The Regulatory Role of Small RNASeptember 24-25, 2008

Weizmann Institute of Science

Sponsored by The Kahn Family Research Center for Systems Biology of the Human Cell

Prog

ram September 24, 2008

9:30 Conference opening (B. Shilo, E. Domany)

Keynote sessionIntro: E. Hornstein

9:40 Witold Filipowicz (Friedrich Miescher Institute, Basel)Mechanisms and reversibility of the miRNA-mediated repression in mammalian cells

10:20 Reuven Agami (NKI-AVL, Amsterdam)Cancerous miRNAs and regulatory RNA binding proteins

11:00 Timothy W. Nilsen (CWRU,Cleveland)Mechanisms of miRNA-mediated gene regulation in animal cells

11:40 Lunch Break

Molecular mechanisms of small RNA regulationChair: R. Agami

12:55 Shulamit Michaeli (BIU)How do small RNAs control the life of trypanosomes?

13:15 David Mirelman (WIS)Epigenetic gene silencing in Entamoeba histolytica : possible involvment of a non coding RNA from a SINE retroposon

13:35 Michael Walker (WIS)Transcriptional control of miRNA gene expression: regulating the regulators

13:55 Rivka Dikstein (WIS)Links between proximal promoter elements, transcription elongation and protein translation

14:15 Break

miRNA in developmentChair: S. Michaeli

14:45 Sebastian Kadener (HUJI)Role of miRNAs on circadian rhythms in Drosophila

15:05 Eithan Galun (HUJI)miRNA in liver development

15:25 Eran Hornstein (WIS)A miRNA that controls osteoclast differentiation

15:45 Yuval Eshed (WIS)Species specific roles of ta-siRNAs in leaf developoment

16:05 Break

miRNA in stem cellsChair: Y. Eshed

16:20 Tamas Dalmay (U.East Anglia))Experimental approach to identify miRNA targets in mammalian cells

16:40 Yechiel Elkabetz (Sloan-Kettering Institute)miRNA contribute to neuronal stem cell differentiation

17:00 Yoav Soen (WIS)miRNA involvement in regulation of human embryonic stem cells differetiation

17:20 David Givol (WIS)miRNA in glioblasoma stem cells and its use for inhibiting tumor cell growth

Prog

ram September 25, 2008

RNA regulation of gene expression Chair: T.W. Nilsen

09:30 Yael Mandel Gutfreund (Technion)Regulation of alternative splicing: Lessons from the Human genome

09:50 Gil Ast (TAU)The battle between miRNA processing and RNA splicing

10:10 Gidi Rechavi (TAU)Regulation of gene expression by RNA Editing of 3’UTRs

10:30 Break

11:00 Ruth Sperling (HUJI)Regulation of pre-mRNA processing

11:20 Asaph Aharoni (WIS)The TPP riboswitch regulates the plant vitamin B1 biosynthesis pathway by affecting alternative splicing and mRNA stability

11:40 Joseph Sperling (WIS)A potential role for initiator-tRNA in pre-mRNA splicing regulation

12:00 Lunch Break

Bioinformatics of small RNA Chair: E. Domany

13:15 Eran Segal (WIS)How much of the variability in gene expression can be explained by miRNAs?

13:35 Nitzan Rosenfeld (Rosetta Genomics)miRNA-based diagnostic tools for cancer

13:55 Noam Shomron (TAU)Determinants of miRNA targeting

14:15 Rotem Sorek (WIS)Genome-wide discovery of non coding RNAs in prokaryotes using next generation sequencing

14:35 Break

miRNA in disease Chair: W. Filipowicz

15:05 Varda Rotter (WIS)p53-repressed miRNAs are involved with E2F in a feed forward loop promoting proliferation

15:25 Karen Avraham (TAU)miRNA profiling and target prediction in the mouse inner ear: implications for deafness

15:45 Ofer Mandelboim (HUJI)Control of immune response to stress by human and viral miRNAs

16:05 Mona Soreq (HUJI)miRNA regulate brain to body anti-inflammatory signaling

16:25 Closing remarks