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The Value of 3 Tesla Magnetic Resonance Imaging for the Detection and Aggressiveness Assessment of Prostate Cancer

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  • The Value of 3 Tesla Magnetic ResonanceImaging for the Detection and Aggressiveness

    Assessment of Prostate Cancer

    - From Theory to Practice -

    THOMAS HAMBROCK

    SIEMENS

  • The Value of 3 Tesla Magnetic Resonance Imaging for the Detection and Aggressivenes

    Assessment of Prostate Cancer

    From Theory to Practice

    THOMAS HAMBROCK

    1

  • The studies presented in this thesis were carried out at the Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, This project was supported by the Queen Wilhelmina Fund from the Dutch Cancer Society.

    Nov 2012

    Copyright Thomas Hambrock

    Publisher:

    ISBN:

    2

    'UXNNHULM(IFLsQW1LMPHJHQ

    .

    978-90-9027256-6

    Nov 2012

    Copyright Thomas Hambrock

    Publisher: Drukkerij Efficint Nijmegen

    ISBN: 978-90-902756-6

  • The Value of 3 Tesla Magnetic Resonance Imaging for the Detection and Aggressivenes

    Assessment of Prostate Cancer

    From Theory to Practice

    PROEFSCHRIFT

    TER VERKRIJGING VAN DE GRAAD VAN DOCTOR AAN DE RADBOUD UNIVERSITEIT NIJMEGEN OP GEZAG VAN DE RECTOR MAGNIFICUS, PROF.

    MR. S.C.J.J. KORTMANN, VOLGENS BESLUIT VAN HET COLLEGE VAN DECANEN IN HET OPENBAAR TE VERDEDIGEN OP DINSDAG 4 DECEMBER

    2012 OM 13:30 UUR PRECIES

    DOOR

    THOMAS HAMBROCK

    GEBOREN OP 1 SEPTEMBER 1978 TE PRETORIA, ZUID-AFRIKA

    3

  • PROMOTOR : Prof. dr. J.O. Barentsz

    COPROMOTOREN : Dr. ir. H.J. Huisman

    Dr. ir. T.W.J. Scheenen

    Dr. C.A. Hulsbergen-van de Kaa

    MANUSCRIPTCOMMISIE : Prof. dr. J. van Krieken

    Dr. E. van Lin

    Prof. dr. A. Villers (University of Lille)

    4

    PROMOTOR : Prof. dr. J.O. Barentsz

    COPROMOTOREN : Dr. ir. H.J. Huisman

    Dr. ir. T.W.J. Scheenen

    Dr. C.A. Hulsbergen-van de Kaa

    MANUSCRIPTCOMMISIE : Prof. dr. J. van Krieken

    Dr. E. van Lin

    Prof. dr. G. Villeirs (University of Gent)

  • Dedicated to my grandfather . . . . . .

    HERMANN AUGUST HAMBROCK * 8. MAY 1907 -

    Who died at the young age of 63 years due to metastatic prostate cancer.

    5

  • ,WLVIXWLOHWRSRQGHURQWKHPHDQLQJRIOLIH Sir Bertrand Russels (1872-1970)

    6

  • Table of Contents

    PART ONE - INTRODUCTION AND BACKGROUND

    Chapter 1 . . . . 11 28

    Introduction.

    Chapter 2 . . . . 29 59

    Background to functional MR imaging.

    PART TWO - DETECTION OF PRIMARY AND RECURRENT PROSTATE CANCER -

    Chapter 3 . . . . 61 82

    32-Channel 3T MR guided biopsies of prostate tumor suspicious regions identified on multi-

    modality 3T MR imaging : Technique and feasibility. Invest Radiol 2009[HAMBROCK T,

    FTTERER JJ, HUISMAN HJ et al.]{Impact factor 4.7}

    Chapter 4 . . . . 83 100

    MRI guided prostate biopsies in men with repetitive negative biopsies and elevated PSA.

    J Urol 2010 [HAMBROCK T, SOMFORD DM, HOEKS C et al.]{Impact factor 3.9}

    Chapter 5 . . . . 101 114

    MR guided prostate biopsies of DCE-MR imaging suspicious tumor regions for the diagnosis

    of prostate cancer following radiotherapy. Invest Radiol 2010 [YAKAR D; HAMBROCK T,

    HUISMAN HJ et al.] {Impact factor 4.7}

    Chapter 6 . . . . 115 140

    Multiparametric MR imaging for detection and localization of low vs. high-grade transition

    zone prostate cancer. Radiology Accepted [HOEKS C, HAMBROCK T, YAKAR D et al.]

    {Impact factor 6.1}

    7

  • Table of Contents

    PART THREE - ASSESSMENT OF PROSTATE CANCER AGGRESSIVENESS -

    Chapter 7 . . . . 142 -165

    The Relation of Apparent Diffusion Coefficient and prostate cancer Gleason grade in

    Peripheral Zone. Radiology 2011 [HAMBROCK T, SOMFORD DM, HUISMAN HJ et al.]

    {Impact factor 6.1}

    Chapter 8 . . . . 166 182

    Initial experience with identifying high-grade prostate cancer using diffusion-weighted MR

    imaging in patie -guided biopsy. Invest

    Radiol2012[HAMBROCK T, SOMFORD DM, OORT I et al.]{Impact factor 4.7}

    Chapter 9 . . . . 183 199

    In vivo assessment of prostate cancer aggressiveness using three-dimensional proton MR

    spectroscopy at 3T with the combined endorectal coil and pelvic phased array coil. Eur

    Urol 2011[KOBUS T, HAMBROCK T, HULSBERGEN C et al.] {Impact factor 8.8}

    Chapter 10 . . . . 200 219

    Prospective Assessment of Prostate Cancer Aggressiveness using 3 Tesla diffusion weighted

    MR imaging guided biopsies versus a systematic 10-Core transrectal ultrasound prostate

    biopsy cohort Eur Urol 2012 [HAMBROCK T, HOEKS C, HULSBERGEN C et al.] {Impact

    factor 8.8}

    PART 4 CALIBRATION/COMPUTER ASSISTED DIAGNOSIS OF PROSTATE CANCER -

    Chapter 11 . . . . 221 236

    The effect of inter-patient normal peripheral zone apparent diffusion coefficient variation

    on the prediction of prostate cancer aggressiveness. (Radiology Accepted) [LITJENS G,

    HAMBROCK T, BARENTSZ JO et al.]{Impact factor 6.1}

    Chapter 12 . . . . 238 259

    Computer-aided diagnosis of prostate cancer using multiparametric 3T MR imaging: Effect

    on observer performance. Radiology Accepted[HAMBROCK T, VOS P, BARENTSZ JO et

    al.] {Impact factor 6.1}

    8

    Table of Contents

    PART THREE - ASSESSMENT OF PROSTATE CANCER AGGRESSIVENESS -

    Chapter 7 . . . . 142 -164

    The Relation of Apparent Diffusion Coefficient and prostate cancer Gleason grade in

    Peripheral Zone. Radiology 2011 [HAMBROCK T, SOMFORD DM, HUISMAN HJ et al.]

    {Impact factor 6.1}

    Chapter 8 . . . . 165 182

    Initial experience with identifying high-grade prostate cancer using diffusion-weighted MR

    imaging in patie -guided biopsy. Invest

    Radiol2012[HAMBROCK T, SOMFORD DM, OORT I et al.]{Impact factor 4.7}

    Chapter 9 . . . . 183 199

    In vivo assessment of prostate cancer aggressiveness using three-dimensional proton MR

    spectroscopy at 3T with the combined endorectal coil and pelvic phased array coil. Eur

    Urol 2011[KOBUS T, HAMBROCK T, HULSBERGEN C et al.] {Impact factor 8.8}

    Chapter 10 . . . . 200 220

    Prospective Assessment of Prostate Cancer Aggressiveness using 3 Tesla diffusion weighted

    MR imaging guided biopsies versus a systematic 10-Core transrectal ultrasound prostate

    biopsy cohort Eur Urol 2012 [HAMBROCK T, HOEKS C, HULSBERGEN C et al.] {Impact

    factor 8.8}

    PART 4 CALIBRATION/COMPUTER ASSISTED DIAGNOSIS OF PROSTATE CANCER -

    Chapter 11 . . . . 221 236

    The effect of inter-patient normal peripheral zone apparent diffusion coefficient variation

    on the prediction of prostate cancer aggressiveness. (Radiology Accepted) [LITJENS G,

    HAMBROCK T, BARENTSZ JO et al.]{Impact factor 6.1}

    Chapter 12

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