the sparks and the soup i wonder whether anybody during my few remaining years will yet discover...
TRANSCRIPT
The ”sparks” and the ”soup”
”I wonder whether anybody during my few remaining years will yet discover either of the (probably) two missing transmitters concerned in your monosynaptic excitatory and inhibitory effects on different motoneurones”.
Dale to Eccles, October 1, 1953
OH
NH2
COOHOH
NH2
COOH
OH
OH
NH2OH
OH
NH2OH
OH
tyrosine DOPA
dopamine noradrenaline
Biosynthetic pathway for noradrenaline
Hans Corrodi, 1929-1974
A New Concept (1970s):Medicinal chemistry and pharmacology
Under the same roof In academic setting
High
Low
Normal
Psychomotor activation
Dopamine stabilizer
High
Low
Normal
Psychomotor activation
Standard antipsychotic
Dopamine Stabilizers
n-Pr
SO2CH
3
N
H
Structure of (-)-OSU6162
Future Vision:Restart Our Drug Research
According to the Previous ConceptSupported by The Arvid Carlsson Fund