the ionetix ion-12sc compact superconducting cyclotron ......• scientific and physics design, beam...
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
The ION-12SC Compact Superconducting Cyclotron for Production of Medical Isotopes
Xiaoyu Wu, Ph.D. Senior PhysicistIonetix CorporationLansing, MichiganUSA
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
OUTLINE
• Scientific and physics design, beam dynamics simulations for Ion-12SC have been discussed previously– V. Smirnov, S. Vorozhtsov, J. Vincent, “Design study of an ultra-compact
superconducting cyclotron for isotope production”, Nuclear Instruments and Methods in Physics Research A 763 (2014) pp. 6-12
• Engineering• Manufacturing• Accelerator system hardware• Beam commissioning• Experience at the 1st customer site
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
POSITRON EMISSION TOMOGRAPHY (PET)
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• Radioisotope injected into patient
• PET scanner detects gamma rays produced by radioisotope as it decays
• Scanner measures amount of metabolic activity at the site in the body and translates signals into images
• Provides information about function and metabolism of body’s organs (unlike CT or MRI)
PET imaging is an effective, non-invasive and painless diagnostic commonly used in oncology, cardiology and neurology diagnostics
Image Source: ABC News and PET Solutions
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
STRONG DEMAND FOR SHORT LIVED PET RADIOISOTOPES
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United States/Europe/Japan
13N-ammonia for cardiology
• Demand will be driven by aging demographics, unstable supply of SPECT radiopharmaceuticals and superior imaging
• Estimated cardiac market opportunity by 2020: >$3 billion1
Emerging Markets (China/India)
18F-FDG for oncology
• Demand will be driven by aging demographics, rising incidence of disease and increase in scanner installations
• Estimate oncology market opportunity by 2020: >$1.5 billion
TWO MAJOR MARKETS
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
THE SOLUTION: ION-12SC SUPERCONDUCTING CYCLOTRON
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Short lived PET radioisotopes have had limited adoption due to
the size, weight, and cost of conventional
cyclotrons
The ION-12SC is based on proprietary superconducting cyclotron technology
• Significantly smaller size, lighter weight and lower cost than conventional cyclotrons
• Lower power consumption and require less radiation shielding
• Significantly shorter installation time and simpler operations
• Compact size/weight allows for placement in hospital or clinic without special infrastructure.
• True dose-on-demand medical isotope production system
1stOF ITSKIND
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
ION-12SC COLLABORATORS
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Ionetix Corporation, USA J. Vincent, Ph.D.*G. Blosser*G. Horner*K. StevensN. Usher*X. Wu, Ph.D.*
JINR, Dubna, Russia S. Vorozhtsov, D. Sc.V. Smirnov, Ph.D.
Superconducting Systems Incorporated, USA
Prototype SC Magnet Engineering, Construction, & Development.
Tesla Engineering LTD, UK Relocatable SC Magnet Design and Manufacturing
Technalogix Inc., Canada Solid State RF Amplifier
* Formally worked at National Superconducting Cyclotron Laboratory (NSCL), Michigan State University. Experienced in R&D for K500, K1200, CCP, K100, K250, and K250S superconducting cyclotrons.
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
ION-12SC CYCLOTRON MAIN PARAMETERS
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Parameter Value
Cyclotron type Compact, Isochronous
Accelerated particle Proton
Injection type Internal PIG source
Magnet type Superconducting
Central magnetic field 4.5 Tesla
Final beam energy 12.5 MeV
Max. Beam Intensity ~25 uA
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
SIGNIFICANT REDUCTION IN SIZE AND WEIGHT
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Parameter Value
Final acceleration radius 115 mm
Target position radius 141 mm
Cyclotron diameter 884 mm
Cyclotron height 1955 mm
Magnet weight ~2041 kg
Cyclotron weight ~2268 kg
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
COMPARISON WITH EXISTING SYSTEMS
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Ionetix ION-12SC Siemens Eclipse GE PETtrace
Room Requirements 12’ x 11’2” 22’ x 26’ 15’ x 18’
Cyclotron Weight 2.3 tons 11 tons 22 tons
Shielding Minimal 39 tons additional shielding
47 tons additional shielding
Price ~$1.5mn (no specialinfrastructure required)
$2.5mn (plus >$7.5M infrastructure costs)
$2.5mn (plus >$7.5M infrastructure costs)
Staff Required 1 2-5 2-5
Power Requirement 34 kW 35 kW 70 kW
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
INTEGRATED ACCELERATOR SYSTEM
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
PLANNED IONETIX ISOTOPE PRODUCTION FACILITY, SARASOTA, FLORIDA (VAULT NEEDED FOR F18 PRODUCTION )
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Cyclotron vault
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
BETA UNIT INSTALLATION AT UM JANUARY 2016
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
BETA UNIT INSTALLATION AT UM JANUARY 2016
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
BETA UNIT INSTALLATION AT UM JANUARY 2016
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
ION-12SC ACCELERATOR SYSTEM
• Superconducting magnet• RF system• Ion source• Internal target and beam probe• Controls & Instrumentation
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
ION-12SC MAGNET SYSTEM
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
ION-12SC WARM BORE SECTORS, ION SOURCE, AND RF SYSTEM
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
WARM BORE SECTOR
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
ION-12SC TESLA MAGNET: MAGNETIC FIELD
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
ION-12SC RF SYSTEM
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RF resonator
Parameter Value
Drive Power <6 kW
Nominal Impedance 50 Ohms
VSWR <1.5
Tuning Range 66 -69 MHz
Water Cooling 4 GPM
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
ION-12SC RF SYSTEM
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3kW RF amplifier
RF Combiner
RF Controller
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
ION-12SC ION SOURCE
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Parameter Value
Ion Source Type Cold cathode
Cathode Material Tungsten
Chimney Diameter 2 .0 mm
Slit Opening 2.0x0.5 mm 30 degree bevel
Current 0.1 - 15 mA
Voltage 0.6 - 1.6 kV
Gas Flow 0.1 – 1.0 sccm
Lifetime >400 hours
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
ION-12SC INTERNAL TARGET AND BEAM PROBE
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Parameter Value
Target Type Internal
Target Position 141 mm
Target Volume 3.0 ml
Target window Aluminum(Graphene under
development)
Probe Range 46 - 151 mm
Intensity Probe Head Carbon
Energy Probe Head Borosilicate Glass
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
ION-12SC CONTROLS & INSTRUMENTATION
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Standard 19” electronics rack• RF amplifiers• RF combiner• RF controller (based on PLC and PCB)• Magnet power supply• Ion source power supply• Cryogenics control• Cooling water control
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
ION-12SC OPERATION EXPERIENCE
• Engineering prototype unit: July 2015 – September 2015– Ready to be shipped to MIT Nuclear Physics Department
• Manufacture unit #1: December 2015 – January 2016– Installed at the University of Michigan
• Manufacture unit #2: June 2016 - Now– The “Golden Master” of the Ionetix R&D facility
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
ION-12SC OPERATION EXPERIENCE – DEE VOLTAGE
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0
2
4
6
8
10
12
14
16
18
20
0 1 2 3 4 5 6 7
Dee
Vo
ltag
e (k
V)
Forward RF Power ( kW)
Measure cavity X-Ray spectrum to accurately determine Dee voltage
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
ION-12SC OPERATION EXPERIENCE – BEAM INTENSITY
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Magnet Current 129.2 A
Magnet Lateral Adjustment
0.619 mm
Magnet Vertical Adjustment
0.0 mm
Puller Gap 1.5 mm
Source Offset 2.0 mm
Source Gas 0.6 sccm
Source Aperture 0.635 mm x 2 mm with 30 degree
bevel
RF Frequency 67.123 MHz
Dee Voltage 17.0 KV Peak
Operation Conditions
0
5
10
15
20
25
30
0 2 4 6 8 10 12 14
Cu
rre
nt
(uA
)
Ion Source Current (mA)
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
ION-12SC OPERATION EXPERIENCE – BEAM SPOT & ENERGY
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Measured beam stopping distanceTotal thickness: 0.848 mm Borosilicate GlassBeam Energy: ~ 12.1 MeV SRIM calculationSlides 1 – 5 = 0.728 mm, 5.5 – 6 = 0.120 mmBeam spot radial width: ~ 12 mm
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
SUMMARY
• R&D and commissioning for the ION-12SC superconducting cyclotron for medical isotope production have been successfully completed
• ION-12SC have significant advantages over existing machines– Size and weight– Cost– Power consumption and shielding– Installation and operations
• Mass production at Ionetix soon to satisfy expected world demand.
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IONETIX CORPORATION ONE FERRY BUILDING, SUITE 255 SAN FRANCISCO, CA 94111
THANK YOU
For more information please contact:
Xiaoyu Wu, Ph.D. Senior PhysicistEngineering & New Product DevelopmentIonetix Corporation
517.252.4069 ext. [email protected]
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