the catana protontherapy beam delivery system

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The CATANA Protontherapy Beam Delivery System Laboratori Nazionali del Sud (INFN) Via S. Sofia 44 Catania, ITALY Cuttone G., Cirrone G.A.P., Lojacono P.A., Lo Nigro S., Raffaele L., Rovelli A.,Sabini M.G., Salamone V.

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The CATANA Protontherapy Beam Delivery System. Cuttone G., Cirrone G.A.P., Lojacono P.A., Lo Nigro S., Raffaele L., Rovelli A.,Sabini M.G., Salamone V. Laboratori Nazionali del Sud (INFN) Via S. Sofia 44 Catania, ITALY. - PowerPoint PPT Presentation

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Page 1: The CATANA Protontherapy Beam Delivery System

The CATANA

Protontherapy Beam Delivery System

Laboratori Nazionali del Sud (INFN)Via S. Sofia 44Catania, ITALY

Cuttone G., Cirrone G.A.P., Lojacono P.A., Lo Nigro S., Raffaele L., Rovelli A.,Sabini M.G., Salamone V.

Page 2: The CATANA Protontherapy Beam Delivery System

LNS Superconducting Cyclotron is the

unique machine in in Italy and South Europe used for protontherapy

Treatment of the choroidal melanoma

In Italy about 300 new cases for year

Page 3: The CATANA Protontherapy Beam Delivery System

•0 ° respect the switching magnet

•80 meter after extraction

•3 m proton beam line

LAYOUT OF LNSPRESENT TREATMENT ROOM

Page 4: The CATANA Protontherapy Beam Delivery System

OUR HISTORY STARTED THREE YEARS AGO......

1999

WITH A BARE BUT VERY STABLE TABLE

AND A SUPERCONDUCTOR CYCLOTRON SUITABLE FOR62 AMeV PROTON BEAM

Page 5: The CATANA Protontherapy Beam Delivery System

FIRST OF ALL WE TOOK IN CONSIDERATION TWO

PARAMETER FOR THE DEVELOPMENT OF OUR PROTON

BEAM DELIVERY SYSTEM:

ENERGY In order to obtain ranges up to 30 mm E.T.

OMOGENEITY In terms of lateral dose distribution in air

In order to reach a proton beam irradiation field:

Omogeneus within 2.5 %

With lateral penumbra of about 1mm

At least 30 mm in diameter

at isocenter in air

Page 6: The CATANA Protontherapy Beam Delivery System

WE DECIDED FOR A PASSIVE SCATTERER SYSTEM AND STUDIED THREE DIFFERENT EXPERIMENTAL

CONFIGUARATIONS

SIMULATION TOOLKIT : TRIM2000 UNDER NT OS

GEANT3.0 UNDER LINUX RED HAT 6.1 OS

SINGLE SCATTERER FOIL300 m Tantalum

DOUBLE SCATTERER FOIL80 m + 20 m Tantalum

DOUBLE SCATTERER FOIL WITH CENTRAL STOPPER15 m + 25 m + 7 mm thick copper beam stopper

Page 7: The CATANA Protontherapy Beam Delivery System

SIMULATION RESULTS

TRANSMITTED ENERGY [AMeV]

PRACTICAL RANGE

[mm WATER]

LATERAL OMOGENEITY [mm][FROM 95% TO 95%]

SINGLE FOIL

57.248 28.43 27

DOUBLE FOIL

57.625 29.12 24

DOUBLE FOIL WITH

BEAM STOPPER

60 30.97 47

Page 8: The CATANA Protontherapy Beam Delivery System

0

20

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60

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100

120

140

-40 -30 -20 -10 0 10 20 30 40

Distance from Isocenter [mm]

Nor

mal

ized

Dos

e D

istri

butio

n [%

]

MONTE CARLO SIMULATION

EXPERIMENTAL RESULT(Silicon Diode)

EXPERIMENTAL RESULTS

OUR BEAM PROFILE WITH A 50 mm DIAMETER FINAL COLLIMATOR

SIMULATION VS. EXPERIMENTAL RESULT

Page 9: The CATANA Protontherapy Beam Delivery System

0

20

40

60

80

100

120

0 5 10 15 20 25 30 35 40

Depth in Water [mm]

No

rmal

ized

Do

se

EXPERIMENTAL RESULTS

LNS PURE BRAGG PEAK

PRACTICAL RANGE

[mm water]

PEAK/PLATEAU RATIO

FWHM [mm

water]

DISTAL FALL-OFF [mm water]

Energy [AMeV]

EXPERIMENTAL DATA 30.9 4.5 3 0.8 60

SIMULATION DATA 30.97 4.47 2.7 0.6 60

Page 10: The CATANA Protontherapy Beam Delivery System

Scatterer system

Modulator & Range shifter

Monitor chambers

Ligth field

Laser

Page 11: The CATANA Protontherapy Beam Delivery System

WE EVALUATED THE PROTON BEAM LATERAL DISTRIBUTION ALONG OUR BEAM LINE

1. JUST AFTER THE FIRST SCATTERER

0

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140

-35 -25 -15 -5 5 15 25 35

Page 12: The CATANA Protontherapy Beam Delivery System

2. AFTER THE SECOND SCATTERER

0

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140

-35 -25 -15 -5 5 15 25 35

Page 13: The CATANA Protontherapy Beam Delivery System

3. AT ISOCENTER WITH A 25 mm COLLIMATOR

0

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80

100

120

140

-35 -25 -15 -5 5 15 25 35

Page 14: The CATANA Protontherapy Beam Delivery System

The actual distance beetwen modulator and range shifter is 33 cm

IN COLLABORATION WITH CCO WE PRODUCED A PRELIMINARY SET OF MODULATORS

0

10

20

30

40

50

60

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80

90

100

110

0 5 10 15 20 25 30 35

Depth in water [mm]

No

rmal

ized

Dep

th D

ose

Dis

trib

utio

n

It is interesting to note we didn’t find any difference in the experimental results, varing this distance from 15 cm up to 33 cm

Page 15: The CATANA Protontherapy Beam Delivery System

1999

ACTUALLY THE BEAM LINE IS READY

2002, February

Page 16: The CATANA Protontherapy Beam Delivery System

WE ACKNOWLEDGE FOR THEIR SUPPORT AND ENCOURAGEMENT:

CCO A. Kacperek

M. Sheen

PSI E. Egger

TRIUMF E. Blackmore

MGH B. Gottshalk

AND LAST BUT NOT AT LEAST

Prof. G. Biti University of Florence

For his support in clinical authorization