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The Faculty of Medicine of Harvard University Curriculum Vitae

Date Prepared: December 12, 2017

Name: Rosalynn M. Nazarian, MD

Office Address: 55 Fruit Street, Warren 834 Boston, MA 02114

Home Address: 15 Framar Road Wellesley Hills, MA 02481

Work Phone: (617) 726-8304

Work Email: rmnazarian@partners.org

Work FAX: (617) 726-8711

Place of Birth: Queens, New York, USA

Education

1999 BS magna cum laude

Biomedical Engineering Boston University College of Engineering

2003 MD Medicine Boston University School

of Medicine Postdoctoral Training

07/03 - 06/04 Intern General Surgery St. Elizabeth’s Medical Center

07/04 - 06/08 Resident Anatomic & Clinical Pathology Massachusetts General

Hospital 03/07 - 06/07 Chief Resident Clinical Pathology Massachusetts General

Hospital 07/08 - 06/09 Fellow Dermatopathology Harvard Combined

Program Faculty Academic Appointments

07/09 - 09/12 Instructor Pathology Harvard Medical School 09/12 - present Assistant Professor Pathology Harvard Medical School

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Appointments at Hospitals/Affiliated Institutions Past

07/09 - 07/13 Assistant in Pathology

Pathology Service Massachusetts General Hospital

Current

08/13 - present Assistant Pathologist Pathology Service Massachusetts General Hospital

06/13 - present Member Melanoma Program Dana-Farber/Harvard

Cancer Center Other Professional Positions Past

2016 Member, Board of Directors Global Fibrosis Foundation Current

2010 - present Medical Advisory Council Global Fibrosis Foundation 2017 - present President Global Fibrosis Foundation Major Administrative Leadership Positions Local

2014 - present Departmental Diversity Leader, Pathology Massachusetts General Hospital Committee Service Local

2002 Institutional Review Board Boston University Medical Center 2006 - 2008 Residency Training Review Committee Department of Pathology and Laboratory

Medicine, Massachusetts General Hospital 2010 Anatomic Pathology Laboratory

Information Systems Committee Department of Pathology, Massachusetts General Hospital

2010 - present Dermatopathology Fellowship Selection

Committee Departments of Pathology and Dermatology, Harvard Medical School Combined Program

2013 - present Computational Pathology Initiative Clinical and Laboratory Performance

Analysis Working Group, Pathology

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Service, Massachusetts General Hospital 2014 - present Diversity Committee Pathology Service, Massachusetts

General Hospital 2014 - present Leader 2014 - present Clinical Guidelines Development Multidisciplinary Calciphylaxis Team,

Massachusetts General Hospital 2014 - present Committee on Uniform Reporting Pathology Service, Massachusetts

General Hospital 2015 - present Anatomic and Molecular Pathology

Quality Assurance/Quality Improvement (QA/QI) Professional Advisory Committee

Pathology Service, Massachusetts General Hospital

National

2012 - present National Contributing Editor, Pathologist Recertification Individualized Self-Assessment Examination (PRISE) Committee

American Society of Clinical Pathology

International 2016 - present International Calciphylaxis Consensus

Panel American Society of Nephrology

Professional Societies

1995 - 1999 Biomedical Engineering Society Member 1996 - 1999 Society of Women Engineers, Boston

University Chapter Member

1996 - 1999 Vice President 1999 - 2003 Armenian Student’s Association, Boston

University Member

1999 - 2003 Treasurer 1999 - present Massachusetts Medical Society Member 2003 - present Armenian American Medical Association Member 2015 - present Secretary, Armenian American Medical

Association of Boston 2004 - present College of American Pathologists Member 2005 - 2008 New England Pathology Residents

Society Member

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2005 - present United States and Canadian Academy of Pathology

Member

2012 - present American Academy of Dermatology Member 2013 - present American Society of Dermatopathology Fellow Member 2015 - present Member, Continuing Education &

Research Committee

Grant Review Activities

2012 - present Study Section Global Fibrosis Foundation 2012 - present Ad hoc Member 2013 Study Section Swiss National Science Foundation 2013 Ad hoc Member Editorial Activities Ad hoc Reviewer

Advances in Dermatology and Allergology

American Journal of Clinical Pathology

American Journal of Pathology

Archives of Pathology and Laboratory Medicine

Cleveland Clinic Journal of Medicine

Cytometry

International Journal of Dermatology

Journal of the American Academy of Dermatology

Journal of Cutaneous Pathology

Journal of Investigative Dermatology

Melanoma Research

PLoS One

Proceedings of the National Academy of Sciences

Other Editorial Roles

2014 - present Associate Editor Journal of Cutaneous Pathology (Medical Dermatology, Drug Reactions, and Inflammatory Diseases Section)

2015 - present Editorial Board American Journal of Clinical Pathology

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Honors and Prizes

1995 - 1999 Dean’s List Boston University College of Engineering

1996 Member Golden Key International

Honour Society

1997 Alpha Eta Mu Beta National Honor Society for

Biomedical Engineers

1997 Selected for early admission Engineering/Medical Integrated

Curriculum (ENGMEDIC), Boston University School of Medicine

1998 Etchmiatzin Lodge

Scholarship Award Knights of Vartan

1999 Tau Beta Pi National Honor Society for

Engineers

1999 Senior Project First Place

Award Department of Biomedical Engineering, Boston University

1999 - 2001 Women Graduates’ Club

Scholarship Award Boston University

2000 Alumni Scholarship Award Boston University School of

Medicine

2000 Jerome Serchuck Summer

Research Award Boston University School of Medicine

2006 Second Pathology Prize Massachusetts General Hospital

Clinical Research Day

2006 Most Helpful Resident Award Massachusetts General Hospital 2011 First Junior Research Grant

Award Global Fibrosis Foundation

2011 Eleanor and Miles Shore

Fellowship Award Harvard Medical School

2012 Partners in Excellence

Award for Leadership and Innovation

Massachusetts General Hospital

2013 Partners in Excellence

Subspecialty Frozen Section Project Team Award for Operational Efficiency

Massachusetts General Hospital

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Report of Funded and Unfunded Projects Funding Information Past

2010 - 2012 Do Polymorphisms in TGF-1 gene Predispose Patients for the Development of Nephrogenic Systemic Fibrosis?

MGH Pathology Translational Research Grant, Austin L. Vickery Award Principal Investigator ($1,658.35) The goal of this study was to examine TGF-1 gene polymorphisms at codons 10 (T/C)

and 25 (G/C) for association with nephrogenic systemic fibrosis in patients with renal impairment and previous exposure to gadolinium.

2011 - 2012 Wnt and Hedgehog Signaling Pathway Activation in Cutaneous Fibrosing Disorders: a

Tissue Microarray Study Global Fibrosis Foundation, First Junior Investigator Award Principal Investigator ($10,000) MGH Pathology Mini-grant Principal Investigator ($2,000) The goal of this study was to screen for Wnt and Hedgehog signaling pathway protein

overexpression in keloid, hypertrophic scar, scleroderma and nephrogenic systemic fibrosis to offer a rationale for the use of Wnt and/or Hedgehog pathway inhibitors in fibrosing disorders of the skin. These results may potentially be generalized to fibrosing disorders involving other organ systems.

2011 - 2013 Characterization of T helper Cell Transcription Factors and Cytokine Signatures in

Acute Erythroderma and Chronic Dermatitis Eleanor and Miles Shore 50th Anniversary Fellowship Program in Medicine Principal Investigator ($25,000) The aim is to confirm the Th1- and Th2-skewed immune phenotype of psoriasis and

atopic dermatitis, respectively, and determine whether clinically acute exacerbations reflect loss of immune polarity towards Th17 expression predominance. The findings may form the basis for future clinical trials and therapeutic strategies aimed at shifting the Th1/Th2 balance during acute disease exacerbations to improve patient morbidity and mortality profiles.

2011 - 2016 The Vitamin D Receptor: Ligand-Dependent and Independent Actions National Institutes of Health R01 DK46974 Co-investigator (PI: Marie Demay, MD) My collaborative role in this study is to explore aberrant cutaneous wound healing in

Vitamin D receptor deficient mice using histopathology and immunohistochemical studies.

2013 - 2015 The effect of OASIS® Ultra on Critical Sized Wound Healing Healthpoint Biotherapeutics Co-investigator (PI: Daniel Yeh, MD) The aim of this study is to evaluate the speed and quality with which the dermal

substitute, OASIS® Ultra (tri-layer porcine small intestinal submucosa extracellular matrix), increases wound healing in the critical sized defect. My role is to histologically assess the amount of cellular recruitment, collagen deposition and neovascularization

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present in serial wound-edge patient skin biopsies. The composition of wounds with the dermal substitute and control wounds will be analyzed for healing time, healed wound quality (e.g. re-establishment of a dermis for further skin graft application), and hospital stay as compared with standard of therapy.

2014 - 2016 mTOR, VEGF, and c-kit Signaling Pathway Molecules in Kaposi Sarcoma MGH Pathology Translational Research Grant, Austin L. Vickery, Jr. Award Principal Investigator ($5,000.00) Current therapeutic options for advanced Kaposi sarcoma include radiation,

chemotherapy, and interferon-alpha, which are limited by low efficacy and high patient toxicity. Activation of mTOR, VEGF and c-kit signaling pathway molecules have been implicated in Kaposi sarcoma pathogenesis and may suggest a novel therapeutic role for inhibitors, including Rapamycin and Gleevec. Via this international research collaboration with the Aga Khan Hospital (Kisumu, Kenya), we analyze protein expression in 250 Kaposi sarcoma patients using a tissue microarray approach.

Current

2012 - 2017 Role of Vitamin D analogues, Stanniocalcin and Statins in the Development of Calcific

Uremic Arteriolopathy MGH, Department of Medicine, Renal Unit Funds Co-investigator (PI: Ravi Thadhani, MD) My collaborative role in this study is to evaluate cutaneous expression of stanniocalcin

1 (STC1) in patients with and without calciphylaxis; aid in the evaluation of vitamin D analogue administration and development of calciphylaxis in hemodialysis patients, and use of statins, agents which have anti-calcification, anti-thrombotic, and anti-inflammatory properties, in calciphylaxis (calcific uremic arteriolopathy) patients.

2014 - 2017 Phase I Trial of LDE225 for Steroid-Refractory cGVHD After Allogeneic HSCT Novartis Corporation (#LDE225XUS16T) Co-investigator (PI: Yi-Bin Chen, MD) Collaboration in correlative studies of a Phase I clinical trial using a Hedgehog pathway

inhibitor (LDE225, smoothened antagonist) in the treatment of refractory chronic graft-versus-host disease (cGVHD) in patients following allogeneic hematopoietic stem cell transplantation (HSCT). My role is to investigate pre- and post-treatment patient skin biopsies for the degree of pathologic fibrosis seen in cGVHD as assessed by myofibroblast mesenchymal cell proliferation and assayed for protein expression of Hedgehog signaling pathway molecules using immunohistochemistry. The safety and efficacy of LDE225 will be assessed for therapeutic response in cGVHD and shortened duration of corticosteroid therapy.

2015 - 2017 Does TNF- inhibitor therapy modulate Keratin 17 and ameliorate psoriasis? MGH Pathology Translational Research Grant, Austin L. Vickery, Jr. Award Principal Investigator ($5,000.00) TNF- binding to keratinocyte cell surface receptor, mediated by effect of keratin 17 on

TNF- receptor associated death domain (TRADD), activates transcription of downstream vascular cell adhesion molecule-1 (VCAM-1) which is recruited to endothelial cells by intercellular adhesion molecule-1, (ICAM-1) in response to proinflammatory cytokines. Keratin 17 expression in activated keratinocytes has been shown to induce Th1 and Th17 cytokine production which have been reported to play an etiopathogenic role in psoriasis. We examine the Th cell immune phenotype,

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epidermal keratin 17 expression, and endothelial cell ICAM and VCAM expression in

patients with TNF- treated psoriasis and untreated psoriasis as compared to patients

with TNF- induced psoriasiform dermatitis, and atopic dermatitis. These investigations will expand our understanding of the role of keratin 17 in psoriasis pathophysiology and

TNF- antagonist mechanism of action, and may implicate keratin 17 as a marker for monitoring clinical treatment response.

2016 - 2018 Polarized immune infiltrates in localized scleroderma and eosinophilic fasciitis – a

potential marker for histopathological differentiation? MGH Pathology Mini-Grant Program for Clinical Research Principal Investigator ($2,000.00) Localized scleroderma and eosinophilic fasciitis are rare fibrosing disorders that can

pose a diagnostic challenge. Both are postulated to be autoimmune, with T-cell mediated immunity playing a major pathogenic role. Animal and serological studies have shown polarized Th1 and Th2 immune responses in localized scleroderma and eosinophilic fasciitis. Limited data is available on the role of the more recently identified helper T-cell subtypes, Th17 and Th22, in fibrosis. We investigate whether T-cell immune polarization enables histopathologic distinction between localized scleroderma and eosinophilic fasciitis in patient skin biopsy specimens. Our findings may inform anti-fibrotic therapeutic strategy.

Unfunded Current Projects

2010 - present Telepathology consultations in Dermatopathology, Massachusetts General Hospital Principal Investigator The object of this work is to provide diagnostic support to pathologists in resource-poor

settings wherein access to expert subspecialty second-opinion consultations are limited by cost and lack of subspecialty training.

2012 - present Cambridge Hospital Alliance Digital Pathology Consultation Pilot Study, Massachusetts

General Hospital Participant The goal is to assess the diagnostic accuracy and feasibility of whole slide imaging for

interinstitutional consultations in dermatopathology as compared with clinical glass slide diagnosis.

2015 - present Immune-Related Trafficking and Signaling in Human Skin Associated with Low-Power,

Infrared Laser Treatment Co-Investigator, (PI: Mark Poznansky MD, PhD) The aim is to demonstrate that a non-painful and non-damaging dose of continuous

wave near infrared laser results in alteration of cytokine and chemokine signaling and a significant increase in the number of dendritic cells as assessed by histological and immunohistochemical analysis of human laser-treated and control skin punch biopsies.

2016 - present Wnt pathway expression in keloid and hypertrophic scarring: further evidence of a

wound healing continuum? Principal Investigator To determine whether fundamental differences exist in Wnt signaling pathway proteins

in abnormal healing resulting in keloids and hypertrophic scar formation.

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Report of Local Teaching and Training Teaching of Students in Courses

1999 - 2000 Tutor, Medical Physiology Boston University School of Medicine 1st year medical students 12 teaching sessions 2005 - 2007 Laboratory Instructor, Laboratory

Medicine Teaching Day Harvard Medical School

2nd year medical students 3 lab sessions 2007 - present Course Instructor, Principal Clinical

Experience (PCE) Conference Harvard Medical School

3rd medical year students 5 interactive clinical case-based sessions 2006 - 2014 Course Instructor, Immunology,

Microbiology & Pathology (IN754.0) Harvard Medical School

1st year medical students 4 lecture and slide review sessions per semester

2010 - 2015 Small Group Leader, Dermatology

(IN757.DER) Harvard Medical School

2nd year students 5 small group discussion sessions per semester

Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs)

2007 - 2008 Lecturer, Daily Bigelow Team Rounds Internal Medicine Department, MGH Internal medicine residents 64 1hour didactic sessions 2008 - 2009 Pathological Discussant, Patient Grand

Rounds Department of Dermatology, HMS

Dermatology attendings, residents, dermatopathology fellows and medical students

9 1 hour case based presentations

2009, 2011, 2014

Lecturer, Urgent Diagnoses in Dermatopathology

Pathology Service, MGH

Pathology residents 1 hour interactive lecture 2009 - 2015 Lecturer, Epidermal Cysts and Tumors Department of Dermatology, MGH Dermatology residents, fellows and

medical students 1 hour interactive lecture

2010 - 2015 Lecturer, Metabolic Disorders of the Skin Department of Dermatology, MGH Dermatology residents, fellows and

medical students 1 hour interactive lecture

2010 - 2016 Lecturer, Epithelial Neoplasms and Cystic

Lesions of the Skin Pathology Service, MGH

Pathology residents 1 hour interactive lecture

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2011 - 2012 Lecturer, Dermatopathology Unknowns Cases

Department of Dermatology, MGH

Dermatology residents, fellows and medical students

1 hour interactive lecture

2014 - 2016 Lecturer, Dermatopathology Jeopardy on

Inflammatory Reaction Patterns: Medical Dermatopalooza

Pathology Service, MGH

Pathology residents 1 hour interactive lecture 2014 - 2016 Lecturer, Dermatopathology Jeopardy on

Inflammatory Reaction Patterns: Medical Dermatopalooza (Mock Boards Review)

Department of Dermatology, MGH

Dermatology residents, medical students and dermatopathology fellows

1 hour interactive lecture

2015 - 2016 Lecturer, Introduction to

Dermatopathology, Core Curriculum Lecture Series

Department of Pathology, MGH

Pathology residents and visiting fellows 1 hour didactic session 2015 - 2016 Lecturer, Emergencies in

Dermatopathology, Resident Didactic Teaching Session

Department of Pathology, MGH

Pathology residents and visiting fellows 1 hour didactic session Clinical Supervisory and Training Responsibilities

2009 - present Teaching / Dermatopathology Sign-out Attending / Massachusetts General Hospital

Daily sessions, 34-40 weeks per year

Formally Mentored Harvard Medical, Dental and Graduate Students

2011 Elizabeth D. Chao, Medical Student, Harvard Medical School, Class of 2012 co-Sponsored her End-of-Rotation Case Presentation on Sezary Syndrome 2014 Oluwatobi Ogbechie, Medical Student, Harvard Medical School, Class of 2014 oral presentation entitled, Neutrophilic Panniculitis Associated With Vemurafenib

Therapy at the Gross and Microscopic Symposium, American Academy of Dermatology, 72nd annual meeting, and two poster presentations at the American Society of Dermatopathology 51st annual meeting.

2015 Amrita Goyal, Medical Student, Harvard Medical School, Class of 2015 Mentored funded research investigation on differential expression of hedgehog and

snail in cutaneous fibrosing disorders published in the American Journal of Clinical Pathology.

Mentored Trainees and Faculty

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2011 Katy R. Linskey, MD / Resident in Pathology, MGH Career stage: resident. Mentoring role: Molecular Pathology Research Conference

Sponsor. Accomplishments: 2 presentations at the Molecular Pathology Research Conference, MGH; (1) The Immunomodulatory Role of Keratin 17 in Basal Cell Carcinoma Pathogenesis; (2) Wnt signaling mediates epithelial and melanocytic stem cell cooperation in the hair follicle.

2011 Hilary F. Luderer, PhD / Instructor in Medicine, Endocrine Unit, MGH Career stage: Post-doc Mentoring role: NIH Career Development (K) Award Advisor.

Accomplishments: NIH Career Development (K) Award Advisor, The Vitamin D Receptor: Ligand-Dependent and Independent Actions in Wound Repair.

2012 Jason F. Solus, MD / Resident in Pathology, Massachusetts General Hospital Career stage: resident. Mentoring role: First-authored scholarship of mentored clinical

research. Accomplishments: oral presentation selected for the 13th Annual Duel in Dermatopathology, "Basaloid carcinoma of the breast – a potential diagnostic pitfall” at the 49th Annual Meeting of the American Society of Dermatopathology, which was awarded the 2nd place prize.

2012 Andrea Primiani, MD / Resident in Pathology, Massachusetts General Hospital Career stage: resident. Mentoring role: Gross Pathology Roundup Conference

Sponsor. Accomplishments: case presentation of Stewart-Treves Syndrome. 2012 Omonigho Aisagbonhi, MD / Resident in Pathology, Massachusetts General Hospital Career stage: resident. Mentoring role: Gross Pathology Roundup Conference

Sponsor. Accomplishments: case presentation of Blue Nevus. 2012 Amir Aboutalebi, MD, Dermatology Resident, Harvard Combined Program Career stage: resident. Mentoring role: Research Elective Faculty Mentor.

Accomplishments: abstract entitled, “Aleukemic Leukemia Cutis” presented at the 49th Annual Meeting of the American Society of Dermatopathology and manuscript published in Journal of Cutaneous Pathology.

2012 Katy R. Linskey, MD / Fellow in Dermatopathology, Harvard Combined Program Career stage: fellow. Mentoring role: First-authored scholarship of mentored clinical

research. Accomplishments: mentored her clinical research leading to a peer-reviewed publication, a plenary talk at the Yale Fibrosis Symposium, and three abstracts accepted for presentation.

2013 Andrea Primiani, MD / Resident in Pathology, Massachusetts General Hospital Career stage: resident. Mentoring role: First-authored scholarship of mentored clinical

research. Accomplishments: sponsored her presentation on Muir-Torre syndrome at the HMS Dermatopathology Update CME Course, Boston, MA. Mentored research investigation on the overlap in immune phenotype in acute psoriasis and acute atopic dermatitis, presented at the 50th annual meeting of the American Society of Dermatopathology and Massachusetts General Hospital Clinical Research Day (selected for Pathology Department award).

2013 Julie Tse, MD / Resident in Pathology, Massachusetts General Hospital Career stage: resident. Mentoring role: First-authored scholarship of mentored clinical

research. Accomplishments: sponsored her presentation on Ewing's sarcoma at the HMS Dermatopathology Update CME Course, Boston, MA. Mentored research

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investigation on the distribution of melanocytes in normal anal mucosa versus primary anal mucosal melanoma, presented at the MGH Clinical Research Day (selected for Pathology Department award).

2013 Jessica Wang, MD / Resident in Pathology, Massachusetts General Hospital Career stage: resident. Mentoring role: Molecular Pathology Research Conference Co-

sponsor. Accomplishments: presentation entitled, IQGAP1 and the RAS-MAP Kinase Pathway at Molecular Pathology Research Conference.

2014 Jonathan England, MD / Resident in Pathology, Massachusetts General Hospital Career stage: resident. Mentoring role: Molecular Pathology Research Conference Co-

sponsor. Accomplishments: presentation entitled, Melanoma: A Drug Addict? at Molecular Pathology Research Conference.

2014 - 2016 Andrea Primiani Moy, MD / Resident/Fellow in Pathology, Massachusetts General

Hospital, Harvard Combined Dermatopathology Fellowship Program Career stage: resident, fellow. Mentoring role: First-authored scholarship of mentored

clinical research. Accomplishments: 2014: oral presentation entitled, “Infantile GM1 Gangliosidosis: Clinicopathologic and Ultrastructural Findings” in the 15th annual Duel in Dermatopathology abstract competition at the 51st annual meeting of the American Society of Dermatopathology. 2015: Mentored funded research investigation on helper T-cell subtypes 17 and 22 in erythrodermic psoriasis and atopic dermatitis published in JAMA Dermatology. 2016: Mentored funded research investigation on keratin 17

expression and immune phenotype of anti-TNF- refractory psoriasis and anti-TNF- related psoriasiform dermatitis presented at the 105th United States and Canadian Academy of Pathology annual meeting. Mentored funded research investigation on helper T-cell immune polarization in localized scleroderma and eosinophilic fasciitis presented at the 53rd annual meeting of the American Society of Dermatopathology.

2014 Julie Tse, MD / Fellow in Dermatopathology, Harvard Combined Program Career stage: fellow. Mentoring role: First-authored scholarship of mentored clinical

research. Accomplishments: oral presentation on BRAFV600E immunohistochemical staining in anorectal mucosa – an important pitfall when evaluating anorectal melanoma selected for the Fellows’ Case Presentations of the American Society of Dermatopathology, 51st annual meeting.

2014 Darcy Kerr, MD / Resident in Pathology, Massachusetts General Hospital Career stage: resident. Mentoring role: Molecular Pathology Research Conference

Sponsor. Accomplishments: presentation entitled, Chemokines unleashed: tumor aggressiveness in Kaposi sarcoma at Molecular Pathology Research Conference.

2014 Satya V.P. Busarla, MD, Department of Pathology, Aga Khan Hospital, Kisumu,

Nyanza, Kenya Career stage: resident pathologist. Mentoring role: Clinical research mentor.

Accomplishments: oral presentation on: mTOR, VEGF, and c-kit signaling pathway activation in Kaposi Sarcoma: using a tissue microarray approach, at the XXXth International Congress of the International Academy of Pathology in Bangkok, Thailand

2015 Darcy Kerr, MD, Fellow in Bone and Soft Tissue Pathology, Massachusetts General

Hospital Career stage: fellow. Mentoring role: First-authored scholarship of mentored clinical

research. Accomplishments: Mentored research investigation on mTOR, VEGF, and c-

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kit signaling pathway activation in Kaposi Sarcoma presented at the 104th United States and Canadian Academy of Pathology annual meeting.

2017 Emmanuela Menard-Jeudy, inaugural intern in Diversity and Inclusion, and Core lab

employee, Massachusetts General Hospital Pathology Service Career stage: graduate student, Lesley University. Mentoring role: Internship site-

supervisor and first-authored scholarship of mentored clinical research. Accomplishments: Designed and supervised her internship as a component of her graduate studies in Intercultural Relations at Lesley University. Mentored research on “Characterization of applicants for residency training in pathology: does diversity exist?” submitted for the 2017 Harvard Medical School Pathology Annual Retreat.

2017 Diane Brackett, MD, Resident in Anatomic and Clinical Pathology, Massachusetts

General Hospital Career stage: resident. Mentoring role: Gross Pathology Roundup Conference

Sponsor. Accomplishments: case presentation of Proliferating Pilar Tumor at Gross Pathology Roundup Conference.

2017 Kristine M. Albin, MD, Resident in Anatomic and Clinical Pathology, Massachusetts General Hospital

Career stage: resident. Mentoring role: Faculty mentor to provide support, guide learning, and assist in the early stages of career development.

Formal Teaching of Peers (e.g., CME and other continuing education courses) No presentations below were sponsored by outside entities.

2008 Sclerosing Dermopathy 25 minute lecture Harvard Dermatopathology CME Course:

Dermatopathology Update with Minisymposium on Lymphoma and its Mimics

Boston, MA

2008 A 48-year-old woman with chronic kidney disease,

leg swelling, and a skin rash Clinicopathological Conference

Harvard Dermatopathology CME Course Boston, MA 2009 Fibrosing Disorders of the Skin with emphasis on

Nephrogenic Systemic Fibrosis 30 minute didactic lecture

Harvard Medical School CME course: Current Concepts in Surgical Pathology

Boston, MA

2010 Cutaneous Reaction to Novel Therapeutics 50 minute lecture Harvard Dermatopathology CME course:

Dermatopathology Update with Minisymposiums on Epidermal and Dermal Tumors, Inflammatory Dermatoses, and Melanocytic Lesions

Boston, MA

2011 Dermal Mucinoses 35 minute lecture Harvard Dermatopathology CME course:

Dermatopathology Update with Minisymposiums on Inflammatory Dermatoses, Melanocytic Lesions and Soft Tissue

Boston, MA

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2012 Vasculopathic Reaction Pattern – A case-based

approach 30 minute lecture

Harvard Dermatopathology CME Course: Dermatopathology Update with Minisymposiums on Inflammatory Dermatoses, Diagnostic Testing for Melanocytic Lesions, and “hands-on” slide seminar on Pediatric Dermatopathology

Boston, MA

2013 Vasculitis and Vasculopathy - Parts I & II 40 and 45 minute lectures Harvard Dermatopathology CME Course:

Dermatopathology Update with Minisymposiums on Inflammatory Dermatoses and Melanocytic Lesions, and “hands-on” slide seminar on Molecular signatures in Dermatopathology

Boston, MA

2013 Fibroproliferative Disorders of the Skin: Diagnostic

Considerations 30 minute lecture

Harvard Dermatopathology CME Course: Current Concepts in Surgical Pathology

Boston, MA

2014 Vasculitis and Vasculopathy: A diagnostic approach 30 minute lecture Harvard Medical School CME course: Current

Concepts in Surgical Pathology Boston, MA

2014 Small Group Slide Seminar, Dermatopathology:

Cutaneous Fibrosis and Inflammation 30 minute interactive digital case presentation

Harvard Medical School CME course Boston, MA 2015 Fibrosing Disorders of the Skin 45 minute interactive digital

case presentation Harvard Medical School CME course: Current

Concepts in Surgical Pathology Boston, MA

2015 Dermatopathology: Cutaneous Fibrosis and

Inflammation Small Group Slide Seminar

Harvard Medical School CME course: Current Concepts in Surgical Pathology

Boston, MA

2015 Vasculitis and Vasculopathy: a case-based approach 30 minute lecture Harvard Dermatopathology CME Course:

Dermatopathology Update Boston, MA

2015 A 65-year-old man with end-stage renal disease and

a pruritic rash, Case Records of the Massachusetts General Hospital

Clinicopathological Conference

Harvard Dermatopathology CME Course: Dermatopathology Update

Boston, MA

2016 Basal Cell Carcinoma and Differential Diagnosis 45 minute lecture Harvard Dermatopathology CME Course:

Dermatopathology Update Boston, MA

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2016 Emergencies in Dermatopathology 30 minute lecture Harvard Medical School CME course: Current

Concepts in Surgical Pathology Boston, MA

2016 Dermatopathology: Cutaneous Fibrosis and

Inflammation Small Group Slide Seminar

Harvard Medical School CME course: Current Concepts in Surgical Pathology

Boston, MA

2017 Vasculitis and Vasculopathy 30 minute lecture Harvard Dermatopathology CME Course:

Dermatopathology Update Boston, MA

2017 Cutaneous Manifestations of Systemic Disease 45 minute lecture Harvard Medical School CME course: Current

Concepts in Surgical Pathology Boston, MA

Local Invited Presentations

No presentations below were sponsored by outside entities. 2009 Headington Protocol for the Evaluation of Alopecia / Lecture Pathology Service, Massachusetts General Hospital 2009 Pathological Discussant, Pediatric Pathology Conference / Patient based presentation

and discussion Department of Surgery, Massachusetts General Hospital 2010 Pathological Discussant, Clinicopathological Conference, A 79-year-old man with

diffuse rash, hand swelling, and ocular erythema, Case Records of the Massachusetts General Hospital / Grand Rounds

Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital 2010 Pathological Discussant, Clinicopathological Conference, A 43-year-old woman with

fever and a generalized skin rash, Case Records of the Massachusetts General Hospital / Grand Rounds

Department of Dermatology, Massachusetts General Hospital 2011 Pathological Discussant, Ichthyosiform Dermatoses / Chief of Service Conference Pediatric Service, Massachusetts General Hospital for Children and Satellite Centers

via Teleconference (NWH, NSMC, CHA) 2011 Pathological Discussant, Junctional Epidermolysis Bullosa / Chief of Service

Conference Pediatric Service, Massachusetts General Hospital for Children and Satellite Centers

via Teleconference (NWH, NSMC, CHA) 2013 Pathological Discussant, Clinicopathological Conference, A 68-year-old man with

multiple myeloma, skin tightness, arthralgias, and edema, Case Records of the Massachusetts General Hospital / Medical Case Conference

Department of Medicine, Massachusetts General Hospital

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2013 Pathological Discussant, Calciphylaxis / Renal Grand Rounds Division of Nephrology, Massachusetts General Hospital and Brigham & Women's

Hospital via Teleconference 2015 The Fibrotic Dermis: in Health and in Disease / Grand Rounds (Joint presentation with

Drs. Andrew Tager and Marie Demay) Department of Pathology, Massachusetts General Hospital 2016 Pathological Discussant, Clinicopathological Conference, A 57-year-old woman with

fatigue, sweats, weight loss, headache, and skin lesions, Case Records of the Massachusetts General Hospital / Medical Grand Rounds

Department of Medicine, Massachusetts General Hospital 2016 Pathological Discussant, Calciphylaxis: A Multidisciplinary Approach / Medical Grand

Rounds Department of Medicine, Massachusetts General Hospital 2017 Secrets of Success / Invited speaker, STEM Youth Scholars Program Massachusetts General Hospital Center for Community Health Improvement

Report of Regional, National and International Invited Teaching and Presentations Invited Presentations and Courses

No presentations below were sponsored by outside entities. Regional

2012 The Vasculopathic Reaction Pattern: A Case Based Approach / Grand Rounds Department of Pathology and Laboratory Medicine, Boston University Medical Center,

Boston, MA 2012 Wnt and Hedgehog Signaling Pathway Activation in Cutaneous Fibrosing Disorders /

Plenary Talk (abstract) 6th Annual Yale Fibrosis Symposium, New Haven, CT 2014 Clinical and Academic Career Development Session / Panel Speaker Northeast Biomedical Engineering Career Conference, Sponsored by the Biomedical

Engineering Society, Hosted by Northeastern University, Boston, MA 2015 Dermatopathologic Manifestations of Intravenous Drug Use / Invited speaker Annual Meeting of the Armenian American Medical Association of Boston, Boston, MA 2016 A Case-based Approach to Vasculitis and Vasculopathy / Invited speaker Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH National

2006 Mitf, bcl-2 and iNOS Expression in Melanocytic Tumor Progression Using a Tissue

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Microarray Approach / Invited speaker Keystone Symposium: Advances in the Understanding and Treatment of Melanoma,

Santa Fe, NM 2008 Melanocytic Tumor Progression Tissue Microarray - Skin SPORE Update / Invited

speaker SPORE Summer Workshop, New Haven, CT 2008 From Nephrogenic Fibrosing Dermopathy to Nephrogenic Systemic Fibrosis, What

Have We Learned? / Invited speaker Department of Dermatology, New York University School of Medicine, New York, NY 2008 From Nephrogenic Fibrosing Dermopathy to Nephrogenic Systemic Fibrosis, What

Have We Learned? / Invited speaker Department of Pathology, MD Anderson Cancer Center, Houston, TX 2011 Cutaneous Vasculopathy and Vasculitis: A Clinicopathologic Approach / Invited

speaker American Society for Clinical Pathology via Teleconference 2012 Forum on: Vasculitis and Vasculopathy: An Update / Invited speaker American Academy of Dermatology, 70th Annual Meeting, San Diego, CA 2013 Nephrogenic Systemic Fibrosis: An Update / Grand Rounds Department of Pathology, Mayo Clinic, Rochester, MN 2013 Forum on: Vasculitis and Vasculopathy: An Update / Invited speaker American Academy of Dermatology, 71st Annual Meeting, Miami, FL 2014 Forum on: Vasculitis and Vasculopathy: An Update / Invited speaker American Academy of Dermatology, 72nd Annual Meeting, Denver, CO 2016 Vasculopathy and the Vasculopathic Reaction Pattern: A Case-based Approach /

Forum leader American Academy of Dermatology, 74th Annual Meeting, Washington, DC 2016 Calciphylaxis: A Case-Based Multidisciplinary Approach to Diagnosis and Treatment /

Invited speaker National Kidney Foundation, 2016 Spring Clinical Meeting, Boston, MA 2016 Difficult Differentials in Dermatopathology from the Massachusetts General Hospital /

Invited speaker Department of Dermatology, Rush University Medical Center, Chicago, IL 2016 Histopathology of Cutaneous Calciphylaxis / Invited speaker Kidney Week, 50th Anniversary of the American Society of Nephrology, Chicago, IL 2017 Cutaneous Calciphylaxis: An Update / Invited speaker Department of Pathology, University of Chicago, Chicago, IL 2017 Non-Langerhans Cell Histiocytoses, Short Course III / Invited speaker American Society of Dermatopathology, 54th Annual Meeting, Baltimore, MD

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International

2014 Vasculitis and Vasculopathy: A Case-based Approach / Grand Rounds Vardanants Center for Innovative Medicine, Yerevan, Armenia 2014 Whole Slide Imaging Teleconsultation Practice in Dermatopathology / Invited Speaker 2nd International Congress of the International Academy of Digital Pathology, Boston,

MA 2015 Hematoxylin and Eosin versus Immunohistochemistry in the Evaluation of Primary and

Metastatic Non-melanoma Skin Cancers / Invited speaker 23rd World Congress of Dermatology, Vancouver, Canada 2015 Dermatopathologic Manifestations of Intravenous Drug Use / Plenary Talk (abstract) 4th International Medical Congress, Yerevan, Armenia

Report of Clinical Activities and Innovations Current Licensure and Board Certification

2008 Massachusetts Medical License, Full 2008 Diplomate, American Board of Pathology, combined Anatomic Pathology and Clinical

Pathology 2010 Diplomate, American Board of Pathology and American Board of Dermatology,

Dermatopathology 2017 - present Physician Leadership Development Certificate Program, Massachusetts General

Hospital Physicians Organization Practice Activities

2009 - present Attending Dermatopathology Unit, Department of Pathology, MGH

Daily sessions, 34-40 weeks per year

Clinical Innovations

First Quantitative Approach to the Histopathologic Diagnosis of NSF

First-authored a publication reporting the first quantitative approach to the histopathologic diagnosis of Nephrogenic Systemic Fibrosis (NSF) using a simple, low-cost method based on enumerating dermal cellularity. A diagnostic cut-off range was established and no association between dermal cellularity and patient age, gender, duration of skin lesions, level of plasma creatinine, and symptom-preceding or cumulative gadolinium containing contrast agent dose was found suggesting that quantitative assessment of dermal cellularity is a reliable diagnostic aid in NSF cases.

Adoption of a Restrictive Gadolinium Policy at MGH Helps Prevent NSF

Co-authored a frequently cited publication describing the reduced incidence of NSF following the adoption of a restrictive gadolinium policy at MGH, a major public health achievement. After implementing strict guidelines on the

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use of gadolinium containing contrast agents for magnetic resonance imaging studies in patients with impaired renal function, we reported no new cases of NSF in MGH patients suggesting that this strategy effectively prevents the occurrence of this potentially lethal, rapidly progressive systemic fibrosing disorder.

Application of Static- Image Telepathology in East Africa

Senior-authored a study establishing the use of a static-image telepathology system for dermatopathology consultations in East Africa. This MGH-based study revealed that telepathology is a feasible means of rendering diagnoses on dermatopathology cases and is a cost-effective technology for obtaining much needed second opinions in resource poor settings.

Histopathology Quality Improvement Initiative at MGH

Improved the histopathologic evaluation of onychomycosis by a simple, rapid, cost-effective strategy utilizing a 20% sodium hydroxide (NaOH) pretreatment technique for processing the nail plate, a frequently problematic histologic specimen. This technique led to improved quality of tissue sections reducing the need for repeat sections, thereby reducing costs and preventing delays in turnaround time, and has been adopted nationally.

Histologic scoring parameters proposed to characterize wound healing

Identified a modified method for the histological assessment of cutaneous wound healing utilizing parameters of acute inflammation and tissue repair, as standardized criteria for the quantitative assessment of cutaneous wound healing remain undefined. Employing this practical, semi-quantitative scoring system enables rapid evaluation of suboptimal wound repair or advanced wound healing in serial skin biopsies without necessitating costly immunohistochemical stains.

Immunologic underpinnings of erythroderma revealed

Clinically, acute exacerbations of psoriasis and atopic dermatitis can result in erythroderma, a severe dermatitis characterized by diffuse erythema and scaling that can be life-threatening. Although psoriasis and atopic dermatitis show clinical and histopathological differences during chronic disease, they are difficult to distinguish during erythrodermic exacerbations. This senior-authored investigation published in JAMA Dermatology reveals an immunologic overlap of helper T-cell subtypes 17 and 22 in erythrodermic psoriasis and atopic dermatitis that belies the clinically and histopathologically indistinguishable erythrodermic state.

T-helper immune phenotype a clue to

‘paradoxical’ anti-TNF- therapy related psoriasiform dermatitis

Therapeutics targeting TNF-are effective for psoriasis, however, their mechanism of action has not been fully elucidated. Paradoxically, a subset of patients with psoriasis may worsen and psoriasiform dermatitis may arise de novo in patients treated for other disorders, such as inflammatory bowel disease. This senior-authored work demonstrates a skewed immune phenotype with Th1:Th2 reduction and Th17:Th1 increase in this patient

subset and supports a rationale for therapeutic targeting of IL17 and TNF- in combination.

Report of Education of Patients and Service to the Community No activities below were sponsored by outside entities. Activities

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2000 - present Judge, Massachusetts State Science and Engineering Fair, Massachusetts Institute of Technology, Cambridge, Massachusetts

2007 - 2009 Judge, Annual Science Fair of the Boston Public Schools, Northeastern University,

Boston, Massachusetts 2010 - present Dermatopathology Consultant, web-based telepathology program through Remote

Access for Health Professionals (RAHP), funded by the Aga Khan Development Network.

RAHP is telemedicine program that provides diagnostic and educational support to pathologists, physicians and house officers practicing at the Aga Khan University network hospitals in Kenya and Tanzania on challenging clinical and pathological cases.

2013 - present Job Shadow Host, National Job Shadow Day, sponsored by the MGH Center for

Community Health Improvement Youth Program and the Boston Private Industry Council.

Provide a job shadow experience in Pathology to increase awareness about diverse health careers among Boston public high school students.

2014 - present Massachusetts Institute of Technology (MIT) Student Host, MGH-MIT Physician

Shadow Program, sponsored by the MIT Global Education and Career Development Center.

Joint collaboration to generate interest in careers in medicine among MIT students. Recognition 2013 “Most Cited Article”: adverse cutaneous eruptions in

patients on TNF- antagonists

Journal of Cutaneous Pathology

2015 Publicity online: T-cell subtypes do not differentiate between erythrodermic psoriasis and dermatitis published in JAMA Dermatol

Managed HealthCare Connect

2017 Publicity online: chronic urticaria linked to a

Th2/Th17 shift in skin lesions published in JCP BrainImmune: Trends in Neuroendocrine Immunology

Report of Scholarship Peer-Reviewed Scholarship in print or other media Research Investigations

1. Wang Y, Lee HM, Avakian R, Winchester PA, Khilnani NM, Trost D. Timing algorithm for bolus

chase MR digital subtraction angiography. Magn Reson Med. 1998 May;39(5):691-696. PMID: 9581598.

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2. Ptak T, Hunter GH, Avakian R, Novelline RA. Clinical significance of cavernous carotid calcifications encountered on head computed tomography scans performed on patients seen in the emergency department. J Comput Assist Tomogr. 2003 Jul-Aug;27(4):505-509. PMID: 12886133.

3. Hull MJ*, Nazarian RM*, Wheeler AE, Black-Schaffer WS, Mark EJ. Resident physician opinions on

autopsy importance and procurement. Hum Pathol. 2007 Feb;38(2):342-350. PMID: 17134740. DOI: 10.1016/j.humpath.2006.08.011. *Equal contribution by authors

4. Koreishi AF, Nazarian RM, Saenz AJ, Klepeis VE, McDonald AG, Farris AB, Colvin RB, Duncan LM,

Mandal RV, Kay J. Nephrogenic systemic fibrosis: a pathologic study of autopsy cases. Arch Pathol Lab Med. 2009 Dec;133(12):1943-1948. PMID: 19961249. DOI: 10.1043/1543-2165-133.12.1943.

5. Abujudeh HH, Kaewlai R, Kagan A, Chibnik LB, Nazarian RM, High WA, Kay J. Nephrogenic systemic fibrosis after gadopentetate dimeglumine exposure: case series of 36 patients. Radiology. 2009 Oct;253(1):81-89. PMID: 19709997. DOI: 10.1148/radiol.2531082160.

6. Nazarian RM, Kapur P, Rakheja D, Piris A, Duncan LM, Mihm MC Jr, Hoang MP. Atypical and malignant hidradenomas: a histological and immunohistochemical study. Mod Pathol. 2009 Apr;22(4):600-610. PMID: 19252473. DOI: 10.1038/modpathol.2009.18.

7. Kabbarah O, Nogueira C, Feng B, Nazarian RM, Bosenberg M, Wu M, Scott KL, Kwong LN, Xiao Y, Cordon-Cardo C, Granter SR, Ramaswamy S, Golub T, Duncan LM, Wagner SN, Brennan C, Chin L. Integrative genome comparison of primary and metastatic melanomas. PLoS One. 2010 May 24;5(5):e10770. PMID: 20520718. PMCID: PMC2875381. DOI: 10.1371/journal.pone.0010770.

8. Jané-Valbuena J, Widlund HR, Perner S, Johnson LA, Dibner AC, Lin WM, Baker AC, Nazarian RM, Vijayendran KG, Sellers WR, Hahn WC, Duncan LM, Rubin MA, Fisher DE, Garraway LA. An oncogenic role for ETV1 in melanoma. Cancer Res. 2010 Mar 1;70(5):2075-2084. PMID: 20160028. PMCID: PMC2846410. DOI: 10.1158/0008-5472.CAN-09-3092.

9. Nazarian RM, Prieto VG, Elder DE, Duncan LM. Melanoma biomarker expression in melanocytic tumor progression: a tissue microarray study. J Cutan Pathol. 2010 Apr;37 Suppl 1:41-47. PMID: 20482674. DOI: 10.1111/j.1600-0560.2010.01505.x.

10. Cao H, Nazarian A, Ackerman JL, Snyder BD, Rosenberg AE, Nazarian RM, Hrovat MI, Dai G, Mintzopoulos D, Wu Y. Quantitative (31)P NMR spectroscopy and (1)H MRI measurements of bone mineral and matrix density differentiate metabolic bone diseases in rat models. Bone. 2010 Jun;46(6):1582-1590. PMID: 20188225. PMCID: PMC2875334. DOI: 10.1016/j.bone.2010.02.020.

11. Nazarian RM, Mandal RV, Kagan A, Kay J, Duncan LM. Quantitative assessment of dermal cellularity in nephrogenic systemic fibrosis: a diagnostic aid. J Am Acad Dermatol. 2011 Apr;64(4):741-747. PMID: 21414498. DOI: 10.1016/j.jaad.2010.05.034.

12. Wang Y, Alkasab TK, Narin O, Nazarian RM, Kaewlai R, Kay J, Abujudeh HH. Incidence of nephrogenic systemic fibrosis after adoption of restrictive gadolinium-based contrast agent guidelines. Radiology. 2011 Jul;260(1):105-111. PMID: 21586680. DOI: 10.1148/radiol.11102340.

13. Linskey KR, Dias-Santagata D, Nazarian RM, Le LP, Lam Q, Bellucci KS, Robinson-Bostom L, Mihm MC Jr, Hoang MP. Malignant neurocristic hamartoma: a tumor distinct from conventional melanoma and malignant blue nevus. Am J Surg Pathol. 2011 Oct;35(10):1570-1577. PMID: 21934481. DOI: 10.1097/PAS.0b013e31822389b7.

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14. Nazarian RM, Due B, Deshpande A, Duncan LM, Misdraji J. An improved method of surgical pathology testing for onychomycosis. J Am Acad Dermatol. 2012 Apr;66(4):655-660. PMID: 21816506. DOI: 10.1016/j.jaad.2011.05.046.

15. Hawryluk EB, Linskey KR, Duncan LM, Nazarian RM. Broad range of adverse cutaneous eruptions in patients on TNF-alpha antagonists. J Cutan Pathol. 2012 May;39(5):481-492. PMID: 22515220. DOI: 10.1111/j.1600-0560.2012.01894.x.

16. Frangos JE, Duncan LM, Piris A, Nazarian RM, Mihm MC Jr, Hoang MP, Gleason B, Flotte TJ, Byers HR, Barnhill RL, Kimball AB. Increased diagnosis of thin superficial spreading melanomas: A 20-year study. J Am Acad Dermatol. 2012 Sep;67(3):387-394. PMID: 22153791. DOI: 10.1016/j.jaad.2011.10.026.

17. Gimbel DC, Sohani AR, Prasad Busarla SV, Kirimi JM, Sayed S, Okiro P, Nazarian RM. A static-image telepathology system for dermatopathology consultation in East Africa: the Massachusetts General Hospital Experience. J Am Acad Dermatol. 2012 Nov;67(5):997-1007. PMID: 22341607. DOI: 10.1016/j.jaad.2011.12.036.

18. Hawryluk EB, Sober AJ, Piris A, Nazarian RM, Hoang MP, Tsao H, Mihm MC Jr, Duncan LM. Histologically challenging melanocytic tumors referred to a tertiary care pigmented lesion clinic. J Am Acad Dermatol. 2012 Oct;67(4):727-735. PMID: 22521204. DOI: 10.1016/j.jaad.2012.02.036.

19. Luderer HF, Nazarian RM, Zhu ED, Demay MB. Ligand-dependent actions of the vitamin D receptor are required for activation of TGF-β signaling during the inflammatory response to cutaneous injury. Endocrinology. 2013 Jan;154(1):16-24. PMID: 23132743. PMCID: PMC3529380. DOI: 10.1210/en.2012-1579.

20. Stewart RC, Bansal PN, Entezari V, Lusic H, Nazarian RM, Snyder BD, Grinstaff MW. Contrast-enhanced CT with a high-affinity cationic contrast agent for imaging ex vivo bovine, intact ex vivo rabbit, and in vivo rabbit cartilage. Radiology. 2013 Jan;266(1):141-150. PMID: 23192774. PMCID: PMC3528972. DOI: 10.1148/radiol.12112246.

21. Kapoor R, Piris A, Saavedra AP, Duncan LM, Nazarian RM. Wolf isotopic response manifesting as postherpetic granuloma annulare: a case series. Arch Pathol Lab Med. 2013 Feb;137(2):255-258. PMID: 23368868. DOI: 10.5858/arpa.2011-0643-OA.

22. Chan MP, Duncan LM, Nazarian RM. Subcutaneous Sweet syndrome in the setting of myeloid disorders: a case series and review of the literature. J Am Acad Dermatol. 2013 Jun;68(6):1006-1015. PMID: 23399459. DOI: 10.1016/j.jaad.2012.12.954.

23. Nigwekar SU, Bhan I, Turchin A, Skentzos SC, Hajhosseiny R, Steele D, Nazarian RM, Wenger J, Parikh S, Karumanchi A, Thadhani R. Statin use and calcific uremic arteriolopathy: a matched case-control study. Am J Nephrol. 2013;37(4):325-332. PMID: 23548843. PMCID: PMC4110510. DOI: 10.1159/000348806.

24. Le LP, Garibyan L, Lara D, Finberg KE, Iafrate AJ, Duncan LM, Kay J, Nazarian RM. Fibrosis-associated single-nucleotide polymorphisms in TGFB1 and CAV1 are not associated with the development of nephrogenic systemic fibrosis. Am J Dermatopathol. 2013 May;35(3):351-356. PMID: 23051628. DOI: 10.1097/DAD.0b013e31826c5508.

25. Corcoran RB, Rothenberg SM, Hata AN, Faber AC, Piris A, Nazarian RM, Brown RD, Godfrey JT, Winokur D, Walsh J, Mino-Kenudson M, Maheswaran S, Settleman J, Wargo JA, Flaherty KT, Haber

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DA, Engelman JA. TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanoma. Sci Transl Med. 2013 Jul 31;5(196):196ra98. PMID: 23903755. PMCID: PMC3867020. DOI: 10.1126/scitranslmed.3005753.

26. Linskey KR, Gimbel DC, Zukerberg LR, Duncan LM, Sadow PM, Nazarian RM. BerEp4, cytokeratin 14, and cytokeratin 17 immunohistochemical staining aid in differentiation of basaloid squamous cell carcinoma from basal cell carcinoma with squamous metaplasia. Arch Pathol Lab Med. 2013 Nov;137(11):1591-1598. PMID: 24168496. DOI: 10.5858/arpa.2012-0424-OA.

27. Aboutalebi A, Korman JB, Sohani AR, Hasserjian RP, Louissaint A Jr, Le L, Kraft S, Duncan LM, Nazarian RM. Aleukemic cutaneous myeloid sarcoma. J Cutan Pathol. 2013 Dec;40(12):996-1005. PMID: 24274424. DOI: 10.1111/cup.12231.

28. Nazarian RM*, Primiani A*, Doyle LA, Linskey KR, Duncan LM, Odze RD, Zukerberg LR. Cytokeratin 17: an adjunctive marker of invasion in squamous neoplastic lesions of the anus. Am J Surg Pathol. 2014 Jan;38(1):78-85. PMID: 24335642. DOI: 10.1097/PAS.0000000000000111. *Equal contribution by authors.

29. Jones NC*, Nazarian RM*, Duncan LM, Kamionek M, Lauwers GY, Tambouret RH, Wu CL, Nielsen GP, Brachtel EF, Mark EJ, Sadow PM, Grabbe JP, Wilbur DC. Interinstitutional whole slide imaging teleconsultation service development: assessment using internal training and clinical consultation cases. Arch Pathol Lab Med. 2015 May;139(5):627-635. PMID: 25415180. DOI: 10.5858/arpa.2014-0133-OA.

30. Moy AP, Murali M, Kroshinsky D, Duncan LM, Nazarian RM. Immunologic Overlap of Helper T-Cell Subtypes 17 and 22 in Erythrodermic Psoriasis and Atopic Dermatitis. JAMA Dermatol. 2015 Jul;151(7):753-760. PMID: 25760640. DOI: 10.1001/jamadermatol.2015.2.

31. Nigwekar SU, Kroshinsky D, Nazarian RM, Goverman J, Malhotra R, Jackson VA, Kamdar MM, Steele DJ, Thadhani RI. Calciphylaxis: risk factors, diagnosis, and treatment. Am J Kidney Dis. 2015 Jul;66(1):133-146. PMID: 25960299. PMCID: PMC4696752. DOI: 10.1053/j.ajkd.2015.01.034.

32. Cruz C, Abujudeh HH, Nazarian RM, Thrall JH. Ischemic colitis: spectrum of CT findings, sites of involvement and severity. Emerg Radiol. 2015 Aug;22(4):357-365. PMID: 25732355. DOI: 10.1007/s10140-015-1304-y.

33. Tse JY, Adisa M, Goldberg LJ, Nazarian RM. Dermatopathologic manifestations of intravenous drug use. J Cutan Pathol. 2015 Nov;42(11):815-823. PMID: 26345172. DOI: 10.1111/cup.12622.

34. Goyal A, Solus JF, Chan MP, Doyle LA, Schaffer A, Thakuria M, Horn TD, Duncan LM, Nazarian RM. Cytokeratin 17 is highly sensitive in discriminating cutaneous lymphadenoma (a distinct trichoblastoma variant) from basal cell carcinoma. J Cutan Pathol. 2016 May;43(5):422-429. PMID: 26968559. DOI: 10.1111/cup.12700.

35. Tse JY, Chan MP, Zukerberg LR, Nazarian RM. Assessment of melanocyte density in anorectal mucosa for the evaluation of surgical margins in primary anorectal melanoma. Am J Clin Pathol. 2016 May;145(5):626-634. PMID: 27247367. DOI: 10.1093/ajcp/aqw047.

36. Moy AP, Murali M, Nazarian RM. Identification of a Th2- and Th17-skewed immune phenotype in chronic urticaria with Th22 reduction dependent on autoimmunity and thyroid disease markers. J Cutan Pathol. 2016 Apr;43(4):372-378. PMID: 26785710. DOI: 10.1111/cup.12673.

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37. Song L, Papaioannou G, Zhao H, Luderer HF, Miller C, Dall'Osso C, Nazarian RM, Wagers AJ, Demay MB. The Vitamin D receptor regulates tissue resident macrophage response to injury. Endocrinology. 2016 Oct;157(10):4066-4075. PMID: 27526034. PMCID: PMC5045513. DOI: 10.1210/en.2016-1474.

38. Goyal A, Linskey KR, Kay J, Duncan LM, Nazarian RM. Differential expression of Hedgehog and Snail in cutaneous fibrosing disorders: implications for targeted inhibition. Am J Clin Pathol. 2016 Dec;146(6):709-717. PMID: 28077400. DOI: 10.1093/ajcp/aqw192.

39. Wang GY, Nazarian RM, Zhao L, Hristov AC, Patel RM, Fullen DR, Chan MP. Protein gene product 9.5 (PGP9.5) expression in benign cutaneous mesenchymal, histiocytic, and melanocytic lesions: comparison with cellular neurothekeoma. Pathology. 2017 Jan;49(1):44-49. PMID: 27914685. DOI: 10.1016/j.pathol.2016.09.061.

40. Nigwekar SU, Bloch DB, Nazarian RM, Vermeer C, Booth SL, Xu D, Thadhani RI, Malhotra R. Vitamin K-dependent carboxylation of matrix G1a protein influences the risk of calciphylaxis. J Am Soc Nephrol. 2017 Jan 3. pii: ASN.2016060651. PMID: 28049648. DOI: 10.1681/ASN.2016060651.

41. Yeh DD*, Nazarian RM*, Demetri L, Mesar T, Dijkink S, Larentzakis A, Velmahos G, Sadik KW. Histopathological assessment of OASIS Ultra on critical-sized wound healing: a pilot study. J Cutan Pathol. 2017 Jun;44(6):523-529. PMID: 28256051. DOI: 10.1111/cup.12925. *Equal contribution by authors.

42. Jank BJ, Goverman J, Guyette JP, Charest JM, Randolph MA, Gaudette GR, Gershlak JR, Purschke M, Javorsky E, Nazarian RM, Leonard DA, Cetrulo CL, Austen WG Jr, Ott HC. Creation of a bioengineered skin flap scaffold with a perfusable vascular pedicle. Tissue Eng Part A. 2017 Mar 21. [Epub ahead of print] PMID: 28323545. DOI: 10.1089/ten.TEA.2016.0487.

43. Moy AP, Maryamchik E, Nikolskaia OV, Nazarian RM. Th1- and Th17-polarized immune infiltrates in

eosinophilic fasciitis-A potential marker for histopathologic distinction from morphea. J Cutan Pathol. 2017 Jun;44(6):548-552. PMID: 28393380. DOI: 10.1111/cup.12947.

44. Kerr DA, Busarla SVP, Gimbel DC, Sohani AR, Nazarian RM. mTOR, VEGF, PDGFR, and c-kit signaling pathway activation in Kaposi Sarcoma. Hum Pathol. 2017 Jul;65:157-165. PMID: 28506734. DOI: 10.1016/j.humpath.2017.05.002.

45. Nigwekar SU, Jiramongkolchai P, Wunderer F, Bloch E, Ichinose R, Nazarian RM, Thadhani RI, Malhotra R, Bloch DB. Increased Bone Morphogenetic Protein Signaling in the Cutaneous Vasculature of Patients with Calciphylaxis. Am J Nephrol. 2017 Nov;46(5):429-438. PMID: 29130990. DOI: 10.1159/000484418.

46. Inoue Y, Liu YM, Otawara M, Calero CI, Nam AS, Yu YM, Chang P, Butler KL, Nazarian RM, Goverman J, Vakoc BJ, Irimia D. Resolvin D2 Limits Secondary Tissue Necrosis after Burn Wounds in Rats. J Burn Care Res. 2017 Aug 31. [Epub ahead of print] PMID: 28877131. DOI: 10.1097/BCR.0000000000000617.

47. Moy AP, Murali M, Kroshinsky D, Horn T, Nazarian RM. T-helper immune phenotype may underlie

‘paradoxical’ TNF-alpha inhibitor therapy related psoriasiform dermatitis. Clin Exp Dermatol. 2017 Sep 22. [Epub ahead of print]. PMID: 28940220. DOI: 10.1111/ced.13227.

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48. Tse JY, Chan MP, Ferry JA, Deshpande V, Sohani AR, Nardi V, Schaffer A, Nazarian RM, Zukerberg LR. Syphilis of the digestive tract: a clinicopathologic study. Am J Surg Pathol. 2017 Nov 9. [Epub ahead of print]. PMID: 29135519. DOI: 10.1097/PAS. 0000000000000987.

49. DeFilipp Z, Nazarian RM, El-Jawahri A, Li S, Brown J, Del Rio C, Smith M, Valles B, Ballen KK, McAfee SL, Rosenblatt J, Antin JH, Cutler CS, Chen, YB. A phase I study of the Hedgehog signaling pathway inhibitor sonidegib for steroid-refractory chronic graft-versus-host disease. Blood Adv. In Press.

Reviews, chapters, monographs and editorials

1. Nazarian RM, Duncan LM. Pleomorphic Melanoma with Osteoclast-like Giant Cells. In: Zembowicz A, volume editor. Cases in Dermatopathology: Common Problems in Diagnosis of Pigmented Lesions. Brisbane, Queensland, Australia: Knowledge Books and Software; 2006. pp. 177-187.

2. Nazarian RM, Zembowicz A, Duncan LM. Warfarin-Induced Skin Necrosis. In: Zembowicz A, volume editor. Cases in Dermatopathology: Critical Diagnoses in Dermatopathology. Brisbane, Queensland, Australia: Knowledge Books and Software; 2007. pp. 97-108.

3. Baran JL, Nazarian RM, Duncan LM. Rocky Mountain Spotted Fever. In: Zembowicz A, volume

editor. Cases in Dermatopathology: Critical Diagnoses in Dermatopathology. Brisbane, Queensland, Australia: Knowledge Books and Software; 2007. pp. 39-43.

4. Nazarian RM, Laposata M. Anticoagulant Therapies. In: McKean SC, Bennett AL, Halasyamani LK,

volume editors. Hospital Medicine – Just the Facts. New York, USA: McGraw-Hill Publishers; 2008. pp. 506-514.

5. Nazarian RM, Mihm, Jr MC. Inflammatory Myxohyaline Tumor. In: Hoang MP, volume editor. Cases

in Dermatopathology: Diagnostic Pitfalls in Dermatopathology. Brisbane, Queensland, Australia: Knowledge Books and Software; 2008. pp. 71-85.

6. Nazarian RM, Mandal RV, Duncan LM. Nephrogenic Systemic Fibrosis. In: Hoang MP, volume

editor. Cases in Dermatopathology: Diagnostic Pitfalls in Dermatopathology. Brisbane, Queensland, Australia: Knowledge Books and Software; 2008. pp. 57-69.

7. Nazarian RM, Piris A, Hoang MP. Cutaneous Metastasis of Squamous Cell Carcinoma. In: Hoang

MP, volume editor. Cases in Dermatopathology: Suboptimal Biopsies in Dermatopathology. Brisbane, Queensland, Australia: Knowledge Books and Software; 2009. pp.157-168.

8. Nazarian RM. Book Review of: Biopsy Interpretation of the Skin: Primary Non-Lymphoid Cutaneous

Neoplasia, by A. Neil Crowson, Cynthia Magro and Martin C. Mihm, Jr., American Journal of Surgical Pathology, 2010.

9. Linskey KR, Nazarian RM. Melanoma Regression versus Halo Nevus. In: Hoang MP, volume editor.

Cases in Dermatopathology: Mimicry in Melanocytic Lesions. Brisbane, Queensland, Australia: Knowledge Books and Software; 2010. pp. 21-30.

10. Nazarian RM. Book Review of: Dermatopathology: a volume in the series Foundations in Diagnostic

Pathology, by Klaus J. Busam, series editor: John R. Goldblum. Diagnostic Cytopathology, 2010. 11. Gimbel D, Nazarian RM. Cutaneous Zygomycosis (Rhizopus). In: Hoang MP, volume editor. Cases

in Dermatopathology. Brisbane, Queensland, Australia: Knowledge Books and Software; 2011. pp. 15-22.

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12. Kay J, Nazarian RM. Nephrogenic Systemic Fibrosis. In: Matucci-Cerinic M, Piette W, editors.

Rheumatic Diseases and the Skin. Philadelphia, PA, USA: Elsevier, Inc; 2011. pp. 247-254. 13. Solus JF, Nazarian RM. Supernumerary digit. In: Hoang MP, volume editor. Cases in

Dermatopathology: Pediatric Dermatopathology. Brisbane, Queensland, Australia: Knowledge Books and Software; 2012. pp. 13-19.

14. Primiani A, Nazarian RM. Dystrophic epidermolysis bullosa. In: Hoang MP, volume editor. Cases in

Dermatopathology: Pediatric Dermatopathology. Brisbane, Queensland, Australia: Knowledge Books and Software; 2012. pp. 55-65.

15. Goyal A, Goyal K, Carter JB, Barnes JA, Nazarian RM, Hoang MO, Piris A, Kupper T, Duncan LM.

Mycosis Fungoides. In: Carter JB, Goyal A, Duncan LM, editors. Atlas of Cutaneous Lymphomas: Classification and Differential Diagnosis. Cham: Springer; 2015. pp. 31-60.

16. Wigley F, Nazarian RM. Case 8-2015: A Man with Multiple Myeloma, Skin Tightness, Arthralgias, and Edema. N Engl J Med. 2015 Jun 18;372(25):2466. PMID: 26083221. DOI: 10.1056/NEJMc1504514.

17. Moy AP, Dehner L, Nazarian RM. Chapter 69: Non-Langerhans cell histiocytoses. In: Gru A, Schaffer

A, editors. Hematopathology of the Skin: A Clinical and Pathological Approach. Philadelphia, PA USA: Wolters Kluwer Health; 2017. pp. 647-658.

18. Moy AP, Dehner L, Nazarian RM. Chapter 72: Intralymphatic histiocytosis and Melkersson-Rosenthal

syndrome. In: Gru A, Schaffer A, editors. Hematopathology of the Skin: A Clinical and Pathological Approach. Philadelphia, PA USA: Wolters Kluwer Health; 2017. pp. 671-678.

19. Bledsoe J, Dehner L, Nazarian RM. Chapter 67: Benign and Malignant Langerhans Cell

Proliferations. In: Gru A, Schaffer A, editors. Hematopathology of the Skin: A Clinical and Pathological Approach. Philadelphia, PA USA: Wolters Kluwer Health; 2017. 633-640.

20. Bledsoe J, Dehner L, Nazarian RM. Chapter 70: Reticulohistiocytoma and Reticulohistiocytosis. In:

Gru A, Schaffer A, editors. Hematopathology of the Skin: A Clinical and Pathological Approach. Philadelphia, PA USA: Wolters Kluwer Health; 2017. pp. 659-664.

Case reports

1. Su HS, Nazarian RM, Scott JA. Case report. Appearance of nephrogenic fibrosing dermopathy on a bone scan. Br J Radiol. 2009 Feb;82(974):e35-36. PMID: 19168688. DOI: 10.1259/bjr/20570152.

2. Nazarian RM, Van Cott EM, Zembowicz A, Duncan LM. Warfarin-induced skin necrosis. J Am Acad Dermatol. 2009 Aug;61(2):325-332. PMID: 19615543. DOI: 10.1016/j.jaad.2008.12.039.

3. Kroshinsky D, Kay J, Nazarian RM. Case records of the Massachusetts General Hospital. Case 37-

2009. A 46-year-old woman with chronic renal failure, leg swelling, and skin changes. N Engl J Med. 2009 Nov 26;361(22):2166-2176. PMID: 19940302. DOI: 10.1056/NEJMcpc0907802.

4. Kroshinsky D, Stone JH, Nazarian RM. Case records of the Massachusetts General Hospital. Case

22-2011. A 79-year-old man with a rash, arthritis, and ocular erythema. N Engl J Med. 2011 Jul 21;365(3):252-262. PMID: 21774714. DOI: 10.1056/NEJMcpc1100929.

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5. Mackool BT, Goverman J, Nazarian RM. Case records of the Massachusetts General Hospital. Case 14-2012. A 43-year-old woman with fever and a generalized rash. N Engl J Med. 2012 May 10;366(19):1825-1834. PMID: 22571205. DOI: 10.1056/NEJMcpc1111572.

6. Prasad Busarla SV, Sayed S, Nazarian RM, Gimbel DC, Moloo Z, Sohani AR. Kaposi sarcoma in

association with molluscum contagiosum: an uncommon diagnosis in a single biopsy and potential diagnostic pitfall. Am J Dermatopathol. 2012 Feb;34(1):e7-9. PMID: 22262366. DOI: 10.1097/DAD.0b013e31822438c6.

7. Crotty R, Nazarian RM, Song PI, Van Cott EM. Heparin, warfarin, or calciphylaxis? Am J Hematol.

2014 Jul;89(7):785-786. PMID: 24470428. DOI: 10.1002/ajh.23679. 8. Allegretti AS, Nazarian RM, Goverman J, Nigwekar SU. Calciphylaxis: a rare but fatal delayed

complication of Roux-en-Y gastric bypass surgery. Am J Kidney Dis. 2014 Aug;64(2):274-277. PMID: 24787764. DOI: 10.1053/j.ajkd.2014.02.029.

9. Kedrin D, Masia R, Nazarian RM, Garber JJ. Mycobacterium chelonae bacteremia after first dose of

infliximab for ulcerative colitis. Am J Gastroenterol. 2014 Sep;109(9):1501-1502. PMID: 25196883. PMCID: PMC4423733. DOI: 10.1038/ajg.2014.209.

10. Nambudiri VE, Solus JF, Staszewski R, Winkfield KM, Duncan LM, Nazarian RM, Carter JB. Isolated

nodule on the ear. J Am Acad Dermatol. 2015;72(1):e21-22. DOI: http://dx.doi.org/10.1016/j.jaad.2014.06.041.

11. Cohen JM, Nazarian RM, Ferry JA, Takvorian RW, Carter JB. Rare presentation of secondary

cutaneous involvement by splenic marginal zone lymphoma: report of a case and review of the literature. Am J Dermatopathol. 2015 Jan;37(1):e1-4. PMID: 25238446. DOI: 10.1097/DAD.0000000000000055.

12. Wigley F, Friday RP, Shepard JA, Nazarian RM. Case records of the Massachusetts General

Hospital. Case 8-2015. A 68-year-old man with multiple myeloma, skin tightness, arthralgias, and edema. N Engl J Med. 2015 Mar 12;372(11):1056-1067. PMID: 25760359. DOI: 10.1056/NEJMcpc1409840.

13. Vedak P, Nazarian RM, Kroshinsky D. A case of eczematid-like purpura of Doucas and Kapetanakis

in a child. Pediatr Dermatol. 2015 Mar-Apr;32(2):291-292. PMID: 25641544. DOI: 10.1111/pde.12507.

14. Solus JF, Goyal A, Duncan LM, Nazarian RM. Basaloid Carcinoma of the Breast Mimicking

Cutaneous Basaloid Neoplasms. Am J Dermatopathol. 2015 Sep;37(9):e102-106. PMID: 25229570. DOI: 10.1097/DAD.0000000000000209.

15. Vedak P, St John J, Watson A, Garibyan L, Mihm MC, Nazarian RM, Levins PC, Cetrulo CL Jr,

Schalock P, Kroshinsky D. Delayed type IV hypersensitivity reaction to porcine acellular dermal matrix masquerading as infection resulting in multiple debridements. Hernia. 2017 Jun;21(3):489-492. PMID: 26693715. DOI: 10.1007/s10029-015-1440-z.

16. Nambudiri VE, Nambudiri NS, Nazarian RM, Tsao SS. A rash starting on the palms and soles. BMJ.

2015 Oct 19;351:h5452. PMID: 26481515. 17. Lorenzo ME, Carter JB, Barnes JA, Nazarian RM. Case records of the Massachusetts General

Hospital. Case 19-2016. A 65-Year-Old Man with End-Stage Renal Disease and a Pruritic Rash. N

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Engl J Med. 2016 Jun 23;374(25):2478-2488. PMID: 27332907. DOI: 10.1056/NEJMcpc1512457. 18. Moonsamy P, Nazarian RM, Schulz JT, Goverman J. Acute Marjolin's Ulcer Arising in a Split-

Thickness Skin Graft Postburn Injury. Eplasty. 2016 Jul 25;16:ic31. PMID: 27563371. PMCID: PMC4980804.

19. Khosravi H, Akabane AL, Alloo A, Nazarian RM, Boland GM. Metastatic melanoma with spontaneous

complete regression of a thick primary lesion. JAAD Case Rep. 2016 Dec 3;2(6):439-441. PMID: 27981212. PMCID: PMC5144746. DOI: 10.1016/j.jdcr.2016.09.011.

20. Storer M, Nazarian RM, Kourosh AS. Nonphoto-exposed initial cutaneous manifestation of lupus

after zoster: A case of Wolf's isotopic reaction. JAAD Case Rep. 2016 Nov 30;2(6):425-427. PMID: 27942574. PMCID: PMC5133640. DOI: 10.1016/j.jdcr.2016.04.009.

21. Kuye IO, Adisa M, Nazarian RM, Arvikar SL, Smith GP. Granulomatous skin involvement in a patient

with an unusual NOD2 mutation. Australas J Dermatol. 2017 May;58(2):142-144. PMID: 26768519. DOI: 10.1111/ajd.12441.

22. Monach PA, Stone JH, Sharma A, Nazarian RM. Case 6-2017. A 57-year-old woman with fatigue,

sweats, weight loss, headache, and skin lesions. N Engl J Med. 2017 Feb 23;376(8):775-786. PMID: 28225681. DOI: 10.1056/NEJMcpc1613461.

23. Levandoski KA, Nazarian RM, Asgari MM. Hypertrophic lichen planus mimicking squamous cell

carcinoma: The importance of clinicopathologic correlation. JAAD Case Rep. 2017 Mar 21;3(2):151-154. PMID: 28374001. PMCID: PMC5367790. DOI: 10.1016/j.jdcr.2017.01.020.

24. Bartenstein DW, Song JS, Nazarian RM, Hawryluk EB. Evolving Childhood Melanoma Monitored by

Parental Photodocumentation. J Pediatr. 2017 Mar 24. pii: S0022-3476(17)30341-30344. PMID: 28347477. DOI: 10.1016/j.jpeds.2017.02.075.

25. Song H, Song JS, Merola MC, Nazarian RM, Hawryluk EB. Pigmented purpuric dermatosis: a striking

but benign cutaneous entity. Arch Dis Child. 2017 Mar 16. pii: archdischild-2016-312598. PMID: 28302631. DOI: 10.1136/archdischild-2016-312598.

26. Williams RF, Nazarian RM, Smith G. Telangiectasia Macularis Eruptiva Perstans Associated with a

Sicca Complex: Causative or Concomitant? Dermatol Online J. In press.

27. Bartenstein DW, Coe, TM, Gordon SC, Friedmann AM, Senna MM, Kelleher CM, Antonescu CR, Nazarian RM. Hawryluk EB. Lipofibromatosis-like neural tumor: Case report of a unique infantile presentation. JAAD Case Rep. In press.

Professional Educational Materials or Reports in print or other media

1. Dermatopathology Fellowship Manual, Developed and maintain an updated survival guide to the Harvard Combined Dermatopathology Fellowship program. 2010 - present.

2. Immunofluorescence primer, Created a primer for interpreting direct and indirect immunofluorescence studies used by Dermatopathology Fellows in the Harvard Combined program. 2011.

3. Dermatopathology Slide Teaching Set, Compiled and maintain a curriculum-based glass-slide and

whole-mount digital slide teaching set with over 200 cases for board preparation used by Pathology Residents at Massachusetts General Hospital, and Dermatology Residents and Dermatopathology

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Fellows in the Harvard Combined program. 2011 - present. 4. Digital Podcast, Vasculopathy and the Vasculopathic Reaction Pattern: A Case-based Approach,

Interview by Dr. Jackie Dosal, Editor, Dialogues in Dermatology, American Academy of Dermatology, 74th Annual Meeting, Washington, DC (www.aad.org/dialogues). 2016.

Thesis

Fast Black-Blood Magnetic Resonance Angiography of the Thoracic Aorta with Cardiac-Synchronization. Advisors: Hernan Jara, PhD (Boston University, Department of Radiology) and Kenneth Lutchen, PhD (Boston University, Department of Biomedical Engineering). 1998-1999. Abstracts, Poster Presentations and Exhibits Presented at Professional Meetings

1. J. Solus, E. Brachtel, R.M. Nazarian. Basaloid carcinoma of the breast – a potential diagnostic pitfall. American Society of Dermatopathology, 49th Annual Meeting, Chicago, IL, oral presentation selected for the 13th Annual Duel in Dermatopathology and awarded 2nd place prize (2012).

2. K. Linskey, J. Kay, L.M. Duncan, R.M. Nazarian. Wnt signaling pathway activation in cutaneous

fibrosing disorders.

American Society of Dermatopathology, 49th Annual Meeting, Chicago, IL, oral presentation selected for the Fellows Case Presentations. 2012.

102nd United States and Canadian Academy of Pathology Annual Meeting, Baltimore, MD, poster presentation selected for the Stowell-Orbison and Surgical/Autopsy Pathology Awards Competition. 2013.

3. J. Tse, M.P. Chan, L.R. Zukerberg, R.M. Nazarian. A Study of the Distribution of Melanocytes in

Normal Anal Mucosa versus Primary Anal Mucosal Melanoma. Massachusetts General Hospital Clinical Research Day, poster presentation selected for Pathology Department award (2013).

4. A. Primiani, M. Murali, D. Kroshinsky, L.M. Duncan, R.M. Nazarian. Overlap in Immune Phenotype in

Acute Psoriasis and Acute Atopic Dermatitis. Massachusetts General Hospital Clinical Research Day, poster presentation selected for Pathology Department award (2013).

5. Vedak P, Nazarian RM, Kroshinsky D. Allergic Contact Dermatitis Secondary to Biological Mesh

Mimicking Cellulitis and Debrided 17 Times. American Academy of Dermatology, 72nd Annual Meeting, Denver, CO, poster presentation. 2014.

6. Vedak P, Nazarian RM, Kroshinsky D. A case of eczematid-like purpura of Doucas and Kapetanakis

in a child. American Academy of Dermatology, 72nd Annual Meeting, Denver, CO, poster presentation. 2014.

7. Strazulla L, Tsiaras W, Baker M, Duncan L, Nazarian RM, Miloslavsky E, Kroshinsky D.

Dermatomyositis in the Setting of Myxoid Chondrosarcoma. American Academy of Dermatology, 72nd Annual Meeting, Denver, CO, poster presentation. 2014.

8. Ogbechie O, Maloney K, Sajeed D, Tsao S, Nazarian RM. Neutrophilic Panniculitis Associated with Vemurafenib Therapy. American Academy of Dermatology, 72nd Annual Meeting, Denver, CO, oral presentation at the Gross & Microscopic Dermatology Symposium. 2014.

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9. Primiani A, Nazarian RM. Immunologic Overlap of Th17 and Th22 cells in Acute Psoriasis and Acute Atopic Dermatitis. Harvard Medical School Pathology Retreat, Boston, MA, poster presentation. 2014.

10. Vedak P, Watson A, Velez N, Garibyan L, Nazarian RM, Levins P, Schalock P, Kroshinsky D. Contact dermatitis to biologic mesh masquerading as infection resulting in multiple débridements. American Academy of Dermatology, Summer Academy Meeting, Chicago, IL, selected for oral presentation. 2014.

11. Ogbechie O, Nazarian RM. Lichenoid Interface Dermatitis Associated with Vitiligo. American Society of Dermatopathology, 51st Annual Meeting, Chicago, IL, poster presentation. 2014.

12. Ogbechie O, Senna MM, Nazarian RM. Non-resolving Verrucous Papule on the Chin. American Society of Dermatopathology, 51st Annual Meeting, Chicago, IL, poster presentation. 2014.

13. Solus JF, Girouard S, Nazarian RM. Cutaneous Kikuchi-Fujimoto disease. American Society of Dermatopathology, 51st Annual Meeting, Chicago, IL, poster presentation. 2014.

14. Solus JF, Nazarian RM. Cutaneous Lymphadenoma. American Society of Dermatopathology, 51st Annual Meeting, Chicago, IL, poster presentation. 2014.

15. Mutyambizi-Maloney K, Nazarian RM. A case of Cutaneous Perivascular Epithelioid Cell Tumor Masquerading as a Hemangioma. American Society of Dermatopathology, 51st Annual Meeting, Chicago, IL, poster presentation. 2014.

16. Primiani Moy A, Kroshinsky D, Nazarian RM. Infantile GM1 Gangliosidosis: Clinicopathologic and Ultrastructural Findings in the Skin. American Society of Dermatopathology, 51st Annual Meeting, Chicago, IL, oral presentation selected for the 15th Annual Duel in Dermatopathology Resident Abstract Competition. 2014.

17. Tse JY, Nazarian RM. The skinny on cutaneous lipomatous neurofibromas. American Society of Dermatopathology, 51st Annual Meeting, Chicago, IL, poster presentation. 2014.

18. Prasad Busarla SV, Kerr DA, Sohani AR, Nazarian RM. mTOR, VEGF, and c-kit signaling pathway activation in Kaposi sarcoma: A tissue microarray study. The XXXth Congress of The International Academy of Pathology, Bangkok, Thailand, selected for oral presentation. 2014.

19. Cruz Romero C, Nazarian RM, Abujudeh HH. Frequency of IV contrast CT findings and most frequent sites of involvement in pathologically proven cases of ischemic colitis. Radiological Society of North America, 100th Scientific Assembly and Annual Meeting, Chicago, IL, poster presentation. 2014.

20. Jiramongkolchai P, Nigwekar SU, Nazarian RM, Malhotra R, Bloch KD, Thadhani RI, Bloch DB. Calcific Uremic Arteriolopathy is Characterized by Increased Arteriolar Bone Morphogenetic Protein Signaling. American Heart Association, Chicago, IL, poster presentation. 2014.

21. Nazarian RM*, Jones NC*, Duncan LM, Kamionek M, Lauwers GY, Tambouret RH, Wu CL, Nielsen

P, Brachtel EF, Mark EJ, Sadow PM, Grabbe JP, Wilbur DC. Interinstitutional Whole Slide Imaging Teleconsultation Service Development: Assessment Using Clinical Consultation Cases. Massachusetts General Hospital Clinical Research Day, poster presentation. 2014.

22. Tse JY, Chan MP, Zukerberg L*, Nazarian RM*. Non-specific staining for BRAFV600E

immunohistochemistry in anorectal mucosa: an important pitfall when evaluating anorectal

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melanoma. Massachusetts General Hospital Clinical Research Day, poster presentation, and American Society of Dermatopathology, 51st Annual Meeting, Chicago, IL, oral presentation selected for the Fellows’ Case Presentations. 2014.

23. Moy AP, Murali M, Nazarian RM. Identification of a Skewed Immune Phenotype in Chronic Urticaria

Independent of Autoimmunity and Thyroid Disease Markers. Massachusetts General Hospital Clinical Research Day, poster presentation. 2014.

24. Nazarian RM*, Jones NC*, Duncan LM, Wilbur DC. MGH Whole Slide Imaging Teleconsultation

Practice in Dermatopathology. Analytical Cellular Pathology, vol. 2014, Article ID 347147, 1 page, 2014. doi:10.1155/2014/347147.

25. Tse JY, Chan MP, Zukerberg LR, Nazarian RM. Assessment of Melanocyte Density in Anal Mucosa

for the Evaluation of Surgical Margins in Primary Anal Melanoma

Harvard Medical School Pathology Annual Retreat, poster presentation. 2015.

104th United States and Canadian Academy of Pathology Annual Meeting, Boston, MA, poster presentation. 2015.

26. Kerr DA, Busarla SVP, Sohani AR, Nazarian RM. mTOR, PDGFR, and c-kit Signaling Pathway

Activation in Kaposi Sarcoma.

Massachusetts General Hospital Clinical Research Day, poster presentation. 2014.

104th United States and Canadian Academy of Pathology Annual Meeting, Boston, MA, poster presentation. 2015.

27. Kuye I, Adisa M, Nazarian RM, Arvikar SL, Smith GP. Granulomatous Skin Involvement in a patient

with an Unusual NOD2 Mutation (Blau Syndrome). American Academy of Dermatology, 73rd Annual Meeting, San Francisco, CA, poster presentation. 2015.

28. Nambudiri VE, Solus JF, Staszewski R, Winkfield KM, Duncan LM, Nazarian RM, Carter JB. Indolent

Nodule on the Ear. Harvard Dermatology Science Fair, poster presentation. 2015. 29. Vedak P, Smith BL, Nazarian RM. Radiation-induced morphea: an under-recognized phenomenon.

American Society of Dermatopathology, 52nd Annual Meeting, San Francisco, CA, poster presentation. 2015.

30. Shih AR, Senna MM, Wilbur DC, Nazarian RM. Post-Irradiation Extragenital Lichen Sclerosus: An

Inductive Phenomenon. American Society of Dermatopathology, 52nd Annual Meeting, San Francisco, CA, poster presentation. 2015.

31. Goyal A, Tse JY, Nazarian RM. “Wicked” cold panniculitis. American Society of Dermatopathology,

52nd Annual Meeting, San Francisco, CA, poster presentation. 2015. 32. Moy AP, Murali M, Kroshinsky D, Horn TD, Nazarian RM. Effect of TNF-alpha inhibition in psoriasis

and anti-TNF-alpha related psoriasiform dermatitis.

Massachusetts General Hospital Clinical Research Day, poster presentation. 2015.

American Society of Dermatopathology, 52nd Annual Meeting, San Francisco, CA, poster presentation. 2015.

33. Wang G, Nazarian RM, Zhao L, Hristov A, Patel R, Fullen D, Chan MP. Protein gene product 9.5

(PGP9.5) immunoexpression in a spectrum of benign cutaneous mesenchymal, histiocytic, and melanocytic lesions. American Society of Dermatopathology, 52nd Annual Meeting, San Francisco, CA, poster presentation. 2015.

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34. Moy AP, Murali M, Nazarian RM. Identification of a Th2 and Th17 skewed immune phenotype in

chronic urticaria independent of autoimmunity and thyroid disease markers. 23rd World Congress of Dermatology, Vancouver, CA, poster presentation. 2015.

35. Nathan N, Trowbridge R, Plovanich M, Nazarian RM, Hawryluk E, Kroshinsky D. An unusual case of

tumid lupus mimicking pseudolymphoma in a Kuwaiti man with hyper-IgM syndrome. American Academy of Dermatology, 74th Annual Meeting, Washington, D.C., poster presentation. 2016.

36. Moy AP, Murali M, Kroshinsky D, Horn TD, Nazarian RM. Keratin 17 expression and immune

phenotype of anti-TNF- refractory psoriasis and anti-TNF- related psoriasiform dermatitis.

Harvard Medical School Pathology Annual Retreat, poster presentation. 2016.

105th United States and Canadian Academy of Pathology Annual Meeting, Seattle, WA, poster presentation. 2016.

37. Moy AP, Smith G, Nazarian RM. Chronic penile lymphedema. American Society of

Dermatopathology, 53rd Annual Meeting, Chicago, IL, poster presentation. 2016. 38. Moy AP, Nazarian RM. Ipilimumab-induced sarcoidosis in a patient with metastatic Melanoma.

American Society of Dermatopathology, 53rd Annual Meeting, Chicago, IL, poster presentation. 2016.

Harvard Medical School Pathology Annual Retreat, poster presentation. 2017. 39. Raff A, Mackool B, Nazarian RM. Spontaneously resolving figurate erythema. American Society of

Dermatopathology, 53rd Annual Meeting, Chicago, IL, poster presentation. 2016. 40. Tse JY, Walls A, Sober A, Nazarian RM. Ipilimumab-induced photo recall-type dermatitis. American

Society of Dermatopathology, 53rd Annual Meeting, Chicago, IL, poster presentation. 2016. 41. Nikolskaia O, Moy AP, Nazarian RM. Polarized immune infiltrates in localized scleroderma and

eosinophilic fasciitis offer novel insights for differentiation and treatment strategy.

American Society of Dermatopathology, 53rd Annual Meeting, Chicago, IL, poster presentation. 2016.

Harvard Medical School Pathology Annual Retreat, poster presentation. 2017. 42. Bartenstein D, Antonescu CR, Nazarian RM, Hawryluk E. Infantile presentation of rare LMNA-NTRK1

fusion lipofibromatosis-like neural tumor. Society for Pediatric Dermatology, 29th Annual Pre-AAD Meeting, Orlando, FL, oral presentation selected for the Dermatology Cases of the Year Symposium. 2017.

43. Ko LN, Wallace EB, Song P, Nazarian RM, Masiakos P, Kroshinsky D. Junctional epidermolysis

bullosa with pyloric atresia. American Academy of Dermatology, 75th Annual Meeting, Orlando, FL, oral presentation selected for the Gross & Microscopic Dermatology Symposium. 2017.

44. Riemenschneider K, Charrow A, Nazarian RM, Freeman E, Hawryluk E. Restrictive dermopathy: a

rare cause of taut skin and dysmorphic features in a neonate. American Academy of Dermatology, 75th Annual Meeting, Orlando, FL, oral presentation selected for the Gross & Microscopic Dermatology Symposium. 2017.

45. DeFilipp Z, Nazarian RM, Li S, Brown J, Ballen KK, El-Jawahri AR, McAfee SL, Antin JH, Cutler CS,

Rosenblatt J, Chen YB. Sonidegib (LDE-225), a sonic hedgehog pathway inhibitor, for the treatment of steroid-refractory chronic graft-versus-host disease. Biol Blood Marrow Transplant.

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2017;23:S3645. 46. Menard EJ, Hasserjian R, Black-Schaffer WS, Pappadia T, Louis DN, Nazarian RM. Characterization

of applicants for residency training in pathology: does diversity exist? Harvard Medical School Pathology Annual Retreat, poster presentation. 2017.

47. Rohani P, Nazarian RM, Neel V. Eruptive Pilomatricoma Secondary to Blunt Trauma in an Adult

American Society or Dermatologic Surgery Annual Meeting, Chicago, IL, poster presentation. 2017.

48. Compton LA, Nazarian RM. Hydroxyurea-related squamous dysplasia in a sun-protected site. American Society of Dermatopathology, 54th Annual Meeting, Baltimore, MD, poster presentation. 2017.

49. Rush PS, Stagner A, Deshpande V, Nazarian RM. Angiolymphoid Hyperplasia with Eosinophilia Epithelioid Hemangioma): a Mimic of IgG4-Related Skin Disease or Two Sides of the Same Coin? American Society of Dermatopathology, 54th Annual Meeting, Baltimore, MD, oral presentation selected for the Fellows Case Presentations. 2017.

Narrative Report I am a full-time Dermatopathologist in the Pathology Service at Massachusetts General Hospital. I completed my residency training here in anatomic & clinical pathology in 2008, followed by a Dermatopathology fellowship in the Harvard Combined Program prior to joining the Harvard Medical School faculty in 2009. I have carved a unique niche in the pathology of medical (non-neoplastic) dermatology encompassing inflammatory and fibrosing disorders of the skin. My goal is to expand on my established national reputation as an expert physician scientist providing insights into the pathogenesis and potential therapeutic avenues for inflammatory dermatoses and cutaneous fibrosis. In addition to clinical service and teaching responsibilities (80% of my professional effort), the position affords me dedicated time and resources to further develop this academic interest internationally. In addition to my clinical responsibilities as a full-time dermatopathologist diagnosing a high-volume of inpatient and outpatient cases, I serve as a consultant in the diagnosis of Nephrogenic Systemic Fibrosis (NSF), eosinophilic fasciitis, morphea, calciphylaxis, aberrant wound healing, and drug-related dermatitides, such as vasculitis. My keen interest in elucidating the pathophysiologic basis for inflammatory and fibrosing disorders has led to 30 peer-reviewed publications (including 13 senior-authored reports and 3 first-authored reports, with innovation of a quantitative method for the diagnosis of NSF), 4 book chapters, over 20 abstracts presented at national and international meetings, and 14 national and international invited lectures. As the first Junior Investigator Award recipient of the Global Fibrosis Foundation, I investigated TGFβ, Wnt and Hedgehog signaling pathway activation in NSF, scleroderma, hypertrophic scar, and keloid that may inform future targeted therapies. Funded by the Vickery Pathology Translational Research Grant, I studied whether TGFB1 gene polymorphisms associated with development and progression of fibrosis in several organ systems predispose patients for NSF. As an Eleanor Shore Fellowship award recipient, I investigated T-cell transcription factors and cytokine signatures in acute erythroderma and chronic dermatitis (psoriasis and eczema) in collaboration with Internal Medicine colleagues. More recently, I have furthered the findings in these investigations resulting in subsequent works that demonstrate novel insight into the ‘paradoxical’ relationship between

psoriasiform dermatitis and therapeutic blockade of TNF and offer a rational for Th1/Th2 immune regulation and Th17 inhibition in anti-fibrotic therapeutic strategy. My efforts have been recognized by selection of presentations for awards at national meetings, health news articles highlighting my research findings, recognition of published work among “Most Cited Articles” indices, and a Partners in Excellence Award for Leadership and Innovation. My publications to date have achieved a citation index of 21 (H-

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index). I have also developed close ongoing collaborations with key investigators in Endocrinology exploring aberrant cutaneous wound healing in Vitamin D receptor deficient mice, investigators in Nephrology exploring calciphylaxis (a rare and enigmatic vasculopathic systemic disease), and investigators in Surgery studying histopathologic alterations in cutaneous wounds. I have served on the Medical Advisory Council of the Global Fibrosis Foundation since 2010 striving to support research in the prevention and treatment of fibrosing disorders, and have recently been elected President. My educational activities range from instructing in the former HMS Dermatology (IN757) and Immunology, Microbiology & Pathology (IN754) courses, to teaching gross and microscopic dermatopathology to HMS students, residents, and fellows, to invited lectures at national and international meetings. These efforts have been rewarded with superb evaluations for the quality of my teaching contributions. I have mentored seven residents in their intradepartmental Molecular Pathology and Gross Pathology Research Conferences and was an NIH Career Development Award Advisor to an MGH post-doctoral fellow. My mentorship has led to 12 peer-reviewed publications, 8 book chapters, and over 20 abstracts, several of which have been recognized with awards. I have developed Dermatopathology educational materials including an Immunofluorescence primer for MGH trainees, MGH Fellows Handbook, and a curriculum-based glass-slide teaching set. Locally, regionally, nationally, and internationally I participate in educating my peers through invited lectures at CME courses and the annual meeting of the American Society of Dermatopathology and the American Academy of Dermatology, including as forum leader. My other activities include service as Associate Editor for the Journal of Cutaneous Pathology (medical dermatology, drug reactions, and inflammatory diseases section), Editorial board member of the American Journal of Clinical Pathology, ad hoc reviewer, and fostering quality improvement initiatives, including an approach to nail-plate processing published in JAAD, and interdepartmental clinicopathological correlations. I serve on the Continuing Education and Research Committee of the American Society of Dermatopathology. I am also a contributing member of the International Calciphylaxis Consensus Panel. Locally, I judge the Massachusetts State Science and Engineering Fair encouraging academically precocious high school students to enter science and technology careers. Regionally, I participate in pipeline initiatives involving Massachusetts Institute of Technology students and Boston public high school students to generate awareness of and interest in diverse careers in medicine. Globally, I volunteer as teledermatopathology consultant providing web-based diagnostic and educational support to physicians practicing in East Africa through Remote Access for Health Professionals, an international program funded by the Aga Khan Development Network, which has led to two publications and a recent senior-authored investigation on molecular pathways underlying HIV-associated Kaposi sarcoma published in Human Pathology. In addition, I direct programs in diversity and inclusion as a Departmental Diversity Leader. The supportive environment of the MGH Dermatopathology Unit, the resources provided by the MGH Pathology Service, physician leadership training I have received through the Massachusetts General Hospital Physicians Organization, and the expertise shared by my clinical collaborators has allowed me to establish dermatopathology of inflammatory and fibrosing disorders as my academic area of excellence. To my knowledge, this represents the sole medical dermatopathology area of expertise among dermatopathologists throughout the teaching institutions of the Harvard Medical School. Through my accomplishments to date, I have demonstrated an enduring commitment to academic dermatopathology with established excellence in teaching, clinical care and research activities, and have developed a regional and national reputation for my contributions to the understanding, diagnosis and treatment of inflammatory and fibrosing diseases in the skin.