the key to every biological problem must finally be sought in the cell, for every

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The key to every biological problem must ﬁnally be sought in the cell, for every living organism is, or at some time has been, a cell. E. B. Wilson, 1925

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The key to every biological problem must finally be sought in the cell, for every living organism is, or at some time has been, a cell. E. B. Wilson, 1925. Distribuição dos grânulos P = divisão assimétrica E geração da linhagem germinativa. Susan Strome, 19. 5 m m. 1 m m. - PowerPoint PPT Presentation

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Page 1: The key to every biological problem must finally be sought in the cell, for every

The key to every biological problem mustfinally be sought in the cell, for everyliving organism is, or at some time hasbeen, a cell.

E. B. Wilson, 1925

Page 2: The key to every biological problem must finally be sought in the cell, for every

Distribuição dos grânulos P = divisão assimétricaE geração da linhagem germinativa

Susan Strome, 19

Page 3: The key to every biological problem must finally be sought in the cell, for every

Corte óptico tangencial

5 m

Corte óptico transversal

1 m

Grânulos P nos ovócitos “sinciciais”

1 m

Pitt e cols., Devel. Biol. 219, 315-333, 2000

Page 4: The key to every biological problem must finally be sought in the cell, for every

Entrada do espermatozóideFim da meioseCorrentes citoplasmáticasInteração corticalMigraçãoPseudoclivagemCentralizaçãoRotaçãoMetáfaseDeslocamento do fusoCitocinese

Anterior Posterior

Divisão assimétrica

Primeira clivagem em 12 passos

Schneider & Browerman, Annu. Rev. 37, 221-249, 2003

Page 5: The key to every biological problem must finally be sought in the cell, for every

G nczy, Trends Cell Biol. 12, 332-339, 2002

Mitose simétrica e assimétrica

Page 6: The key to every biological problem must finally be sought in the cell, for every

Posicionamento do fuso

G nczy, Trends Cell Biol. 12, 332-339, 2002

Page 7: The key to every biological problem must finally be sought in the cell, for every

Eventos temporais na ovogênese, meiose e primeira divisão mitótica

Schneider & Browerman, Annu. Rev. 37, 221-249, 2003

Page 8: The key to every biological problem must finally be sought in the cell, for every

ANTERIOR POSTERIOR

PAR-3PAR-6

PKC-3

Proteínas quinase C atípica

Proteínas com domínio PDZ

PAR-1

PAR-2

Ser-Thr quinase

Proteína “ring-finger”

PAR-4PAR-5

Uniformementedistribuídas

Proteínas envolvidas na polaridade do ovo

Page 9: The key to every biological problem must finally be sought in the cell, for every

Hierarquia das proteínas PAR em C. elegans

Pellettieri & Seydoux, Science 298, 1946-1950, 2002

Page 10: The key to every biological problem must finally be sought in the cell, for every

G nczy, Trends Cell Biol. 12, 332-339, 2002

centríolo

grânulo P

núcleo

PAR-2

âncoracortical

Acoplamento da mitose e redistribuição citoplasmática

Page 11: The key to every biological problem must finally be sought in the cell, for every

Orientação do fuso mitótico e localização de par-3

Page 12: The key to every biological problem must finally be sought in the cell, for every

MES-4 associa-se a autossomos mas não aos cromossomos X

anti-cromatina anti-MES-4 sobreposição

Fong e cols., Science 296, 2235-2238, 2002

Page 13: The key to every biological problem must finally be sought in the cell, for every

Modelo de como a distinção de soma e germe é estabelecida e mantida no germe

Shin & Mello, Curr. Opinion Genet Devel. 13, 455-462, 2003

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Cell Structure and Function. The key to every biological problem must finally be sought in the cell, for every living organism is, or at some time has