The Role of Cortisol in Health & Longevity

Presented by William Kraemer, Ph.D.Professor of KinesiologyUniversity of Connecticut

This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited.

What is Cortisol?

• Cortisol is the body’s primary stress hormone• “Fight-or-Flight” response• Regulates inflammation, carbohydrate metabolism, cardiovascular function, etc…

• BUT too much cortisol for too long leads to health concerns

Normal Diurnal Cortisol Rhythm

Cortisol Levels Throughout the Day

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STRESS

Epel et al. Psychosom Med 2000;62(5):623-32

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M. Altemus, Cornell University.Trier Social Stress Test(public speaking & arithmetic)

Cortitrol™ STRESS CONTROL FORMULA

Presented by Shawn Talbott, Ph.D.Director, Scientific AffairsPharmanex, LLC

Supports healthy cortisol levels*

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited.

What is Cortisol?

• Cortisol is the body’s primary stress hormone• “Fight-or-Flight” response• Required by the body for survival • Regulates carbohydrate metabolism, cardiovascular function, etc…

•BUT too much cortisol for too long leads to problems

• Repeated exposure to stressful situations (personal, family, work)• Modern stressors do not permit fight or flight • Stress hormones may not dissipate• Stress leads to health consequences

Figure 1.1 The “normal” stress response

A Stress occurs!

B Stress response

begins in the brain (lots of chemistry) D

Stress response ends and stress

hormones dissipate

C Fight or Flight

Yikes!!!!! Whew!

Robert Sapolsky, PhDStanford stress researcher

Cortitrol™ Helps Control Cortisol to Cope with Stress

Cortisol Levels Throughout the Day

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Stress

• Stressful situations

• Sleep deprivation

• Dieting / Restrained eating

Cortisol Levels Are Elevated In...

Adults who need to control cortisol levels are… • Frequently confronted with stressful situations• Getting less than 8 hours of sleep every night• Generally feel run down, lack mental focus• Limiting caloric intake to lose weight

Psychological demands at work that exceed one’s capacity to cope produce a variety of physiological responses that, over time, lead to health concerns.

Work demands and low level of job control lead to changes in cortisol levels.

Stress and the Workplace

Ganster et al. Journal of Applied Psychology, 2001, 86, 954-964.

Cortisol in the Media

More Than 1,000 News Articles Over the Past Year!• Time, Washington Post, Men’s Health, Prevention, Glamour, Shape, Woman’s World, Reader’s Digest, Reuters, ABC, MSNBC…

1st International Symposium on Cortisol, Stress and Health

• May 2002 - Experts from United States, Canada, and Europe gathered in Park City, Utah presented emerging research related to cortisol

New Book: The Cortisol Connection• Published September 2002

The Solution: Cortisol Management

You can control cortisol levels via:

Stress Management Techniques • meditation, coping strategies, etc…

Exercise• Pharmanex Body Design

Nutrition • Pharmanex Body Design

Dietary Supplements* • LifePak™ + Cortitrol™ STRESS CONTROL

FORMULA* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Common Anti-Stress Solutions

ValerianKava KavaMelatoninTyrosine

None of these supplements directly address cortisol control

Cortitrol™ STRESS CONTROL FORMULA- Health Benefits -

• Enhances feelings of wellbeing and control in response to stressful situations*

• Improves performance and increased vigor throughout the day*

• Better mental concentration and focus*

• Supports weight maintenance efforts*

Hint… CORTITROL for CORTIsol conTROL

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

• Comprehensive formula addresses both direct cortisol modulation and stress control

• Scientifically-validated ingredients in clinically significant dosages

• Magnolia Bark (2% Honokiol), Ashwagandha, Passion Flower• Epimedium (6:1 water extract), Garlic• L-Theanine (70:1 all-natural extract)• Phosphatidylserine• Beta-sitosterol

Proprietary Stress Control Formula

Magnolia Bark • anti-stress effects; non-sedating

Epimedium• reduces cortisol levels during high stress; promotes energy levels

L-Theanine• increase alpha brain wave production; promotes relaxed alertness and concentration; non-sedating

Phosphatidylserine• reduces cortisol levels following strenuous exercise; improves mental function

Beta-sitosterol• balances cortisol:DHEA ratio; supports immune function

Scientific Substantiation

*References available from Pharmanex, LLC

Competitive Advantage

• First patent-pending dietary supplement that supports healthy cortisol levels*

• Proprietary blend + Comprehensive Approach• Modulates cortisol levels• Helps combat stress• Improves mental function

• Contains a proprietary, all-natural form of theanine extracted from green tea leaves

• Manufactured according to the Pharmanex® 6S® Quality Process* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Recommended Usage

• Everyone should use Cortitrol! • Frequently confronted with stressful situations• Getting less than 8 hours of sleep every night• Generally feel run down, lack mental focus• Limiting caloric intake to lose weight

• Combine with LifePak® Family• Vitamin C, B vitamins, calcium, magnesium

Directions for UseTake 2 capsules with your evening meal. For optimal results take an additional (1) capsule with your morning meal.

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