the urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. ·...
TRANSCRIPT
![Page 1: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/1.jpg)
The urinary system
Dr zubair
![Page 2: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/2.jpg)
Urinary system• Kidney is compound tubular type of gland
• The tubules are URINIFEROUS TUBULES.
• Secreting tubules are known as NEPHRON
• Excretory tubules are known as COLLECTING
TUBULES.
• Uriniferous tubule is the structural unit of the kidney
while nephron is the functional unit of the kidney.
![Page 3: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/3.jpg)
Urinary system• The two kidneys produce about 125 mL of
filtrate per minute; of this amount, 124 mL is
absorbed in the organ, and only 1 mL is released
into the ureters as urine.
• About 1500 mL of urine is formed every 24 h.
![Page 4: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/4.jpg)
RENAL PARENCHYMA SURROUNDS A CAVITY
INSIDE THE KIDNEY, KNOWN AS RENAL
SINUS OPENS AT THE HILUS
RENAL SINUS
![Page 5: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/5.jpg)
The renal
parenchyma
consists of an
outer zone known
as
CORTEX
CORTEX
![Page 6: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/6.jpg)
The renal
parenchyma consists
of an inner zone
known as
MEDULLA
MEDULLA
![Page 7: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/7.jpg)
Cortex is Granular in appearance while
medulla shows Radial striations.
![Page 8: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/8.jpg)
Some regions of cortex appear granular due to presence of glomeruli and
convoluted tubules, are known as PARS CONVOLUTA or CORTICAL
LABYRINTH.
Pars convoluta are separated by regions which contain straight tubules and appear
as radiating columns are known as PARS RADIATA or MEDULLARY RAYS.
PARS CONVOLUTA/
CORTICAL LABYRINTH.
PARS RADIATA /
MEDULLARY RAYS
![Page 9: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/9.jpg)
medullaConsists of
8-18 conical shaped lobes or
PYRAMIDS.
The pyramids are separated by regions known as the
RENAL COLUMNS or COLUMNS OF BERTINI.
PYRAMIDS.
RENAL COLUMNS
![Page 10: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/10.jpg)
The apices of 2-3 pyramids unite to forma single PAPILLA.
Each papilla project into the MINOR CALYX.
MINOR CALYX.
![Page 11: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/11.jpg)
Each pyramid with its associated overlying cortex is regarded as a
LOBE OF KIDNEY.
![Page 12: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/12.jpg)
Photomicrograph of fetal kidney. Human fetal kidney shows
the cortex, the medulla, and two associated pyramids.
Note each surface convexity corresponds to a kidney lobe. During postnatal life the lobar convexities disappear and the kidney then exhibits a smooth surface.
![Page 13: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/13.jpg)
A KIDNEY LOBULE consists of a medullary
ray at its center and half of the adjacent cortical labyrinth on
either side
![Page 14: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/14.jpg)
KIDNEY LOBULE
![Page 15: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/15.jpg)
Kidney Posses a connective tissue (capsule) frame work and renal parenchyma.
![Page 16: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/16.jpg)
PARENCHYMA OF THE KIDNEY CONSISTS OF A LARGE NUMBER OF CLOSELY PACKED
URINIFEROUS TUBULES,BETWEEN WHICH ARE PRESENT BLOOD VESSELS AND A SCANTY AMOUNT OF INTERSTITIAL
CONNECTIVE TISSUE
![Page 17: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/17.jpg)
URINIFEROUS TUBULE
Nephron (30-40 mm) long, derived from metanephric blastema,responsible for secretion of urine.
COLLECTING TUBULE (20mm) long, derived from ureteric bud, conveys urine to the renal pelvis.
![Page 18: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/18.jpg)
types of nephrons
A long looped nephron
a short-looped nephron
. The inverted cone-shaped area in the cortex represents a
medullary ray.
![Page 19: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/19.jpg)
The parts of the Uriniferous tubule are indicated by number:1 renal corpuscle including
the glomerulus and Bowman’s capsule;2, proximal convoluted tubule;
3, proximal straight tubule; 4, descending thin limb; 5,ascending thin limb;6, thick ascending limb (distal straight
tubule);7, macula densa located in the final
portion of the thick ascending limb;8, distal convoluted tubule;
9, connecting tubule;9*, collecting tubule that forms an arch (arched collecting tubule);10, cortical collecting duct;11, outer medullary collecting duct; and
12, inner medullary collecting duct.
![Page 20: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/20.jpg)
Nephron
1. Bowman's capsule
2. Proximal convoluted tubule
3. Straight segment of the proximal convoluted tubule
4. Thin segment of Henles loop
5. Thick segment of Henles loop
6. Distal convoluted tubules
![Page 21: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/21.jpg)
Collecting tubules
1. Arched collecting tubules
2. Straight collecting tubules
3. Papillary ducts
![Page 22: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/22.jpg)
Location of nephron and collecting tubules in kidney
Cortical Portion of the kidney Portion of the tubule
Pars convoluta orcortical labyrinth
GLOMERULUS AND BOWMAN’S CAPSULE (renal corpuscle/ malpighian corpuscle)
PROXIMAL CONVOLUTED TUBULE
DISTAL CONVOLUTED TUBULES
ARCHED COLLECTING TUBULES
Pars radiata or medullary rays
Thick segment of Descending limb of Henles loopThick segment of ascending limb of Henles loop
Straight collecting tubules
![Page 23: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/23.jpg)
Location of nephron and collecting tubules in kidney
Medulla of the kidney
Portion of the tubule
Outer zone
Thick segment of Descending limb of Henles loopThin segment of henles loop.Thick segment of ascending limb of Henles loop.Bends of short loop of henles.Straight collecting tubules
Inner zone
Thin segment of henles loop.Straight collecting tubulesPapillary ducts
![Page 24: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/24.jpg)
![Page 25: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/25.jpg)
Mesangial cellsIn addition to endothelial cells and podocytes, the glomerular capillaries have
Mesangial (Gr. mesos, middle, + angeion, vessel) cells adhering to their walls
Mesangial cells are contractile and have receptors for angiotensin II. When these receptors are activated, the glomerular flow is reduced.
Mesangial cells also have receptors for the natriuretic factor produced by cardiac atria cells. This factor is a vasodilator and relaxes the mesangial cells, probably increasing the blood flow and the effective surface area available for filtration.
They give structural support to the glomerulus Synthesize extracellular matrix, Endocytose and dispose of normal and pathological (immune complex)
molecules trapped by the glomerular basement membrane. Probably produce chemical mediators such as cytokines and
prostaglandins. In the vascular pole but outside the glomerulus, there are the so-called
extraglomerular mesangial cells that form part of the juxta glomerular apparatus
![Page 26: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/26.jpg)
Proximal Convoluted TubuleThe proximal convoluted tubule receives the ultrafiltrate from the urinary space of Bowman’s capsule. The cuboidal cells of the proximal convoluted tubule have the elaborate surface specializations associated with cells engaged in absorption and fluid transport. They exhibit the following features:
• A brush border, composed of relatively long, closely packed, and straight Microvilli
• A junctional complex, consisting of a narrow, tight junction that seals off the intercellular space from the lumen of the tubule and a zonula adherens that maintains the adhesion between neighboring cells
• Plicae or folds located on the lateral surfaces of the cells, which are large flattened processes, alternating with similar processes of adjacent cells
• Extensive interdigitation of basal processes of adjacent cells .
• Basal striations, consisting of elongate mitochondria concentrated in the basal processes and oriented vertically
to the basal surface
![Page 27: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/27.jpg)
Henle's Loop
Henle's loop is a U-shaped structure consisting of a thick descending limb, a thin descending limb, a thin ascending limb, and a thick ascending limb.
The thick limbs are very similar in structure to the distal convoluted tubule
In the outer medulla, the thick descending limb, with an outer diameter of about 60 m, suddenly narrows to about 12 m and continues as the thin descending limb.
The lumen of this segment of the nephron is wide because the wall consists of squamous epithelial cells whose nuclei protrude only slightly into the lumen .
![Page 28: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/28.jpg)
Henle's Loop
Approximately one-seventh of all nephrons are located near the corticomedullary junction and are therefore called juxta medullary nephrons.
The other nephrons are called cortical nephrons.
All nephrons participate in the processes of filtration, absorption, and secretion.
Juxta medullary nephrons, however, are of prime importance in establishing the gradient of hyper tonicity in the medullary interstitium.
![Page 29: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/29.jpg)
Henle's LoopOn the basis of the kidneys' ability to produce
hypertonic urine.
Juxta medullary nephrons have very long Henle's loops, extending deep into the medulla. These loops consist of a short thick descending limb, long thin descending and ascending limbs, and a thick ascending limb.
Cortical nephrons, on the other hand, have very short thin descending limbs and no thin ascending limbs
![Page 30: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/30.jpg)
Distal Convoluted Tubule
• This tubule, like the ascending limb, is lined with simple cuboidal epithelium
• The distal convoluted tubules differ from the proximal convoluted tubules (both found in the cortex) because they have no brush border, no apical canaliculi, and smaller cells.
• Because distal tubule cells are flatter and smaller than those of the proximal tubule, more nuclei are seen in the distal tubule than in the proximal tubule.
![Page 31: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/31.jpg)
Juxta glomerular Apparatus
• Adjacent to the renal corpuscle, the tunica media of the afferent arteriole has modified smooth muscle cells. These cells are called juxta glomerular (JG) cells
• Secretions of JG cells play a role in the maintenance of blood pressure.
• The macula densa of the distal convoluted tubule is usually located near the region of the afferent arteriole that contains the JG cells; together, this portion of the arteriole and the macula densa form the JG apparatus.
• Also a part of the JG apparatus are some light-staining cells. They are called extraglomerular mesangial cellsor lacis cells.
![Page 32: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/32.jpg)
![Page 33: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/33.jpg)
![Page 34: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/34.jpg)
![Page 35: The urinary systemmbbsmc.edu.pk/wp-content/uploads/2020/05/urinary-system... · 2020. 5. 21. · Urinary system •The two kidneys produce about 125 mL of filtrate per minute; of](https://reader033.vdocuments.net/reader033/viewer/2022051606/6020cd817b8d94147e15c3cb/html5/thumbnails/35.jpg)