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CHRISTOPHE SCHILLING, Ph.D.

TAGLIO DI PO, ROVIGO, ITALY

SEPTEMBER 30TH, 2016

THE VALUE OF A STRATEGIC PARTNERSHIP TO BUILD TECHNOLOGICAL

LEADERSHIP

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4 Strategic Partnership for the Bioeconomy…starting with BDO Collaboration grounded in shared principles that drive successful commercialization of high impact technologies

pioneering innovation mindset

belief in the power of biotechnology

passion for sustainable development

Genomatica Innovation Center San Diego, California

About Genomatica

• Bioengineering Technologies for the chemical industry • Privately-held, founded in 2000 • San Diego, California a US biotechnology hub • ~ 80 employees • > 50% advanced technical/business degrees

6 Bioengineering innovations disrupting traditional value chains Complete platform to “industrialize” biotechnology; combining synthetic biology and bioprocess engineering

7 Driving Technologies from Concept to Commercial Realization

Core competencies across computation, experimentation, and bioprocessing, all tightly integrated

optimizing cell factories

integrating process design & engineering

engineering enzyme components

high fidelity scaling to commercial

Enabling Science& Discoveries

CommercialRealization

in silico design &prototyping pathways

guiding with techno-economics

Innovation Engine systems bioengineering

optimalpathway

bank

Lab Pilot Demo Commercial

$/ton

Scalable Engineering

Idea Conception & Modeling Analysis

8 Global Symbol for the Bioeconomy Novamont’s Mater-Biotech BDO Plant harnesses the power of biotechnology with the Genomatica GENO BDO Process

9 Ideation and design of the optimal BDO Organism - 2007 Metabolic Engineering designs for the first organism to produce 1,4-Butanediol from sugars

Carbohydrates

1,4-Butanediol

O

HO OHOH

OHHO

six-carbon sugars (ex. dextrose)

five-carbon sugars (e.x. xylose)

disaccharides (ex. sucrose)

10 The First BDO Producting Organisms - 2008 Genetically engineering E. Coli bacteria converting sugar into 1,4-butanediol

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O

HO

OH

OH

OH

OPO3

O

OH

OH

HO

HO

OPO3

“Single Step Biocatalyst” converting Sugar into Butanediol Sequence of biochemical reactions convert sugar into BDO inside the organism

O

HO

OH

OH

OH

HO

O

OPO3

OH

HO

HO

OPO3

OH

O

OPO3

O

OH

OPO3

OPO3

OH

OPO3

O

OPO3

OH

OPO3

O

OH

OH

OPO3

O

OH

OH

OPO3

O

OH

OPO3

OH

O

OH

OPO3

OH

O

OH

OPO3

O

OH

OPO3

O

Dextrose Sugar 1,4-Butanediol

12 Purified 1,4-Butanediol - 2009 Designed and tested full process to produce on-spec BDO from sugars

13 Scaling-up the GENO BDO Process – 2010 to 2013 Move from Lab-Scale to Commercial-Scale validation with partners facilities and cooperation

3,000 Liter piloting

2010

Integrated Demonstration Plant

2011

Shipping Tons of Product

2012

Commercial Scale Campaigns

2013

14 The Journey toward the Mater-Biotech BDO Plant Setting new standards, 5 years concept to commercial scale, and now the world’s first dedicated bio-BDO plant

Mater-Biotech BDO Plant

family of biodegradable & compostable bioplastics

• enabling strategic partnership

• world’s 1st bio-based plant for a major intermediate chemical

• differentiated BDO applications

3,000L

13,000L

2013…Commercial scale

2012 campaignsShipping tons

2011Integrated demo plant

2010Piloting

2009Purified BDO

2008BDO producing organisms

GENO BDOTM Process Technology

15 Potential to serve existing BDO market applications $4B global market producing 2 Million tons – exact same chemical made a better way

1,4-Butanediol(BDO)

THFTetrahydrofuran

PBTPolybutylene Terephthalate

Spandex / Elastane

Polyurethane

Polyester

GBLGamma-Butyrolactone

Direct useDerivativesDownstream

Exact same chemical …now made a better way

16 Driving a Broader Transformation toward Green Chemicals Technologies targeting Large Existing Markets in Basic, Intermediate, and Specialty Chemicals

Applications for Renewables packaging apparel automotive carpeting cosmetics personal care nutraceuticals

Volume

$/ton

* Not to scale

Pharma, FlavorFragrance

Intermediate Chemicals ~30 products Ave. $9Bn each

Butadiene$20Bn+

BDO $4Bn

CPL$10Bn

ADA$6Bn

HMD$3Bn

Basic Chemicals 7 products Ave. $37Bn each

Specialty Chemicals 100’s of products $100M-1Bn each

$1-2Tn Core of the Chemical Industry

Genomatica Process Technologies

17 Accelerating the Pace of Bioprocess Technology Development New Strategic Alliance between Genomatica and Ginkgo Bioworks, a leader in organism engineering

• New alliance announced September 29 between technology leaders with highly complementary platforms

• Brings more capabilities to rapidly engineer organisms leveraging automation and ‘semi-conductor like’ foundries

• Advances in biotechnology continue to reduce the cost of R&D, and accelerate the potential for new technologies

18 Bright Future for the Bioeconomy Combined Team of Talented Passionate People have made this Achievement Possible

Team Novamont – leadership, vision, courage, drive, and determination

Investors – financiers supporting Novamont, Genomatica, and the Mater-Biotech project

National & Regional Support – openness to local revitalization and a bioeconomy vision

Mater-Biotech Team – dedication in construction, commissioning, start-up, and operations

On behalf of everyone at Genomatica we wish to acknowledge and provide our deepest thanks to:

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CHRISTOPHE SCHILLING, Ph.D.

TAGLIO DI PO, ROVIGO, ITALY

SEPTEMBER 30TH, 2016

THE VALUE OF A STRATEGIC PARTNERSHIP TO BUILD TECHNOLOGICAL

LEADERSHIP

20 Bio-based Butadiene together with Versalis Joint Venture developing combined technology for renewable butadiene with a annual volumes 10x larger than BDO

100% bio-based poly-butadiene synthetic rubber – February 2016

most advanced program for renewable & on-purpose butadiene