0900

THE CARDIAC EXERCISE RESEARCH GROUP: PAST-PRESENT-FUTURE

PHYSICAL ACTIVITY AND CARDIOVASCULAR DISEASE: PAST – PRESENT - FUTURE Chair: Professor Martin Halle, Techniche Universität München, Germany.

Carl “Chip” Lavie

0900-0930

John Ochsner Heart and Vascular Institute, Ochsner Clinical School, New Orleans, USA

Physical activity and cardiovascular disease: Past and Present

Steven Blair

0930-1000

Prevention Research Center Public Health Research, University of South Carolina, USA

Physical activity and cardiovascular disease: The future

Ben Levine

1000-1030

Institute for Exercise and Environmental Medicine, Dallas, Texas, USA

Impact of lifelong exercise "dose" on left ventricular compliance and distensibility

1030-1100 COFFEE & FRUIT

EXERCISE TRAINING IN HEART FAILURE

Chair: Professor Volker Adams, University of Leipzig, Germany

Øyvind Ellingsen

1100-1130

K.G. Jebsen Center of Exercise in Medicine, NTNU

Moderate versus high intensity exercise training in heart failure with reduced ejection fraction

Mark Haykowsky

1130-1200

University of Texas at Arlington, Texas, USA

Heart failure with preserved ejection fraction—what do we know and what do we need to know?

Anthony Rosenzweig

1200-1230

Harvard Medical School and Massachusetts General Hospital, Boston, USA

Molecular mediators of exercise: Can we deliver the benefits effects of exercise in a pill?

1230-1330 LUNCH

BRAIN HEALTH

Chair: Linda Ernstsen, K.G. Jebsen Center of Exercise in Medicine, NTNU

Lene J. Rasmussen

1330-1400

Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen

Denmark

Role of mitochondrial dysfunction and genomic instability in Alzheimer`s disease: a search for

therapeutic strategies

Linda H. Bergersen

1400-1430

Brain and Muscle Energy Group and Healthy Brain Aging Centre at University of Oslo.

Lactate transport and signaling in the brain: potential therapeutic targets via exercise training?

Jorge Ruas

1430-1500

Molecular and Cellular Exercise Physiology, Karolinska Institutet, Sweden.

Therapeutic avenues for treating depression by targeting skeletal muscle

1500-1530 REFRESHMENT AND SNACKS (1903 BUILDING)

1530-1630

POSTER-UPDATE FROM K.G. JEBSEN CENTER OF EXERCISE IN MEDICINE Chair: Øivind Rognmo, K.G. Jebsen Center of Exercise in Medicine, NTNU

1830-2300 OUTDOOR DINNER FOR SPEAKERS AND INVITED – BUS PICK UP AT 1830

Program 18th

December 2015

Seminar on Exercise in Medicine, Trondheim

ENERGY METABOLISM IN HEALTH AND DISEASE Chair: Professor Bård Kulseng, St. Olavs University Hospital, Trondheim, Norway.

Juleen Zierath

0900-0930

Department of Molecular Medicine and Surgery, Karolinska Institutet, Sweden.

Exercise training as treatment of diabetes: Past – Present – Future

Johan Auwerx

0930-1000

The Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale in Lausanne,

Switzerland

Molecular physiology and systems genetics to understand metabolism in health, aging and disease

1000-1030 COFFEE & FRUIT

ACTIVE & SUCCESSFUL AGING

Chair: Professor Jorun Helbostad, Department of Neuroscience, NTNU

Dorthe Stensvold

1030-1100

K.G. Jebsen Center of Exercise in Medicine, NTNU

A randomized controlled study of the long-term effects of exercise training on mortality in elderly

people: The Generation 100 study

Maria A.F. Singh

1100-1130

University of Sydney, Sydney, Australia

Novel applications of progressive resistance training in older adults

Bjarne M. Nes

1130-1200

K.G. Jebsen Center of Exercise in Medicine, NTNU

HUNT 4 Fitness

1200-1300 LUNCH

TELEMEDICINE

Chair: Christian Gutvik, Technology Transfer Office, NTNU

Pinar Øztruk

1300-1330

Department of Computer and Information Science, NTNU

Telemedicine in chronic disease management: Past – Present – Future

Lasse Berre

1330-1400

Berre, Trondheim, Norway

Innovation: Listen to your heart

1400-1430 COFFEE & FRUIT

CARDIOVASCULAR IMAGING Chair: Professor Toril N. Hernes, Department of Circulation and Medical Imaging, NTNU

Lasse Løvstakken

1430-1500

Centre for Innovative Ultrasound Solutions at Department of Circulation and Medical Imaging, NTNU

Ultrasound imaging and quantification of cardiovascular disease: present and future directions

1500-1515 CONCLUDING REMARKS

1900-2200

MAN IN EXTREME ENVIRONMENT Chair: Svein Erik Gaustad

Emil Eide Eriksen

Rowing the Atlantic

Justin Jones Tasman expedition: Crossing the Ditch - Daring to dream then riding out the storm

James Castrission

Antarctic expedition: Extreme South - A journey to hell and back

The speakers

Steven Blair

Professor in the Departments of Exercise Science and Epidemiology and

Biostatistics at the Arnold School of Public Health, University of South

Carolina. His research focuses on the associations between lifestyle and

health, with a specific emphasis on exercise, physical fitness, body

composition, and chronic disease.

Lene Juel Rasmussen

Professor at the University of Copenhagen and Managing Director of the

interdisciplinary aging center, Center for Healthy Aging, residing within the

faculty of Health and Medical Sciences. Her research aims to unravel the

complex molecular basics of aging and the development of aging

associated diseases.

Maria Fiatarone Singh

Professor and a geriatrician, board certified in both Internal Medicine and

Geriatric Medicine in the USA and Australia, who has held the inaugural

John Sutton Chair of Exercise and Sport Science in the Faculty of Health

Sciences, and Professorship, Sydney Medical School, at the University of

Sydney since 1999. Her research, clinical, and teaching career has focused

on the integration of medicine, exercise physiology, and nutrition as a

means to improve health status and quality of life in older adults.

Jorge Ruas

Assistant Professor at the Department of Physiology and Pharmacology,

Karolinska Institutet, and group leader for the Molecular and Cellular

Exercise Physiology research group. He received his Pharm.D. degree from

the University of Lisbon, his Ph.D. from Karolinska Institutet, and returned

to Sweden after pursuing postdoctoral studies at Harvard Medical School.

Benjamin D. Levine

Founder and Director of the Institute for Exercise and Environmental

Medicine at Texas Health Presbyterian Hospital Dallas where he also holds

the S. Finley Ewing Chair for Wellness and the Harry S. Moss Heart Chair

for Cardiovascular Research. He is Professor of Internal

Medicine/Cardiology and Distinguished Professor of Exercise Sciences at

the University of Texas Southwestern Medical Center. His global research

interests center on the adaptive capacity of the circulation in response to

exercise training, decondition, aging, and environmental stimuli such as

spaceflight and high altitude.

Juleen R. Zierath

Professor of Clinical Integrative Physiology and head of the Section of

Integrative Physiology at the Dept. of Molecular Medicine and Surgery and

the Dept. of Physiology and Pharmacology at Karolinska Institutet. She is

also appointed Professor of Integrative Physiology at University of

Copenhagen, where she is a Scientific Director at the Novo Nordisk

Foundation Center for Metabolic Research. Her research has provided

evidence for the physiological regulation of insulin signaling pathways in

skeletal muscle, revealing key steps are impaired in diabetic patients.

Mark Haykowsky

Professor and Moritz Chair in Geriatrics in the College of Nursing and

Health Innovation at The University of Texas at Arlington. His Research

program examines (1) the biologic mechanisms responsible for the decline

in health related fitness across the heart failure continuum, and the role of

exercise training to improve cardiovascular and skeletal muscle function;

(2) the efficacy of exercise training to reverse chemotherapy mediated

cardio-toxicity in women with breast cancer, and; (3) cardiac mechanics

and left ventricular remodeling in athletes.

Anthony Rosenzweig

Chief of cardiology and co-director of the Corrigan Minehan Heart Center.

He specializes in general noninvasive cardiology, with a particular interest

in cardiovascular genetics and cardiovascular disease prevention. Dr.

Rosenzweig's research is focused on heart failure and understanding the

clinical implications of fundamental biological processes regulating cell

growth, death and regeneration in the heart.

Linda Hildegard Bergersen

Professor in Neurobiology and work as a group leader at the Department

of Anatomy University of Oslo, Brain and Muscle energy group which is

part of Nansen Neuroscience Network. She is also a guest Professor at the

Center for Healthy Aging at the Panum Institute in Copenhagen. The main

goal in her group is to understand enegy failure in the brain and how we

both can rescue and cure enegy failure in the brain.

Johan Auwerx

Professor at the École Polytechnique Fédérale in Lausanne, Switzerland,

where he occupies the Nestle Chair in Energy Metabolism. Dr. Auwerx has

been using molecular physiology and systems genetics to understand

metabolism in health, aging and disease. Much of his work is focused on

understanding how diet, exercise and hormones control metabolism

through changing the expression of genes by altering the activity of

transcription factors and their associated cofactors.

Carl “Chip” Lavie

Dr. Lavie is Professor of Medicine and Medical Director, Cardiac

Rehabilitation and Preventive Cardiology; Director, Exercise Testing

Laboratory; and Staff Cardiologist, Echocardiographic Laboratory at the

John Ochsner Heart and Vascular Institute in New Orleans, Ochsner

Clinical School-The University of Queensland School of Medicine and he

previously served for 10 years as Associate Director of the Internal

Medicine Training program.

Øyvind Ellingsen

Øyvind Ellingsen is a Professor of Cellular Cardiology at the Norwegian

University of Science and Technology (NTNU) and a Consultant Physician

at the Department of Cardiology, St. Olavs Hospital, Trondheim, Norway.

Dr. Ellingsen founded the Laboratory of Cellular Cardiology at NTNU in

1996. The focus of the lab is Exercise in Medicine. Its long-term goals are

to understand the mechanisms of the beneficial effects of exercise in

cardiovascular disease, to translate them into better programs for

prevention and rehabilitation, and to identify new targets for medical

therapy.

Dorthe Stensvold

Dorthe Stensvold, Post Doctor at K.G. Jebsen Center of Exercise in

Medicine, NTNU, Trondheim, is project leader of Generation 100, a large

randomized clinical study that evaluates the effect of regular exercise

training on morbidity and mortality in elderly people.

Bjarne M. Nes

Post Doctor at K.G. Jebsen Center of Exercise in Medicine, NTNU,

Trondheim. His research focuses on exercise and cardiorespiratory fitness

in cardiovascular disease prevention by using population based studies

from the large HUNT-cohort.

Lasse Løvstakken

Lasse Løvstakken is Professor at the Dept. of Circulation and Medical

Imaging, NTNU, Trondheim. His research interests is targeted towards

medical ultrasound imaging, a method where echoes from high-frequency

sound waves emitted into the body can be used to make images and

measure properties of tissue and blood flow.

Pinar Øzturk

Pinar Øzturk is Associate Professor at Dept. of Computer and Information

Science at NTNU, Trondheim. Pinar’s main research area is artificial

intelligence but she does multidisciplinary research linking AI with other

parts of cognitive science. Her research activities lie in knowledge

representation and modellling, case-based reasoning, multiagent systems,

and recently text mining/information extraction areas.

Lasse Berre Lasse Started BERRE in 1996 after returning from more than 6 years in

California, where he studied photography and later worked as a

photographer within fashion and advertising. He has since worked with

photography, visual concepts, communication and brand building for both

well known national and international brands. Lasse is educated from

Brooks Institute of Photography, Santa Barbara, CA.