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THE OPIATE EXPERTFOR A PAIN FREE WORLD
AGRICULTURALRESEARCH
ALKALOID EXTRACTION
TRACEABILITY
SECURITY
AGRICULTURAL PRODUCTION
S A N O F I G R O U P
80 YEARS OF ALKALOID EXTRACTION
40 YEARS OF INDUSTRIAL SCALE POPPY CULTIVATION
30 YEARS OF EXPORT EXPERTISE
A MAJOR OPIATE PLAYERIN THE WORLD
FRANCOPIA
2FRANCOPIA_THE OPIATE EXPERT - For a pain free world
Created in 1932, Francopia is today one of the world’s major opiate producers. Specialist in the supply of active ingredients, the company is a key player involved in pain and addiction treatment.
3FRANCOPIA_THE OPIATE EXPERT - For a pain free world
1 - AGRICULTURAL RESEARCH Creating varieties and producing seeds
2 - AGRICULTURAL PRODUCTION Using a dedicated team to provide the narcotic raw material
3 - INDUSTRIAL PRODUCTION Manufacturing 20 active pharmaceutical ingredients
and intermediates
4 - DISTRIBUTION Applying the highest security standards, adapted to each country, to deliver to customers worldwide
Security and quality at each step of the process
Francopia, a Sanofi company, within the CEPiA network Within the Industrial Affairs Division of Sanofi, CEPiA (Commercial & External Partnership, Industrial Affairs) is an organisation exclusively dedicated to third party sales. CEPiA offers a wide range of solutions, including:• A portfolio of 200 intermediate
and active ingredients • Custom Synthesis • Toll manufacturing3 TYPES OF
PRODUCTS
Morphine Derivatives
Thebaine Derivatives
Synthetic Opioids
A FULLY INTEGRATED ACTIVITYFROM POPPY SEEDS TO ACTIVE PHARMACEUTICAL INGREDIENTS
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RESEARCH FOCUSING ONPRODUCTIVITY
The main steps in genotype creation:• Crossing between elite lines• Evaluation of the chemical and agricultural
potential • Multiplication of progeny.
Once these steps are complete, the new variety can move to agricultural production scale production.
AGRICULTURAL RESEARCH
For more than 40 years, Francopia has focused its research on breeding alkaloid rich plants suitable for industrial scale cultivation.
Investing in the future: a strong commitment1000 poppy genotypes are tested each year by a team of agriculture engineers. Thus, more than 40 new varieties have already progressed to agricultural scale production.The role of this team of highly qualified researchers includes:
Genotype hybridisation
Research of innovative genotypes
Identification of genes of interest
Chemical analysis and genetic tagging
Variety selection by statistical and genomic methods
Certification of phytosanitary products
1000 "GENOTYPES" TESTED EVERY YEAR
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COLLABORATION WITH KEY PLAYERS
R&D FRANCOPIA
French Ministry ofthe Environment
French Agency for Medicine Security
(ANSM)
Phytosanitary companies
Poppy growers
Sanitary and safety organisations and control agencies
Private and public research
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SECURING POPPY CULTIVATION
The Francopia agricultural team controls the whole supply chain, ensuring the traceability and safety of products.
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AROUND
10,000 ha
Crop sowing techniques
Selection of phytosanitary treatments
Development of specific agricultural machinery
Organisation of harvesting
Field geolocalisation for traceability and registration with police
Dehydration
Production of poppy straw pellets
Storage under controlled atmosphere
GETTING THE BESTOUT OF A FRAGILE CROP
AGRICULTURAL PRODUCTION
Francopia produces a high yielding poppy using a network of contracted farmers and agriculture related organisations.A dedicated team ensures the perpetuation of the highly technical know-how throughout all stages of the production, such as :
The power of the Group Francopia relies on the strong network of Sanofi manufacturing sites, each with its own expertise and tailored skills to ensure customer supply.
A vegetal extraction site• Expert in alkaloid extraction since 1963• Production of 150 metric tons of active ingredients annually• Packaging and logistics within closed units
The second site• The largest chemical and biotechnological site
of the Sanofi Group in Europe • Specialised in the manufacturing of synthetic
opioids
Unmatched experienceWith over 80 years of solid experience in vegetalextraction and chemical synthesis, Francopia industrial teams have fine tuned their manufacturing processes in line with the need to produce the very safest, highest quality products. The industrial sites are continually audited and checked by the major regulatory bodies such as the FDA (US), ANSM (France), PMDA (Japan), ANVISA (Brazil)…
Francopia meeting customers' specific needs• Adaptation of regulatory documents to local
regulations• Physical quality on demand: sieving, milling and
micronisation• Chemical and physical analyses with cutting edge
technology (NRM, LC-MS…), allowing to respond to specific demands
• Development team dedicated to toll manufacturing responding to the need for changing processes or specifications and developing new molecules
SANOFI’SINDUSTRIAL EXPERTISE
INDUSTRIAL PRODUCTION
MORE THAN
150 METRIC TONSOF ACTIVE INGREDIENTS SHIPPEDEACH YEAR
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ACTING FOR SUSTAINABLE DEVELOPMENT
The development of Francopia is based on a continuous drive to improve processes and minimise environmental impacts. Our principal plant has implemented and constructed a waste and energy recovery treatment unit. The large solar panels, installed in 2012, produce the equivalent of the annual energy consumption of 350 households.Our sites are certified ISO 14001 and 50001.
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PRODUCINGUNDER TIGHT CONTROL
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The International Narcotics Control Board (ONU-INCB) monitors the worldwide narcotics market.
In accordance with the 1961 Single Convention on Narcotic Drugs, each country is obliged to declare all production, import, export, consumption, manufacturing and stock.
Francopia ensures the safety of all movements, under the control of the Ministry of Interior and the French Police.Francopia is AEO certified (Authorised Economic Operator)*.
* Global certification that recognises the high quality of different regulations, practices, and procedures in terms of customs compliance and security of the supply chain for the administration of international trade operations.
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Working with you worldwideThanks to a global presence with strong local representation, 75% of our sales are achieved through export. Francopia currently distributes its range of active pharmaceutical ingredients in over 80 countries.
Meeting customer needs…• Tailor made services (packaging, labelling, sieving, milling,
micronisation, specific analyses...)• Operational responsiveness and reliability in the supply chain• A fully dedicated team (commercial, logistics, quality and
regulatory support)
… towards a long term partnershipFRANCOPIA_THE OPIATE EXPERT - For a pain free world
CEPiA Offices
Local Francopia representatives
Francopia headquarter and manufacturing site
FRANCOPIA A GLOBAL NETWORK CLOSE TO ITS CUSTOMERS
SELLING IN MORE THAN
80 COUNTRIES
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Für eine Welt ohne Schmerz
За мир без боли
致力于无痛世界
P a r a u n m u n d o s i n d o l o r
For a pa in f ree world
痛みのない世界のために
Pou r u n monde sa ns dou leu r
Francopia, a subsidiary of the Sanofi Group, member of the CEPiA network
Contacts
France+33 1 55 71 27 34
United States+1 908 981 55 18
Eastern Europe +421 2 33 100 700
India+91 98 33 77 44 68
Japan+81 3 6301 3450
China+86 21 22 266 032
Rest of the World+33 1 55 71 27 34