the role of nutrition and immune support for sports ... … · kerry’s proprietary process • a...

The Role of Nutrition and

Immune Support for Sports

Performance

Laura Collins PhD (Immunology)

Nutrition Analyst

2 | Taste & Nutrition

Agenda

• Immune health & the

consumer

• The impact of nutrition on

immune health

• Wellmune® overview and

new studies

Immune health & the

consumer


Consumer Health & Wellness Consumers are evolving in their behavior by taking a proactive approach to health and wellness.

Vitality Taking Care Preventative Long-term Proactive


Strong Demand for Immune Health Products

87% of consumers are interested in products with immune health benefits. Immune health is the #2 most desired benefit, behind only general

health & wellness.

87%

Source: Global Data 2015 survey of nearly 28,000 consumers in 31 markets. Q: “How interested are you in food or drink that provide the following

benefit…?”

100

90

80

70

60

50

40

30

20

10

0


Immune Health & Consumers

A healthy immune system is important to everyone, but especially for:

Families with

Children

Athletes &

Weekend Warriors

Older Adults Anyone

Experiencing Stress


Sources Of Variation In Immune Function

Immune

Function Gender

Age

Hormonal Status

Early Life Events

Obesity

Alcohol Consumptio

n

Exercise

Stress

Exposure to Pathogens Nutrient

Status (Diet)

Smoking

Genetics

British Journal of Nutrition (2002), 88, S165–S176


The impact of nutrition

on the immune system


Nutrition in the Immune System

There is already a defined role for nutrition in the Immune System.

• Undernutrition is related to decreased immune

function

• Overnutrition and related obesity can contribute

to chronic low grade inflammatory changes


Immunity Relationships

Infection

Impaired Host Defense

Undernutrition

Interrelationship Between Undernutrition, Impaired Immunity And Infection

Proceedings of the Nutrition Society (2013), 72, 299–309


Nutritional Interventions Have The Ability To Restore

“Optimal Immune Function”

‘Optimal Immune

Function’

Hyperactive Chronic Inflammation Allergies

Hypoactive Impaired Infection Resistance

‘Optimal Health’

‘Danger’

Pathogens, insults,

allergens, metabolic

stress…

• Ageing

• Diet

• Smoking

• Alcohol

• (Lack of) Exercise

• Sleep Deprivation

• Hygiene


J-Curve Hypothesis

URTI incidence drops as exercise intensity

increases until it reaches an inflection

point and begins to increase as exercise

intensity increases from moderate to

“severe”.

Figure adapted from "Exercise, Upper Respiratory Tract Infection, and the Immune System." Medicine & Science in Sports & Exercise. (1994) 26:128-139.

Sedentary Moderate Prolonged/Intense

Low

Me

diu

m

Hig

h

Infe

ctio

n R

isk

Exercise Dose


Modulating Immunity Through

Nutrition Interventions

Nutrition is one of the key

modifiable factors

• It is well defined that adequate

and balanced supply of nutrients

is essential for a healthy

functioning immune system

• It is an area of discovery for

nutritional interventions to aid

people with compromised

immune health


Effectiveness of the Immune System…

…Can Be Impacted by What We Eat!


Defined Immune Modulating Nutritional Factors

Protein

LCPUFA

Prebiotics

Vitamins – A, C, D, E

Minerals – Iron, Zinc, Selenium

Probiotics

Functional Ingredients - Wellmune®

Immunonutrition

Wellmune®


Introducing Wellmune®

• Wellmune® is a natural food, beverage and supplement ingredient

clinically proven to help strengthen the immune system.

• A proprietary baker’s yeast beta 1,3/1,6 glucan, Wellmune makes it

easier for people of all ages to be well and stay well.


What is Wellmune® and How Does it Work?

What is Wellmune?

Kerry’s Proprietary Process

• A natural form of beta 1,3/1,6 glucan found in

the cell wall of baker’s yeast.

• Purifies & strips away yeast cell wall.

• Gives body direct access to Wellmune.

How Does Wellmune Work?

• Consumed orally, Wellmune is taken up in the body by Peyer’s Patches in the intestines.

• Immune cells called macrophages (located in the Peyer’s Patches) ingest Wellmune and travel to the immune organs throughout the body.

• Macrophages break down Wellmune into smaller fragments that bind to neutrophils, the most abundant immune cells in the body.

• Primed by Wellmune, neutrophils move more quickly to recognize and kill foreign challenges.


Clinical Research


Wellmune® Clinical Studies

• 1402 healthy normal adults

– Physical stress studies (742)

– Psychological stress studies (372)

– Aging population (100)

– Other studies (188)

• 669 healthy children, ages 1-4

– Wellmune children’s study (156)

– Sponsored children’s studies (513)

Health benefit studies include over 2,000 adults and children.


Wellmune® Clinical Studies

Reduction

in URTI

symptoms*

Improvement

in POMS

scores

Reduction

in allergy

symptoms

Wellmune physical &

psychological health benefits

# of

studies: 8 adults

2 children 3 adults

1 adult

1 child

URTI = Upper Respiratory Tract Infection POMS = Profile of Mood States

* Reduction is # subjects or days


Wellmune® Clinical Research – Summary

Focus

Texas Marathon

Lifestyle Stress, 12 Weeks

Exercise Stress

Lifestyle Stress, 4 Weeks

Older Adults

Allergy

Cold/Flu

Children

Medical Students

Firefighters

Study Type Published

Health Effects & Biomarkers in Older Adults

Health Effects in Children

Physical Stress Health Effects

Biomarkers

Allergic Rhinitis Health Effects

Physical and Lifestyle Stress

Lifestyle Stress Health Effects

Lifestyle Stress Health Effects

Health Effects in General Population

California Marathon Physical Stress Health Effects

Physical Stress Health Effects

Nutrition, 2017

Journal of Nutrition & Food Sciences, 2016

Journal of Dietary Supplements, 2013

British Journal of Nutrition, 2013

Food Science & Nutrition, 2013

Nutrition, 2012

Journal of American College of Nutrition, 2012

Agro FOOD Industry Hi-Tech, 2010

Journal of Applied Research, 2009

Journal of Sports Science & Medicine, 2009

Presented at American Society of Sports

Medicine*, 2008

* Pending Publication


Study: Older Adults

Study Protocol

Study Site

Population

Age

Design

Duration

Serving

University of Southampton School of Medicine, UK

100 healthy adults (54 men, 46 women)

50-68 (average 59 years)

Randomized, double blinded, placebo controlled, parallel arm study

90 days

Participants were split into two groups and consumed one of the following once daily: • 250mg Wellmune • placebo


Study: Older Adults

Wellmune demonstrated a strong trend towards reducing the number of upper respiratory tract infections

(URTIs) and reducing symptom days of a cold. Participants taking Wellmune had:

4.5

4

3.5

3

2.5

2

1.5

1

0.5

0

16% decrease in total URTI

symptom days.

Wellmune Placebo

16% A

ve

rag

e n

um

be

r o

f sy

mp

tom

s

+

+ p=0.067, * p=0.016 “Yeast-Derived Beta 1,3/1,6 Glucan, Upper Respiratory Tract Infection and Innate Immunity in Older Adults.” (2017) Nutrition 39-40:30-35.

0

20

40

60

80

100

120

140

160

Baseline Day 0-45 Day 0-90

Interferon - γ

Wellmune Placebo

pg

/ml

Wellmune

Placebo

*


Study: Texas Marathon

Study Protocol

Study Site

Population

Age

Design

Duration

Serving

Department of Health and Human Performance, University of Houston, USA

182 runners (96 men, 86 women) who completed the 2011 LiveStrong Marathon in Austin, Texas with an average finish time of 4 hours


Randomized, double blinded, placebo controlled, parallel arm study

4 weeks

Participants were split into three groups, and consumed one of the following once daily: • 250mg Wellmune soluble • 250mg Wellmune dispersible • placebo


Study: Exercise Stress

Study Protocol

Study Site

Population

Age

Design

Duration

Serving

Department of Health and Human Performance, University of Houston, USA

60 recreational athletes (29 men, 31 women)


Randomized, double-blinded, placebo-controlled, crossover study

10 days supplementation with Wellmune or placebo; seven-day wash out period; 10 days supplementation with Wellmune or placebo.

Participants were split into two groups, and consumed the following once daily for 10 days, in two separate instances: • 250mg Wellmune

• placebo

Additional Study Details:

After the 10 day supplementation period, participants rode an exercise bicycle for one hour in a heat-stress chamber.


Wellmune prevented the drop in white blood cells that occurs following intense exercise, and it supports immune

health in elite athletes by maintaining higher levels of LPS-stimulated cytokines.


2600

2550

2500

2450

2400

2350

2300

2250

Wellmune

Placebo

pg

/ml

Interferon-γ

Baseline Pre Post 2h

9100

9050

9000

8950

8900

8850

8800

8750

Wellmune

Placebo

pg

/ml

Interleukin-4


*

*

*

*

*p≤0.05, **p≤0.01, ***p≤0.001 “Baker’s Yeast ß-glucan Supplementation Increases Monocytes and Cytokines Post-Exercise: Implications for Infection Risk?” (2013) British Journal of Nutrition109:478-486.


Two hours post-exercise, Wellmune improved salivary IgA recovery by 32% compared to the placebo, thus

helping IgA levels rebound more quickly.


40

35

30

25

20

15

10

5

Wellmune

Placebo

pg

/ml

Salivary IgA


*

*p≤0.05, **p≤0.01, ***p≤0.001 “Baker’s Yeast Beta Glucan Supplementation Increases Salivary IgA and Decreases Cold/Flu Symptomatic Days After Intense Exercise.” (2013) Journal of Dietary Supplements 10:171-183.



HEALTHY

ZONE

CHALLENGE

ZONE

Many immune biomarkers show a quick drop that lasts

for 2-6 hours following exercise.

“Open Window Effect”

Wellmune Placebo


Meeting the Immune Health Needs of Today

• Consumers are taking a proactive approach to

health & wellness – using foods, beverages and

supplements to help with their goals.

• Immune health is the foundation of overall wellness –

good nutrition is essential to a strong immune system.

A healthy immune system is important to everyone,

but especially for children, athletes and the elderly.

• There is a well defined role for nutrition in supporting

the immune system

• Wellmune ® has been clinically proven to support a

large array of life stages such as children, athletes

and the elderly.

http://www.eatright.org/resource/health/wellness/preventing-

illness/protect-your-health-with-immune-boosting-nutrition

the role of nutrition and immune support for sports ... … · kerry’s proprietary process • a...

Documents