the use of high-risk donors decreases one-year survival in high-risk lung recipients matthew...
TRANSCRIPT
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The use of high-risk donors decreases one-year survival in high-risk lung
recipients
Matthew Mulligan, Pablo G Sanchez, Charles F Evans, Sina Rahimpour, Irina Timofte, Keshava Rajagopal,
Aldo T Iacono, June Kim, James S Gammie, Bartley P Griffith, Si M Pham
University of Maryland School of Medicine
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Disclosure• I have no conflicts of interest
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• 56% of lung transplants used extended donors (Reyes 2010)
• Use not associated with reduced survival (Gabbay 1999; Bhorade 2000; Orens 2003; Meers 2010)
• Paucity of data on matching donor quality and recipient severity
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• Single Institutional review
• Use of extended donors not associated with reduced survival in extended recipients
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High-Risk Donors
&High-Risk Recipients
Poor Outcomes
Clinical Impression
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We hypothesize that use of high-risk donors with high-risk recipients is associated with decreased 1-year survival
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Methods• Review of UNOS Database
– 2005-2012– Post LAS
• 9,015 Transplant Recipients• Inclusion: ≥18 years old• Exclusion: ECMO, Re-transplants
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High-Risk Donors
Low-Risk Donors Low-Risk Recipients
High-Risk Recipients
Vs.
Outcomes:• 1-year transplant survival• 1-year post registration survival
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Donor Risk Stratification
• High-Risk Donors?
• Multivariable Cox-hazard regressions
• Deviations from ideal donor factors on 1-year transplant survival
Bhorade et al. JHLT 2000
Standard Donor Criteria
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Donor Risk Stratification
Donor Variables HR (95% CI)
Age≥55 1.2 (1.1-1.5)
Cigarette Use ≥ 20 P-Y 1.2 (1.0-1.4)
Diabetes 1.3 (1.1-1.6)
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Donor Risk Stratification
Donor Variables Hazard Ratio (95% CI)
PaO2≤300 1.0 (0.9-1.1)
Abnormal Chest X-Ray 0.9 (0.8-1.0)Purulent Secretions 1.0 (0.9-1.2)
Blood Infection 1.0 (0.8-1.2)
No association
with1-year
survival
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Donor Risk Stratification
High-Risk Donors
Age≥55 or
Smoking ≥20 pack-years
orDiabetes
24% (n=2,155)
Low-Risk Donors
Everyone else
76% (n=6,680)
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Recipient Risk Stratification• High-Risk Recipients?
• LAS≥60 associated with decrease in survival after transplant (Liu 2010)
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Recipient Risk Stratification
High-Risk Recipients
LAS≥60
8% (n=679)
Low-Risk Recipients
LAS<60
92% (n=8,336)
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OUTCOMES
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1-Year Transplant Survival
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• Lower survival associated with high-risk donors in high-risk recipients
• Benefit of using high-risk donors over no transplantation?
• 1-year post registration survival
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1-Year Post-Registration Survival
• Waitlist Mortality
• Candidates not transplanted
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Summary• Independent donor variables that affect 1-year survival
– age≥55, smoking≥20 P-Ys, diabetes High-risk Donor
• High-risk donors in recipients with LAS<60: marginal survival disadvantage
• High-risk donors in recipients with LAS≥60: markedly decreased survival
• Nevertheless high-risk donors into high-risk recipients: better survival than no transplant.
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Conclusion• First large database analysis demonstrating
that matching donor quality with recipient status is critical to achieve optimal outcomes in lung transplantation
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Thank You