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Thank you for viewing this presentation.
We would like to remind you that this
material is the property of the author.
It is provided to you by the ERS for your
personal use only, as submitted by the
author.
2016 by the author
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Solitary pulmonary nodules: approach options
Stefano GaspariniUniversità Politecnica delle MarcheS.O.D. di PneumologiaAzienda Ospedali RiunitiAncona - Italy
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Conflict of interest disclosure
I have no real or perceived conflicts of interest that relate to this presentation.
I have the following real or perceived conflicts of interest that relate to this presentation:
This event is accredited for CME credits by EBAP and EACCME and speakers are required to disclose their potential conflict of interest. The intent of this disclosureis not to prevent a speaker with a conflict of interest (any significant financial relationship a speaker has with manufacturers or providers of any commercial productsor services relevant to the talk) from making a presentation, but rather to provide listeners with information on which they can make their own judgments. It remainsfor audience members to determine whether the speaker’s interests, or relationships may influence the presentation. The ERS does not view the existence of theseinterests or commitments as necessarily implying bias or decreasing the value of the speaker’s presentation. Drug or device advertisement is forbidden.
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CLINICAL CASE
- Man, 67 yrs
- History of COPD (FEV1.0 = 47% pred)
- For persistent cough: chest X-ray e CT scan (without c.m.)
TC: spiculated nodule (1.5 cm) of RUL anterior segment
(suspected for malignancy)
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CLINICAL CASE
- Bronchoscopy with BAL for cytological evaluation through
right upper lobe bronchus
- No evidence of atypical cells
- A CT guided percutaneous approach is planned
At least three procedural mistakes….
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SOLITARY PULMONARY NODULE (SPN)
Single, approximately round and well
circumscribed radiographic opacity which is less or
equal to 3 cm in diameter and which is completely
surrounded by normal aereated lung parenchyma,
without other abnormalities such as lymph node
enlargement, atelectasis or pleural effusion
DEFINITION
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ALL SPN: THE SAME APPROACH?
< 1 cm 1-3 cm
GGO
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SOLITARY PULMONARY NODULE ?
Problem: Peripheral Pulmonary Lesions (PPL)
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CLINICAL CASE
At least three procedural mistakes….
1) CT scan performed without CM
At a careful examination of images, there is the suspect of
a right hilar lymph node enlargement…
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SOLITARY PULMONARY NODULE
< 0.8 cm
•Increased identification of small subcentimetric nodules(CT-based screening programmes)
•More than 95% of lesions < 0.8 mm do not represent malignancy(malignancy: 0,2% of nodules < 3 mm, 0.9% of nodules 4-7 mm)(Diederich S. Cancer Imaging 2003; 3: 117)
•Very low sensitivity of PET and biopsy techniques
•Strategy of careful observation with serial CT in patients with nodules < 0.8 cm-Ost D, Fein AM, Feinsilver SH. N Engl J Med 2003; 348: 2353- Guidelines Fleischner Society 2005; ACCP 2013
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GUIDELINES FOR MANAGEMENT OF PULMONARY NODULES DETECTED ON CT SCANS:
A STATEMENT FROM THE FLEISCHNER SOCIETY
Size(mm) Low-Risk Patient High-Risk Patient
≤ 4
4 - 6
6 - 8
> 8
No follow-up needed
Follow-up CT at 12 mo;
if unchanged: no further follow-up
Follow-up CT at 6-12 mo.
then at 18-24 mo. if no change
Follow-up CT at 3, 9, and 24 mo;
PET and/or biopsy
Follow-up CT at 12 mo.;
if unchanged, no further follow-up
Follow-up CT at 6-12 mo.,
then at 18-24 mo. if no change
Follow-up CT at 3-6 mo.
then at 9-12 and 24 mo. if no change
Same as for low-risk patients
Radiology, 2005; Chest, 2013
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SOLITARY PULMONARY NODULE
Ground glass opacity
• Histotype more frequently responsible for GGO is ADK
• Growth rate of GGO may be slower than solide nodules
(mean volume doubling time = 813±375 days)
(two years stability as a criterion to classify the nodule as benign is not valid)
• GGO < 5 mm don’t require further evaluation
• GGO > 5 mm: annual surveillance with chest CT
(if grow or development of a solid component: resection)
• Part-solid nodule: high incidence of malignancy
(repeat chest CT at 3 months and biopsy/surgery if persists)
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SOLITARY PULMONARY NODULE ≥ 8 mm
•Resection without delay of all malignant nodules
•Avoid useless surgery of benign nodulesReduction of risks (1-4% thoracotomy mortality)Reduction of costs
GOAL
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Chest 2013; 143(5)(Suppl):e93S-e120S
SOLITARY PULMONARY NODULE
Pretest probability of malignancy
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SOLITARY PULMONARY NODULE ≥ 8 mm
When serial CT surveillance is indicated?
(3-6-9-12 and 18-24 months)
• When the clinical probability of malignancy is very low (< 5%)
• When clinical probability is low (30-40%) and the lesion is
not hypermetabolic by PET
• When a fully informed patient prefers this nonaggerssive
management approach
Chest 2013; 143(5)(Suppl):e93S-e120S
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SOLITARY PULMONARY NODULE ≥ 8 mm
When nonsurgical biopsy is indicated?
Chest 2013; 143(5)(Suppl):e93S-e120S
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SOLITARY PULMONARY NODULE > 0.8 cm
IMMEDIATE SURGERY?
•Resection without delay of all nodules with high probability of
malignancy in patients good candidate for surgery
Pulmonary Unit - Azienda Ospedali Riuniti - Ancona
Jan 1985 - Dec 2000: 1,432 pts with solitary pulmonary nodule
272 (19%): contraindic. for surgery (age, cardioresp. impairment)458 (32%): high risk for surgery160 (11%): suspect of mediastinal lymphonode involvement
98 (6.8%): suspect of metastasis (history of previous cancer)62 (4.3%): surgery without diagnosis refused by the patient
382 (27%): Good candidate for immediate surgery
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SOLITARY PULMONARY NODULE
BIOPSY TECHNIQUES
TRANSBRONCHIAL PERCUTANEOUS
The majority of patients needs a biopsy
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Is bronchoscopy useful in patients with SPN?
•Arsitizabal et al. Chest 1998; 113: 1244-1249
64 pts with peripheral pulmonary carcinoma Bronchoscopy detected unsuspected endobronchial lesionsin 17% (three of these patients had SPN < 3 cm)
•Schwarz et al. Eur Respir J 2013; 41: 177-182
225 pts with SPNs (88% malignant)Unsuspected endobronchial lesions in 5.5% of pts with cancer
Bronchoscopy changed the planned surgical approach in 5 cases
•Zhang et al. J Thorac Cardiovasc Surg 2015; 159: 36-40
1026 pts with SPNs (80.5% malignant)Unsuspected endobronchial findings in 7.8% Surgery cancelled in 2 and modified in 36 (3.5%) because of bronchoscopic findings
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TRANSBRONCHIAL APPROACH:TECHNIQUE OF GUIDANCE
FLUOROSCOPY
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TRANSBRONCHIAL APPROACH TECHNIQUES OF GUIDANCE
FLUOROSCOPY EBUS miniprobe
NAVIGATION SYSTEMLUNG POINT
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A miniature ultrasound probe
(20 MHz, mechanical-radial Type)
Endoscopic US system
US-probe Catheter
EBUS GUIDANCE: MINIPROBE
Thanks to Ales Rozman
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8 mm
Don’t forget radial EBUS (if the nodule is adjacent to larger airways)
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ADK
1 cm
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ELECTROMAGNETIC NAVIGATION
BRONCHOSCOPY
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iLOGIC
ELECTROMAGNETIC NAVIGATION BRONCHOSCOPY
SPiNView navigation systemTransbronchial and percutaneous approach
(Endo/Perc)
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F. 75 y
No smoker
GGO first observation
November 2011
CT scan stable after
7 mounths
TBLB with ENB
Adenomatous atipical
hyperplasia
RL lobectomy
Microinvasive
Adenocarcinoma
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FLUOROSCOPY EBUS NAVIGATION SYSTEM
• Large availability
• Radiation exposure
• Cheap
(if C-arm fl. available)
• Not all lesions visible
• No radiation exposure
• Expensive (+)
• No radiation exposure
• Expensive (+++)
• No real time visualization
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BRONCHOSCOPIC APPROACH TO SPN
Fluoroscopy EMN EBUS
Pts studied
Overall sensitivity
Sensitivityfor SPN < 2 cm
5742
78%
33-58%
260
67%
61%
662
71.2%
60%
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Few randomized studies comparing the different guidance techniques
ERJ 2002; 20: 972
50 pts: prospective study
fluoroscopy and EBUS in random
orderNS NS
304 pts
No difference in diagnostic outcome
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CLINICAL CASE
At least three procedural mistakes….1) CT scan performed without CM2) Bronchoscopy performed without guidance system
USELESS BRONCHOSCOPY WITHOUT GUIDANCE SYSTEM!Very low sensitivity of BAL: < 10%
In case of SPN: do not perform bronchoscopy if you do not havethe availability of a guidance system!!!
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SENSITIVITY OF TRANSBRONCHIAL APPROACH to SPN
37%(Clark et al., 1978)
98%(Ono et Al., 1981)
- Size of the lesion
- Sampling instruments used
- Relationship between the airways and the lesion
- Number of samples
- Time taken
- Operator’s experience
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FACTORS AFFECTING RESULTS OF TRANSBRONCHIALAPPROACH TO SPNs
SIZE OF THE LESION
Sensitivity> 2 cm. 76 - 83%< 2 cm. 33 - 58%
Dasgupta A, Mehta AC: Clinics in Chest Medicine, 1999
SAMPLING INSTRUMENTS USED
- Curette- Washing- Biopsy forceps- Brush- Transbronchial needle
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Author N. Patients Sampling instruments Sensitivity
Ellis1975
Cortese, Mc Dougall1979
Shure, Fedullo1983
Wang et al1984Gasparini et al1995
Katis et al1995
107
48
42
20
570
37
brushingbiopsybrushing + biopsybrushingbiopsybrushing + biopsybiopsytransbronchial needlebiopsy + needle + brushingbiopsy + brushing transbronchial needlebiopsytransbronchial needlebiopsy + needlewashingbiopsytransbronchial needlewashing+biopsy+needle
42%68%69%40%46%60%36%52%69%25%68%53%69%75%24%38%62%70%
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BRONCHUS SIGN:“presence of a bronchus leading to or contained within the nodule”
51 Patients with peripheral pulmonary lesion.20 positive bronchus sign: TBPB positive in 11 (55%)31 negative bronchus sign: TBPB positive in 10 (32%)
FACTORS AFFECTING RESULTS OF TRANSBRONCHIALAPPROACH TO SPNs
SPNs: CT-BRONCHOSCOPIC CORRELATION
Naidich D.P. et Al: Chest 1988; 93: 595-598
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117 patientsPresence of bronchus sign only indipendent predictor of all predefinited outcomeSensitivity 87.3%Diagnostic accuracy 86.7%
51 pts with SPN
Diagnostic yield of EMN: 67%
-with bronchus sign: 79%
-without bronchus sign: 31%
ENB diagnostic yield is highly
dependent on the presence of a
bronchus sign on CT imaging
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Main factor that limits sensitivity of transbronchial approach to SPN:
lack of a bronchus leading into the lesion
SENSITIVITY
no more than
75-80%
(whichever guidance system)
No way to reach the target!
How to hole this wall?
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Thorax 2015; 70: 1-7
Respiration 2016;91:302-306
6 ptsA tunnel pathway was created in 5 (using a set of catheterbased tools)Adequate biopsy in 5 pts2 pneumothorax
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TRANSBRONCHIAL APPROACH: ADVANTAGES AND DISADVANTAGES
Information for staging
airways exploration;
TBNA of lymphonodes;
sincronous lung cancer.
Lower incidence of complications (expecially pneumothorax)
Lower value of sensitivity
Higher value of sensitivity (82-90%)
Higher incidence of complications (expecially pneumothorax 15-25%)
No information for staging
PERCUTANEOUS APPROACH: ADVANTAGES AND DISADVANTAGES
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CLINICAL CASE
At least three procedural mistakes….1) CT scan performed without CM2) Bronchoscopy performed without guidance system3) Suggested percutaneous approach…(very high risk of pneumothorax in a COPD patient and no information for staging)
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CLINICAL CASE
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BIOPTIC APPROACH TO SPN
BRONCHOSCOPY
Exploration of upper airwaysand of bronchial tree
Fluoroscopy
If not visible:EMN
TRANSBRONCHIAL BIOPSIES
(3-5)
IMMEDIATECYTOLOGICALEXAMINATION
Immunocyto-chemestry
Electron microscopy
Microbiologicalcultures
InadequateRepeat sampling
Inadequate
PERCUTANEOUS APPROACH(fluoroscopic guidance
without moving the patient)
Diagnostic
STOP
TBNA for mediastinal lymphnode staging
TBNA of the nodule
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TBPB TBNA TBPB+
TBNA
PCNA TBPB+
TBNA+
PCNA
52.070.1
77.0
92.8 95.0
SENSITIVITY%
Gasparini S et al, Chest 1995
Integration of transbronchial and percutaneous approachin the diagnosis of SPNs
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CONCLUSIONS
•Transbronchial approach, using fluoroscopy or new guidance systems, should
usually be performed before PCNA especially:
- in patients candidate to surgery (staging)
- in patients with impairment of respiratory function
•Please, don’t performe bronchoscopy in cases of SPN if you don’t have a system
of guidance (very low sensitivity of BAL)
•PCNA should be performed when transbronchial technique has failed
•Transbronchial and PCNA: complementary techniques
•The creation of teams able to utilize both approaches at the same time
should be encouraged in order to optimize the diagnostic management of SPN
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THANK YOU !