the 4 arrows - aldosterone action-nw2017
TRANSCRIPT
Kidney: Juxtaglomerular
(JG) cells Kidney: Juxtaglomerular
(JG) cells
Fall in renal perfusion pressureRenin
Renin
Fall in blood volume
and/or pressure
Renin Renin
Increased sympathetic discharge
Baroreceptor reflex
Increased sympathetic discharge
Fall in blood volume
and/or pressure
Kidney: Juxtaglomerular
(JG) cells
Kidney: Juxtaglomerular
(JG) cells
Renin Renin
Angiotensinogen Angiotensin I
Angiotensin II
Angiotensin Coverting Enzyme
Aldoster
one
Angiotensin II
Adrenal
Cortex
Adrenal
Cortex
Aldoster
one
Aldoster
one
High plasma
K+ levels
Adrenal
Cortex
Adrenal
Cortex
Aldoster
one
Aldoster
one
Aldostero
neC o l l e c t i n g d u c t c e l l s
4 arrows
T u b u l a r f l u i d I n t e r s t i t i a l f l u i d B l o o d
Aldoster
one
Action
H2O
Na+
K+
H+or
4 arrows
T u b u l a r f l u i d I n t e r s t i t i a l f l u i d B l o o d
Aldoster
one
Action
H2O
Na+
K+
H+or
H2O
Na+
K+
Blood volume blood pressure
Regulation of
plasma
potassium levels
4 arrows
T u b u l a r f l u i d I n t e r s t i t i a l f l u i d B l o o d
Aldoster
one
Action
H2O
Na+
K+
H+or
H2O
Na+
K+
Blood volume blood pressure
Regulation of
plasma
potassium levels
Conn’s syndrome (Primary hyperaldosteronism)
Hypervolemia
Hypertension
Hypokalemia
Metabolic alkalosis
[H+]
Conn’s syndrome (Primary hyperaldosteronism)
HypervolemiaHypertension
Metabolic alkalosis
Hypokalemia
HypovolemiaHypotension
Hyperkalemia
Metabolic acidosis
Addison’s Disease(Primary hypo-aldosteronism)
HypovolemiaHypotension
Hyperkalemia
Metabolic acidosis
Addison’s Disease(Primary hypo-aldosteronism)