the relationship between csf flow and physical activity · the relationship between csf flow and...
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The relationship between CSF flow and physical activity
preliminary data from the USC LEARNit trial
Judy Pa, PhD Assistant Professor of Neurology, Neuroscience, and Biomedical Engineering
University of Southern California
Spring ADC meeting April 21, 2018
iADlimaging Alzheimer’s & Dementia lab
Judy Pa, PhD, USC - CSF Flow and Physical Activity
Judy Pa, PhD, USC - CSF Flow and Physical ActivityChoroid Plexus
Lateral Ventricles
3rd Ventricle
4th Ventricle
Subarachnoid Space Venous Outflow
Judy Pa, PhD, USC - CSF Flow and Physical Activity
Cerebral Aqueduct
Choroid Plexus Lateral Ventricles
3rd Ventricle
4th Ventricle
Subarachnoid Space Venous Outflow
Judy Pa, PhD, USC - CSF Flow and Physical Activity
Cerebral Aqueduct
Preliminary analysis (n=12) • Age: 68+6.3 years, 6 women• Older adults with early MCI• Continuous monitoring of
physical activity for 30 days via accelerometer
Imaging Outcome • Phase-contrast MRI scan for
CSF flow
Choroid Plexus Lateral Ventricles
3rd Ventricle
4th Ventricle
Subarachnoid Space Venous Outflow
Judy Pa, PhD, USC - CSF Flow and Physical Activity
Cerebral Aqueduct
Preliminary analysis (n=12) • Age: 68+6.3 years, 6 women• Older adults with early MCI• Continuous monitoring of
physical activity for 30 days via accelerometer
Imaging Outcome • Phase-contrast MRI scan for
CSF flow
Choroid Plexus Lateral Ventricles
3rd Ventricle
4th Ventricle
Subarachnoid Space Venous Outflow
r=.70, p=.015
10
20
30
40
50
60
70
80
90
100
110
0 5 10 15 20 25 30 35 40
Pred
icte
d St
roke
Vol
ume
(mm
3 )
Average Time Spent in MVPA per Day (min)
CSF Flow X Physical Activity
adjusted for age
Judy Pa, PhD, USC - CSF Flow and Physical Activity
Validation paper: Sakhare, Isenberg & Pa (under revision)
Cerebral Aqueduct
Preliminary analysis (n=12) • Age: 68+6.3 years, 6 women• Older adults with early MCI• Continuous monitoring of
physical activity for 30 days via accelerometer
Imaging Outcome • Phase-contrast MRI scan for
CSF flow
Physical activity = CSF flow
• Potential mechanistic pathway for exercise as a disease-modifying intervention • amyloid, tau PET scans
• Full trial will address this question NIH AD Clinical Trial R01-AG055469
Choroid Plexus Lateral Ventricles
3rd Ventricle
4th Ventricle
Subarachnoid Space Venous Outflow
r=.70, p=.015
10
20
30
40
50
60
70
80
90
100
110
0 5 10 15 20 25 30 35 40
Pred
icte
d St
roke
Vol
ume
(mm
3 )
Average Time Spent in MVPA per Day (min)
CSF Flow X Physical Activity
adjusted for age
Acknowledgements
THANKS TO OUR RESEARCH PARTICIPANTS
USC CollaboratorsErin FitzgeraldBeth FisherCarolee WinsteinWendy MackChristina Dieli-ConwrightTodd SchroederHussein Yassine Helena ChuiPeter ContiLon SchneiderScott NeuArthur Toga
Pa Lab *Ashwin Sakhare *Lisette Isenberg Teresa Monreal Joy Stradford Jocelyn Argueta Joey Contreras Chris Patterson Vincent Yang
iADl
FundingNational Institute on Aging
USC Alzheimer’s Disease Research Center & USC CTSI