The Clean Cleanse Science & Products

Instructional PPT

We live in a toxic world.

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Scientists estimate that everyone alive today carries within her or his body at least 700 contaminants.

We are toxic at birth.

“…up to 232 toxic chemicals in the umbilical cord blood of 10 babies…The findings constitute hard evidence that each child was exposed to a host of dangerous substances while still in its mother’s womb.”

http://www.ewg.org/minoritycordblood/executivesummary, Accessed 8/28/12 3

!- Drinking Water - Carpet & Paint - Foods - Workplace Chemicals - Household Cleaners - Personal Care Products - Pesticides - Cigarette/Cigar Smoke - Auto Exhaust - Air Pollution - Plastics - Bacteria/Viruses/Fungi - Organochlorines

Potential Sources of Toxicity

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Clinical conditions that may be connected to toxicity

• ADHD • Fatigue • Obesity • Diabetes • Fibromyalgia • Cognitive difficulties • Mood disorders • Tremors • Chronic neurological

illnesses

• Asthma • Allergies • Chemical sensitivities • Autoimmune conditions • Chronic bacterial, fungal,

and viral infections • Certain cancers • Infertility • Hormonal imbalances

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Toxins are endocrine disruptors.

Includes: – Industrial compounds – Plastics and

plasticizers – Fungicides – Pesticides – Pharmaceuticals

Gore, Hormones 2010; 9(1):16-27; Latini et al., Mini-Reviews in Medicinal Chemistry, 2010, 10, 846-855

“Endocrine disruptors may be found in many everyday products– including plastic bottles, metal food cans, detergents, flame retardants, food, toys, cosmetics, and pesticides.”NIEHS-NIH: http://www.niehs.nih.gov/health/topics/agents/endocrine/index.cfm, Accessed 8/28/10

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Common Toxins to Avoid

Bisphenols Persistent Organic Pollutants Heavy Metals

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Why doesn’t everybody just get easily rid of toxins?1. Increased exposure to toxins 2. Poor elimination 3. Intestinal dysbiosis 4. Nutritional deficiencies 5. High sugar, low protein diets 6. Oxidative stress 7. Chronic inflammation 8. Stress and emotional trauma 9. Polymorphisms (SNPs) in phase I & II enzymes 10. Compromised liver function

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Is “cleansing” an unscientific fad?

The Spectrum of Detoxification Practices

“Detox approaches…are contrary to scientific consensus and medical evidence and are not consistent with the principle that diets should reflect balance, moderation and variety.”

Clemens and Pressman, Food Technology 59(5): 2005.

Conflicting opinions, lack of medical consensus on detox

Chemical Sensitivity (CS) as a 21st Century Medical Phenomenon

• “The emerging problem of ubiquitous adverse toxicant exposures in modern society has resulted in escalating numbers of individuals developing a CS disorder.”

• “As usual in medical history, iconoclastic ideas and emerging evidence regarding novel disease mechanisms, such as the pathogenesis of CS, have been met with controversy, resistance, and sluggish knowledge translation.”

Clin Ther. 2013 May;35(5):572-7. doi: 10.1016/j.clinthera.2013.04.003. Epub 2013 May 1.

Clinical Detoxification has yet to gain traction in mainstream medicine

In a general sense, detoxification is the balance of toxic substances in the body.

The science of pharmacokinetics has illustrated how drugs are metabolized and excreted, thus providing a good foundation for understanding the body’s detoxification processes

Pharmacokinetic research has highlighted processes involved in toxin metabolism and excretion

• Hepatic detoxification pathways ✓ “Phase I reactions involve the formation of a new or modified functional

group or a cleavage (oxidation, reduction, hydrolysis)… Phase II reactions involve conjugation with an endogenous compound (e.g., glucuronic acid, sulfate, glycine)”

!• The relationship between urine pH and toxin clearance

rates ✓ “pH of voided urine varies from 4.5 to 8.0. This variation in pH may markedly

affect the rate of drug excretion” !

• The role of individual variability ✓ “Some patients metabolize ... so rapidly that therapeutically effective blood

and tissue concentrations are not achieved; in others, metabolism may be so slow that usual doses produce toxic effects.” !

Merck Manual Section 22, Chapter298

Detoxification Program for Chronic Fatigue

“The results of this study confirm our hypothesis that patients who present with symptoms of chronic fatigue and who are given the specific medical food supplement described would have had a significant improvement in their clinical outcome compared with that of the control patients, who received only the calorie-restricted oligoantigenic diet.”

Alternative Therapies in Health and Medicine. 1995;1(5):62-71

The Detoxification Enzyme Systems

“The scientific literature suggests an association between impaired detoxification and certain diseases, including cancer, Parkinson’s disease, fibromyalgia, and chronic fatigue/immune dysfunction syndrome.”

Liska DJ. Altern Med Rev 1998;3(3):187-198

Liver Detoxification PathwaysLiska DJ. Altern Med Rev 1998;3(3):187-198

Mono- and Bi-functional DetoxificationLiska DJ. Altern Med Rev 1998;3(3):187-198

Acid-Alkaline Balance & Detox

“Metabolic detoxification using a high vegetable diet in conjunction with supplementation of an effective alkalizing compound, such as potassium citrate, may shift the body’s reserves to become more alkaline.”

Minich and Bland. ALTERNATIVE THERAPIES, Jul/Aug 2007, VOL. 13, NO. 4

Clinical Detoxification for Fibromyalgia

“Program B was shown to be a safe and efficacious botanically derived medical food treatment program for the amelioration of FM symptoms.”

Altern Ther Health Med. 2011;17(2):36-44.

How do you measure toxicity?• Questionnaires

– Medical Symptoms Questionnaire (MSQ) – Intake of symptoms

• Laboratory Measurements • Urinary Measurements for Heavy Metals, Parabens,

Phthalates • Nutrient Sufficiency/Deficiency - RBC Micronutrients

(e.g., selenium, copper, zinc) • Hormone Metabolites • Liver Function Tests (ALT, AST, GGT) • Genetic Variants: SNPs for COMT, MTHFR, GST

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How can you get clean with The

Clean Program?

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1st

STEP IS TO REMOVE:

Minimize Exposure to Toxicants

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2nd

STEP IS TO SUPPORT:

5 Major Organs that Help Remove Toxins

• Gut • Liver • Kidney • Lung • Skin

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Keep the Gut Clean• Drink water • Eat more fiber to ensure healthy bowel

movements • Avoid allergens and trigger foods • Let go of that which needs letting go!

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Food Categories: Foods to Include: Foods to Exclude:

FruitsUnsweetened  fresh,  frozen  water  packed  or  canned;  unsweetened  fruit  juices  except  orange

Oranges

VegetablesAll  fresh  raw,  steamed,  sautéed,  juiced,  or  roasted  vegetables

Corn;  creamed  vegetables

Starch Rice,  oats,  millet,  quinoa,  amaranth,  teff,  tapioca,  buckwheat

Wheat,  corn,  barley,  spelt,  kamut,  rye;  all  gluten-­‐containing  products

Bread/Cereal Products  made  from  rice,  oat,  buckwheat,  millet,  potato  flour,  tapioca,  arrowroot,  amaranth,  quinoa

Products  made  from  wheat,  spelt,  kamut,  rye,  barley;  all  gluten-­‐containing  products

Legumes All  beans,  peas  and  lentils  unless  otherwise  indicated Soybeans,  tofu,  tempeh,  soy  milk,  other  soy  products

Nuts and seedsAlmonds,  cashews,  walnuts;  sesame  (tahini),  sunflower  and  pumpkin  seeds;  butters  made  from  these  nuts  and  seeds

Peanuts,  peanut  butter

Meat All  canned  or  fresh  chicken,  turkey,  wild  game,  lamb Beef,  pork,  seafood,  fish,  cold  cuts,  frankfurters,  sausage,  canned  meats,  eggs

Dairy Products and Milk Substitutes

Milk  substitutes  such  as  rice  milk,  almond  milk,  oat  milk,  coconut  milk,  other  nut  milks

Milk,  cheese,  cottage  cheese,  cream,  yogurt,  butter,  ice  cream,  frozen  yogurt,  “non-­‐dairy”  creamers

FatsCold,  expeller-­‐pressed  olive  flax,  canola,  safflower,  sunflower,  sesame,  walnut,  pumpkin  or  almond  oils

Margarine,  butter,  shortening,  processed  (hydrogenated)  oils,  mayonnaise,  spreads

BeveragesFiltered  or  distilled  water,  herbal  tea,  seltzer  or  mineral  water

Soft  drinks,  alcoholic  beverages,  coffee,  tea,  other  caffeinated  beverages

Spices and Condiments

All  spices  unless  otherwise  indicated.    For  example:  cinnamon,  cumin,  dill,  garlic,  ginger,  carob,  oregano,  parsley,  rosemary,  tarragon,  thyme,  turmeric,  vinegar

Chocolate,  ketchup,  mustard,  relish,  chutney,  soy  sauce,  barbecue  sauce,  other  condiments

SweetenersBrown  rice  syrup,  fruit  sweetener,  blackstrap  molasses,  stevia

White  or  brown  refined  sugar,  honey,  maple  syrup,  corn  syrup,  high  fructose  corn  syrup,  candy  desserts  made  with  these  sweeteners

The Importance of Eating Pure – The Functional Medicine Elimination Diet

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Food intolerances may “register” in the body as “toxins”

Dtsch Arztebl Int. May 2009; 106(21): 359–370.

Keeping the Liver Clean• Get adequate nutrients

– Protein – Foods that help the detox process

• Green tea • Pomegranate • Cruciferous vegetables • Citrus • Watercress • Turmeric

• Emotion associated with liver: Anger Transform anger into action!

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A 3-Step Process of Cleaning in the Liver

1. Make the toxin water-soluble. 2. Couple the water-soluble toxin with a

compound to make it easy for the body to excrete.

3. Excrete through bile, stool, urine.

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Liska DJ. Altern Med Rev 1998;3(3):187-198

Phase I Phase II Excretion

Keep the Kidneys Clear• Drink adequate fluid • Eat foods that are alkalizing to promote a

healthy internal pH – Cruciferous vegetables – Other non-starchy vegetables

• Emotion associated with kidneys: Fear; Use fear as a motivator rather than attaching to it

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Keep the Lungs Clear• Deep breathing

– Four-square breath • Watch for fumes of products • Exercise in good-quality air • Get outside – indoor air is twice as toxic

as outdoor air • Emotion associated with lungs: Grief

Importance of tears in releasing inflammatory cytokines

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Keeping the Skin Clear• Read labels of personal care products or

minimize their use • Avoid aluminum-containing deodorant • Sweat • Sauna use if appropriate • Skin brushing • Emotion associated with skin:

Acceptance; Releasing low self-esteem

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The Clean Program Supports Keeping Clean through Targeted Nutrients for

Detoxification

The Cleanse Program• Shake • Probiotic • Digestive Enzyme • Berberine Formula

Shake (AM) Meal Shake (PM)

Benefits of Intermittent Fasting• Reduces inflammation • Decreases body mass • Lower concentrations of triglycerides, glucose, and low-density lipoprotein cholesterol, and increased

concentrations of high-density lipoprotein cholesterol • Helps improve immune function

Exp Neurol. 2014 May 5. pii: S0014-4886(14)00119-8. doi: 10.1016/j.expneurol.2014.04.017. [Epub ahead of print] Endocrinology. 2014 May 5:en20132057. [Epub ahead of print] Nutr Rev. 2014 May;72(5):308-18. doi: 10.1111/nure.12104. Epub 2014 Apr 16. Scand J Immunol. 2014 May;79(5):315-24. doi: 10.1111/sji.12163. !

Benefits of a Liquid Shake• Convenience • Nutrient Density !

• Nutrient- and Protein-Dense Meal to Support the Liver and Gut

• Facilitates Cleansing and Repair

Clean Shake

Clean Shake• Contains Cleanse-Targeted Ingredients:

o Hypoallergenic, Complete Rice Protein Concentrate and Rice Syrup Solids

o Detoxification-Specific Nutrients for Phase II Liver Detox: Vitamins, Minerals, Potent Antioxidants

o Essential Fatty Acids for Liver Support and Healthy Cell Functioning and Transport of Toxins

o Fiber and Inulin for Regular Elimination and Nourishment of Beneficial Microflora

o Superfoods to Support Liver Activity: Pomegranate, Broccoli Seed Extract

Clean Shake Superfood: Pomegranate Whole Food Extract

• Powerful anti-oxidant, anti-inflammatory also containing anti-fungal & anti-viral properties.

• Supports Phase II detox !!

!!!Pomegranate seed extract Photochem Photobiol. 2012 September; 88(5): 1126–1134. PP Published online 2012 January 13. doi: 10.1111/j.1751-1097.2011.01063.x The Role of Detoxification in the Prevention of Chronic Degenerative Diseases – Deann J. Liska, PhD Applied Nutritional Science Reports 650 8/02 Rev 8/05 RD Effect of ellagic acid on hepatic and pulmonary xenobiotic metabolism in mice: studies on the mechanism of its anticarcinogenic action. Das M, Bickers DR, Mukhtar H.

Clean Shake SuperfoodsSupports healthy

immune functioning, Phase I & Phase II

detox, and encourages production of

glutathione, the super anti-oxidant

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Broccoli Seed extract: • E.H. Jeffery, Phytochemical Review, 2008. •

The Role of Detoxification in the Prevention of Chronic Degenerative Diseases

• – Deann J. Liska, PhD • Applied Nutritional Science Reports 650 8/02 Rev 8/05.

Cleanse Probiotic

L. acidophilus NCFM® is one of the most extensively tested and effective probiotic strains. !It supports gut health, reduces bloating, improves digestion, and it is hearty - survives through the gut digestion process better than other strains of beneficial bacteria. !Probiotics:

• Used to reinoculate the digestive tract with beneficial bacteria

• May support the assimilation of various vitamins, minerals and nutrients

• May produce short chain fatty acids necessary to promote healthy intestinal tissue

• May decrease intestinal permeability

• May protect again toxins

• May prevent against infection by pathogenic bacteria

• May support the healthy metabolism of fat and cholesterol • Stable at room temperature Rountree, Robert, MD. Proven Therapeutic Benefits of High Quality Probiotics.Applied Nutritional Science Reports 2002;ANP614: 1-6 Liska D, Lukaczer D. Gut Dysfunction and Chronic Disease: The Benefits of Applying the 4R® GI Restoration Program. Applied Nutritional Science Reports 2001; 558 10/01 Rev. 3/03: 1-8

Cleanse Digestive Enzyme

• Plant-based enzymes to support the breakdown of carbohydrate, protein, fat, and plant cellulose for better nutrient absorption !– Protease: Helps breakdown and digest protein – Amylases: Helps breakdown and digest

carbohydrates – Lipases: Helps breakdown and digest fats – Cellulases: Helps breakdown cellulose

Cleanse Berberine Formula

• Antimicrobial with berberine to support healthy immune, detoxification, and elimination functions

• Encourages a healthy intestinal environment and supports detoxification of liver and gallbladder.

• Includes synergistic blend of Chinese herbs to harmonize the action of other herbs in the formula.

Cleanse Berberine Formula

!(1) Altern Med Rev. 2000 Apr;5(2):175-7

(2) Mycopathologia 1979; 66(3):161-67

(3) J. Ethnopharmacol 1995; 45(1):43-52

(4) Tokai J Exp Clin Med 1990;15(6):417-23

Berberine • Coptis Root

• Anti-microbial • Chinese Licorice Root

• Anti-inflammatory • Anti-microbial

• Ginger • Anti-inflammatory

• Chinese Rhubarb • Antiseptic • Anti-inflammatory

• Phellodendron Bark • - Anti-microbial • Chinese Skullcap • - Anti-inflammatory • - Antihistamine

The Whole Program

1. Focus on minimizing environmental toxin exposure

2. Support the 5 organs involved with toxin excretion

3. Utilize the Clean System with enhanced nutrients for additional nourishment to fuel detoxification processes in liver and gut