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    TherapeuticUltrasound

    lecture VIII

    Dr. Amaal H.M.Ebrahim

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    Introduction

    Therapeutic

    ultrasound (US) is

    one of the most

    common physical

    agents used in

    rehabilitation.

    Ultrasound is amechanical not

    electric energy.

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    Introduction

    Ultrasound is a form of a caustic vibration

    propagated in the form of longitudinal waves

    consisting of areas of compression and

    rarefaction at frequencies too high and cannot

    be heard by human ears

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    IntroductionParticles of a material, when exposed to a sound

    wave will oscillate about a fixed point rather than

    move with the wave itself. As the energy within the

    second wave is passed to the material it will causeoscillation of the particles of that material. Clearly

    any increase in the molecular vibration in the tissue

    can result in heat

    generation, and ultrasound can be used to produce

    thermal changes in the tissues.

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    Introduction Sound waves of audible range are within

    frequency 20Hz to 20000Hz. Waves below

    these frequencies are called infrasonic

    waves.

    The amplitude of a longitudinal wave is the

    greatest distance which a particle moves from

    its rest position.

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    Introduction The wave length of longitudinal wave is the

    distance from the middle of one compression tothe middle of the next.

    If the frequency is 1MHz and the velocity is

    about 1500m.s in water and tissue, then thedistance from the compression to

    another will be one millionth of 1500m, or 1.5

    mm. At higher frequencies the wave length will be

    less.

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    The Frequency

    The frequency of longitudinal wave motion is the number of thecomplete waves which pass a fixed point in unit time.

    Velocity = Frequency x Wave length.

    Most medical applications employ frequencies between 1MHzand 15 MHz:

    1- Physiotherapy equipment has frequency 0.75MHz,

    0.87MHz, 1MHz, 1.5MHz, 3MHz.

    2- Diagnostic equipment has frequency between 1MHz and10MHz.

    3- Surgical equipment has frequency between 1MHz and5MHz.

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    Propagation and speed of

    ultrasound waves The human body processes a characteristic

    resistance against the propagation of

    ultrasound. Each tissue in the body has a

    characteristic impedance (Z).

    It is directly proportional to the velocity of

    propagation (V) and the density (P) of the

    tissue.

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    The brothers, Pierre and Jacques Curie,

    discovered that when a quartz crystal is

    stressed, a potential difference is produced

    across its faces. This is called piezoelectriceffect. In 1917 Langevin discovered that by

    vibrating a quartz crystal with a high

    frequency alternating current ultrasoundcould be produced.

    Production of US

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    Production of US Piezoelectric effect: is the ability of some materials

    (notably crystals and certain ceramics) to generate an

    electric potential in response to applied mechanical

    stress. When crystals are deformed (compressed),they produce small electric charges. The electropiezo

    effect (reverse of piezoelectric effect) occurs when an

    electrical current passed through a crystal causes the

    crystal expand or contract.

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    Production of US Using the electropiezo effect, ultrasound units produce high

    frequency waves by passing an alternating current through a

    piezoelectric crystal. The higher the current's frequency, the

    higher the frequency of the ultrasonic output.

    Crystal usually vibrates at a natural frequency which depends

    largely on its thickness. The frequency of vibration remains

    constant for a given generator, but the intensity, in terms of

    amplitude can be varied.

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    he ultrasonic generator

    The therapeutic ultrasonic valve generator produces a

    high frequency AC from about 0.75MHz to 3MHz. the

    resonant frequency of the current is at the same

    natural frequency as thatof the crystal. The high frequency current is applied to

    the crystal.

    In front of the crystal lies the transducer head which is

    made to vibrate mechanically by the acoustic

    vibration energy of the crystal.

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    he ultrasonic generator

    The transducer or treatment head is a crystal inserted

    between two electrodes. The crystal translates the

    electrical oscillations directly into mechanical

    vibrations which pass through a metal cap into thebody through the coupling medium

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    he ultrasonic generator

    For therapeutic purposes the applicator should have

    a radiating surface which is slightly smaller than the

    total applicator surface.

    This makes it easier to maintain full contact betweenthe head and the treatment area.

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    he ultrasonic generator

    When the machine is switched on the frequency

    energy applied to the crystal is increased to the

    required level. The average ultrasonic

    intensity is expressed in watts per square centimeter

    (w.cm). it is obtained by measuring the total output

    of the applicator (power),

    and then dividing it by the size of the radiatingsurface of the applicator (area). Large applicators are

    preferable.

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    he ultrasonic generator

    As air is not dense enough to transmit ultrasonicenergy, a transmission medium is required to allowthe energy to pass from the sound head to the

    tissues. Sound waves cannot exit transducer when no medium is present. Operating the

    ultrasound unit when its head is not in contact with atransmission medium can damage its

    transducer. Many units have sensors that can detectwhen there is insufficient coupling and automaticallyshut down the generator.

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    he ultrasonic generator

    Once in the bodys tissues, the sound waves cause

    the molecules to vibrate, creating various thermal

    and mechanical effects. As the ultrasonic energy

    passes through the tissue layers and meets differentdensities, its energy attenuates.

    Ultrasound passes through water-rich tissues and

    preferentially heats those tissues

    that have a high collagen content.

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    SOME PHYSICAL PHENOMENA OF

    ULTRASOUND

    Reflection

    When ultrasound passes from one medium to

    another it is important to know the acoustic

    impedance (Z) of each medium.

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    SOME PHYSICAL PHENOMENA OF

    ULTRASOUND

    Reflection

    If there is an acoustic

    mismatch between the two

    media a certain amount ofreflection will occur at the

    interface between the media.

    If the two media have the

    same characteristic acousticimpedance there will be no

    reflection

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    SOME PHYSICAL PHENOMENA OF

    ULTRASOUNDBone periosteum interface

    As periosteum and bone tissue have different acoustic

    impedance, about 70% of the energy is reflected,and the balance

    (30%) is absorbed by the bone. The total load on the periosteum

    is equal to the total incident power plus the reflected power. This

    causes shear waves to occur around the periosteum. The particles

    of both media oscillate at right angles to the direction of

    propagation and, as the wavelength is different in each medium,

    the particles move in different directions and cause a shear stressat the boundary.

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    SOME PHYSICAL PHENOMENA OF

    ULTRASOUND

    Bone periosteum interface

    This is called a shear stress wave, and is rapidly absorbed at the

    periosteum. The periosteum is a vascular, and no cooling effect

    occurs, so it quickly heats up and causes a periosteal pain. Thepatient will soon complain of the heating sensation, because the

    periosteum is temperature-sensitive

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    SOME PHYSICAL PHENOMENA OF

    ULTRASOUND

    Tissue-air interface

    Reflection also occurs at tissue-air interface.

    Here air acts as a reflector, and the ultrasound beam is reflected

    back to the surface of the tissue area being treated. Excessiveheating will occur, causing a heating pain in the skin. This can

    occur if ultrasound is given to a thin area such as the palm of the

    hand.

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    SOME PHYSICAL PHENOMENA OF

    ULTRASOUND

    Transducer head-skin interface with an air pocket

    If the metal of the ultrasound head and the tissue arenot completely intact with another and there is a small

    air pocket, reflection in the transducer head will cause

    excessive heating of the head and the skin lead to

    danger of burn

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    SOME PHYSICAL PHENOMENA OF

    ULTRASOUND

    Refraction

    When the angle of the incidence is 15degree, refraction of a beam is 90 degreeand will run parallel to the interface.Refraction is deviation that meansultrasonic energy invades the tissue atone angle and continues at a differentangle (angle of refraction). Only for

    angles of incidence of less than 15degree will any energy pass into thetissue refraction occurs particularlywhere tendon join bone and lead toconcentration of energy

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    Transmission of Ultrasound

    For ultrasound to be an effective

    agent, the US wave must be

    transmitted from the unit to the tissue

    via a conducting medium. The most common transmission

    mediums include US gel, mineral oil,

    lotions, gel pads, and water.

    Ultrasound gels and pads appear to bethe best conducting mediums.

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    Transmission of Ultrasound

    . Ultrasound treatments conducted when the target

    tissue is immersed in water are often used for areas

    with irregular surfaces where it is difficult tomaintain contact on the treatment area. However,

    immersed ultrasound is not as effective as

    ultrasound applied directly to the tissue via gel

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    Transmission of Ultrasound

    Another consideration with ultrasound is the type of tissue

    being treated, or what tissue the US must travel through to

    reach the target. Ultrasound energy is absorbed at different

    rates by different tissues and this is related to both the waterand protein content of the tissue.

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    Transmission of Ultrasound

    Skin and adipose tissue absorb less acoustic energy than

    muscle, tendon, and ligament. Nerve tissue and bone absorb

    the greatest amount of US energy. Therefore, you should

    consider not only the depth of the tissue to be treated, butalso the type of tissue when determining treatment

    parameters

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    Transmission of Ultrasound

    Attenuation: is the progressive loss of the acoustic power as

    ultrasonic travels through a medium. The amount of

    attenuation varies from tissue to tissue. Attenuation is linear

    and inversely proportional to the frequency. If the frequencyis changed from 1MHz to 3MHz the attenuation in muscle

    changes from 2% to 6% per millimeter. For a frequency of

    3MHz, attenuation is 50%

    at 25 millimeter, while at 0.75MHz the attenuation is 50% at90 millimeter

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    Transmission of Ultrasound

    Absorption of ultrasound: it is generally accepted that absorption of

    ultrasound energy takes place at molecular level, the proteins are the

    major absorbers. The protein in nerve is sensitive to ultrasound. Muscles

    absorb twice as much as fat. The viscosity of the medium opposes the

    particle motion, and so absorption of energy occurs. Absorption ofultrasonic energy depends on the following

    1- Acoustic impedance of the tissue.

    2- Propagation velocity of sound.

    3- Density of tissue.

    4- Frequency of ultrasound

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    Transmission of Ultrasound

    5- Protein content.

    6- Fat and water content.

    7- Angle of incidence of acoustic energy. 8- Viscosity of fluid.

    9- Reflection.

    10- Refraction. 11- Shear waves.

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    Pulsed Ultrasound

    Most ultrasound generator gives pulsed ultrasound

    of 2 ms (2 thousands of second) pulses. The ratio of

    pulse time to the off

    time is variable from 1:1 to 1:4 modes, or as the dutycycle, which is the ratio of the pulse time to the total

    time of pulse and pulse interval represented as a

    percentage

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    Pulsed Ultrasound

    If pulsed ultrasound is applied at a mark

    : space ratio of 1:1 the amount of

    introduced energy is one-half of thatintroduced by continuous ultrasound

    applied for the same period of time and

    the same intensity.

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    Pulsed Ultrasound

    So the therapist can apply pulsed ultrasound withthe same intensity but with double time oftreatment or double the intensity with the sametime of application to produce the same amount of

    ultrasound energy. Yet the effect is not the same as continuous

    ultrasound because with pulsed ultrasound there istime for the heat to be dissipated by conduction in

    the tissues and in the circulating blood. The pulsedultrasound is safety because the average heating isreduced.

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    Effect of Pulsed Ultrasound

    1- Increase rates of ion diffusion across cell

    membrane due to increase particle movement

    on the either side of the membrane.

    2- Increase motion of the phospholipids and

    proteins that form the membrane.

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    Beam Characteristics

    Beam Profile

    Ultrasound generatorsproduce an irregularly-shapedbeam. This is caused by thewaves originating from manyindividual points on the face ofthe transducer. As this energytravels away from the

    transducer, it merges with otherwaves forming areas of peakintensity known as hot spots.

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    Beam Characteristics

    Beam Non Uniformity Ratio

    The output intensity presented on the ultrasound

    unit's meter represents the average output within the

    beam's near field in total watts or W/cm2

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    Spatial Average Intensity

    Ultrasonic output

    may be measured

    either in terms of

    total watts (W) or

    watts per square

    centimeter

    (W/cm2), thespatial average

    intensity (SAI).

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    Spatial Average Intensity

    In the examplesabove, 10 watts

    being passed

    through an effective

    radiating area of 10cm2 results in a SAI

    of 1.0 W/cm2.

    Passing 10 watts

    through a 5 cm2

    ERA doubles the

    SAI to 2.0 w/cm

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    Beam Divergence

    An ultrasound beam tends

    to diverge as it leaves the

    sound head. The degree ofdivergence is dependent on

    the size of the sound head

    and the output frequency.

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    Beam Divergence

    Ultrasound having a frequency of 1 MHz

    produces a more divergent beam than 3

    MHz ultrasound, which produces a

    collimating beam.

    Likewise, sound heads having a smaller

    ERA produce a more divergent beamthan heads having a larger ERA.

    O P (C i d

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    Output Parameters (Continuous and

    pulsed US) Duty Cycle

    Ultrasound can be delivered to the body using

    continuous (thermal) or pulsed (non-thermal)

    modes. The duty cycle is the relationship betweenthe pulse length (on time) and the pulse interval (off

    time)

    O P (C i d

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    Output Parameters (Continuous and

    pulsed US) Duty Cycle

    Duty cycle is calculated by:

    Duty cycle = Pulse length / (Pulse length + Pulse

    interval) X100 Higher duty cycles primarily produce thermal

    effects within the body. Lower duty cycles result in

    predominantly mechanical (non-thermal) effects

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    Physiological effects of ultrasound

    The sonic energy that absorbed from ultrasound

    causes oscillation of particles about their mean

    position. This sonic energy is converted into heat

    energy which is proportional to the ultrasoundintensity and causing thermal effects in the tissues.

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    Thermal Effects

    The thermal effect increases tissue temperature

    which must be maintained between 40 and 45C for

    at least 5 minutes.

    Heating fibrous tissue structures such as jointcapsules, ligaments, tendons and scar tissue can

    cause a temporary increase in their extensibility and

    hence a decrease in joint stiffness.

    Mild heating can reducing pain and muscle spasmand promoting healing processes.

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    Non-thermal Effects

    a-Cavitation

    Is a very small gas bubble filled

    voids within the tissues and

    body fluids. There are twotypes, first, stable cavitations

    which are tine bubbles

    oscillate to and fro within theultrasound pressure waves but

    remain intact.

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    Non-thermal Effects

    a-Cavitation Second, unstable cavitations

    (transient or collapsed) areformation of tiny bubbles with

    changing volume at high intensities. The collapsed

    bubbles causing high pressureand

    temperature changes areresulting in gross damage totissue.

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    Non-thermal Effects

    b- Acoustic streaming

    As a result of both types of cavitations, thereis a very small localized unidirectional fluid

    movement around the vibrating bubbles andcells called acoustic streaming. These acousticstreaming is affecting the permeability of cellmembrane leading to alter the rate of

    diffusion and permeability of ions across cellmembrane.

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    Non-thermal Effects

    b-Acoustic streaming

    For example, calcium which is a second

    messenger may result in the stimulationof healing processes. Also sodium may

    alter the electrical activity of nerves

    leading to relief pain.

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    Non-thermal Effects

    c-Standing waves

    The reflected waves of ultrasound causestationary waves with peaks of high pressure

    (antinodes) and another with no pressure(nodes). This pressure pattern causes stasis ofcells in blood stream exposing the epitheliumof the blood vessels to damage, (thrombosis

    formation).

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    Non-thermal Effects

    d-Micromassage

    Micromassage is a mechanical effect

    cause molecules to vibrate, possiblyenhance tissue inter change and affect

    tissue mobility.

    It can used to reduce edema.

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    Non-thermal Effects

    e-Role of US in Tissue Repair

    US plays an important role in enhancement of

    tissue repair and reduces of inflammation as

    follow :

    1- During acute stage (inflammation)

    a-US produces gentle agitation of the tissue

    fluid causing stimulation of histamine andother growth factors from mast cells.

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    Non-thermal Effects

    e-Role of US in tissue repair

    1- During acute stage (inflammation)

    b- US increases calcium ion diffusion across thecell membrane causing degranulation.

    c- US increases the rate of phagocytosis and themovement of particles and cells.

    d- US has a pro-inflammatory action not ananti- inflammatory action.

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    Non-thermal Effects

    e-Role of US in tissue repair 2- Granulation stage:

    Start approximately three days after injury.

    a- Connective tissue framework is laid down by

    flbroblasts.

    b- US promote collagen synthesis (due to increase cellmembrane permeability.

    c- US allow the entry of calcium ions for more control of

    cellular activity.

    d- US encourage the growth of new capillaries in chronicischemic tissues.

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    Non-thermal Effects

    e-Role of US in tissue repair

    3- Remodeling stage

    This stage takes months or years.

    a- US can improve the extensibility of mature

    collagen (scar tissue).

    b- This is believed to occur by promoting the

    reorientation of the fibers leading to more

    elasticity without loss of strength.