the logical & scientific facts about cholesterol
TRANSCRIPT
The Logical & Scientific Facts about
Cholesterol
Dr. Fathi Neana, MDChief of Orthopaedics
Dr. Fakhry & Alrajhy Hospital - ArabiaNovember, 29 - 2016
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Many people have been asking the Question :
“How to reduce blood cholesterol naturally without using harmful drugs? ”
But nobody ask the real question:
“Does high cholesterol really cause heart disease?”.
The answer to this question may be surprising to many!
My intention here is not to suggest that statins have no place in the treatment of
heart disease. My intention is to initiate brain storming and give you the objective
information needed to (Decide along withyour Doctor) whether they are appropriate for you.
The decision whether to take them should be based on whether you have pre-existing heart disease, what your
overall risk of a heart attack is, how healthy your diet and lifestyle is, what other treatments you’ve already tried, and
your own risk, tolerance and worldview.
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Era of informationsReal time communications
Evolution of evidence based scienceEra of Biochemistry
Way of thinking and change of Concepts
Global vs. key hole visionPriorities and the real threat
To whom we direct our arrows
New dietary guidelines : Shift away from focusing on specific nutrients toward a general focus on eating real food
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Alexandria is too cold in winterWe used to eat such foods
What happen > 1980
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Since the low-fat guidelines came out, the prevalence of obesity has
skyrocketed
This graph shows that the obesity epidemic started
full-force at the same time the low-fat advice
was peaking.
The type 2 diabetes epidemic followed soon
after.
The 2015 - 2020 Dietary Guidelines for Americans is the 8th edition released and remains the current edition until the 2020-2025 Dietary Guidelines for
Americans is released since 1980. Check out the archive of Previous Dietary Guidelines for Americans
Good News: after 4 decades in the Gail accusing the wrong enemyLimit on Dietary Cholesterol Has Been Removed
“Cholesterol is not considered a nutrient of concern for overconsumption.”8
In the past, the guidelines suggested a limit of 300 milligrams (mg) per day; equivalent of two eggs. Now, the limit on dietary
cholesterol removed entirely
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Dietary Guidelines for Americans 2015 - 2020
A healthy eating pattern limits
Saturated fat (?? Why included) Trans fats
Added sugars (?? Non fiber Carbohydrates why not stressed upon)
Sodium
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Saturated fat (?? Why included) The widely circulated assumption that
eating a diet high in saturated fats leads to heart disease is simply wrong, as they are actually necessary to promote health and
prevent diseaseReducing saturated fat intake to reduce LDL cholesterol seems to be specific to the (large, buoyant (type A) LDL
particles). In fact the (small, dense (type B) LDL) particles)
(responsive to Carb. & Trans fat intake) are implicated in cardiovascular disease.
Recent prospective cohort studies: No significant association between saturated fat intake and cardiovascular risk.
Instead, saturated fat has been found to be protective."
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In Summary, Saturated Fats Are Healthy
•They increase LDL levels, but they increase the (large fluffy particles type A LDL) that are not associated with an increased
risk of heart disease•They Increase HDL levels . This compensates for any increase in
LDL•Do NOT cause heart disease as made clear in all the above-
referenced studies•Do not damage easily as other fats. no double bonds to be
damaged through oxidation•Serve to fuel mitochondria
•Produce far less damaging free radicals than carbohydratesFoods that are naturally rich in saturated fats, like grass-fed meats, grass-fed butter, pastured eggs and coconuts, come in a near-perfect package, as they are typically loaded with healthy,
fat-soluble vitamins like A, D, E and K
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HEALTH: Cholesterol: The big fat lie, plus how to prevent heart disease
By SARAH STACEY FOR THE MAIL ON SUNDAYPUBLISHED: 00:02 GMT, 12 July 2015 | UPDATED: 00:04 GMT, 12 July 2015
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The graph is generated from data that represents food selection for the last two weeks.
Review of the molecular biology required to optimize mitochondrial function
It is best to seek to have about 75 percent of your total calories as fat. That leaves approximately 10 percent of your calories as protein and 15 percent as carbs which should be twice as many fiber carbs as non-fiber carbs, like vegetables, seeds and nuts.
Dietary Guidelines for Americans 2015 - 2020
A healthy eating pattern limits
Saturated fat (?? Why Included) Trans fats
Added sugars (?? Non fiber Carbohydrates why not stressed upon)
Sodium
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Harmful Effects of Sugar(NB: Non fiber Carb rapidly absorbed)
1- Lipoprotein Oxidation & Glycation
2- Hyper insulinemia syndrome -> Insulin resistance (type 2 DM…),
-> increased triglycerides VLDL ->Cholesterol (small dense LDL particles)
3- State of chronic inflammation
(?? Non fiber Carbohydrates why not stressed upon)
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What is Cholesterol? A waxy substance – technically a sterol
(unsaturated steroid alcohol)
>80% of cholesterol is made in the liver, the rest is absorbed from food . It is Synthesized in many
cells, but mostly in the liver and intestine
Cholesterol travels in particles called lipoproteins: high-density lipoproteins (HDL) and low-Density
Lipoproteins (LDL)
Acetyl coenzyme A (acetyl CoA) is the precursor to cholesterol synthesis
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What is Cholesterol?All cholesterol is the same. LDL & HDL, are referred to
lipoproteins
Saturated fats raise protective HDL and also increase LDL. There are different types of LDL.
• Large, "fluffy" LDL cholesterol (Type A)• Small, dense LDL cholesterol (Type B)
Saturated fat, increases (large, fluffy, —benign — LDL (Type A))Synthetic trans fat & sugar increases (small, dense LDL (Type
B)) Saturated Fats Increase (Large, Fluffy LDL Cholesterol Type A )
That's a Good Thing
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How to reduce blood cholesterol naturally without using harmful drugs.This is the wrong question.
The real question to be answered is“Does high cholesterol really cause heart
disease?”
You may be surprised to learn the answer to this !
Why We’ve Been Asking the Wrong Question
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HypotoniaMuscle pain -
crampsMyopathie
s Rhabdomy
olysis
Vit DDefiecinc
y
STATINS
HMG CoA Reductas
e(3-hydroxy-3-
methyl-glutaryl-CoA Reductase
Cholesterol
phobia
Vit D deficient Rickets & Osteomalacia spread like
an epidemic(PTH – VITD – Ca - ALK
PHOS)
Egg yolk +Vit D rich food vs. Cholesterol phobia
Walk & Exercises vs. Muscle pain & dysfunction
+ Body pain (statin induced)
Why this lecture ?Is it related to Orthopedic
practice ?
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What is Dolichol, Cholesterol, Coenzyme Q10?Statins are non selective - What is the side effects
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Registered as a hepatoprotector) in relation to neurodegenerative diseases (including
Alzheimer's disease
Biosynthesis of biologically important N-linked glycoproteins.
A major part of glycoproteins are those for our emotions, our neuropeptides.
Aggression, hostility, sensitivity, paranoia, road rage type feelings, depression, suicidal ideation, homocidal ideation and a number of
both suicides and homocide attempts all associated with statin drug use.
Dolichol, cholesterol, coenzyme Q10?Why we need Dolichol
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Dolichol, Cholesterol, Coenzyme Q10?Why we need Cholesterol
• Vitamin D precursor
• Precursor to Hormones Deal with stress (Cortisones) Sex hormones (like estrogen, progesterone, & testosterone)
• Cell membrane) Rigidity to our cells organ dysfunction
• Keep the intestinal wall healthypreventing “leaky gut”
• Bile salts – Digestion of fats
• (Powerful antioxidant)Did you catch this last surprise ?
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Similar to a vitamin. It is found in every cell of the body.
cells use it to produce energy , cell growth and maintenance. It is functions as an antioxidant &
Coenzymes help enzymes to digest food and perform other body processes, protect the heart and skeletal
muscles.
What is CoQ10 used for?Help in : heart failure, cancer, muscular dystrophy,
periodontal diseasesIt boost energy and speed recovery from exercises
Some people take it to help reduce the effects certain medicines on the heart, muscles, and other organs.particularly high in organ meats such as heart, liver,
and kidney, beef, soy oil, sardines, mackerel, and peanuts.
Dolichol, cholesterol, coenzyme Q10?Why we need Coenzyme Q10?
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http://www.functionalmedicineuniversity.com/statin-CoQ10.pdfThe CoQ10-Statin Secret
Ronald Grisanti D.C., D.A.B.C.O., D.A.C.B.N., M.S.What many people are unaware of is the fact that : CoQ10 depletion causes
LDL cholesterol Oxidation. The Oxidized LDL cholesterol drill holes in the arterial wall causing major inflammation. This increases the risk of getting a
heart attack or stroke.CoQ10 deficiency can cause fatal cardiomyopathy, heart attack, congestive heart
failure (which usually carries a death sentence of 5 years), exhaustion, cancer, myopathy, depression resistant to anti-depressants, high blood pressure, gum disease
and tooth loss, hair loss, liver disease, sudden complete memory loss or amnesia, cataracts, angina, cancer, folic acid deficiency, damaged cell membranes, and much
more.This a major reason why taking statins drugs is no guarantee you will not die of a heart
attack. the pharmaceutical giant, Merck, decided to add CoQ10 to a statin medication zocor.
should be illegal to prescribe a statin without also prescribing CoQ10. any doctor who prescribes a statin medication then turns you loose without prescribing
CoQ10 shows lack of scientific Knowledge of the very drug he is authorized to prescribe.
Take a look at the wealth of scientific references listed below.
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References:Thomas S. R., Neuzil J., Stocker R, Inhibition of LDL oxidation by ubiquinol-10. A protective mechanism of coenzyme Q in atherogenesis? Mol Asp Med, 18 (suppl.): s 85-103, 1997Bargossi AM, Battino M, Gaddi A, et at. Exogenous CoQ10 preserves plasma ubiquinol levels in patients treated with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, Internal J Clin Lab Res, 24: 171-6, 1994Fuke C, Krikorian, SA, Couris RR, Coenzyme CoQ10: A review of essential functions and clinical trials, Pharmacist, 28-41, Oct 2000Langsjoen PH, Langsjoen AM, Coenzyme Q10 in cardiovascular disease with emphasis on heart failure and myocardial ischaemia, Asia Pacific Heart J ,7; 3: 160-168, 1998Langsjoen PH, et al, Treatment of statin adverse effects with supplemental coenzyme Q10 and statin drug discontinuation, BioFactors, 25 (1-4): 147-52, 2005Langsjoen PH, et al, The clinical use of HMG CoA-reductase inhibitors and the associated depletion of coenzyme Q10. A review of animal and human publications, BioFactors, 18 (1-4): 101-11, 2003Mabuchi H, et al, Reduction of serum ubiquinol-10 and a ubiquinone-10 levels by atorvastatin in hypercholesterolemia, patients, J Atheroscler Thromb, 12; 2:111-19, 2005Lamperti C, Muscle, coenzyme Q10 level in statin-related myopathy, Arch Neurol, 62; 11: 1109-12, Nov 2005Mortensen AS, et al, Coenzyme Q10: clinical benefits with biochemical correlates suggesting a scientific breakthrough in the management of chronic heart failure, Int J Tissue React, 12; 3: 155-62, 1990Folkers K, Langsjoen P, Tamagawa H, Lovastatin decreases coenzyme levels in humans, Proc Nall Acad Sci USA, 1990; 87:8931-34Bliznakov EG, Wilkins DJ, Biochemical and clinical consequences of inhibiting coenzyme Q10 biosynthesis by lipid-lowering HMG COA reductase inhibitors (statins): a critical overview, Advances in Therapy, 15; 4:219-28, Jul/Aug 1998Ghirlanda G, Oradei A, Manto A, et al, Evidence of plasma CoQ 10-lowering effect of HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study, J Clin Pharmacol, 33: 226-29, 1993Willis RA. Folkers K, Tucker JL, Tamagawa H., et al., Lovastatin decreases coenzyme Q levels in rats, Proc Nat Acad Sci USA, 87: 8928-30. 1990Folkers K, Langsjoen P, et al, Lovastatin decreases coenzyme Q10 levels in humans, Proc Nat Acad Sci USA, 87:8931-4, 1990Bliznakov EG, Lipid-lowering to drugs (statins), cholesterol, and coenzyme Q10. The Baycol case-¬-a modern Pandora's box, Biomed Pharmacother, 56:56-9, 2002Jameson S, Statistical data support prediction of death within six months on low levels of coenzyme Ql0 and other entities, Clin Invest, 71 (suppl):137-39, 1993
Logical Observations
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By reading and studying Dr. Bernstein Diabetes solution book extensively; I knew how to use insulin the right way and knew how to eat. I cut all sugars, Juices, most of fruits and fast acting Carbohydrate and finally I was able to get my A1C
from 11 to 55.
My mentor in Diabetes and Nutrition are Dr. Richard Bernstein, Gary Taubes, Dr. David Perlmutter, Dr. William Davis, Dr.
Rob Thompson, Dr. Atkins, Maria Emmrich and Dr. Garry Fettke.I am the owner of diabetes management Facebook page
https://www.facebook.com/amdiabetic
About Me - Ahmed Afifi
I am a T1 Diabetic and a Mechanical Engineer who savor life, able to smell the beauty out of soft
breeze, appreciate the taste of coffee, quit smoking, in love with fishing, love my wife and feel happy
when helping people and support whoever in need.
Logical Observations
Logical Observations
Breast milk is ideally rich in Cholesterol
& contains a special enzyme for the baby to properly utilize it.
Babies and children need Cholesterol for proper growth and development of the Brain, nervous system, and
immune function.
Logical ObservationsEgg Yolk (very rich in
Cholesterol) contain full package of nutrients
needed for the embryo
Again Cholesterol is important for proper
growth and development especially for the
Brain, nervous system, and immune function.
NORTH CAROLINAEGG ASSOCIATIONRepresenting NC
Farmers.
Quick Linksincredibleegg.orgEgg-cyclopediaEgg Nutrition CenterEgg Safety CenterEgg RecipesEducator Lesson Plans K-12
The yolk is about 34% of the liquid weight of the egg
It contains all of the fat in the egg & a little less than half of the protein
The yolk of a large egg contains about 55 calories
With the exception of niacin & riboflavin, It contains a higher proportion of the egg’s vitamins than the white, as vitamins B6
and B12, folic acid, pantothenic acid & thiamin.
All of the egg’s vitamins A, D, E , K are in the yolk. (Fat soluble vitamins)
Egg yolks are one of the few foods naturally containing vitamin D.
It contains, calcium, copper, iron, manganese, phosphorus, selenium & zinc more than the white.
Egg Yolk
Albumen accounts for about 66%. of an egg’s liquid weight
It contains more than half the egg’s total protein, a majority of the egg’s niacin, riboflavin, magnesium,
potassium , sodium, and none of the fat.
The white of a large egg contains about 17 calories
Albumen color is opalescent and doesn’t appear white until an egg is beaten or cooked. The cloudy appearance comes from carbon dioxide. As eggs age, carbon dioxide escapes, so the
albumen of older eggs is more transparent than that of fresher eggs.
Egg White (Albumen)
The egg boasts all the nine Essential amino acids ( histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan and valine) In a pattern that matches very
closely the pattern the human body needs, In addition to the nine essential amino acids, there are nine other
amino acids in an egg.The Biological Value (BV) of eggs
is rated between 88 and 100, only whey protein rated higher (100).
Each Large egg provides a total of 6.29 grams of high-quality, complete protein
(eggs are classified with meat in the Protein)
Egg Protein & Other Nutrients
The inuit diet consists primarily of protein and fat . Similar to the low-
carbohydrate diets (Ketogenic diet) a popular weight-reducing diets
The currently established human essential nutrients are water, energy, amino acids (histidine, isoleucine, leucine, lysine, methionine,
phenylalanine, threonine, tryptophan, and valine), essential fatty acids (linoleic and α-linolenic acids), vitamins (ascorbic acid, vitamin A, vitamin D, vitamin E, vitamin K,
thiamine, riboflavin, niacin, vitamin B-6, pantothenic acid, folic acid, biotin, and vitamin B-12), minerals (calcium, phosphorus, magnesium, and iron), trace minerals (zinc, copper, manganese, iodine, selenium, molybdenum, and chromium), electrolytes
(sodium, potassium, and chloride), and ultratrace minerals
Note the absence of specific carbohydrates from this list. A little evidence that exogenous carbohydrate is needed for human
function
Logical Observations
Logical ObservationsThe Sources of
Vitamin D Anti oxidants
Fat soluble VitaminsAll are very rich in Cholesterol and
fatsWhether Plant or Animal sources e.g. Seed
oils, Polyunsaturated plant oils, Nuts, seeds, Sea food, Meat, liver, milk, butter,
egg yolk
المأكوالت واشهى انفع فى دائما الكوليسترول لماذاIs it logical to discard all these items due to Cholesterol phobia ?
1- What is behind the excessive endogenous
Cholesterol production ?? 2- Protective mechanism
against what ??
Logical ObservationsIt very clearly shows
that there is no correlation between
cholesterol and heart disease.
Notice that the country with the highest levels of
cholesterol —Switzerland — has one of the lowest rates of
heart disease.
Endogenous production of Cholesterol > 80%. means that There is a feedback mechanism (means an increased demand as a protective mechanism)
It’s clear that statins reduce heart disease as well as the risk of death in those below 80 y.
that have already had a heart attack,Who already tried diet and lifestyle interventions
without much impact on lipid or inflammatory markers
Logical ObservationsEra of evidence based medicine vs old delusions & myths
But after 40 years “Statins used in a very wide scale 1 out of 2 men and 1 out of
3 women Significant Increase in heart diseases,
sudden death, memory disturbances, Alzheimer, cancer, aggression & mood
changes
Cholesterol levels naturally rise with age and are beneficial to the elderly. Women with the highest cholesterol actually live
the longest
Cholesterol is needed to repair damaged cells.!
That is why there is a risk of severe muscle damage (myopathy & rhabdomyolysis) with
statins in the elderly
Logical ObservationsEra of evidence based medicine vs old delusions & myths
. Hypercholesterolemia is not a risk factor for mortality in persons older than 70 years & risks from statin drugs are more increased
after age 85.[1]
Vitamin D deficient Osteomalacia in adultsWhy do we need Cholesterol ? Do you know that Cholesterol is a Vitamin D precursor
Vitamin D deficient Osteomalacia in adultsWhy do we need Cholesterol ? Do you know that Cholesterol is a Vitamin D precursor
Vitamin D deficient Osteomalacia in adultsWhy do we need Cholesterol ? Do you know that Cholesterol is a
Vitamin D precursor
Vitamin D deficient Osteomalacia in adultsSecondary hyperparathyroidism &
parathyroid adenoma
Primary hyperparathyroidismThe most common reason a non-cancerous parathyroid adenoma Too much PTH cause
calcium to be too high in the blood, and poor bone health
Sometimes doctors treat primary hyperparathyroidism surgically
Secondary hyperparathyroidismLong term vitamin D deficiency or kidney failure.
This can be corrected by treating vitamin D deficiency.
In kidney failure, activated vitamin D.
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Vitamin D deficient Osteomalacia in adults
Vitamin D deficient Osteomalacia in adults
Vitamin D: Sunshine Vitamin
Cardiac Dysfunction, Hypertrophy and Failure. The leading cause of mortality in the developed
world
Essential for blood clotting.Stabilizes blood pressure.
Contributes to normal brain function.Critical for communicating essential information
among cells.Helps insulin open cells to glucose
Chemicals that transmit a signal from a nerve cell to a target cell
(for example, when a nerve tells a muscle to move)Facilitates the actual process of contraction of the
muscle cellAssists the movement of sperm to fertilize the egg
Calcium Non-bone functionsonly 1 percent of the calcium in the body is found outside the bone
This form of calcium is critical for many functions in the body
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Functions of Vitamin D Calcium and Phosphorus
Homeostasis Calcium and Phosphorus absorption (small intestine)
Calcium reabsorption (bone and kidney)
Maintain blood calcium levels Bone formation Stimulate calcium uptake for
deposition as calcium phosphate (Osteoblasts: bone-
forming cells) Hormone
Regulation of gene expression Cell growth
PTH:Parathyroid Hormone
Vitamin D: Sunshine Vitamin (Sources) Body can make it if exposed to enough
sunlight Made from cholesterol & stored in
the skin Synthesized in body
Plants (ergo sterol) Sun-cured forages
Fluid milk products are fortified with vitamin D
Oily fish Egg yolk
Butter Liver
Daily Value 10 micrograms
Vitamin D (Calciferol) There are 2 major precursor forms
7-dehydrocholesterol Vitamin D3 = chole calciferol
Produced photo chemically by the action of sunlight or ultraviolet light from the
precursor sterol 7-dehydrocholesterol
ErgosterolVitamin D2 = ergo calciferol
Completely synthetic form produced by the irradiation of the plant steroid ergosterol
Calcitriol (1,25-dihydroxy-cholecaliferol, 1,25 DHCC)
Vitamin D Deficiency symptomsRickets in children
Inadequate calcification, resulting in misshapen bones (bowing of legs)
Enlargement of ends of long bones (knees, wrists) Deformities of ribs (bowed, with beads or knobs)
Delayed closing of fontanel, resulting in rapid enlargement of head
Lax muscles resulting in protrusion of abdomen Muscle spasms
Vitamin D Deficiency symptomsOsteomalacia in adults
Bones that fracture very easily are the most common symptom.
Loss of calcium -> soft, flexible, brittle, & deformable bones
Bone pain, hips dull, aching spread to lower back, pelvis, knees, legs, & ribs
Progressive muscle weakness. a hard time walking and a waddling gait.Non Skeletal symptoms
Irregular heart rhythmsNumbness around the mouth, in arms &
legsSpasms in hands and feet
Sleep disturbances, depression
Cholesterol is the (vitamin D precursor)
What other functions of cholesterol ?• Precursor to Hormones deal with stress (Cortisones) Sex hormones (like estrogen, progesterone, &
testosterone)
• Gives rigidity to our cells (cell membrane) organ dysfunction
• Keep the intestinal wall healthy preventing “leaky gut”
•Powerful antioxidantDid you catch the last one?
Cholesterol – The Unsung AntioxidantSEPTEMBER 25, 2012
Unsung : not noticed or praised for hard work, courage, or great achievementsan unsung heroIt is easy to assume that cholesterol is bad
( In reality, cholesterol is the unsung antioxidant)
It serves an important role in the health of our
body.
Our body produces it ! by most of its cells & the liver.
Endogenous production > three times the dietary intake!
We know antioxidants in berries, dark green vegetables and other foods
But cholesterol is a powerful antioxidant ? we are told to avoid ????
Cholesterol is the rescue of cells damaged by free radicals and help repair damage done to the arteries?
Cholesterol, is not the culprit of heart disease, but an antioxidant rushing to the scene of an accident to help with repairs.
Leucocytosis treatment vs. Hypercholesrolaemia treatment
High blood cholesterol levels indicate that the body is in need of it to protect itself from free radicals and the damage they cause. It seems that we have been blaming the firefighters for the fire
Cholesterol is a powerful antioxidant !
The major source of dietary cholesterol is eggs, beef, pork, cheese, poultry, fish
and shrimp.
It is time to stop robbing our bodies of these excellent sources of animal fats,
proteins and antioxidants.
Cholesterol is a powerful antioxidant !
They are good for you!Get your antioxidants from dark green veggies, berries
but don’t skip out good quality sourcesStop blaming the firefighters and the vultures !
Thanks to Almighty Allah for the Endogenous Production of substances necessary for our life like (Cholesterol)
Elsheikh Alshaarawy
Allah in His infinite Wisdom has designed everything on this planet earth so there is No monopoly with
life dependant issues (Air – Sun – Water - etc )
Myth – 2015 High Cholesterol Does NOT cause Heart Disease
Myth : a widely held but false belief or idea.The Old Concept : High Cholesterol level contribute
to heart disease by clogging the arteries
The latest literature :
Hypercholesrolaemia is not the reason for heart disease or atherosclerosis .
Heart disease is caused by a state of chronic inflammation of blood vessels (which is the
Culprit)
1- What is behind state of chronic inflammation ??
2- How it affect the heart ??
Myth – 2015 High Cholesterol Does NOT cause Heart Disease
1- Chronic inflammation -> endothelial injury & increased permeability
2- Oxidation of Small dense particles LDL (Chronic inflammation + Hyperinsulinemia) -> accumulation in the
intimal sub endothelium
Monocytes migrate to the subendothelial space Mature into Macrophages and uptake oxidized LDL -> 'foam' cells that
eventually form the lipid core of the atherosclerotic plaque after apoptosis occurs
The inflammatory mediator cascade promotes a phenotype change of vascular smooth muscle cells (VSMCs) from the
'contractile' phenotype state to the active 'synthetic' state. VSMCs in the synthetic state can migrate and proliferate from
the media to the intima,
where they produce excessive amounts of extracellular matrix (e.g., collagen, elastin and proteoglycans) that
transforms the lesion into a fibrous plaque
The typical atherosclerotic plaque comprises of the lipid core and the fibrous cap, and is the most commonly classified histologically by the American Heart Association
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1- Chronic inflammation 2- Oxidized Small dense particles LDL
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2- Small dense particles LDL) is a type B of LDL cholesterol .
It isn’t only the quantity of LDL circulating it’s the quality, too. Smaller and heavier than typical LDL cholesterol Small enough to penetrate the walls of arteries, Susceptible to being oxidized (electron donor)
Stays in the blood stream longer.Electron donor = (Antioxidant)
1- Chronic inflammation 2- Oxidized Small dense particles LDL
Small, dense LDL particles was associated with1- more than a three-fold increase in the risk of CHD.
2- Rarely an isolated disorder Usually with the insulin resistance syndrome
The treatment should not only aim at reducing plasma triglyceride levels, but also at improving all features of the insulin resistance syndrome
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CHD
INFLAMMATION PROCESSED FOOD
(SUGAR – NON FIBERCARBOHYDRATE
)OXIDANTSBACTERIA
TOXINS-POLLUTION HOMOCYSTEINE
SUGAR+ NONFIBERCARBOHYD
RATEHYPERGLYCAEMIA
HYPERINSULINAEMIAINSUINSULIN RESISTANCEDYSLIPIDAEMIA
OBESITY
1 -ENDOTHELIAL PERMEABILITY
2 -SMALL DENSE LDL
EASY OXIDIZABLEELECTRON DONOR
(ANTIOXIDANT)
Way of thinking who is (The Culprit)Broad minded vs. key hole vision
Processed foodToxins - Oxidants
Dietary sugarNon fiber Carbohydrate
Triglycerides VLDL Hypercholesterolemia
(small dense LDL particles)
Electron donor (antioxidant)
Hyperglycemia1- Lipoprotein Oxidation
& Glycation2- Hyper insulinemia -> Insulin resistance
-> increased triglycerides VLDL
3- State of chronic inflammation (The Culprit)
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How to Lower the Risk of Heart Disease Without Drugs ?
The answer is the Control of1- Chronic inflammation
2- Small dense particles LDL
How ? The answer is by 1- Anti-inflammatory lifestyle
Example: Pay attention to your oral health.. In one 2010 study,20 those with the worst oral hygiene increased their risk of developing heart disease by 70 percent, compared to
those who brush their teeth twice a day. 2- Control hyper- insulinaemia & insulin resistance
s.Example : Reduce dietary sugar and non fiber carbohydrates
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Myth – 2015 High Cholesterol Does NOT cause Heart DiseaseChronic inflammation of blood vessels is the enemy
Etiological factorsProcessed & Fried foods
diet high in Sugar & trans fatty acids
Chronic inflammation is caused by a laundry list of items such as:
Oxidized cholesterol (cholesterol that has gone rancid, such as that from overcooked, scrambled
eggs)Eating lots of sugar and grains
Eating foods cooked at high temperaturesEating trans fats
So to sum it all up, in order to lower your inflammation and cholesterol levels naturally,
you must address the items on this list.The more refined foods humans consume, the
more the inflammation switch is turned on, minute by minute, hour by hour, and day by day. Your body was not meant nor designed to deal
with such excesses.
Processed foods creates overloaded fat cells that dump out large quantities of pro-
inflammatory chemicals that cause injury by having high blood sugar.
As the inflammatory process continues unabated, it becomes a vicious cycle that creates heart disease, diabetes, high blood
pressure, and finally Alzheimer's.
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Myth – 2015 High Cholesterol Does NOT cause Heart DiseaseChronic inflammation of blood vessels is the
enemyEtiological factors
Processed & Fried foods diet high in Sugar & trans fatty acids
Homocysteine (non-protein amino acid a causes
endothelial injury -> inflammation in the blood vessels -> atherogenesis and
result in ischemic injuryToxins, Oxidants
(pollution , alcohol ,smoking)Wide spectrum of Infectious
agents
Risk factors
Sedentary indoor lifestyleEmotional stress
Overweight or Obese (almost half of U.S. adults).
Family history of heart disease
High blood pressureDiabetes
High cholesterol has been blamed for heart problems for far too long.
Its time to set the record straight and stop worrying about high cholesterol!
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SUMMARY
The major source of dietary cholesterol is eggs, beef, pork, cheese, poultry, fish and shrimp. It is time to stop robbing our bodies of these excellent sources of animal fats, proteins and
antioxidants.
Cholesterol is a Vitamin D precursor & a powerful
antioxidant !
Get your antioxidants from dark green veggies, berries
But don’t skip out good quality sources
Thank you
Stop blamingThe firefighters for the fire
and The vultures for the cow’s
death