the biological war threat anthrax, black plague, and bird flu , oh , my !
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The Biological War Threat Anthrax, Black Plague, and Bird Flu , Oh , My !. Kimothy L. Smith, DVM PhD. Nevada Counties with Cases of Anthrax. Played in Las Vegas at the House of Blues in Feb 2012. MUSIC OF MASS DESTRUCTION. Overview. A Brief Bit of History Biological Warfare Programs - PowerPoint PPT PresentationTRANSCRIPT
The Biological War Threat
Anthrax, Black Plague, and Bird Flu, Oh, My!
Kimothy L. Smith, DVM PhD
Nevada Counties with Cases of Anthrax
MUSIC OF MASS DESTRUCTIONPlayed in Las Vegas at the House of Blues in Feb 2012
Overview
• A Brief Bit of History• Biological Warfare Programs• Bio-Terrorism and Biodefense• Emerging Infectious Diseases• Summary and Discussion
A Brief Bit of History
• The Siege of Caffa• European Settlement of America• George Washington
Locator Map of Caffa
Present Day Feodosija, Ukraine. Establish in 1266
Siege of Caffa
• The year 1346• First known use of Biological Warfare• Responsible for spreading the Black Death
from Crimea to Europe
European Settlement of America• In 1763 Lord Jeffrey Amherst purposely
distributed Smallpox virus contaminated blankets to American Indians
• In the mid-1800’s at least four different major epidemics struck the Plains tribes
George Washington
• Personal physician recorded in his journal that Washington had Anthrax
• Surgically removed the lesion from his thigh• Kept very secret
Recommended Reading
Biological Warfare Programs
• Country Program Status and Sverdlovsk• Biological Weapons Convention• Military vs. Civilian and Agricultural Threats
Program Status KeyProbablePossibleResearchFormer
SverdlovskAnthraxIncident
1979
Military housing south of Compound 19
Sverdlosvk 1979
Between 120 and 400 persons sick
At least 75 died
Initial report blamed contaminated meat
Later linked to release from bio-weapons facility
Multiple fragment sizes for vrrA loci
Biological and Toxin Weapons Convention
• The 1925 Geneva Protocol prohibited use of Biological Weapons
• The BTWC was opened for signature in 1972 and entered into force in 1975
• The Convention bans the development, production, stockpiling, acquisition and retention of microbial or other biological agents or toxins, in types and in quantities that have no justification for prophylactic, protective or other peaceful purposes.
Sec. of State Clinton at BWC Review Conference 7
“The nature of the problem is evolving. The advances in science and technology make it possible to both prevent and cure more diseases, but also easier for states and non-state actors to develop biological weapons. A crude, but effective, terrorist weapon can be made by using a small sample of any number of widely available pathogens, inexpensive equipment, and college-level chemistry and biology. Even as it becomes easier to develop these weapons, it remains extremely difficult…to detect them, because almost any biological research can serve dual purposes. The same equipment and technical knowledge used for legitimate research to save lives can also be used to manufacture deadly diseases.”
Military vs. Civilian and Agricultural Threat
• On the battlefield the threat of BW may be as effective (or more!) as actual use
• Is the enemy objective to kill or hinder (incapacitating agents) or consume resources?
• Control of BW agent after release may be difficult or impossible due to drift, etc., or use of infectious agent
Military vs. Civilian and Agricultural Threat
• Military use of BW agent on a civilian population? Biological Warfare or Bio-Terrorism?
• Attack on agricultural targets could be potentially more devastating, at least economically
• Accomplished by State or Non-state actors
Bioterrorism and Biodefense
• Aum Shinrikyo and Amerithrax• Biodefense Spending vs. Readiness• DIY Bio and Synthetic Biology• “The Birds are Already Doing That…”
Aum ShinrikyoAnthrax Attack
1993
Aum leader Chizuo Matsumotoaka Shoko Asahara
SterneLivestockVaccineStrain
Kameido(Aum Shinrikyo)
Isolate
vrrB1
vrrA
vrrC1
vrrC2
vrrB2CG3pXO1-AAT
-Both isolates lack pXO2 plasmid-Fragment sizes match for 7 loci
Sept. 18, 2001 Trenton Mailing of anthrax letters to NBC and NY Post and probably to the National
Enquirer.
Sept. 20 St. Petersburg Mailing of hoax letters to NBC and probably to NY Post [and National Enquirer?]
Sept. 21 place? Mailing of accusatory letter to Quantico Marine Base accusing Dr. Asaad, former USAMRIID scientist, as terrorist.
Sept. 19-25 NYC NBC received and opened ANTHRAX letter (brown granular sandy); not
recognized as dangerous, and not reported by media.
Sept. 25 NYC NBC received and opened HOAX letter postmarked 20 Sept; notified FBI but incident not reported by media.
Oct. 1 DC Washington Times article quoting SH (reprint from 11 Aug 97).
Oct. 2 Boca Raton Stevens (AMI) checked into hospital, near death, undiagnosed.
Oct. 4 Boca Raton First report of anthrax case, 5pm (Stevens, AMI).
Oct. 5 Boca Raton Death of first anthrax victim (Stevens, inhalation anthrax).
Oct. 5 St. Petersburg Mailing of hoax letters hoax letters to J. Miller at NY Times and H. Troxler at St. Petersburg Times.
Oct. 5-8 US media Suspicion of possible bioterrorism is increasing but mail not implicated.
Oct. 6-7 Boca Raton At AMI, spores found in 2nd worker and on Stevens' computer keyboard.
Oct. 8 Boca Raton2nd worker (Blanco, mailroom worker) at AMI sick, nasal spores detected; FBI takes over investigation, seals AMI office. Blanco later confirmed to have inhalation anthrax.
Oct. 9 US media Looks like bioterrorism (letters not yet recognized as source).
Oct. 9 St. Petersburg Troxler (St. P Times) opened hoax letter.
Oct. 9 Trenton Mailing of anthrax letters to Daschle and Leahy.
Oct. 10 Boca Raton 3rd AMI worker (2nd in mailroom) tests positive for anthrax. FBI now conducting criminal investigation. Anthrax strain appears to be Ames.
Oct. 10-12 US media First suspicion that source of anthrax at AMI might be a letter (not found), since two of those affected work in mailroom.
Oct. 12 NYC Miller at NYT opened hoax letter.
Oct. 12-13 US media First reports of any anthrax of hoax letters to media.
Oct. 12 NYC NBC cutaneous anthrax case reported (Brokaw's Assistant). First symptom was 25 Sept.
CSF smearThoracic radiograph
Bruce Ivins
Amerithrax
• The total cost of Amerithrax is incalculable
• 5 deaths and 24 infected person (known)
• Did the U.S. reaction cause this to be a “Black Swan” event?
Biodefense Spending
Federal Agency Biodefense Funding, FY2010-FY2011Biosecurity and Bioterrorism: Volume 8, Number 2, 2010
Civilian Biodefense Funding by Agency, FY2011 (in $millions)
Federal Agency Biodefense Funding, FY2010-FY2011Biosecurity and Bioterrorism: Volume 8, Number 2, 2010
Bio-Response Report Card
The Bipartisan WMD Terrorism Research Center’s Bio-Response Report Card October 2011, WMD Center Wash., DC wmdcenter.org
Do-it-yourself: Cathal Garvey, 26, poses in the biology laboratory he created in his mother's spare bedroom. – MIT Technology Review 2/13/12
DIY Bio
The Cat’s Out of the Bag
“The Birds are Already Doing That…”• National Institutes of Health funded
study to genetically modify H5N1 Influenza virus (Bird Flu) to be more easily transmitted between humans
• The research prompted the National Science Advisory Board for Biosecurity (NSABB), which advises the Department of Health and Human Services (HHS), to recommend that Science and Nature redact key information prior to publication
• Both NSABB and HHS expressed concerns that published details about the papers' methodology and results could become a blueprint for bioterrorism.
Emerging Infectious Diseases• West Nile Virus• Severe Acute
Respiratory Syndrome (SARS)
• Avian Flu• Swine Flu• Ebola Reston Virus• XDR TB
Summary and Discussion• BW Threat of yesterday likely
doesn’t exist today• Bioterrorism and EID’s are
“Black Swan” events• Balanced approach between
Biodefense and building Public Health Capability and Capacity is the most sound approach
• Despite fears of DIY Bio and Synthetic Biology openness of research keeps us safer
Questions or Comments?