the international cardioncology society an update for 2014
DESCRIPTION
The International CardiOncology Society An Update for 2014. Daniel J Lenihan , MD Professor, Division of Cardiovascular Medicine Director, Clinical Research Vanderbilt University. The International CardiOncology Society An Update. Exactly what does this society mean? - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/1.jpg)
The International CardiOncology SocietyAn Update for 2014
Daniel J Lenihan, MDProfessor, Division of Cardiovascular MedicineDirector, Clinical ResearchVanderbilt University
![Page 2: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/2.jpg)
The International CardiOncology SocietyAn Update
• Exactly what does this society mean?• How do we do things?• What are our goals?• How do we achieve them?• Is there really a future for this?
![Page 3: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/3.jpg)
ICOS is:
• A collection of interested providers focused on improving cardiac health in cancer patients
• A mix of academic, practice, governmental, regulatory, and industry professionals
• Committed to our patients wherever they are
![Page 4: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/4.jpg)
The International CardiOncology SocietyAn Update
• Exactly what does this society mean?• How do we do things?• What are our goals?• How do we achieve them?• Is there really a future for this?
![Page 5: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/5.jpg)
We do things in many ways:• Day to day improvement in our practices• Monthly webinars available to all• Periodic presentations at major meetings• Annual ICOS congresses• Development of current “Best Practice”• Data review for ongoing early phase and late phase
clinical trials• Ongoing participation in major professional society
efforts• Ongoing individual and multicenter research• Consistent involvement with regulatory agencies in many
countries
![Page 6: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/6.jpg)
The International CardiOncology SocietyAn Update
• Exactly what does this society mean?• How do we do things?• What are our goals?• How do we achieve them?• Is there really a future for this?
![Page 7: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/7.jpg)
ICOS goals• Research
– Engage large databases– Cardiac safety endpoint
adjudication– Hypothesis testing
research
• Advocacy• Patients/families• Providers
• Education– Provider case review– Patient directed – Professional meetings– Industry/regulatory webinars– Trainee organization
• Be a Resource• Up to Date information• Identify Goals for the future• Provide innovation• Be an example of
collaboration
![Page 8: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/8.jpg)
![Page 9: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/9.jpg)
0
50
100
150
200
250
300
350
400
Chart TitleNumber of PUBMED articles on Cardio-Oncology
1971 2014
![Page 10: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/10.jpg)
www.oncoreview.pl
![Page 11: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/11.jpg)
The International CardiOncology SocietyAn Update
• Exactly what does this society mean?• How do we do things?• What are our goals?• How do we achieve them?• Is there really a future for this?
![Page 12: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/12.jpg)
PREDICT Study: A multicenter study in Patients undergoing
anthRacycline-based chemotherapy to assess the Effectiveness of using biomarkers to Detect and Identify Cardiotoxicity and describe Treatment
Daniel J Lenihan, MDProfessor, Division of Cardiovascular MedicineVanderbilt UniversityCCOP Annual Meeting 2010
![Page 13: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/13.jpg)
TotalAccrual:597 patients
![Page 14: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/14.jpg)
Slamon D et al; NEJM 2011:365:1273-83
In the case of HER2+ breast cancer, treatment clearly benefitted the disease but came at a cost
![Page 15: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/15.jpg)
0%0%0%
1-2
7%
28%
64%
0
20
40
60
80
100
2-4 4-6 6-8 8-10 10-12 >12
0%
(n=75) (n=35) (n=20) (n=12) (n=8) (n=7) (n=44)
months
Res
pon
der
s (%
)
D Cardinale, et al. JACC 2010, jan 26.
The effect of time for initiation of HF therapy and the percent of patients who
improve
![Page 16: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/16.jpg)
In regards to Ischemic insults, we have a paradigm
Kloner et al, Circ 2001; p2981
![Page 17: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/17.jpg)
Statin therapy prior to and during chemotherapy was protective
JACC 2012, p 2384
![Page 18: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/18.jpg)
Prevention of Cardiotoxicity is possible
Bosch, X et al, JACC 2013, p 2355
![Page 19: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/19.jpg)
Are there things on the cancer therapy horizon that could be concerning for
cardiomyopathy?
![Page 20: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/20.jpg)
There is a balance between protein synthesis and degradation
Monte S. Willis, M.D., Ph.D., and Cam Patterson, M.D., M.B.A. NEJM 2013;368:455-64.
![Page 21: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/21.jpg)
Dick,LR and Flemming,PE Drug Discovery Today ;15 (5/6) March 2010
![Page 22: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/22.jpg)
![Page 23: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/23.jpg)
The International CardiOncology SocietyAn Update
• Exactly what does this society mean?• How do we do things?• What are our goals?• How do we achieve them?• Is there really a future for this?
![Page 24: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/24.jpg)
![Page 25: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/25.jpg)
Kouri M et al. Circulation 2012
A Paradigm for Cardiology Oncology Cooperation
![Page 26: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/26.jpg)
ICOS=
A public, private, patient, provider, regulatory, governmental PARTNERSHIP
![Page 27: The International CardiOncology Society An Update for 2014](https://reader035.vdocuments.net/reader035/viewer/2022081519/568138e6550346895da097c5/html5/thumbnails/27.jpg)
www.icosna.org