the advanced bilirubin stat-analyzer™ photometer

The Advanced® Bilirubin Stat-Analyzer™ Photometer

Models BR2 and BR2E for Neonatal samples

Service Manual

BR25SM Rev8 082416

3 The Advanced® Model BR2 Service Manual

1. IntroductionInstrument Specifications . . . . . . . . . . . .7

General Description and Purpose . . . . . .8

The Service Manual . . . . . . . . . . . . . . . .8

Service Assistance . . . . . . . . . . . . . . . . .8

Safety . . . . . . . . . . . . . . . . . . . . . . . . . . .8

Safety/Regulatory Information . . . . . . . .9

Symbol Conventions . . . . . . . . . . . . . . .9

General Cautions . . . . . . . . . . . . . . . . . .9

Service & Maintenance Cautions . . . . .10

Hazardous Material Cautions . . . . . . . .11

Regulatory Notices . . . . . . . . . . . . . . . .11

Symbol Conventions . . . . . . . . . . . . . .11

2. General OverviewRemoving the Instrument Cover . . . . .15

Calibration . . . . . . . . . . . . . . . . . . . . . .16

Circuit Description . . . . . . . . . . . . . . . .17

BR2100 Main Board Description . . . .17

BR2950 Display Board Description . .19

Design Changes . . . . . . . . . . . . . . . . . .20

Replacement Parts . . . . . . . . . . . . . . . .21

Supplies & Accessories . . . . . . . . . . . .21

3. MaintenanceOptical Lamp . . . . . . . . . . . . . . . . . . . .25

Optical Filters . . . . . . . . . . . . . . . . . . . .25

4. TroubleshootingInternal Self-Diagnosis Voltage Checks .29

Troubleshooting Table . . . . . . . . . . . . .31

5. AdjustmentsLamp Adjustment . . . . . . . . . . . . . . . . .37

Measuring Circuit Adjustment . . . . . . .39

Direct Zero Adjustment . . . . . . . . . . . .40

6. Replacement InstructionsInterference Filter Set (BR2650) .B2P650

Lamp (BR2625) . . . . . . . . . . . . . .B2P625

Voltage Selection & Fuse

(70027/70028) . . . . . . . . . . . .B2P70011

7. SchematicsBR2003 Schematic

BR2100 Main Board Assembly Drawing

BR2950 Display Board Assembly Drawing

APPENDICESA: Symbol Definitions

B: Product Disposal and Recycling

C: Service Log

Index

Table of Contents

4The Advanced® Model BR2 Service Manual

Notes:

1. Introduction


Model BR2 Specifications

Electrical: Voltage: 100 to 120 VAC (1/4 A) or 200 to 240 VAC 1/8 A) Frequency: 50 or 60 Hz

Fuses: 1/4-Amp time delay for 100-120 VAC; 1/8-Amp time delay for 200-240 VAC Power: 15 Watts

STAT Mode: Power left on continuously

Test Capability: Total and Direct Bilirubin, both on the same serum orplasma sample

Sample Volume: 30 µL

Sample Capacity: Single sample, disposable cuvettes

Readout: Three-digit, seven-segment LED display

Units: mg/dL or µmol/L (S.I. units for export only; 1 mg/dL bilirubin = 17.1 µmol/L)

Range: 0 to 30 mg/dL

Resolution: ±0.1 mg/dL

Performance at Reference Conditions1

Linearity: Within ±0.2 mg/dL from zero to 30 mg/dL (straight-line method)

Repeatability: Within ± 0.2 mg/dL over entire range

Drift: Zero: Less than 0.2 mg/dL/hr after 30-minute

warm-upCalibration: Less than 0.2 mg/dL/24 hr after 30-minute

warm-up

Performance Over Operating Conditions

Hemolysis: No interference from HbO2 levels up to 600 mg/dL

Turbidity: Negligible interference from turbidity associated with triglyceride (TGL) levels up to 500 mg/dL

Operating Conditions

Temperature: 15°C to 32°C (59°F to 90°F)

Room Humidity: 5 to 80% relative humidity; (non-condensing)

Storage Temperature: -40°C to +70°C (-40°F to +160°F)

Test Time: Instantaneous for TOTAL Bilirubin, 2 minutes for DIRECT Bilirubin

Dimensions inches centimetersWidth: 11 28Depth: 13 33Height: 7 18

Weight pounds kilogramsNet: 9 4Shipping: 12 5.5

Warranty: One-year limited warranty on work- manship and all parts except glass, plastic and parts warranted by their makers.

Certification:

Refer to Regulatory Notices (see page 11) for appli-cable standards.

*CE marking only available on units delivered priorto July 22, 2016.

1Reference Conditions: 20 to 25°C (68 to 77°F); 40 to 60% Relative Humidity; tolerances of reference or calibrationsolutions excluded.

*


General Description and Purpose

The Advanced® Models BR2 and BR2E

Bilirubin Stat-Analyzer™ Photometers are

dual-arm, dual-wavelength, narrow-bandpass

photometers that measure Bilirubin (TBR)

and Azobilirubin (DBR) absorbance quantita-

tively. The digital readout is calibrated to

read bilirubin in milligrams per deciliter

(mg/dL) for the BR2, or micromoles per liter

(µmol/L) for the BR2E of serum or plasma.

The BR2 wavelengths are fixed and will not

shift during the life of the instrument.

The Service Manual

The BR2 Service Manual contains:

• instructions for performing repairs;

• guides for troubleshooting operational and

mechanical problems;

• circuit system illustrations; and

• information about replacement parts and

service repairs.

This manual is designed to assist

service technicians, and does not

imply a license to perform repairs

without proper qualifications.

Service Assistance

To contact Advanced Instruments Product

Service:

• Call (800) 225-4034 (toll-free within the

USA and Canada); after normal business

hours, dial extension 2191

• Call +US (781) 320-9000 (elsewhere)

• Or fax (781) 320-3669

When calling Advanced Instruments, have the

model and serial number from the label on

the back of the instrument, and a description

of the problem. Use a telephone as close to

the instrument as possible in order to facili-

tate making recommended diagnostic checks.

A service technician may assist in making

minor repairs over the phone, providing you

with recommended parts (or part numbers),

or may issue an authorization (RMA) to ship

the instrument for factory repair.

The RMA procedure is as follows:

1. Contact Advanced Instruments to obtain

an RMA.

2. Pack and ship the instrument in its origi-

nal carton. Do not send instrument sup-

ply items.

3. Prepay shipment to the factory.

Advanced Instruments cannot accept col-

lect shipments. Insure the shipment or

accept the damage risk.

Safety

Removing the instrument cover

exposes dangerous 200-250 and/or

100-130 AC voltages. Before remov-

ing the cover, make sure the instru-

ment is turned off and unplugged.

The Advanced® Model BR2 Service Manual

To reduce the risk of bodily injury,

electric shock, fire, and damage to

your instrument, please read and

observe the following precautions.

• If the product is used in a manner not in

accordance with the equipment design,

operating instructions or manufacturer's

recommendations, the operation of the

product may be impaired to the extent that

a safety hazard is created.

• Do not attempt to perform electrical work

if you are not fully qualified. This manual

is not a substitute for electrical training.

Symbol Conventions

The exclamation point within an

equilateral triangle is intended to

alert the user to the presence of

important operating and maintenance

(servicing) instructions in the litera-

ture accompanying this product.

The lightning flash with arrowhead

symbol within an equilateral triangle

is intended to alert the user to the

presence of uninsulated dangerous

voltage within the product's enclo-

sure that may be of sufficient magni-

tude to constitute risk of electric

shock to persons.

The static symbol within an equilat-

eral triangle is intended to alert the

user to the presence of internal com-

ponents that could be damaged by

static electricity.

This static symbol is intended to

alert the user to the presence of a

specific component that could be

damaged by static electricity.

This symbol indicates the presence

of alternating current (AC).


of a fuse.


of protective earth ground.

This symbol indicates the power is

ON.

This symbol indicates the power is

OFF.

NOTE Additional symbol definitions are

available in the Symbols section.

General Cautions

• This product should be operated only with

the type of power source indicated on the

product’s electrical ratings label. Refer to

the installation instructions included with

the product.

• If the power cord provided is replaced for

any reason or if an alternate cord is used,

the cord must be approved for use in the

local country. The power cord must be

approved for the product’s listed operating

voltage and be rated at least 20% greater

than the ampere ratings marked on the

product’s electrical ratings label. The cord

end that connects to the product must have

an IEC 60320 connector.

• Plug the product into an approved ground-

ed electrical outlet.

• Do not disable the power cord’s grounding

plug.

• If an extension cord or power strip is used,

make sure that the cord or strip is rated for

the product, and that the total ampere rat-

ings of all products plugged into the exten-

sion cord or strip do not exceed 80% of the

cord’s or strip’s rating limit.

Safety / Regulatory Information

9

The Advanced® Model BR2 Service Manual 10

• Route power cords so that they will not be

walked on, tripped on, or pinched by items

placed upon or against them. Pay particu-

lar attention to the plug, electrical outlet,

and the point where the cord exits the

product.

• Do not pull on cords and cables. When

unplugging cords or cables, grasp the cor-

responding connector.

• Do not install or use this product in any

area subject to extreme short-term temper-

ature variations, or locations that exceed

the specified operating environment tem-

peratures.

• Never use this product in a wet area.

• To avoid injury or fire hazard, do not oper-

ate this product in an explosive atmos-

phere.

• Do not install or use the product on an

unstable, non-level work surface.

• Do not operate this product with the covers

removed or unsecured.

Service & Maintenance Cautions

• Unplug the power cord prior to opening or

removing covers, or else you may be

exposed to electric shock, excessive tem-

peratures, or mechanical hazards.

• Performing service or maintenance not

detailed in the User’s Guide, with or with-

out this Service Manual, should only be

done by a qualified service technician.

• Never restrict airflow into or out of the

product. Occasionally, check the air vents

for blockage.

• Wipe the exterior of the product with a

soft, damp cloth as needed. Using cleaning

products other than those specified, may

discolor or damage the finish.

• If the product requires service for any of

the following reasons, unplug the product

from the electrical outlet and refer service

to a qualified service technician.

- The power cord, extension cord, power

strip or power input module is dam-

aged.

- Liquid has been spilled into the interior

of the product.

- A foreign object has fallen into the

product.

- The product has been dropped or dam-

aged by a falling object.

- There are noticeable signs of overheat-

ing or a burning odor.

- The product does not operate normally

when you follow the operating proce-

dures.

- The main supply fuse(s) or any internal

fuse(s) continually fail.

• A discharge of static electricity from con-

tact with the human body or other conduc-

tor may damage system boards or static

sensitive devices. Never perform internal

maintenance without following recom-

mended static protection procedures.

• The product is equipped with operator

accessible fuses. If a fuse blows, it may be

due to a power surge or failure of a com-

ponent. Replace the fuse only once. If the

fuse blows a second time, it is probably

caused by failure of a component part. If

this occurs, refer service to qualified serv-

ice personnel. Always replace the fuse

with one of the same rating, voltage, and

type. Never replace the fuse with one of a

higher current rating.

• When servicing the product, use only fac-

tory-specified parts.

• WARNING: When returning this product

for service, or shipping this product to a

second location, remove all hazardous

specimens and decontaminate the product

before packaging for shipment. If the

product cannot be decontaminated, consult

with your shipping agent on appropriate

packaging and marking.


Hazardous Material Cautions

• WARNING: Handle all biohazardous

materials according to established good

laboratory practices and follow your insti-

tution’s exposure control plan. Persons

handling human blood and body fluid

samples must be trained in blood-borne

hazards and observe universal precautions.

Universal precautions is an approach to

infection control, where all human blood

and body fluids are treated as if known to

be infectious. Use personal protective

equipment such as gloves, gowns, etc., to

prevent exposure. Store biohazardous

materials in regulated waste containers and

dispose of these materials in a safe and

acceptable manner that is in compliance

with all country, state and local require-

ments.

• If a biohazardous material is spilled on or

inside the equipment, decontaminate the

equipment using a 1% bleach solution, or

as outlined by those policies and proce-

dures established within your institution.

• To avoid injury or fire hazard, do not oper-

ate this product in an explosive atmos-

phere.

Regulatory Notices

• This product has been designed and manu-

factured in accordance with U.S.,

Canadian, and European regulatory

requirements as outlined below.

Modifications made to this product that are

not expressly approved in writing by the

manufacturer will void the user’s authority

to operate this product, previously issued

factory approvals, and the user’s rights

under the warranty.

• The distributor or dealer may have applied

additional local, national, or international

approvals to this product. Consult the dis-

tributor or dealer for more information and

documentation.

Symbol Conventions

This symbol indicates conformity to

relevant European directives.

This symbol indicates the product

was tested to conform to relevant

Canadian and U.S. safety standards

by Intertek Testing Services NA,

Inc. The ETL mark is approved in

the United States as a Nationally

Recognized Testing Lab (NRTL) by

OSHA, and in Canada by the

Standards Council of Canada.

In Vitro Diagnostic Medical Device

complying with EU Directive

98/79/EC.

11


U.S. Safety This product has been listed by ETLtesting laboratories as being in compli-ance with the requirements of UL61010-1 2nd edition, "ElectricalEquipment for Laboratory Use”. The"US" in the lower right of the ETLmark demonstrates this listing.

Canadian Safety This product has been listed by ETLtesting laboratories as being in compli-ance with the requirements ofCAN/CSA C22.2 No. 61010-1 2ndedition, "Safety Requirements forElectrical Equipment for Measure-ment, Control and Laboratory Use”.The "C" in the lower left of the ETLmark demonstrates this listing.

EC Declaration of This product meets the intent ofConformity - EMC Directive 2004/108/EC for

Electromagnetic Compatibility.Compliance was demonstrated usingthe following standards, as listed in theOfficial Journal of the EuropeanCommunities: Consult the Declarationof Conformance certificate shippedwith the product for the latest update.• EN 61326-1:2006, Group 1, Class

B, "Electrical Equipment forMeasurement, Control, andLaboratory Use".

EC Declaration of: This product meets the intent ofConformity - Low Directive 2006/95/EC, the LowVoltage Voltage Directive. Compliance was

demonstrated using the following stan-dards as listed in the Official Journalof the European Communities:Consult the Declaration ofConformance certificate shipped withthe product (if required) for the latestupdate.· IEC/EN 61010-1 2nd edition,

"Safety Requirements for ElectricalEquipment for Measurement,Control and Laboratory Use”.

· IEC 61010-2-101 (2002-01) -“Safety Requirements for ElectricalEquipment for Measurement,Control, and Laboratory Use; Part 2-101: Particular Requirements for InVitro Diagnostic (IVD) MedicalEquipment, First Edition”.

EC Declaration of This product meets the intent ofConformity - IVD Directive 98/79/EC for In Vitro

Diagnostic Medical Devices. Consultthe Declaration of Conformance certifi-cate shipped with the product (ifrequired) for the latest update.

Regulatoryapproval type Description

Regulatoryapproval type DescriptionEC Declaration of This product does not meet the Conformity - WEEE intent of Directive 2012/19/EU for

“Waste Electrical and ElectronicEquipment” (WEEE) due to the presenceof a restricted material, lead (> 0.1%), insome of the electronic components used.Instruments delivered prior to July 22,2016 were in compliance with the ruilesin effect at that time.

EC Declaration of This product does not meet the Conformity - RoHS intent of Directive 2011/65/EU for

“Restriction of the Use of CertainHazardous Substances in Electrical andElectronic Equipment” (RoHS) due to thepresence of a restricted material, lead (> 0.1%), in some of the electronic com-ponents used. Instruments delivered priorto July 22, 2016 were in compliance withthe rules in effect at that time.

FCC - Part 15, This device complies with Part 15 Subpart B, Class B of the FCC Rules. Operation is subject

to the following two conditions: (1) thisdevice may not cause harmful interfer-ence, and (2) this device must accept anyinterference received, including interfer-ence that may cause undesired operation.

Canadian ICES-003 This Class B digital apparatus complieswith Canadian ICES-003.Cet appareil numérique de la classe B est conforme à la norme NMB-003 duCanada.

CB Report A CB report and certificate have CB Certificate been issued for this product. The standard

used was IEC 61010-1, 2nd edition and61010-2-101, 1st edition.

U.S. FDA Listing The Bilirubin Test System, along with thecalibrators and controls manufactured byAdvanced Instruments, are listed withU.S. Department of Health and HumanServices, Food and Drug Administration,as: Bilirubin Test System Class 2 Calibrators Class 2 Controls Class 1

Health Canada The Bilirubin Test System, along withLicense the calibrators and controls manufactured

by Advanced Instruments, are licensedwith Health Canada, TherapeuticProducts Directorate, Medical DevicesBureau, as: Bilirubin Test System Class 2 Calibrators Class 2 Controls Class 2

2. General

Overview


Tool needed: Flat-bladed screwdriver

Warning-Hazardous Voltage

Warning-Internal components may

be damaged by static electricity.

CAUTION: Improper connections

may cause damage to the instrument.

1. Turn off the power and unplug the instru-

ment.

2. Remove the four screws (A) from both

sides of the BR2 and pull the instrument

cover straight up and off.

A

Removing the Instrument Cover


NOTE When the instrument is first turned

on, the measuring circuit requires

thirty minutes’ warm-up (to avoid

frequent re-zeroing to compensate

for initial thermal drift). It should be

left on during STAT duty (electrical

consumption is less than 20 watts).

Calibration Procedure

Verify the stated bilirubin values on the labels

of calibration standards and control sera,

preferably by using an acceptable manual

method. Record the actual values. Then cali-

brate the BR2:

1. Press the Total button.

2. Pipette 1 mL of pH-adjusted saline diluent

from an Advanced Bilirubin Test Kit into

one of the cuvettes provided. Open the

cuvette chamber and load the cuvette into

it so that the light beam passing from right

to left passes through the clear, not the

ribbed sides. Close the cuvette chamber

cover against extraneous light.

3. Adjust the readout to 00.0 with the Zero

knob.

4. Add 30 µL of calibration standard or con-

trol serum to the saline diluent in the

cuvette and mix thoroughly.

NOTE A positive-displacement pipette is

recommended for optimum accu-

racy in pipetting these fluids; at

high TBR concentrations, small

pipetting errors can lead to signif-

icant falsely-low readings. It is

further suggested that the same

pipettes be used each time, to

assure sample-to-sample and day-

to-day consistency.

5. Adjust the readout as necessary, by means

of the Calibrate knob, to the actual value

of the standard or control serum used (as

determined in step 0 above). Repeat

steps 0 through 4 with enough additional

aliquots to verify instrument calibration.

The BR2 is now calibrated and ready for

operation with unknown bilirubin samples.

Calibration


Circuit Description

Signal-conditioning Circuit: This circuit

receives two analog photocurrent signals via

solder terminals X8 and X11 on the front left

side of the Main board, from photodiodes

Sensor 1 and Sensor 2, the 540 and 454-nm

absorbance detectors, respectively.

These photocurrents are applied to IC5 and

IC6, which are fixed-gain, high-impedance

op-amps that have been adjusted by means of

R35 and R39 (the ZERO SET potentiometers

near the left front corner of the Main board)

for outputs at each pin 6 within 0.1 mV of

zero (measured at the ends of R36 and R40

nearest each IC) with the optical light path

through the cuvette holder completely

blocked.

When a cuvette containing a water and saline

diluent “blank” solution is placed in the

cuvette chamber, the output from pin 6 of IC6

changes to its adjusted value of -25 to -29

mV, and IC5 changes to between -55 mV and

-130 mV (the difference is due to unequal

optical characteristics).

These uneven outputs are balanced (with the

water or saline diluent blank still in the

cuvette chamber) by means of R38 and R42

(the two GAIN potentiometers next to the

large, square IC7 near the left center of the

Main board) for 18 mV ±0.1 mV (represent-

ing equal 18-uA currents) measured at the

ends of R37 (TP 540) and R41 (TP 454) near-

est the two potentiometers.

The direct reference voltage is then set (with

the water or saline diluent blank still in the

cuvette chamber) by pressing the Direct but-

ton and adjusting R43 (the SET DIRECT

potentiometer at the left front of the Main

board) for 18 mV ±0.1 mV at the end of R41

(TP 454) nearest R42.

Module IC7 is a log ratio converter which

performs the electrical analogy of the mathe-

matical equation,

The electronic circuits in the BR2 are con-

tained on two printed circuit boards, the Main

board and the Display board.

BR2100 Main Board Description

Power Supply Circuit: The power supply is

required to provide +15 V, - 15 V and +5 V

from either 100-120-V or 200-240-V AC

power. To accomplish this, transformer T1

has two equal primary windings which may

be connected either in series or parallel sim-

ply by positioning the small programming

card in the fuse holder/line cord socket (F1),

as marked on the card. Transformer T1 has

two secondaries, also.

One secondary provides 20-0-20 VAC at pins

8, 9 and 10. These voltages are rectified by

D11, filtered by C1 and C2, and fed to regu-

lators VR1 and VR2, which produce +15 V

and -15 V, respectively.

The other secondary provides 10-0-10 VAC

at pins 5, 6 and 7. These voltages are rectified

by D1 and D2, filtered by C5 and fed to regu-

lator VR3 which produces +5 V.

Lamp Circuit: The function of the lamp cir-

cuit is to tightly control the optical lamp volt-

age. Reference diode D4 supplies divider-

string R2, R3 and R4 with 6.9 V; potentiome-

ter R3 (LAMP ADJ in the right center area of

the Main board) allows the voltage across the

optical lamp to be accurately set at 3.35

±0.01 V (measured between X6 and X7, the

LAMP OUTPUT terminals on the right rear

side of the Main board). IC1 and Q1 form a

current amplifier with the voltage from the

arm of R3 as its reference.

After setting the lamp input voltage, the lamp

light output is optimized, by means of physi-

cal adjustment (see Lamp Adjustment sec-

tion), for an output of -25 to -29 mV from pin

6 of IC6 in the Signal Conditioning Circuit.


where Isig is the 454 nm photocurrent, Iref is

the 540 nm photocurrent, and k is set by

means of R45 to a value of 10.

With a water or saline diluent blank in the

light path, the output at pin 3 of IC7 should

be zero volts if the signal conditioning circuit

has been properly adjusted. Minor unbalance,

seen by the user as a non-zero readout with a

water or saline diluent blank in the light path,

is corrected by adjusting the Zero control

(R48) on the front panel.

Replacement IC7 modules may be supplied

with a different value R46 resistor for

improved Zero response.

When a known bilirubin standard is placed in

the light path, the output at pin 3 of IC7 goes

to a higher value, which is scaled by the user

via the Calibrate control on the front panel,

to calibrate the instrument. The voltage on

the arm of the Calibrate control potentiome-

ter is the calibrated signal input to the digital

voltmeter (DVM) circuit.

Digital Voltmeter (DVM) Circuit: Most of

the DVM circuit is contained within IC4,

which is of LSI (large scale integrated) con-

struction featuring a 0 to 2-volt input range

and automatic zeroing (auto-zero). C15 and

R25 form the time constant for its internal

clock, C16 is the auto-zero storage capacitor,

and C17 is the integration capacitor. Resistor

R27 and potentiometer R26 provide a 1 V ±1

mV reference. The outputs of IC4 are non-

multiplexed, parallel, seven-segment and

directly drive the three-digit LED (light emit-

ting diode) display without need of buffers.

Total/Direct Control Logic Circuit: This cir-

cuit translates the signals from the Total,

Direct, and Direct Timer switches into prop-

er form to correctly control each test selected.

During power-up, flip-flops IC3-C, D and

IC3-A, B are reset, causing pin 10 of IC3 to

turn on Q6 to light the Total LD. At that point

the operator may elect either to complete a

total bilirubin test, or switch to Direct for a

direct bilirubin test (see Bilirubin Test

Instructions).

Pressing the Direct button sets flip-flop IC3-

C, D, placing a high level on the base and

emitter of current amplifier Q4. The high

level on Q4 emitter turns on Q5, which lights

the Direct LED and turns on relay RL1.

Relay RL1 switches the pin 5 Isig input of

IC7 from monitoring the 454 nm signal from

IC6 to a negative reference voltage provided

by divider R44 and R43. This reference volt-

age has been factory-set after the balancing

procedure described in section Signal-

Conditioning Circuit, by switching to Direct

and adjusting R43 (the SET DIRECT ponte-

tiometer at the left front of the Main board)

for a zero readout with the water or saline

diluent blank still in the light path.

After pressing the Direct button for a direct

bilirubin test, the operator adds HC1 to the

cuvette, re-zeros the readout with R48 (the

Zero control on the front panel), adds the

diazo reagent to the cuvette, and presses the

Direct Timer button.

Pressing the Direct Timer button on the front

panel triggers IC1 on, causing its output to go

high for 2 minutes ±10 seconds as factory set

via R8 (the 2 MIN TIMER control on the

right rear edge of the Main board where it

may be adjusted through the round hole in the

back of the instrument cabinet) of the time

constant circuit R7, R8 and C9. While the

output from pin 3 of IC2 is high, it keeps Q2

turned on, lighting the Direct Timer LED.

At the end of the two-minute time period, IC2

turns off Q2, setting flip-flop IC3-A, B. This

causes pin 3 of IC3 to lock the readout dis-

play by placing a high level on pin 1 of IC4.

IC2 also enables Q3, at the end of the two-

minute time period, to repeatedly flash the

Direct Timer LED by means of the astatic

multivibrator circuit using Q7 and Q8.

Built-in Test Circuit: The built-in test circuit

enables the service technician to use the

EO = -k Log10Isig

Iref


DVM of the BR2 to measure and display, inplace of the mg/dl or µmol/1 readout, impor-tant circuit voltages at the following points:540, 454, DIR.POT, LAMP, D4 REF, +5, -15,and +15. This is accomplished by switchingS2 (the NORMAL/TEST toggle switch nearthe center of the Main board) from the NOR-MAL to the TEST position and manipulatingS3 (the long selector switch near the left centerof the Main board) as instructed in theTroubleshooting section, below.

CAUTION Be sure to return S2 to NOR-MAL and S3 to the far right(+15) position as soon as thistest is finished.

NOTE Beginning with instruments producedin 2016 or instruments having themain PCB, BR2100 replaced in 2016,the built-in test circuit will not beavailable.

BR2950 Display Board Description

The Display board contains the three-digit display modules, the Total, Direct and DirectTimer switches and LEDs, and the Zero andCalibrate controls. It is connected to theMain board by means of the J1-J2 ribboncable.


BR2 Description

The serial number suffix (referred in this manual simply as the suffix) indicates the revision of the

instrument. The charts below list the major changes made at each revision of the Model BR2.

Design Changes

No suffix Original model released.

February 1980

Serial Suffix ‘A’

November 1994

Serial Suffix ‘B’ Updated to carry the CE/ETL

August 1996 marks.

BR2E Description

No suffix Original model released.

February 1980

Serial Suffix ‘A’

November 1994

Serial Suffix ‘B’ Updated to carry the CE/ETL

August 1996 marks.


Interference Filter Set BR2650

Lamp BR2625

Display Board BR2950

Main Board BR2100

Fuses

.250-Amp Fuse for 110 VAC 70027

.125-Amp Fuse for 220 VAC 70028

Replacement Parts

Supplies & Accessories

Cuvettes, disposable B2A800

Total Bilirubin Test Kit,

Reagents and Cuvettes for

100 determinations B2A101

Total and Direct Test Kit,

Reagents and Cuvettes for

100 determinations B2A102

Power Cord (specify voltage and

country) ----------

Service Manual BR25SM

User’s Guide BR25

How to order:To order parts, supplies and accessories,

contact the Advanced Instruments Customer

Service.

• 800-225-4034 (toll-free within the USA

and Canada)

• +US 781-320-9000 (elsewhere)

• +US 781-320-3669 (fax)


Notes:

3. Maintenance


Preventive Maintenance

Optical Lamp

The lamp is subject to age-induced opera-

tional changes. Output brightness and color

shift will occur as the filament ages. For

proper operation, it is recommended that a

qualified service technician replace the lamp

and recalibrate the internal circuitry about

every two years.

Optical Filters

Two optical filters are employed, as shown in

the block diagram, below. Both filters have

optical coatings that will degrade over time,

resulting in decreased performance. It is rec-

ommended that the filters be replaced by a

qualified service technician, along with the

lamp, about every two years.

BR2 and BR2E Block Diagram

Cuvette

Lens

Lamp

Fiber opticBeamsplitter

FiltersPhoto

DetectorsSwitch

SignalProcessor

DigitalReadoutmg/dL

orµmol/L

Total

Direct

Notes:

4. Troubleshooting


Left X X X X X X X

S3 Position Label 540 454 DIR.POT LAMP D4 REF +5 -15 +15

mg/dl Readout(within 5%) 1.7 1.7 2.0-4.0 33.5 6.9 5.0 15.0 15.0

Circuit toTroubleshoot Signal Conditioning Lamp Power Supply

Right

Internal Self-Diagnosis Voltage Checks

NOTE Beginning with instruments producedin 2016 or instruments having themain PCB, BR2100 replaced in2016, the built-in test circuit will notbe available.

The built-in self-diagnosis circuit enables theservice technician to use the DVM circuit ofthe BR2 to measure and display (in place ofthe mg/dl or µmol/1 readout) several impor-tant circuit voltages.

Tools needed: Flat-bladed screwdriver, stop-watch.


Warning-Internal components may bedamaged by static electricity.

1. Shut off and unplug the BR2.

2. Remove the four screws from both sidesof the BR2 and pull the instrument coverstraight up and off.

3. Plug in and power the instrument careful-ly so that you do not contact the AC linevoltage between the fuse holder andpower transformer.

4. Press the Total button.

5. Switch S2 (the NORMAL/TEST toggleswitch near the center of the Main board)from NORMAL to TEST position.

6. Switch S3 (the long selector switch nearthe left center of the Main board) slowlyfrom right to left, one position at a time,while monitoring the mg/dl display. Thedisplay should read as shown in the chartbelow (within ±5%).

7. Press the Direct button, move S3 back tothe 454 position and recheck the readout.The 454 position readout listed in thetable above should also be indicated inthe Direct mode. If not, troubleshoot theR43 arm “Direct” reference voltage inputto R42 (see chapter 6, Wiring DiagramBR2003).

NOTE Be sure to return S2 to NORMALand S3 to the far right (+15) positionas soon as this test is finished.

8. Shut off and unplug the BR2. Replacethe instrument cover.


Notes:


1. Abrupt loss of power. a. Connection at both ends of the

line cord.

b. Power availability. Temporarily

unplug the line cord from its

wall outlet and replace with a

known workable lamp or small

appliance.

c. Instrument fuse continuity.

d. Line cord continuity.

Troubleshooting Table

Symptom Check Suggested Action

a. Make sure that the line cord is firmly

plugged into both the wall outlet and the

socket in the back of the instrument.

b. Have power restored.

c. Replace a defective fuse with a new SLO

BLO fuse of the same capacity (correct

capacity is also marked on the panel next

to the fuse holder).

d. Replace line cord.

2. Internal voltages do

not check as indicated

on the chart in section

Internal Self-

Diagnosis Voltage

Checks.

Troubleshoot further, as indicated

in the chart in section Internal

Self-Diagnosis Voltage Checks.

As indicated.

3. No display. a. See #1, above.

b. Power switch S1 in the left side

of the instrument base.

c. Whether LED 15 (in the left

center rear of the Main board) is

lit.

d. For -5 V at pin 26 of IC4.

e. For a 48 kHz clock output at pin

38 of IC4.

f. Ribbon cable J1-J continuity and

connections.

a. See #1, above.

b. Replace (you must pry the corner snaps

into position to hold the switch securely).

c. Replace VR3 (in the large heat sink to the

right of I5).

d. Replace D10, D11 and C2.

e. Replace IC4.

f. Replace ribbon cable J1-J2.

4. One display digit not

working.

a. Output pins of IC4 associated

with that digit.

b. The defective display-digit mod-

ule by substituting one of the

other display modules.

c. Ribbon cable J1-J2 continuity

and connections.

a. Replace IC4.

b. Replace defective display module I6, I7 or

I8.

c. Replace ribbon cable J1-J2.


5. One segment of a dis-play digit not working.

a. Temporarily connect a jumperfrom pin 37 of IC4 to +5 V totest all digit segments.

b. Ribbon cable J1-J2 continuityand connections.


a. Replace defective display module 16, 17or 18.

b.Replace ribbon cable J1-J2.

6. Readout cannot bezeroed using the oper-ating procedure in theUser’s Guide, Chapter2, InstrumentOperation.

a. Optical lamp I1 and the lampcircuit.

b. Pin 6 of IC5 for approximately -80 mV.

c. Pin 6 of IC6 for approximately -40 mV.

d. Pin 3 of IC7 for zero outputwhen the GAIN potentiometeroutputs at TP540 and 454 arebalanced at 20 mV.

e. Pin 36 of IC4 for +1 V with S2in the NORMAL position and itsarm temporarily grounded. If noS2, short jumper wire at S2.

a. Replace I1, IC1, Q1, or D4.

b.Replace IC5.

c. Replace IC6.

d.Replace IC7, R48, or J1-J2 ribbon cable.

e. Replace IC4.

7. Readout cannot be cal-ibrated.

a. Review User’s Guide Chapter 2,Instrument Operation, sectionsA and B.

b. The cuvette.

c. The standard.

d. The instrument.

a. Correct technique.

b. Try a clean cuvette.

c. Try another standard.

d. See item 9, below.

8. Readout cannot be cal-ibrated to read yourstandard correctly.

a. Pin 3 of IC7 for approximately+0.4 V.

b. The arm of S2 (the TEST/NOR-MAL switch near the center ofthe Main board) for approxi-mately +0.4 V. If no S2, usejumper wire at location of S2.

c. The optical filters for damage ordeterioration.

d.R45, R53.

a. Replace IC7.

b.Replace R47 (the Calibrate potentiometeron the Display board).

c. Replace the optical filters.


9. Total or Direct LED

does not light when

toggled with the Total

or Direct button on

the front panel.

a. The Direct button must be

pressed before pressing the


b. Pins 3 and 4 of IC2 for a high

after pressing the Direct Timer

button.


a. Press the Direct button before pressing the


b. Replace IC2, IC3 or Q4.

10. Direct Timer LED

does not light when

the Direct Timer but-

ton is pressed.

11. Direct LED will light,

but the instrument oth-

erwise appears to

remain in the Total

mode.

12. Direct Timer LED I2

does not flash after

two minutes.

a. Pin 3 of IC3 for a high.

b. Flip-flop Q7-Q8.

a. Replace IC3.

b. Replace Q7, Q8, C20, or C21.

For Total, check pin 10 of IC3 for

a high; for Direct, check pin 11 of

IC3 for a high.

Replace IC3, J1-J2 ribbon cable, I3, I4, S4,

S5, Q4, Q5, or Q6.

RL1. Replace RL1.

13. Direct Timer time is

not two minutes ±10

seconds.

a. Try resetting R8 (the control

accessible through the round

hole in the right rear of the

instrument cabinet).

b. IC2.

c. R7, R8 and C9.

a. Readjust R8.

b. Replace IC2.

c. Replace R7, R8 or C9.

14. The readout does not

lock when the Direct

Timer LED flashes at

the end of a Direct

test.

a. Pin 3 of IC3 for a high.

b. Pin 1 of IC4 for a high.

a. Replace IC3.

b. Replace IC4.

15. Light shining through

the cuvette holder

from the optical lamp

appears too dim or too

bright.

a. X6 and X7 (the LAMP OUT-

PUT terminals on the right rear

side of the Main board) for

+3.35 V.

b. If light is too dim but 3.35 V is

correct, replace I1.

c. Reference diode D4 for +6.9 V.

a. Adjust LAMP ADJ in the right center area

of the Main board.

b. Replace optical lamp I1 (see Lamp

Adjustment Procedure).

c. Replace D4.


Notes:

5. Adjustments

The Advanced® Model BR2 Service Manual37

Use this procedure following lamp replace-ment.

Tools needed: Flat-bladed screwdriver, 1/16”or 5 mm hex wrench, sensitive voltmeter*.


Warning-Internal components maybe damaged by static electricity.




4. Fill a cuvette half full of water and placeit in the cuvette holder (A).

5. Temporarily prop a strip of paper in frontof the light-entrance aperture (B) of thecuvette holder to act as a screen.

6. Make sure that S3 (the long selectorswitch near the left center of the Mainboard), if installed, is in the +15 position.Connect the voltmeter between groundand the end of R40 nearest IC6 (in the leftfront corner of the Main board).

7. Loosen the single setscrew in the top ofthe lamp block in the right front corner ofthe instrument base while firmly graspingthe lamp leads (C).

CAUTION Be careful when handling thehot lamp.

8. Gently pull back, then push the lampleads straight into the lamp block while

watching the light spot on the paper stripreduce and focus. Note that as the spotcomes into focus it appears oblong, notround. Rotate the lamp by its leads untilthe long axis of the light spot (i.e., the fil-ament) is vertical.

9. While holding the lamp in this position,remove the paper screen. Watching thevoltmeter readout, push the lamp slowlytoward the half-filled cuvette in thecuvette holder until the voltage peaks,then falls below -20 mV.

10. When the voltage falls below -20 mV,pull the lamp slowly back until it isbetween -25 and -29 mV. With theoblong light spot still held vertical and thevoltage between -25 and -29 mV, gentlyretighten the setscrew in the top of thelamp block until the lamp is held securelyin position, but not crushed.

CAUTION Tightening the lamp setscrewtoo much will either destroy thelamp immediately, or cause it toburn out very quickly. In eithercase, you would have to repeatthis entire adjustment procedurewith a new lamp.

11. When this adjustment has been accom-plished correctly, the light spot falling onthe cuvette holder aperture will be slightlylarger than the aperture, and the IC5 out-put voltage (measured at the end of R36nearest IC5) will be between -55 and -130mV.

If these criteria cannot be met, the lampvoltage may be slightly increased fromthe factory-set 3.35 volts. Follow theMeasuring Circuit Adjustment Procedure,except adjust R3 for a LAMP OUTPUTvoltage of 3.40 V. Then, repeat steps 5through 9, above.

Lamp Adjustment Procedure


12. With the half-full cuvette still in the

cuvette chamber, move the voltmeter

input lead from R36 to the end of R37

(TP 540) nearest R38 (the 540 GAIN

potentiometer next to the large, square

IC7 near the left center of the Main

board). Adjust R38 for a voltmeter read-

ing of 18 ±0.1 mV. Move the voltmeter

lead from R37 to the end of R41 (TP 454)

nearest 454 GAIN potentiometer R42 and

adjust R42 for a voltmeter reading of 18

±0.1 mV.

13. Complete the Direct Zero Adjustment

Procedure.

14. Shut off and unplug the BR2 before

replacing the instrument cover.

38


Use this procedure to readjust the measuring

circuit after replacing any circuit or optical

component.

NOTE Following lamp replacement, per-

form Lamp Adjustment Procedure

before performing Measuring Circuit

Adjustment.

1. Turn on the BR2 and allow it to warm up

for at least 30 minutes.

2. Press the Total button on the front panel.

3. Adjust potentiometer R3 (LAMP ADJ in

the right center of the Main board) so that

the LAMP OUTPUT voltage between ter-

minals X6 and X7 (on the right rear side

of the Main board) measures 3.35 ±0.01

V.

4. Adjust potentiometer R26 (D.V.M. CAL

near the center of the Main board) so that

the reference voltage between pins 36 and

32 of IC4 (the LSI module near the front

center of the Main board) is 1.000 ±0.001

V.

5. Block the optical light path through the

cuvette chamber completely with a black

object and adjust R39 (the 454 ZERO

SET potentiometer near the left front cor-

ner of the Main board) for 0 ±100 µV

measured at the end of R40 nearest IC6

(located in the same area).

6. With the light path still blocked, adjust

R35 (the 540 ZERO SET potentiometer to

the rear of the left front corner of the

Main board) for 0 ±100 µV measured at

the end of R36 nearest IC5 (located in the

same area). Remove the light-blocking

object from the cuvette chamber.

7. Fill a cuvette about half full of water and

load it into the cuvette chamber. Adjust

R38 (the GAIN potentiometer near the

large, square IC7 near the left center of

the Main board) for 18 ±0.1 mV meas-

ured at the end of R37 (TP 540) nearest

R38.

8. With the water blank still in the cuvette

chamber, adjust R42 (the 454 GAIN

potentiometer) for 18 ±0.1 mV measured

at the end of R41 (TP 454) nearest R42.

Retain this setup for the next test.

9. Press the Direct button on the front panel.

10. With the water blank still in the cuvette

chamber, adjust R43 (the SET DIRECT

potentiometer at the left front of the Main

board) for 18 ±0.1 mV at the end of R41

(TP 454) nearest R42 (the same test point

used in step 8, above).

11. Simultaneously start a stopwatch and

press the Direct Timer button. Halt the

watch when the Direct Timer LED begins

to flash. Adjust R8 (the 2 MIN TIMER

control on the right rear edge of the Main

board) and re-time as many times as nec-

essary to obtain a Direct Timer interval of

120 ±10 seconds.

If any of these adjustment steps cannot be

accomplished as indicated, troubleshooting is

required within the appropriate circuit (see

Troubleshooting Table).

Measuring Circuit Adjustment Procedure


Use this procedure to minimize the Zeroadjustment that may be required after switch-ing from Total to Direct during the OperatingProcedure..

Tools needed: Flat-bladed screw-driver.






4. Rotate the ten-turn Zero control knob allthe way either clockwise or counterclock-wise, then exactly five turns back to thecenter.

5. Make sure that toggle switch S2, ifinstalled, is at NORMAL, and selectorswitch S3, if installed, is at +15. AdjustR38 (the 540 GAIN potentiometer next tothe large, square IC7 near the left centerof the Main board) for a readout of exact-ly 00.0.

6. Press the Direct button. Adjust R43 (theSET DIRECT potentiometer at the leftfront of the Main board) for a readout ofexactly 00.0.

7. Shut off and unplug the BR2 beforereplacing the instrument cover.

Refer to the User’s Guide for warm-up, cali-bration and operating instructions. Rememberto allow 15 to 30 minutes warm-up beforerecalibration.

Direct Zero Adjustment Procedure

6. Replacement

Instructions

Interference Filter Set Replacement

BR2650

Reference: Use this instruction with replace-

ment kit BR2650.

Tools Needed: Flat-bladed screwdriver,

5/32” or 4 mm hex wrench,

1/16” or 1.5 mm hex wrench,

sensitive voltmeter*





NOTE Interference filter replacement and

lamp adjustment are indicated every

two years as preventive maintenance,

or when recommended by your serv-

ice representative.

Instruction:


ment.

2. Remove the four screws securing the

cover, and pull the cover straight up and

off.

3. Remove the large cap screw (A) from

each end of the filter block located in the

left front corner of the instrument base.

4. Lift the filter block enough for access to

the retaining screws holding the sensor

assemblies. Remove the two retaining

screws (B) holding the front (454) sensor

assembly.

5. Gently pull out the 454 sensor assembly

for access to the interference filter. Avoid

losing the O-ring.

NOTE Some previous interference filters

had two O-rings. Use only one with

the BR2650 filters.

6. Tap the filter block as necessary to dis-

lodge and remove the 454-nm interfer-

ence filter, and replace it with the appro-

priate filter from the BR2650 filter kit.

For additional information or technical assistance,

please contact Advanced Instruments Hot-Line®

Service Center (U.S. 1-800-225-4034, outside

North America +US 1-781-320-9000).

B2P650 Rev1

(BR25 Service Manual)

Page 1 of 2

A

B

B2P650 Rev1


Page 2 of 2

CAUTION

The two interference filters are not the same,

nor symmetrical. The filter nearest the front

of the instrument must be the one marked

454 or 4540, and the one furthest from the

front of the instrument must be the one

marked 540. Each filter must have its most-

flush, mirrored side inward toward the

fiberoptic beamsplitter, and its most yellow-

glass side outward, toward the sensor.

Avoid fingerprints on the filter faces. Check

them in oblique light and wipe off any finger-

prints with a clean cotton swab before

mounting.

7. Make sure one O-ring is in place. Using

two retaining screws, reinstall the 454

sensor assembly on the filter block.

8. Remove the two retaining screws holding

the 540 sensor assembly.

9. Gently pull out the 540 sensor assembly

for access to the interference filter. Avoid

losing the O-ring.

10. Tap the filter block as necessary to dis-

lodge and remove the 540-nm interfer-

ence filter. Replace it with the appropri-

ate filter from the BR2650 filter kit

(observe CAUTION, above).

11. Make sure one O-ring is in place. Using

two retaining screws, reinstall the 540

sensor assembly on the filter block.

12. Complete Lamp Adjustment Procedure

(see Service Manual).

Lamp Replacement KitBR2625

Reference: Use this instruction with replace-ment kit BR2625.

Tools Needed: Flat-bladed screwdriver,5/32” or 4 mm hex wrench,1/16” or 1.5 mm hex wrench,sensitive voltmeter*



CAUTION Improper connectionsmay cause damage to the instrument.

NOTE Lamp replacement is indicated when-ever the filament burns out or dimsto the extent that Zero adjustmentcannot be accomplished, or aboutevery two years as preventive main-tenance.

Instruction:

1. Turn off the power and unplug the instru-ment.

2. Remove the four screws securing thecover, and pull the cover straight up andoff.

3. Sever the leads of the old lamp from ter-minals X6 and X7 on the right rear sideof the Main board. Firmly secure thetinned tips of the new lamp leads to theseterminals and solder them with rosin-coreelectrical solder.

CAUTION Be careful when handling thehot lamp.

4. Loosen the single setscrew in the top ofthe lamp block in the right front corner ofthe instrument base. Pull the old lampgently by its leads, straight out to theright.

5. Plug in the instrument and turn on thepower.

CAUTION Be careful to avoid the AC linevoltage between the fuse holderand power transformer.

The new lamp should glow brightly.

6. Fill a cuvette half-full of water and placeit in the cuvette holder.

7. Temporarily prop a strip of paper in frontof the light-entrance aperture of thecuvette holder, to act as a screen.

*If a voltmeter capable of distinguishing18 ±0.1 mV is available, follow the“Lamp Adjustment Procedure” (ServiceManual). If a sensitive voltmeter is notavailable, the BR2 self-diagnosis circuitmay be substituted, as follows:

NOTE: Switch S2 and S3 may not beavailable on your instrument. Ifnot, the Service Manual “LampAdjustment Procedure” will berequired.

a. Switch S2 (the NORMAL/TEST toggle switch near the center of theMain board) from the NORMAL tothe TEST position; switch S3 (thelong selector switch near the left center of the Main board) to the 454position.

For additional information or technical assistance,please contact Advanced Instruments Hot-Line®Service Center (U.S. 1-800-225-4034, outsideNorth America +US 1-781-320-9000).

B2P625 Rev1(BR25 Service Manual)

Page 1 of 2

B2P625 Rev1(BR25 Service Manual)

Page 2 of 2

b. Grasping the new lamp by its leads,gently insert it into the lamp blockwhile watching the light spot on thepaper screen reduce and focus.

c. Note that as the spot comes intofocus, it appears oblong, not round.Rotate the lamp by its leads until thelong axis of the light spot (i.e., thefilament) is vertical.

d. While holding the lamp in this posi-tion, remove the paper screen.Watching the BR2 readout, push thelamp slowly toward the half-filledcuvette in the cuvette holder until thereadout peaks, then falls below 1.0.Slowly pull the lamp back until thereadout goes back up to 1.7 (filamentorientation should be retained).

e. At a readout of exactly 1.7, gentlyretighten the setscrew in the top ofthe lamp block so that the lamp isheld securely in position, but notcrushed.

CAUTION Tightening the lamp setscrewtoo much will either destroy thelamp immediately, or cause it toburn out very quickly. In eithercase, you would have to repeatthis entire adjustment procedurewith a new lamp.

8. When adjustment has been correctlyaccomplished, the light spot falling onthe cuvette-holder aperture will be justslightly larger than the aperture.

If this criterion cannot be met, the lampvoltage may be slightly increased fromthe factory-set 3.35 volts: Switch S3 (the

long selector switch) to the “LAMP”position and adjust R3 (LAMP ADJ inthe right center of the Main board) for adisplay readout of 34.0 (3.40 V). Thenswitch S3 back to the 454 position,loosen the lamp setscrew, and repeat step7, above.

9. Set toggle switch S2 to NORMAL andselector switch S3 to +15.

10. Complete the Direct Zero AdjustmentProcedure (see Service Manual).

Voltage Selection & Fuse Replacement

70027

70028

Reference: Use this instruction with replace-

ment part 70027 (.250-Amp) or

70028 (.125-Amp).

Voltage/Position/Fuse:

100-120 250V 1/4-Amp time delay

200-240 250V 1/8-Amp time delay

Tools Needed: Flat-bladed screwdriver.




Instruction:


ment.

2. Insert a flat-bladed screwdriver between

the fuse holder and the power entry mod-

ule. Carefully pry the fuse holder from

the power entry module.

3. Dislodge the old fuses and reinstall the

new fuses by placing them in the fuse

holder brackets.

4. Slide the indicator pin into the correct slot

on the voltage board.

5. Place the fuse holder back into the power

entry module, making sure the indicator

pin extends through the correct pin hole

on the fuse holder.

For additional information or technical assistance,

please contact Advanced Instruments Hot-Line®

Service Center (U.S. 1-800-225-4034, outside

North America +US 1-781-320-9000).

B2P70011 Rev2


Page 1 of 1

Indicator Pin

Voltage Selector Card

Fuse Block

Voltage Selector Card Orientation

7. Schematics

BR2003 Schematic

THIS DESIGN, DRAWING, AND

PRINTS ARE THE PROPERTY

OF ADVANCED INSTRUMENTS.

REPRODUCTION OF ANY KIND

IS PROHIBITED EXCEPT WITH

SPECIFIC PERMISSION OF

ADVANCED INSTRUMENTS.

BR2100 Main Board Assembly Drawing








BR2950 Display Board Assembly Drawing








Appendix A

Symbol Definitions


The following symbols may appear in product literature, or on intruments or product packaging.

On-Off

Feed

Interrupt

Test

Start

Stop

Record Review

Setup

Calibration

Cancel; Delete

Functional Arrow

Printer

Enter

RS232

Bar Code

Attention

Symbol Definitions

Caution Hot Surface

Dangerous Voltage

Lifting Hazard

Calibrator

Content

Control

Negative Control

Positive Control

Flammable

Fragile

Irritant

Keep Dry

Date Manufactured

Sterile

Non-Sterile

Serial Number


Solution

Do Not Open Top

Handle With Care

Toxic

Use Blade To Open

Do Not Re-Use

For In Vitro Diagnostic Use

European Conformity

Temperature Limit

See Instructions

Lot Number

Manufacturer

Use By; Expiration Date

Authorized Representative

Part Number

Sufficient for [x] Tests

Open Here

Low Fluid Level

Keep Hands Clear

Latex-Free

Diluent

See Instructions forTemperature Guidelines

Potential Puncture Hazard

Electronic Equipment -Dispose of Properly

x

Appendix B

Product Disposal and

Recycling


International concern about environmental

pollution resulting from improper disposal of

products and materials at the end of their use-

ful life has resulted in an increase in legisla-

tion to control the methods and procedures

used to handle waste electrical and electronic

equipment. While the regulatory status in

some regions of the world has progressed to

the point where formal legislation is already

in effect, many other regions are in the

process of creating similar legislation or

adopting that already in existence in other

areas. The result in the years ahead will be

more stringent control over disposal of prod-

ucts and recycling of their components once

they are withdrawn from use.

Since regulations governing the disposal of

your instrument and accessories may vary

depending upon your geographic location, the

following guidelines are provided to assist

you in identifying the options available to you

once the decision has been made to replace or

dispose of this product:

• Contact the supplier who sold you the

product. Whether this was Advanced

Instruments itself, or one of its author-

ized dealers, this supplier should be

knowledgeable about the national and

local regulations governing disposal

and recycling of products in your area.

In some cases, this supplier may be

legally obligated to accept the product

from you and arrange for proper dis-

posal or recycling with no further

involvement on your part. Alternately,

the supplier can provide you with spe-

cific instructions for actions that you

can take to dispose of the product prop-

erly.

• Contact your local government agency

responsible for waste collection and

disposal. They can identify procedures

and restrictions in effect to ensure

proper disposal, and available locations

where products can be sent.

• Contact Advanced Instruments Hot-

Line Service:

• 800 225-4034 (toll-free within the

USA and Canada; after normal busi-

ness hours, dial extension 2191)

• +US 781-320-9000 (elsewhere)

• 781-320-0811 (fax)

Service personnel will provide you

with contact information for local dis-

posal, or instructions for returning the

product directly to Advanced

Instruments.

Product Disposal and Recycling

Notes:


Appendix C

Service Log


Service Log

To call for Service: (781) 320-9000 or (800) 225-4034;

after normal business hours, dial extension

2191

FAX (781) 320-0811(

Model Number BR2 Serial Number

Symptoms Repairs, Replacements

or Problems or Changes Serviced by

Symptoms Repairs, Replacements

or Problems or Changes Serviced by



A

Adjustments

Direct Zero 40

Measuring Circuit 39

Lamp 37

C

Calibration 16

Circuit

Built-in Test 18

Description 17

Digital Voltmeter (DVM) 18

Lamp 17

Power Supply 17

Signal-condiitoning 17

Cuvette 16, 21

D

Design Changes 20

Display board 19, 21

E

Errors 16

F

Fuse 7, 10, 17, 21, 29

I

Instrument Specifications 7

L

Lamp 17, 21, 25, 37, 39

Lamp circuit 17

M

Main Board 17, 21

Maintenance 25

O

Optical lamp 17, 25, 29

P

Parts, Replacement 21

Power Supply 17, 29

Printed Circuit Board 17

R

Regulatory Notices 11

Removing the Cover 15

Replacement Parts 21

S

Safety 9

Service Assistance 8

Specifications 7

T

Temperature 7

Transformer 17, 29

Troubleshooting Table 31

V

Voltage 7, 9, 12, 17, 31, 37

Checks 29

Notes:


the advanced bilirubin stat-analyzer™ photometer

Documents