The The Lowe Syndrome TrustLowe Syndrome Trust

“Care today…. cure tomorrow”“Care today…. cure tomorrow”

Here are some UK Lowe Here are some UK Lowe Syndrome Children Syndrome Children

They are born with multiple handicaps including They are born with multiple handicaps including Cataracts, Weak muscles, Kidney, Growth, Brain and Cataracts, Weak muscles, Kidney, Growth, Brain and Bone disorders. This is due to a DNA mutation that Bone disorders. This is due to a DNA mutation that

results in a low level of an essential enzymeresults in a low level of an essential enzyme

There are also some UK Lowe There are also some UK Lowe Syndrome Adults Syndrome Adults

Lowe Syndrome can occur with no Lowe Syndrome can occur with no family history and affects children family history and affects children

worldwide. The severity varies with worldwide. The severity varies with some children blind, unable to walk and some children blind, unable to walk and

severe mental impairment. severe mental impairment.

                         

     

The Trust works with the USA Lowe The Trust works with the USA Lowe Syndrome Association and others and helps Syndrome Association and others and helps

initiate and fund medical research. initiate and fund medical research.

We are helping to fund research projects in We are helping to fund research projects in USA , Gt Ormond Street London, Imperial USA , Gt Ormond Street London, Imperial

College London, University College London College London, University College London and Dundee Universityand Dundee University

Our hope is the researchers and doctors will Our hope is the researchers and doctors will work together in a worldwide effort to treat work together in a worldwide effort to treat

and cure lowe Syndrome and cure lowe Syndrome

The Trust has established a UK Medical and Scientific The Trust has established a UK Medical and Scientific Advisory board which advises on research issues and Advisory board which advises on research issues and research proposals received. research proposals received. Dr William van’t Hoff, Consultant Nephrologist, Great Ormond Street Hospital (GOSH)Dr William van’t Hoff, Consultant Nephrologist, Great Ormond Street Hospital (GOSH) Professor Robert Unwin, Professor of Nephrology & Physiology, University College Professor Robert Unwin, Professor of Nephrology & Physiology, University College

London London Professor Shamshad Cockcroft, Lipid Signalling Group, Department of Physiology, Professor Shamshad Cockcroft, Lipid Signalling Group, Department of Physiology,

University College London.University College London. Dr Philip Beales, Hon Consultant in Clinical Genetics, Institute of Child Health (ICH)Dr Philip Beales, Hon Consultant in Clinical Genetics, Institute of Child Health (ICH) Professor Bruce Caterson, Professor of Research in Orthopaedics and Biochemistry, Professor Bruce Caterson, Professor of Research in Orthopaedics and Biochemistry,

Cardiff University.Cardiff University. Dr Anthony Norden, Clinical Biochemistry, Addenbrooke’s Hospital, Cambridge.Dr Anthony Norden, Clinical Biochemistry, Addenbrooke’s Hospital, Cambridge. Professor Peter Cullen, Professor in Inositol Signalling and Lister Institute Research Professor Peter Cullen, Professor in Inositol Signalling and Lister Institute Research

Fellow, Department of Biochemistry, University of Bristol. Fellow, Department of Biochemistry, University of Bristol.

The Lowe Syndrome Trust Medical Advisors are:The Lowe Syndrome Trust Medical Advisors are: Mike Harrison, Honorary Consultant in Pediatric Dentistry, Guys HospitalMike Harrison, Honorary Consultant in Pediatric Dentistry, Guys Hospital Dr David Taylor, Opthalmic Surgeon, GOSH.Dr David Taylor, Opthalmic Surgeon, GOSH.

The Trustees are:The Trustees are: Lorraine Thomas Lorraine Thomas Undine ReidyUndine Reidy Carolyn MitchellCarolyn Mitchell Catherine McNaughtCatherine McNaught Jonathan RossJonathan Ross

Patrons includePatrons include: : Vanessa Feltz Vanessa Feltz Tris PayneTris Payne Tom ContiTom Conti Penny Lancaster Penny Lancaster

Jonathan ColemanJonathan Coleman Tony HadleyTony Hadley Richard ParkRichard Park

David PerverDavid Perver

We are helping to fund kidney Research at Gt Ormond Street Hospital / ICH

Dundee University Scotland

Imperial College London

The Charity is run by unpaid volunteers, The Charity is run by unpaid volunteers, unpaid scientific and medical advisors and unpaid scientific and medical advisors and

all funds are donated by the public and all funds are donated by the public and though fundraising events though fundraising events

A big thankyou to our sponsors

        

Many thanks to all our Many thanks to all our supporters supporters

For further For further information and information and

contacts seecontacts seewww.lowetrust.comwww.lowetrust.com