the genetic lottery behind the spanish christmas lottery

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D N A The genetic code behind the Spanish Christmas Lottery

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Informative booklet on the analogy between a winning lottery number and a specific gene ID. New values for a lottery ticket. Paula Calleja [Design]

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Page 1: The genetic lottery behind the Spanish Christmas Lottery

D N A

The genetic code behind the Spanish Christmas Lottery

Page 2: The genetic lottery behind the Spanish Christmas Lottery

561694549549595478843146647996325226171421583200640377263369500765328821515

Winners from 1982 to 1996 inverse order

Page 3: The genetic lottery behind the Spanish Christmas Lottery

GSDMC: gasdermin C

Function Protein coding

Species Homo sapiens

Location: 8q24.21

22 exons

Gene expressed in the epitheliumgastrointestinal tract and

especially in metastatic melanoma cells

CHROMOSOME 8

ID: 56169

Page 4: The genetic lottery behind the Spanish Christmas Lottery

ID: 45495

I(2)32AF: lethal (2) 32AF

Function Phenotype only

Species Drosophila melanogaster (fruit fly)

Location: 31E1 - 32A2

QUALITIES UNDER STUDY

Page 5: The genetic lottery behind the Spanish Christmas Lottery

ID: 49595

PIR49595: piRNA class

Function Non-coding RNA

Species Homo sapiens

Location: Full strand

27 exons

CHROMOSOME 13

Gene expressed in antibodies

Page 6: The genetic lottery behind the Spanish Christmas Lottery

ID: 47884

I(1)adl12: lethal (1) adl12

Function Phenotype only

Species Drosophila melanogaster (fruit fly)

Location: 1 - cM

QUALITIES UNDER

STUDY

Page 7: The genetic lottery behind the Spanish Christmas Lottery

ID: 31466

CG12730: -

Function Protein coding

Species Drosophila melanogaster (fruit fly)

Location: 5A2 - 5A2

3 exons

CHROMOSOME

Gene expressed in oxidative stress resistance and gastrulation

Page 8: The genetic lottery behind the Spanish Christmas Lottery

ID: 47996

I(3)EGX13: lethal (3) EGX13

Function Phenotype only

Species Drosophila melanogaster (fruit fly)

Location: 100A1 - 100C3

QUALITIES UNDER STUDY

Page 9: The genetic lottery behind the Spanish Christmas Lottery

ID: 32552

Graf: Graf ortholog (H. sapiens)

Function Protein coding

Species Drosophila melanogaster (fruit fly)

Location: 13E14 - 13E14

14 exons

Gene expressed in leg morphogenesis and

wing hair growth

CHROMOSOME X

Page 10: The genetic lottery behind the Spanish Christmas Lottery

ID: 61714

D5Mit309: -

Function DNA segment

Species Mus musculus (house mouse)

Location: 5 42.22 cM

CHROMOSOME 5

Gene expressed in the formation of the internal ear

Page 11: The genetic lottery behind the Spanish Christmas Lottery

ID: 21583

PBF_21583: -

Function Nucleotide sequence [protein]

Species Bacillus firmus (bacteria)

10 20 30 40 50

MVDADSCPVK EEIVEIANSF TVDAVFVASY AHMQNDLNGA VWKFVDSSKE 60 70 80 90 100

AADLFIMNYV KSGDAVVTQD IGLASTLLLK GVYVLSPRGI LFEESEIRTA

110 120 130 140 LEMRHLSAKA RRRGVYGKGP KPFRQEDRSR FVQQLTKILS NFEGIQ

Page 12: The genetic lottery behind the Spanish Christmas Lottery

ID: 20064

Dere: kinesin-like protein

Function Protein

Species Drosophila erecta (fruit fly)

Protein active in ATP binding+

microtubule motor activity

10 20 30 40 50MDQLSIKQKV FIRRSDGRVH LAEIIKLEGG STNLVTVEWP EGHTVRGKDL 60 70 80 90 100PLELVVLMNP QIFDLPRCSG NATSANQTAS IPPRSMKERM AEGSLLPGLA 110 120 130 140 150AATPRQLTPS VREDDVVHQI ERMRKEREQR REVQARTRQE REQVKSEDPG 160 170 180 190 200NPNWEIAKMI RAQRVQMESQ PVKSCIPNGR AKGHQIVVCV RKRPLRRKEL 210 220 230 240 250TDREVDVVTI PSKDTLVVHE PRKHVNLVKF LENHSFRFDY VFNEDCSNAT 260 270 280 290 300VYEFTARPLI KHIFEGGMAT CFAYGQTGSG KTHTMGGRFP GSQQSSMDGI 310 320 330 340 350YGMAAKDVFS TLKTAPYSRL KLKVTCSFFE IYGTRVYDLL MPGKPQLRVL 360 370 380 390 400EDGKQQVQVV GLTQNAVKNT ADVLNLLEMG NSVRTSGQTS ANSKSSRSHA 410 420 430 440 450VFQIVLRSEA NQRIHGKFSL IDLAGNERGA DNSSADRVTR LEGSEINKSL 460 470 480 490 500LVLKECIRAL GRQSSHLPFR GSKLTQVLRD SFIGGKKVKT CMIAMISPGL 510 520 530 540 550HSVEHTLNTL RYADRVKELS VESMSPKRMQ GPSLESTSMP DIISQSPSKR 560 570 580 590 600LFPSASSTSL RGAGNPAQKE LNTTNDLNRA QKQESKPTSP TTGRQLIRRK 610 620 GRSAQEVSMM LAKSLAEFRG RNFP

Page 13: The genetic lottery behind the Spanish Christmas Lottery

ID: 03772

KCNJ15: potassium channel

Function Protein coding

Species Homo sapiens

Location: 21q22.2

10 exons

Channels in most mammalian cells that allow the entrance of potassium (K).

Key role in gastric acid secretion.

If mutated might cause type 2 diabetes mellitus in Asian patients, especially Japanese.

Page 14: The genetic lottery behind the Spanish Christmas Lottery

ID: 63369

MICPUN_63369: -

Function Protein

Species Micromonas sp. Picoplanktonic green algae

CHROMOSOME 1310 20 30 40 50MHALGPIRAL RPRLQRLTAS LVKRRTPIAA EPRDPPRDIA LRPSHVFLSR 60 70 80 90 100QIPIAVARSR PRAHLVAMAV PPSPKRVNGN KSPKAAKAKA KAPARSPTED 110 120 130 140 150IEDLIGKHPS LASIRDDAPR LRDELLAWYD KSHRILPWRR NFHSHHAPPP 160 170 180 190 200PGPQGGDGCE PKEYWAGCDE TGAPTNVPRD QYAYGVWVSE IMSQQTQIER 210 220 230 240 250VAQYWLRWTE RWPDVSSLAS ATREEVNELW AGLGYYRRAG FLLDGARHVV 260 270 280 290 300DNCDTIFPND AKGLANVPGV GPYTAAAIAS IAFDEPVAAV DGNVIRVCTR 310 320 330 340 350LAAVTGGGDA AKPSSDAAKA VRLCADWLID DSTRPGDFNQ AMMELGATVC 360 370 380 390 400TPKAPACGQC PLRVGCAGAA LESAGSSGFK VTDLPEKEKK PEKREERVAV 410 420 430 440 450RVVERKGGRR DGVPGPADSS FLLVRRPEGG LLGGLWEFPS ANVPDNLEPG 460 470 480 490 500DPDFYASCAD VVHSCGSSGK FSKSRVGLGE VTHTFSHVRH TYVAQHEVWE 510 520 530 540 550TSADDDGDEA PPTRGDTAGG REWRWVTATE LQTLGLSSGV RKIYELLTKR 560 570 EQAKKAPRES AIGKLFAKKA KRGE

Protein active in DNA binding and hydrolase activity

Page 15: The genetic lottery behind the Spanish Christmas Lottery

ID: 50076

PHATDRAFT_50076: -

Function Protein

Species Phaeodactylum tricornutum (protozoan)

CHROMOSOME 26

Protein active in tyrosine phosphatase activity

Page 16: The genetic lottery behind the Spanish Christmas Lottery

ID: 53288

03.MMHAP34FRA.seq: -

Function DNA segment

Species Mus musculus (house mouse)

CHROMOSOME 11

QUALITIES UNDER STUDY

Page 17: The genetic lottery behind the Spanish Christmas Lottery

ID: 21515

Diacylglycerol o-acyltransferase

Function Protein

Species Mycobacterium tuberculosis (bacteria)

Protein active in glycerolipid metabolism

Page 18: The genetic lottery behind the Spanish Christmas Lottery

10 20 30 40 50MMRRLNGVDA LMLYLDGGSA YNHTLKISVL DPSTDPDGWS WPKARQMFEE 60 70 80 90 100RAHLLPVFRL RYLPTPLGLH HPIWVEDPEF DLDAHVRRVV CPAPGGMAEF 110 120 130 140 150CALVEQIYAH PLDRDRPLWQ TWVVEGLDGG RVALVTLLHH AYSDGVGVLD 160 170 180 190 200MLAAFYNDTP DEAPVVAPPW EPPPLPSTRQ RLGWALRDLP SRLGKIAPTV 210 220 230 240 250RAVRDRVRIE REFAKDGDRR VPPTFDRSAP PGPFQRGLSR SRRFSCESFP 260 270 280 290 300LAEVREVSKT LGVTINDVFL ACVAGAVRRY LERCGSPPTD AMVATMPLAV 310 320 330 340 350TPAAERAHPG NYSSVDYVWL RADIADPLER LHATHLAAEA TKQHFAQTKD 360 370 ADVGAVVELL PERLISGLAR SSRAPRA