the need for a triple-drug fixed-dose combination in hypertension
TRANSCRIPT
The need for a triple-drug fixed-dose combination in
hypertension
The need for a triple-drug fixed-dose combination in
hypertension
Prevalence of hypertension continues to increase
Prevalence of hypertension continues to increase
2Kearney PM et al. Lancet. 2005;365(9455):217-223.
2000 2025
1 /3 of hypertensive patients are already treated by 3 or more antihypertensive
drugs
1 /3 of hypertensive patients are already treated by 3 or more antihypertensive
drugs
3Thoenes M et al. J Hum Hypertens. 2010;24:336-344.
18 652 patientsNorthern Europe (Belgium, Germany, Sweden, Switzerland), Southern Europe (Greece, Italy, Spain, Turkey), North America (Canada), Latin America (Columbia, Mexico, Peru), Middle East (Kuwait, Lebanon, Qatar, Saudi Arabia, UAE), Asia (Hong Kong, Indonesia, Korea, Singapore, Taiwan, Thailand, Vietnam, Australia)
60% of hypertensive patients are uncontrolled
by two-drug antihypertensive therapy
60% of hypertensive patients are uncontrolled
by two-drug antihypertensive therapy
4Thoenes M et al. J Hum Hypertens. 2010;24:336-344.
18 652 patientsNorthern Europe (Belgium, Germany, Sweden, Switzerland), Southern Europe (Greece, Italy, Spain, Turkey), North America (Canada), Latin America (Columbia, Mexico, Peru), Middle East (Kuwait, Lebanon, Qatar, Saudi Arabia, UAE), Asia (Hong Kong, Indonesia, Korea, Singapore, Taiwan, Thailand, Vietnam, Australia)
Combination therapy improves compliance
Combination therapy improves compliance
The use of combination vs monotherapy reduces the risk of treatment discontinuation by 73%1
51. Corrao G et al. J of Hypertension. 2010;28:1584-1590. Cohort of 433 680 hypertensive patients2. Bangalore S et al. Am J Med. 2007;120:713-719. Meta-analysis with 20 242 hypertensive patients
Single-pill combination reduces the risk of non compliance by 24% vs free combination2
Single-pill combinations are more efficient
than free combinations
Single-pill combinations are more efficient
than free combinations
“Greater use of single-pill combinations as initial therapy improves hypertension control and cardiovascular outcomes in the first year of treatment.”
6Egan BM, Bandyopadhyay D, Shaftman SR, Shaun Wagner C, Zhao Y, Yu-Isenberg KS. Hypertension. 2012;59:1124-1131.
Triple-drug therapy goes further in terms of BP-lowering efficacy and taget-
organ protection
Triple-drug therapy goes further in terms of BP-lowering efficacy and taget-
organ protection
7Law MR et al. BMJ. 2003;326:1427-1434