The Use Of Electronic Laboratory Notebooks To Automate Manual Data Collection Processes

Robert D. WallaPresented At PITTCON 2003Orlando, FL

Astrix Technology GroupGlobal Solutions Provider To The Regulated Community

Develop And Integrate Data Develop And Integrate Data Management Solutions For Scientific Management Solutions For Scientific

OrganizationsOrganizations

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Data Collection• LIMS Development And Customization• Instrument Workstations• PDA Applications – Remote Data Collection

Data Storage• Data Warehouse Solutions • Data Synchronization • Remote Access Via Web

Data Retrieval• Data Miming• Statistical Analysis• Reporting

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Benefits Of Electronic Data CaptureBenefits Of Electronic Data Capture

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Increases Researcher And Organizational Efficiency Increases Researcher And Organizational Efficiency Increases Quality By Eliminating Manual Data Entry and Increases Quality By Eliminating Manual Data Entry and

Resulting Transcription Errors Resulting Transcription Errors Knowledge RetentionKnowledge Retention Facilitates Access To Data Across The EnterpriseFacilitates Access To Data Across The Enterprise Decreases Product Development CyclesDecreases Product Development Cycles Decreases CostsDecreases Costs

Laboratory Automation Laboratory Automation Market ObservationsMarket Observations

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Laboratory AutomationLaboratory AutomationThe Early YearsThe Early Years

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Data Kept In Paper Formo Notebookso Instrument Printoutso Strip Charts

Tremendous Strides in the Automation of Analytical Techniques

Laboratory AutomationLaboratory Automation1980 - 19991980 - 1999

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Improvements in Data Capture And Processing From Automated Instruments (i.e. Chromatography Data Acquisition Systems)

Introduction Of LIMS o Initially Internally Developed Systemso Commercial LIMS Vendorso Expanded System Functionality To Address

Administrative Requirements, i.e. Sample Tracking, Reporting, Financials, etc.

The Modern LaboratoryThe Modern Laboratory

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Still An Incredible Volume Of Paper• Sample Prep Logs• QA/QC Logs• Observational Analysis• Diagrams/Drawings/Pictures• Researcher Notes

Electronic Laboratory Notebooks Envisioned As The Next Generation System

DriversDrivers

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Elimination of Re-Work (30-70% in Research Environments)

Ability To Use and Share Negative Results High Throughput Screening of Materials and

Formulations Regulations Workforce Turnover/Knowledge Retention

What is an Electronic Lab Notebook?What is an Electronic Lab Notebook?

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Mobile PDA Application? Standalone PC Application? Data Warehouse? LIMS? Document Management System? Scientific Data Management Systems?

Case StudiesCase Studies

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Electronic Notebook That Collects Process Water Chemistry and Equipment Operational Data.

Used by Customers To More Efficiently Manage Cooling Water Systems, Including Functionality For Trend Analysis, Benchmarking and Predictive Modeling.

Case Study 1

Client: Global Water Treatment Company

Case Study 1Case Study 1Global Water Treatment CompanyGlobal Water Treatment Company

Electronic NotebookElectronic Notebook

PC Based Application Introduced in 1998 Deployed In Over 3000 Sites In 12 Countries

Used By Company Representatives Installed At Client Facilities

Provided Valuable Functionality To Client Company Used Data To Predict System Failures Reduced Total Operational Cost

Case Study 1Case Study 1

Electronic Notebook Allowed Customers To View And Analyze Trends

Case Study 1 SuccessCase Study 1 Success

A Company Vice President stated “The A Company Vice President stated “The implementation of Astrix’s system implementation of Astrix’s system leveraged over $ 7.5 million in increased leveraged over $ 7.5 million in increased sales for our Industrial Services sales for our Industrial Services Division in one year.”Division in one year.”

A Company Vice President stated “The A Company Vice President stated “The implementation of Astrix’s system implementation of Astrix’s system leveraged over $ 7.5 million in increased leveraged over $ 7.5 million in increased sales for our Industrial Services sales for our Industrial Services Division in one year.”Division in one year.”

Electronic Notebook To Collect Physical, Performance And Exposure Data On Architectural And Automotive Finishes.

Developed To More Efficiently Capture And Share Research And Development Data. Included The Integration Of Existing Data Systems.

Case Study 2

Client: Global Coatings Company

Case Study 2Case Study 2Global Coatings CompanyGlobal Coatings Company

Electronic NotebookElectronic Notebook

PDA Application Developed Using Visual Basic Used By 120 Scientists Data Synchronization To Data Warehouse Desktop Application Printed Paper Copy For Inclusion

In Paper Lab Notebook Linked Data From LIMS At Manufacturing Sites Developed Web Query Application

Case Study 2Case Study 2

Coating and Colorings Data Coating and Colorings Data WarehouseWarehouse

System TopologySystem Topology

LIMS

LIMS

Formulations Db

Test Data Entry Via Palm

Coatings and ColorantsData Warehouse

Data Access Via Brio Reports

DesktopApplication for

Excel output andsynchronization

Commercial Electronic Notebook Data Capture Product That Collects GLP Regulatory Data For Chemical Registrations. Operates in 5 Languages and Being Used Worldwide By 70% of The Agrichemical Industry.

Case Study 3

Case Study 3Case Study 3Agrichemical IndustryAgrichemical IndustryElectronic NotebookElectronic Notebook

Tablet PC Application Introduced in 1995 Used by Over 70% of the Agrichemical Market

Fortune 50 Chemical Companies Independent Contract Research Organizations

Over 7000 Trials Conducted With FieldNotes GLP Compliant Passed EPA Audits and Regulatory Submissions Operates In Five Languages

Measurable ROIMeasurable ROI

Dr. John Murphy, Director of Residue Dr. John Murphy, Director of Residue Chemistry, Bayer Corporation said "Our Chemistry, Bayer Corporation said "Our Program was budgeted at $2.41 million dollars. Program was budgeted at $2.41 million dollars. We were able to conduct the program for We were able to conduct the program for $1.43 million. We would not realized these $1.43 million. We would not realized these efficiency gains had we not had Astrix’s efficiency gains had we not had Astrix’s assistance. Even with the cost of this assistance. Even with the cost of this assistance factored in we saved $970,000.”assistance factored in we saved $970,000.”

Dr. John Murphy, Director of Residue Dr. John Murphy, Director of Residue Chemistry, Bayer Corporation said "Our Chemistry, Bayer Corporation said "Our Program was budgeted at $2.41 million dollars. Program was budgeted at $2.41 million dollars. We were able to conduct the program for We were able to conduct the program for $1.43 million. We would not realized these $1.43 million. We would not realized these efficiency gains had we not had Astrix’s efficiency gains had we not had Astrix’s assistance. Even with the cost of this assistance. Even with the cost of this assistance factored in we saved $970,000.”assistance factored in we saved $970,000.”

Case Study 3

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Despite The Advance In Automation There Remains Despite The Advance In Automation There Remains

Significant Manual Data Collection Processes Significant Manual Data Collection Processes

Electronic Notebooks Are “What You Need Them To Be” Electronic Notebooks Are “What You Need Them To Be”

Technology (Hardware/Software) Is Available And Technology (Hardware/Software) Is Available And

ImprovingImproving

Progressive Companies Are Taking Iterative Steps And Progressive Companies Are Taking Iterative Steps And

Realizing Near Term Benefits and ROI Realizing Near Term Benefits and ROI

ConclusionsConclusions

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Comments or Questions:

Robert D. Walla 732-661-0400

www.astrixsoftware.com

Astrix Technology GroupGlobal Solutions Provider To The Regulated Community