THE GLENMEDE FUND, INC.

(800) 442-8299

STATEMENT OF ADDITIONAL INFORMATION

May 5, 2017

This Statement of Additional Information (SAI) is not a prospectus but should be read in conjunction with The Glenmede Fund, Inc.s

(Glenmede Fund or the Fund) Prospectus dated May 5, 2017, as amended or supplemented from time to time (the Prospectus).

This SAI is for the Global Secured Options Portfolio (NOVIX) (the Portfolio). No investment in shares of the Portfolio should be

made without first reading the Prospectus of the Portfolio. This SAI is incorporated by reference in its entirety into the Prospectus. The

Funds audited financial statements and financial highlights for the Portfolio appearing in the 2016 Annual Report to Shareholders are

incorporated by reference into this SAI. No other part of the Annual Report is incorporated by reference herein. A copy of the Funds

Prospectus and Annual Report are available without charge, upon request, by calling the Fund at the above telephone number.

Capitalized terms used in this SAI and not otherwise defined have the same meanings given to them in the Funds Prospectus.

TABLE OF CONTENTS

Page

THE FUND ................................................................................................................................. 3 INVESTMENT STRATEGIES................................................................................................... 4 PRICE OF PORTFOLIO SHARES ............................................................................................ 16

PURCHASE OF SHARES .......................................................................................................... 17

REDEMPTION OF SHARES ..................................................................................................... 17

PORTFOLIO TURNOVER ........................................................................................................ 17

DISCLOSURE OF PORTFOLIO HOLDINGS .......................................................................... 17

INVESTMENT LIMITATIONS ................................................................................................. 18

MANAGEMENT OF THE FUND .............................................................................................. 20

INVESTMENT ADVISORY AND OTHER SERVICES .......................................................... 27

PORTFOLIO TRANSACTIONS ................................................................................................ 30

ADDITIONAL INFORMATION CONCERNING TAXES ....................................................... 31

GENERAL INFORMATION ..................................................................................................... 34

FINANCIAL STATEMENTS .................................................................................................... 35

OTHER INFORMATION ........................................................................................................... 35

APPENDIX A DESCRIPTION OF SECURITIES AND RATINGS ...................................... A-1

APPENDIX B PROXY VOTING PROCEDURES ................................................................. B-1

3

THE FUND

The Glenmede Fund was organized as a Maryland corporation on June 30, 1988. The Glenmede Funds Articles of Incorporation,

as amended, authorize its Board of Directors the (Board) to issue 6,000,000,000 shares of common stock, with a $.001 par value. The

Board has the power to subdivide these shares into one or more investment portfolios from time to time. The Board also has the power

to designate separate classes of shares within the same Portfolio. As of the date hereof, the Glenmede Fund is offering shares of the

following eighteen Portfolios, of which the Global Secured Options Portfolio is described herein: Core Fixed Income Portfolio, Equity

Income Portfolio, High Yield Municipal Portfolio, International Portfolio, Global Secured Options Portfolio, Large Cap Core Portfolio

(Advisor Shares and Institutional Shares), Large Cap Growth Portfolio (Advisor Shares and Institutional Shares), Large Cap Value

Portfolio, Long/Short Portfolio, Mid Cap Equity Portfolio (Advisor Shares and Institutional Shares), Responsible ESG U.S. Equity

Portfolio, Secured Options Portfolio (Advisor Shares and Institutional Shares), Short Term Tax Aware Fixed Income Portfolio, Small

Cap Equity Portfolio (Advisor Shares and Institutional Shares), Strategic Equity Portfolio, Total Market Portfolio, U.S. Emerging

Growth Portfolio and Women in Leadership U.S. Equity Portfolio.

The Glenmede Fund is an open-end, management investment company. The Global Secured Options Portfolio (the Portfolio) is a

diversified Portfolio of the Glenmede Fund.

On September 28, 2012, the International Secured Options Portfolio commenced operations, offering a single class of shares.

Effective as of May 1, 2017, the International Secured Options Portfolio changed its name to the Global Secured Options Portfolio.

4

INVESTMENT STRATEGIES

The following investment strategies supplement those set forth in the Portfolios Prospectus. Unless specified below and except as

described under Investment Limitations, the following investment strategies are not fundamental and the Funds Board may change

such strategies without shareholder approval.

The Portfolio will not engage in market timing transactions. However, for temporary defensive purposes, the Portfolio may invest

a significant portion of its assets in cash, short-term instruments issued by U.S. or foreign issuers denominated in dollars, including

short-term certificates of deposit (including variable rate certificates of deposit), time deposits with a maturity no greater than 180 days,

bankers acceptances, commercial paper rated A-1 by S&P Global Ratings (S&P) or Prime-1 by Moodys Investors Service, Inc.

(Moodys), U.S. Government securities, repurchase agreements or in similar money market securities.

Borrowing

As a temporary measure for extraordinary or emergency purposes, the Portfolio may borrow money from banks in amounts not

exceeding one-third of total assets. However, the Portfolio will not borrow money for speculative purposes. If the market value of the

Portfolios securities should decline, the Portfolio may experience difficulty in repaying the borrowing.

As required by the Investment Company Act of 1940, as amended (the 1940 Act), the Portfolio must maintain continuous asset

coverage (total assets, including assets acquired with borrowed funds, less liabilities exclusive of borrowings) of 300% of all amounts

borrowed. If, at any time, the value of the Portfolios assets should fail to meet this 300% coverage test, the Portfolio, within three

days (not including Sundays and holidays), will reduce the amount of its borrowings to the extent necessary to meet this 300%

coverage. Maintenance of this percentage limitation may result in the sale of portfolio securities at a time when investment

considerations otherwise indicate that it would be disadvantageous to do so. Borrowing of securities in connection with short sales and

derivative transactions such as options, futures and swaps are not subject to this limitation. The Portfolio is authorized to pledge

portfolio securities to the lender as collateral in connection with any borrowings. Reverse repurchase agreements constitute borrowings,

and leverage is a related risk.

Credit Risks

Because the Portfolio may invest in fixed income securities, it is subject to credit risk the risk that an issuer will be unable to

make principal and interest payments when due. U.S. Government securities are generally considered to be the safest type of

investment in terms of credit risk. Municipal obligations generally rank between U.S. Government securities and corporate debt

securities in terms of credit safety. Corporate debt securities, particularly those rated below investment grade, may present the highest

credit risk.

Ratings published by Nationally Recognized Statistical Rating Organizations (NRSROs) are widely accepted measures of credit

risk. The lower a bond issue is rated by an agency, the more credit risk it is considered to represent. Lower-rated bonds generally pay

higher yields to compensate investors for the greater risk.

Depositary Receipts

The Portfolio may purchase certain sponsored or unsponsored depositary receipts. In sponsored programs, an issuer makes

arrangements to have its securities traded in the form of depositary receipts. For purposes of the Portfolios investment policies, the

Portfolios investments in depositary receipts will be deemed to be investments in the underlying securities. For example, a depositary

receipt representing ownership of common stock will be treated as common stock. In unsponsored programs, the issuer may not be

directly involved in the creation of the program. Although regulatory requirements with respect to sponsored and unsponsored

programs are generally similar, in some cases it may be easier to obtain financial information from an issuer that has participated in

the creation of a sponsored program. Accordingly, there may be less information available regarding issuers of securities underlying

unsponsored programs and there may not be a correlation between such information and the market value of the depositary receip